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1.
J. bras. nefrol ; 46(1): 29-38, Mar. 2024. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1534776

RESUMO

Abstract Introduction: Glomerulonephritis are the third cause of chronic kidney disease (CKD) requiring dialysis in Brazil. Mineral and bone disorder (MBD) is one of the complications of CKD and is already present in the early stages. Assessment of carotid intima-media thickness (CIMT) and flow-mediated vasodilatation (FMV) are non-invasive ways of assessing cardiovascular risk. Hypothesis: Patients with primary glomerulonephritis (PG) have high prevalence of atherosclerosis and endothelial dysfunction, not fully explained by traditional risk factors, but probably influenced by the early onset of MBD. Objective: To evaluate the main markers of atherosclerosis in patients with PG. Method: Clinical, observational, cross-sectional and controlled study. Patients with PG were included and those under 18 years of age, pregnants, those with less than three months of follow-up and those with secondary glomerulonephritis were excluded. Those who, at the time of exams collection, had proteinuria higher than 6 grams/24 hours and using prednisone at doses higher than 0.2 mg/kg/day were also excluded. Results: 95 patients were included, 88 collected the exams, 1 was excluded and 23 did not undergo the ultrasound scan. Patients with PG had a higher mean CIMT compared to controls (0.66 versus 0.60), p = 0.003. After multivariate analysis, age and values for systolic blood pressure (SBP), FMV and GFR (p = 0.02); and FMV and serum uric acid (p = 0.048) remained statistically relevant. Discussion and conclusion: The higher cardiovascular risk in patients with PG was not explained by early MBD. Randomized and multicentric clinical studies are necessary to better assess this hypothesis.


Resumo Introdução: Glomerulopatias são a terceira causa de doença renal crônica (DRC) com necessidade de diálise no Brasil. Distúrbio mineral e ósseo (DMO) é uma das complicações da DRC e está presente já nos estágios iniciais. A avaliação da espessura médio-intimal de carótidas (EMIC) e da vasodilatação fluxo-mediada (VFM) são maneiras não invasivas de avaliação do risco cardiovascular. Hipótese: Pacientes com glomerulopatias primárias (GP) apresentam alta prevalência de aterosclerose e disfunção endotelial, não explicada totalmente pelos fatores de risco tradicionais, mas provavelmente influenciada pela instalação precoce do DMO. Objetivo: Avaliar os principais marcadores de aterosclerose em pacientes com GP. Método: Estudo clínico, observacional, transversal e controlado. Foram incluídos portadores de GP e excluídos menores de 18 anos, gestantes, menos de três meses de seguimento e os com glomerulopatia secundária. Também foram excluídos aqueles que, no momento da coleta, apresentavam proteinúria maior que 6 gramas/24 horas e uso de prednisona em doses superiores a 0,2 mg/kg/dia. Resultados: 95 pacientes foram incluídos, 88 colheram os exames, 1 foi excluído e 23 não realizaram a ultrassonografia. Os pacientes com GP apresentaram maior EMIC média em relação ao controle (0,66 versus 0,60), p = 0,003. Após análise multivariada, mantiveram relevância estatística a idade e os valores de pressão arterial sistólica (PAS), VFM e TFG (p = 0,02) e VFM e ácido úrico sérico (p = 0,048). Discussão e conclusão: Pacientes com GP apresentaram maior risco cardiovascular, entretanto esse risco não foi explicitado pelo DMO precoce. Estudos clínicos randomizados e multicêntricos são necessários para melhor determinação dessa hipótese.

