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Peeling the onion: the outer layers of Cryptococcus neoformans.
Agustinho, Daniel P; Miller, Liza C; Li, Lucy X; Doering, Tamara L.
Afiliação
  • Agustinho DP; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Miller LC; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Li LX; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Doering TL; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Mem Inst Oswaldo Cruz ; 113(7): e180040, 2018.
Article em En | MEDLINE | ID: mdl-29742198
Cryptococcus neoformans is an opportunistic fungal pathogen that is ubiquitous in the environment. It causes a deadly meningitis that is responsible for over 180,000 deaths worldwide each year, including 15% of all AIDS-related deaths. The high mortality rates for this infection, even with treatment, suggest a need for improved therapy. Unique characteristics of C. neoformans may suggest directions for drug discovery. These include features of three structures that surround the cell: the plasma membrane, the cell wall around it, and the outermost polysaccharide capsule. We review current knowledge of the fundamental biology of these fascinating structures and highlight open questions in the field, with the goal of stimulating further investigation that will advance basic knowledge and human health.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeos / Proteínas Fúngicas / Cryptococcus neoformans / Cápsulas Fúngicas Idioma: En Revista: Mem Inst Oswaldo Cruz Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polissacarídeos / Proteínas Fúngicas / Cryptococcus neoformans / Cápsulas Fúngicas Idioma: En Revista: Mem Inst Oswaldo Cruz Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Brasil