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1.
Braz J Med Biol Res ; 24(2): 215-7, 1991.
Artigo em Inglês | MEDLINE | ID: mdl-1823234

RESUMO

Rats weighing 100 +/- 8 g were used in an in vivo kinetic study of the intestinal absorption of calcium (CaA) from three systems: 1) CaCl2, 2) whole cow's milk (M), and 3) a staple Brazilian diet (SBD). Food substrates were treated with HCl, neutralized and diluted with 0.15 mM NaCl to different concentrations. Each dilution was assayed by introducing 2 ml into the small intestine and the final amount of Ca2+ in the small intestine was determined 30 min later. The values for velocity (v = Vmax (Ca2+)/(Ca2+) + Km) and affinity (1/Km) for the food substrates were 1.35, 15.51 and 2.31 micrograms Ca2+/min and 0.29, 0.016 and 0.266 micrograms Ca2+/ml, respectively. We conclude that the higher affinities observed for CaCl2 and SBD were not correlated with velocity. Factors modifying CaA appear to be protein (stimulator) and phytate and fiber (inhibitors).


Assuntos
Cálcio/farmacocinética , Absorção Intestinal , Intestino Delgado/metabolismo , Animais , Cloreto de Cálcio/farmacologia , Dieta , Masculino , Leite , Ratos
2.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;24(2): 215-7, 1991. tab
Artigo em Inglês | LILACS | ID: lil-99459

RESUMO

Rats weighing 100 ñ 8 g were used in an in vivo kinetic study of the intestinal absorption of calcium (CaA) from there systems: 1) CaCl2, 2) whole cow's milk (M), and 3) a taple Brazilian diet (SBD). Food substrates were treated with HCl, neutralized and diluted with 0.15 mM NaCl to different concentrations. Each dilution was assayed by introducing 2 ml into the small intestine and the final amount of Ca*+ in the small intestine was determined 30 min later. The values for velocity (v= Vmax (Ca*+ in the small intestine was determined 30 min later. The values for velocity (v+Vmax (Ca*+)/(Ca*+) + Km) and affinity (1/Km) for the food substrates were 1.35, 15.51 and 2.31 *g Ca*+/min and 0.29, 0,016 and 0.266 *g Ca*+/ml, respectively. We conclude that the higher affinities observed for CaCl2 and SBD were not correlated with velocity. Factors modifying CaA appear to be protein (stimulator) and phylate and fiber (inhibitors)


Assuntos
Ratos , Animais , Masculino , Cálcio/farmacocinética , Absorção Intestinal , Intestino Delgado/metabolismo , Cloreto de Cálcio/farmacologia , Dieta , Leite
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