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Peeling the onion: the outer layers of Cryptococcus neoformans
Agustinho, Daniel P; Miller, Liza C; Li, Lucy X; Doering, Tamara L.
Afiliação
  • Agustinho, Daniel P; Washington University School of Medicine. Department of Molecular Microbiology. St. Louis. US
  • Miller, Liza C; Washington University School of Medicine. Department of Molecular Microbiology. St. Louis. US
  • Li, Lucy X; Washington University School of Medicine. Department of Molecular Microbiology. St. Louis. US
  • Doering, Tamara L; Washington University School of Medicine. Department of Molecular Microbiology. St. Louis. US
Mem. Inst. Oswaldo Cruz ; 113(7): e180040, 2018. graf
Article em En | LILACS | ID: biblio-894938
Biblioteca responsável: BR1.1
ABSTRACT
Cryptococcus neoformans is an opportunistic fungal pathogen that is ubiquitous in the environment. It causes a deadly meningitis that is responsible for over 180,000 deaths worldwide each year, including 15% of all AIDS-related deaths. The high mortality rates for this infection, even with treatment, suggest a need for improved therapy. Unique characteristics of C. neoformans may suggest directions for drug discovery. These include features of three structures that surround the cell the plasma membrane, the cell wall around it, and the outermost polysaccharide capsule. We review current knowledge of the fundamental biology of these fascinating structures and highlight open questions in the field, with the goal of stimulating further investigation that will advance basic knowledge and human health.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Polissacarídeos / Cryptococcus neoformans Limite: Humans Idioma: En Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: MEDICINA TROPICAL / PARASITOLOGIA Ano de publicação: 2018 Tipo de documento: Article / Project document País de afiliação: Estados Unidos País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Polissacarídeos / Cryptococcus neoformans Limite: Humans Idioma: En Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: MEDICINA TROPICAL / PARASITOLOGIA Ano de publicação: 2018 Tipo de documento: Article / Project document País de afiliação: Estados Unidos País de publicação: Brasil