2.
J Bras Nefrol ; 46(1): 29-38, 2024.
Artigo em Inglês, Português | MEDLINE | ID: mdl-36638246

RESUMO

INTRODUCTION: Glomerulonephritis are the third cause of chronic kidney disease (CKD) requiring dialysis in Brazil. Mineral and bone disorder (MBD) is one of the complications of CKD and is already present in the early stages. Assessment of carotid intima-media thickness (CIMT) and flow-mediated vasodilatation (FMV) are non-invasive ways of assessing cardiovascular risk. HYPOTHESIS: Patients with primary glomerulonephritis (PG) have high prevalence of atherosclerosis and endothelial dysfunction, not fully explained by traditional risk factors, but probably influenced by the early onset of MBD. OBJECTIVE: To evaluate the main markers of atherosclerosis in patients with PG. METHOD: Clinical, observational, cross-sectional and controlled study. Patients with PG were included and those under 18 years of age, pregnants, those with less than three months of follow-up and those with secondary glomerulonephritis were excluded. Those who, at the time of exams collection, had proteinuria higher than 6 grams/24 hours and using prednisone at doses higher than 0.2 mg/kg/day were also excluded. RESULTS: 95 patients were included, 88 collected the exams, 1 was excluded and 23 did not undergo the ultrasound scan. Patients with PG had a higher mean CIMT compared to controls (0.66 versus 0.60), p = 0.003. After multivariate analysis, age and values for systolic blood pressure (SBP), FMV and GFR (p = 0.02); and FMV and serum uric acid (p = 0.048) remained statistically relevant. DISCUSSION AND CONCLUSION: The higher cardiovascular risk in patients with PG was not explained by early MBD. Randomized and multicentric clinical studies are necessary to better assess this hypothesis.


Assuntos
Aterosclerose , Glomerulonefrite , Insuficiência Renal Crônica , Adulto , Feminino , Humanos , Aterosclerose/complicações , Espessura Intima-Media Carotídea , Estudos Transversais , Glomerulonefrite/complicações , Diálise Renal , Fatores de Risco , Ácido Úrico
3.
Int Urol Nephrol ; 56(5): 1669-1676, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-37964112

RESUMO

BACKGROUND: Mineral and bone disease in children with chronic kidney disease can cause abnormalities in calcium, phosphorus, parathyroid hormone, and vitamin D and when left untreated can result in impaired growth, bone deformities, fractures, and vascular calcification. Cinacalcet is a calcimimetic widely used as a therapy to reduce parathyroid hormone levels in the adult population, with hypocalcemia among its side effects. The analysis of safety in the pediatric population is questioned due to the scarcity of randomized clinical trials in this group. OBJECTIVE: To assess the onset of symptomatic hypocalcemia or other adverse events (serious or non-serious) with the use of cinacalcet in children and adolescents with mineral and bone disorder in chronic kidney disease. DATA SOURCES AND STUDY ELIGIBILITY CRITERIA: The bibliographic search identified 2699 references from 1927 to August/2023 (57 LILACS, 44 Web of Science, 686 PubMed, 131 Cochrane, 1246 Scopus, 535 Embase). Four references were added from the bibliography of articles found and 12 references from the gray literature (Clinical Trials). Of the 77 studies analyzed in full, 68 were excluded because they did not meet the following criteria: population, types of studies, medication, publication types and 1 article that did not present results (gray literature). PARTICIPANTS AND INTERVENTIONS: There were 149 patients aged 0-18 years old with Chronic Kidney Disease and mineral bone disorder who received cinacalcet. STUDY APPRAISAL AND SYNTHESIS METHODS: Nine eligible studies were examined for study type, size, intervention, and reported outcomes. RESULTS: There was an incidence of 0.2% of fatal adverse events and 16% of serious adverse events (p < 0.01 and I2 = 69%), in addition to 10.7% of hypocalcemia, totaling 45.7% of total adverse events. LIMITATIONS: There was a bias in demographic information and clinical characteristics of patients in about 50% of the studies and the majority of the studies were case series. CONCLUSIONS AND IMPLICATIONS OF KEY FINDINGS: If used in the pediatric population, the calcimimetic cinacalcet should be carefully monitored for serum calcium levels and attention to possible adverse events, especially in children under 50 months. SYSTEMATIC REVIEW REGISTRATION NUMBER (PROSPERO REGISTER): CRD42019132809.


