Peeling the onion: the outer layers of Cryptococcus neoformans.
Mem Inst Oswaldo Cruz
; 113(7): e180040, 2018.
Article
em En
| MEDLINE
| ID: mdl-29742198
Cryptococcus neoformans is an opportunistic fungal pathogen that is ubiquitous in the environment. It causes a deadly meningitis that is responsible for over 180,000 deaths worldwide each year, including 15% of all AIDS-related deaths. The high mortality rates for this infection, even with treatment, suggest a need for improved therapy. Unique characteristics of C. neoformans may suggest directions for drug discovery. These include features of three structures that surround the cell: the plasma membrane, the cell wall around it, and the outermost polysaccharide capsule. We review current knowledge of the fundamental biology of these fascinating structures and highlight open questions in the field, with the goal of stimulating further investigation that will advance basic knowledge and human health.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Proteínas Fúngicas
/
Cryptococcus neoformans
/
Cápsulas Fúngicas
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Brasil