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1.
Mem Inst Oswaldo Cruz ; 113(7): e180040, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29742198

RESUMO

Cryptococcus neoformans is an opportunistic fungal pathogen that is ubiquitous in the environment. It causes a deadly meningitis that is responsible for over 180,000 deaths worldwide each year, including 15% of all AIDS-related deaths. The high mortality rates for this infection, even with treatment, suggest a need for improved therapy. Unique characteristics of C. neoformans may suggest directions for drug discovery. These include features of three structures that surround the cell: the plasma membrane, the cell wall around it, and the outermost polysaccharide capsule. We review current knowledge of the fundamental biology of these fascinating structures and highlight open questions in the field, with the goal of stimulating further investigation that will advance basic knowledge and human health.


Assuntos
Cryptococcus neoformans , Cápsulas Fúngicas/metabolismo , Proteínas Fúngicas/biossíntese , Polissacarídeos/biossíntese , Parede Celular , Cryptococcus neoformans/química , Cryptococcus neoformans/citologia , Cryptococcus neoformans/patogenicidade , Virulência
2.
Mem. Inst. Oswaldo Cruz ; 113(7): e180040, 2018. graf
Artigo em Inglês | LILACS | ID: biblio-894938

RESUMO

Cryptococcus neoformans is an opportunistic fungal pathogen that is ubiquitous in the environment. It causes a deadly meningitis that is responsible for over 180,000 deaths worldwide each year, including 15% of all AIDS-related deaths. The high mortality rates for this infection, even with treatment, suggest a need for improved therapy. Unique characteristics of C. neoformans may suggest directions for drug discovery. These include features of three structures that surround the cell: the plasma membrane, the cell wall around it, and the outermost polysaccharide capsule. We review current knowledge of the fundamental biology of these fascinating structures and highlight open questions in the field, with the goal of stimulating further investigation that will advance basic knowledge and human health.


Assuntos
Humanos , Polissacarídeos , Cryptococcus neoformans , Membrana Celular , Parede Celular
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