Assuntos
Doenças Ósseas , Distúrbio Mineral e Ósseo na Doença Renal Crônica , Hiperparatireoidismo Secundário , Hipocalcemia , Insuficiência Renal Crônica , Criança , Adulto , Humanos , Adolescente , Recém-Nascido , Lactente , Pré-Escolar , Cinacalcete/efeitos adversos , Cálcio , Calcimiméticos/efeitos adversos , Hipocalcemia/etiologia , Insuficiência Renal Crônica/terapia , Hormônio Paratireóideo , Minerais/uso terapêutico , Distúrbio Mineral e Ósseo na Doença Renal Crônica/etiologia , Distúrbio Mineral e Ósseo na Doença Renal Crônica/complicações , Hiperparatireoidismo Secundário/tratamento farmacológico , Hiperparatireoidismo Secundário/etiologia , Diálise Renal/efeitos adversos
4.
Eur J Clin Nutr ; 77(2): 292-294, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-36329200

RESUMO

BACKGROUND: Myostatin functions as a negative regulator of skeletal muscle growth. The association of myostatin with muscle parameters in dialysis patients is inconsistent, and there are no studies associating myostatin with physical function and outcomes in peritoneal dialysis (PD) patients. Therefore, we assessed the association of serum myostatin with lean mass, physical function, and hospitalization in a prospective cohort of PD patients. METHODS: Lean mass, physical function, and serum myostatin were assessed at baseline. Patients were followed up for at least 24 months and hospitalization was recorded. RESULTS: Serum myostatin levels were positively correlated with handgrip strength and Appendicular Lean Mass Index among male patients. Binary logistic regression models were performed including myostatin levels and physical function parameters as independent variables. Serum myostatin, handgrip strength, gait speed, and Short Physical Performance Battery were associated with hospitalization. CONCLUSION: Lower serum myostatin and physical function were associated with hospitalization in PD patients.


Assuntos
Músculo Esquelético , Diálise Peritoneal , Humanos , Masculino , Força da Mão , Estudos Prospectivos , Miostatina , Hospitalização
5.
BMC Nephrol ; 23(1): 289, 2022 08 18.
Artigo em Inglês | MEDLINE | ID: mdl-35982404

RESUMO

BACKGROUND: Restriction of sodium intake is routinely recommended for patients with chronic kidney disease (CKD). Whether or not sodium intake is associated with the progression of CKD and mortality remains uncertain. We evaluated the association between urinary sodium excretion (as a surrogate for sodium intake) with the occurrence of renal failure and mortality in patients with non-dialytic CKD. METHODS: We conducted a retrospective study of patients followed at a CKD clinic care hospital from October 2006 to March 2017. Adult patients with non-dialytic CKD were included. Using a time-to-event analysis, we examined the association of urinary sodium excretion as a categorical variable (categorized as quintiles: 1st quintile: 0.54-2.51 g; 2nd quintile: 2.52-3.11 g, 3rd quintile: 3.12-3.97 g, 4th quintile: 3.98-5.24 g and 5th quintile: 5.26-13.80 g) and the outcomes of interest. The primary outcome was defined as progression to end-stage renal disease requiring any type of renal replacement therapy. The secondary outcome was mortality. RESULTS: Two hundred five patients were included in the study (mean follow up of 2.6 years) with a mean eGFR of 26 (19-41) ml/min/1.73m2. 37 patients (18%) required renal replacement therapy and 52 (25,3%) died. There was association between urinary sodium excretion and need for renal replacement therapy (adjusted HR 0.245; 95%CI 0.660-0.912). There was no association between urinary sodium excretion and mortality in adjusted models. CONCLUSION: Moderate sodium intake was associated with a lower risk of renal failure.


Assuntos
Falência Renal Crônica , Insuficiência Renal Crônica , Insuficiência Renal , Adulto , Progressão da Doença , Humanos , Falência Renal Crônica/complicações , Falência Renal Crônica/terapia , Insuficiência Renal/complicações , Insuficiência Renal Crônica/complicações , Estudos Retrospectivos , Sódio
6.
J Ren Nutr ; 32(6): 739-743, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-35131413

RESUMO

OBJECTIVE: The aim is to verify the association between nutritional status and muscle strength, considering handgrip strength (HGS) cutoffs associated with sarcopenia and mortality. METHODS: Cross-sectional analysis, including hemodialysis patients. Malnutrition Inflammation Score (MIS) was used to assess nutritional status. Muscle function was assessed by HGS, and the considered cutoffs were established by other studies. Cutoffs for sarcopenia diagnosis were 27 and 16 kg for males and females, respectively; cutoffs associated with mortality were 22 and 7 kg for males and females, respectively. Two binary logistic regression models were built, with HGS categorized according to the cutoff for sarcopenia and mortality as dependent variables. RESULTS: Of the 218 patients who were included, 56.9% were male, the mean age was 58.3 years, and 44.7% diabetic; 132 patients (60.6%) had HGS <27 or 16 kg. Age, prevalence of diabetes, and MIS were higher, creatinine and albumin were lower in patients with HGS below these values; 77 patients (35.2%) had HGS <22 or 7 kg. Age, male, and diabetes prevalence, CRP and MIS were higher, midarm muscle circumference (MAMC), creatinine, albumin, and urea were lower in patients with HGS below these values. In the logistic regression MIS (OR 1.202; 95% CI 1.073-1.347; P < .01), age, male, diabetes, and MAMC were associated with the risk of HGS below the cutoffs for sarcopenia. MIS (OR 1.322; 95% CI 1.192-1.467; P < .01), age, male, and diabetes were associated with the risk of HGS below the cutoffs associated with mortality. CONCLUSION: Worse nutritional status increases the risk of HGS below the cutoffs associated with sarcopenia and mortality in hemodialysis patients.


Assuntos
Diabetes Mellitus , Desnutrição , Sarcopenia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Força da Mão/fisiologia , Sarcopenia/epidemiologia , Estudos Transversais , Creatinina , Desnutrição/epidemiologia , Diálise Renal , Estado Nutricional , Inflamação , Albuminas
7.
PLoS One ; 16(9): e0257293, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34506599

RESUMO

Several methods have been proposed for analyzing differences between test scores, such as using mean scores, cumulative deviation, and mixed-effect models. Here, we explore the pooled analysis of retested Progress Test items to monitor the performance of first-year medical students who were exposed to a new curriculum design. This was a cross-sectional study of students in their first year of a medical program who participated in the annual interinstitutional Progress Tests from 2013 to 2019. We analyzed the performance of first-year students in the 2019 test and compared it with that of first-year students taking the test from 2013 to 2018 and encountering the same items. For each item, we calculated odds ratios with 95% confidence intervals; we also performed meta-analyses with fixed effects for each content area in the pooled analysis and presented the odds ratio (OR) with a 95% confidence interval (CI). In all, we used 63 items, which were divided into basic sciences, internal medicine, pediatrics, surgery, obstetrics and gynecology, and public health. Significant differences were found between groups in basic sciences (OR = 1.172 [CI95% 1.005 CI 1.366], p = 0.043) and public health (OR = 1.54 [CI95% CI 1.25-1.897], p < 0.001), which may reflect the characteristics of the new curriculum. Thus, pooled analysis of pretested items may provide indicators of different performance. This method may complement analysis of score differences on benchmark assessments.


Assuntos
Currículo , Educação de Graduação em Medicina/métodos , Modelos Educacionais , Estudantes de Medicina , Benchmarking , Brasil , Estudos Transversais , Avaliação Educacional , Humanos , Estudos Longitudinais , Modelos Estatísticos , Razão de Chances , Reprodutibilidade dos Testes , Faculdades de Medicina
8.
Front Nutr ; 8: 686245, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34136523

RESUMO

Introduction: Muscle mass depletion, overhydration, and inflammatory state have been related to impaired physical function in chronic kidney disease patients. The relationship between bioelectrical impedance analysis (BIA) parameters, such as hydration status and phase angle (PhA), with physical function in peritoneal dialysis (PD), is still not well-established. Therefore, the objective was to evaluate the association of BIA parameters (overhydration index and PhA) and inflammatory markers with physical function in patients on PD. Methods: The present cross-sectional study enrolled PD patients. Multifrequency BIA was performed to obtain overhydration index and PhA. The Short Physical Performance Battery (SPPB) test battery was applied to assess physical function. The time to complete the 4-m gait test and sit-to-stand test was also considered for physical function assessment. The inflammatory markers tumor necrosis factor-alpha and C-reactive protein levels were determined. Multiple linear regression models were performed, with the physical function variables as dependent variables, adjusted for age, diabetes, and sex. Results: Forty-nine PD patients were enrolled, 53.1% (n = 26) women; mean age, 55.5 ± 16.3 years. There were significant correlations between PhA and SPPB (r = 0.550, p < 0.001), time of 4-m gait test (r = -0.613, p < 0.001) and sit-to-stand test and (r = -0.547, p < 0.001). Overhydration index was significantly correlated with SPPB, 4-m gait test (r = 0.339, p = 0.017), and sit-to-stand test (r = 0.335, p = 0.019). Inflammatory markers were not significantly correlated with physical function parameters. In the multiple linear regression analysis, PhA was associated with physical function parameters, even after adjustments. Overhydration index was associated with all physical function tests only in the models with no adjustments. Conclusion: PhA was independently associated with physical function in PD patients. Inflammatory markers and overhydration index were not associated with physical function.

9.
Kidney Res Clin Pract ; 40(2): 294-303, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34078025

RESUMO

BACKGROUND: Due to the poor outcomes associated with the impairment of physical function and muscle strength in patients on maintenance dialysis, it is important to understand the factors that may influence physical function and muscle strength. The aim of this study was to explore the factors associated with physical function in hemodialysis and peritoneal dialysis patients. METHODS: Patients with chronic kidney disease on dialysis for at least 3 months, aged 18 years old or above, were enrolled. Physical function was assessed by handgrip strength, gait and sit-to-stand tests, and the Short Physical Performance Battery (SPPB). Clinical and laboratory data were collected to verify the association with physical function parameters through binary logistic regression. RESULTS: One-hundred ninety patients on maintenance dialysis were included; 140 patients (73.7%) on hemodialysis and 50 (26.3%) on peritoneal dialysis. The mean age was 57.3 ± 14.9 years, 109 (57.4%) were male, and 87 (45.8%) were older than 60 years. The median SPPB was 8.0 points (6.0-10.0 points) and the mean ± standard deviation of handgrip strength was 24.7 ± 12.2 kg. Binary logistic regression showed that age, type of renal replacement therapy, diabetes mellitus, and serum creatinine were significantly associated with both higher 4-meter gait test times and lower SPPB scores. Only age and diabetes mellitus were associated with higher sit-to-stand test times, while age and ferritin were associated with lower handgrip strength. CONCLUSION: Age, diabetes mellitus, serum creatinine, and hemodialysis modality are factors related to physical function in dialysis patients.

11.
Hemodial Int ; 2021 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-33694274

RESUMO

Morphological, molecular, and physiological effects of vitamin D on skeletal muscle have been analyzed both in animals and humans. Vitamin D may be a potential therapeutic for increasing muscle mass and function. The presence of vitamin D receptors in skeletal muscle cells is already established. However, there is still need for more evidence about the effect of vitamin D on muscle. Some studies have associated vitamin D and skeletal muscle in chronic kidney disease (CKD) patients; most of these studies enrolled hemodialysis patients. FGF-23 and Klotho were recently described in mineral and bone disorders in CKD, resulting in reductions in calcitriol levels. Therefore, both Klotho and FGF-23 may play a role in muscle loss in CKD, which is related to morbidity and mortality risk. Therefore, this article presents a narrative review, aiming to discuss the available information associating skeletal muscle and vitamin D, highlighting the results in CKD and dialysis patients.

12.
Perit Dial Int ; 41(2): 244-252, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-32223522

RESUMO

BACKGROUND: Few studies have evaluated the viability and outcomes between peritoneal dialysis (PD) and haemodialysis (HD) in urgent-start renal replacement therapy (RRT). This study aimed to compare infectious and mechanical complications related to urgent-start PD and HD. Secondary outcomes were to identify risk factors for complications and mortality related to urgent-start dialysis. METHODS: A quasi-experimental study with incident patients receiving PD and HD in a Brazilian university hospital, between July 2014 and December 2017. Subjects included individuals with final-stage chronic kidney disease who required immediate RRT, that is, HD through central venous catheter or PD in which the catheter was implanted by a nephrologist and utilized for 72 h, without previous training. Patients with PD were subjected, initially, to high-volume PD for metabolic compensation. After hospital discharge, they remained in intermittent PD in the dialysis unit until training was completed. Mechanical and infectious complications were compared, as well as the recovery of renal function and survival. RESULTS: In total, 93 patients were included in PD and 91 in HD. PD and HD groups were similar regarding age (58 ± 17 vs. 60 ± 15 years; p = 0.49), frequency of diabetes mellitus (37.6% vs. 50.5%; p = 0.10), other comorbidities (74.1% vs. 71.4%; p = 0.67) and biochemical parameters at the beginning of RRT, that is, creatinine (9.1 ± 4.1 vs. 8.0 ± 2.8; p = 0.09), serum albumin (3.1 ± 0.6 vs. 3.3 ± 0.6; p = 0.06) and haemoglobin (9.5 ± 1.8 vs. 9.8 ± 2.0; p = 0.44). After a minimum follow-up period of 180 days and a maximum follow-up period of 2 years, there was no difference regarding mechanical complications (24.7% vs. 37.4%; p = 0.06) or bacteraemia (15.0% vs. 24.0%; p = 0.11); however, there was a difference regarding infection of the exit site (25.8% vs. 39.5%; p = 0.04) and diuresis maintenance [700 (0-1500) vs. 0 (0-500); p < 0.001], with better results in the PD group. There was better phosphorus control at 180 days in the PD group (62.4% vs. 41.8%; p = 0.008), with a lower requirement for phosphate binder usage (28% vs. 55%; p < 0.001), erythropoietin (18.3% vs. 49.5%; p < 0.001) and anti-hypertensives (11.8% vs. 30.8%; p = 0.003). Time to death was similar between groups. In the multivariate analysis, PD was a predictor of renal function recovery [odds ratio: 3.95 (1.01-15.4)]. CONCLUSION: PD is a viable and safe alternative to HD in a scenario of urgent-start RRT with complication rates and outcomes similar to those of HD, highlighting the results regarding renal function recovery.


Assuntos
Falência Renal Crônica , Diálise Peritoneal , Diálise Renal , Insuficiência Renal Crônica , Brasil , Cateterismo , Hospitais Universitários , Humanos , Falência Renal Crônica/terapia , Diálise Peritoneal/efeitos adversos , Diálise Renal/efeitos adversos
13.
J Ren Nutr ; 31(3): 320-326, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-32958375

RESUMO

OBJECTIVES: After dialysis initiation, a high protein diet is recommended due to significant nutrient losses through dialysate and increased risk of protein energy wasting. In peritoneal dialysis (PD) patients, protein intake can be assessed through different methods that have some advantages and limitations, which affect its use on routine care. The aim of this study is to evaluate the agreement between 2 different methods (24-hour dietary recall and PNA-protein equivalent of total nitrogen appearance) on estimating protein intake in PD patients. DESIGN AND METHODS: Patients on PD for at least 3 months, aged 18 years old or more, were enrolled. To estimate protein intake, 24-hour dietary recall and PNA was used. PNA was calculated from 24-hour urine on the same day of the 24-hour dietary recall. RESULTS: Fifty individuals on PD were included, mean age 55.7 ± 16.2 years, and body mass index 26.0 ± 4.5 kg/m2. The average energy consumption was 1788.79 ± 504.40 kcal/day, which corresponds to 26.81 ± 9.11 kcal/kg current body weight (BW)/day and 29.82 ± 8.39 kcal/kg ideal body weight (IBW)/day. The median of total daily and normalized protein intake estimated using dietary recall was 61.43 (45.28-87.40) g/day, 0.90 (0.58-1.22) g/kg current BW/day, and 1.04 (0.77-1.32) g/kg IBW/day, respectively. Daily protein intake estimated by PNA was 55.75 (48.27-67.74) g/day, protein intake normalized by current BW was 0.81 (0.72-0.99) g/kg and 0.92 (0.83-1.06) g/kg IBW/day. Bland-Altman analysis indicates no systematic bias for the assessment of total protein intake and normalized protein intake for current and ideal BW. Significant proportionality bias was observed for both evaluations, showing there is a dispersion of the values. CONCLUSIONS: Despite the absence of systematic bias in the Bland-Altman analysis, there is no agreement in the assessment of protein intake by dietary recall and PNA, due to the existence of proportionality bias. Thus, values can be influenced biased by the magnitude of the measures.


Assuntos
Nitrogênio , Diálise Peritoneal , Adolescente , Adulto , Idoso , Soluções para Diálise , Proteínas Alimentares , Humanos , Pessoa de Meia-Idade , Diálise Renal
14.
Int Urol Nephrol ; 53(2): 373-380, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32804344

RESUMO

PURPOSE: Peritonitis is a serious complication of peritoneal dialysis and coagulase-negative Staphylococcus (CNS) is the most frequent cause of peritoneal dialysis (PD)-infections in many centers. This study aimed to investigate the molecular epidemiology of CNS isolated from PD-peritonitis in a Brazilian single center, focusing on the genetic determinants conferring methicillin resistance. METHODS: Bacterial strains were isolated from peritoneal fluid of patients presenting PD-peritonitis, identified by phenotypic and molecular methods, and those identified as CNS were submitted to mecA detection, SCCmec, pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). RESULTS: Over the 18-year period of this study (1995-2011), a total of 878 peritonitis episodes were diagnosed in this unit, 115 were caused by coagulase-negative staphylococci of which 72 by Staphylococcus epidermidis. mecA gene was detected in 55 CNS (47.8%), more frequently on the more recent years. SCCmec type III was the most frequent cassette, followed by SCCmec type IV and SCCmec type II. A diverstity of pulsotypes was observed among the S. epidermidis isolates, but five clusters (based on the 80% cutoff) were identified. Diversified sequence types (ST02, ST05, ST06, ST09, ST23, ST59 and ST371) were detected. CONCLUSIONS: Detection of SCCmec type III among coagulase-negative Staphylococcus underscores the role of hospital environments as potential source of methicillin-resistant Staphylococcus causing peritonitis in PD patients.


Assuntos
Staphylococcus aureus Resistente à Meticilina/genética , Diálise Peritoneal/efeitos adversos , Peritonite/microbiologia , Infecções Estafilocócicas/diagnóstico , Infecções Estafilocócicas/epidemiologia , Staphylococcus epidermidis/genética , Coagulase , Humanos , Incidência , Staphylococcus aureus Resistente à Meticilina/enzimologia , Staphylococcus aureus Resistente à Meticilina/isolamento & purificação , Técnicas de Diagnóstico Molecular/métodos , Epidemiologia Molecular/métodos , Estudos Retrospectivos , Infecções Estafilocócicas/microbiologia , Staphylococcus epidermidis/isolamento & purificação
16.
Rev. bras. educ. méd ; 45(3): e166, 2021. graf
Artigo em Português | LILACS | ID: biblio-1288312

RESUMO

Resumo: Introdução: A pandemia da Covid-19 provocou milhares de mortes e levou a incontáveis mudanças na forma de organização de serviços de saúde e nas escolas de Medicina mundo afora. Relato de experiência: Este artigo relata a experiência da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista (Unesp), cujas aulas foram suspensas em função da pandemia. Discussão: Descrevem-se as motivações para a suspensão e os procedimentos para a retomada das aulas do internato, depois de 15 semanas da interrupção. Conclusão: Ressalta-se a importância das decisões coletivas, da comunicação empática, do acolhimento e cuidado com a saúde mental e da parceria com o Hospital das Clínicas na realização de rastreamento para a presença do vírus entre os estudantes. Por fim, destaca-se o aprendizado para o professor ao se defrontar, por um lado, com a impotência diante da morte e do desconhecido, e, por outro, com a potência do cuidado que pode ser oferecido em situação tão singular quanto uma pandemia.


Abstract: Introduction: The COVID-19 pandemic has caused thousands of deaths and led to countless changes in the way health services and medical schools are organized around the world. Experience report: This article reports on the experience of the Botucatu Faculty of Medicine, UNESP, located in the interior of the state of São Paulo, where classes were suspended due to the pandemic. Discussion: The reasons for the suspension of internship classes and the procedures for their resumption, after 15 weeks, are described. Conclusions: The study highlights the importance of collective decisions, empathic communication, mental health care and attention and the partnership with the Hospital das Clínicas in performing track and trace for presence of the virus among the students. Finally, particular emphasis is given to the learning gained by teachers who found themselves feeling, on the one hand, powerless in the face of death and the unknown and, on the other, the strength of the care that can be offered in a situation as unique as the pandemic.


Assuntos
Humanos , Faculdades de Medicina/organização & administração , Estudantes de Medicina/psicologia , COVID-19/prevenção & controle , Ansiedade/psicologia , Medidas de Segurança , Mentores , Internato e Residência/organização & administração
17.
Rev. bras. educ. méd ; 45(supl.1): e113, 2021. tab, graf
Artigo em Português | LILACS | ID: biblio-1279865

RESUMO

Resumo: Introdução: O Programa de Mentoria da FMB foi construído coletivamente durante os anos 2018-2019, com assessoria externa e amplo apoio institucional. O sofrimento psíquico dos alunos de graduação nas áreas da saúde, já descrito na literatura, intensificou-se com a pandemia da Covid-19, fortalecendo a necessidade do programa para os primeiranistas dos cursos de Enfermagem e Medicina. Relato de experiência: Foram realizadas oficinas para formação do grupo gestor do programa e do grupo de mentores. Em agosto de 2020, após divulgação entre representantes e conselhos, a Oficina de Sensibilização com os primeiranistas teve grande adesão. A construção de um ambiente virtual caloroso, leve e lúdico foi prioridade do grupo, assim os mentores foram apresentados aos alunos, e estes receberam o convite para ingresso ao programa. Os alunos declararam suas preferências por seus mentores em questionário que ficou aberto por duas semanas. Formaram-se grupos foram que se encontraram ao menos mensalmente, para que pudessem construir ambientes de acolhimento e afetividade, e discutir temas de interesse e escolha dos alunos. O grupo gestor se reúne com mentores bimestralmente, de modo a priorizar espaços de trocas e compartilhamento das vivências, dos desafios e das superações, e construir um ambiente colaborativo de aprendizado mútuo. Na Enfermagem, a adesão dos alunos foi de 100%, e na Medicina, de 85%. As avaliações dos alunos sobre o programa foram muito positivas. Discussão: O programa propiciou ambiente de diálogo sobre a saúde física e mental, gestão do tempo e atividades acadêmicas, como iniciação científica e extensão universitária. Mentores, mentorados, grupo gestor e instituição vivenciaram momentos de construção de vínculo afetivo e ambiente colaborativo. Conclusão: O programa conseguiu ter visibilidade entre alunos, professores e profissionais, e está conseguindo se firmar como estratégia para resgatar a afetividade e humanizar as relações na instituição, num momento de tantas inseguranças, sofrimentos e desafios.


Abstract: Introduction: The FMB Mentoring Program was built collectively between 2018/19, with external advisory and institutional support. Mental suffering among undergraduate students in the health area is well known, but became more intense with the onset of the Covid-19 pandemic, and programs like mentoring have been especially necessary for first-year students. Experience Report: Workshops were held to create the program steering group and mentoring team. In August 2021, once the program had been presented to representatives and boards, the Awareness Raising Workshop was conducted with high student participation. The group prioritized the construction of a warm, light-hearted and playful virtual environment, and the mentors were introduced to the students in this vein, who in turn received the invitation to join the program. The students named their preferred mentors in a questionnaire that remained available for two weeks. The groups were formed and met at least once a month in a welcoming and affectionate setting to discuss issues of interest to and chosen by the students. The steering group meets with the mentors every two months, focusing on spaces for exchange and sharing of experiences: challenges faced and overcome, and building a collaborative environment of mutual learning. In Nursing, 100% of the students joined the program, and in Medicine, 85%. The student assessments of the program were very positive. Discussion: The program provided an environment of dialogue in mental and physical health, time management, and academic activities such as scientific initiation and university extension. Mentors, mentees, the steering group and institutional coordinators experienced moments of caring, collaboration and affection. Conclusion: The mentoring program attained visibility among students, teachers and professionals and is becoming established as a strategy to retrieve the caring and humanistic aspects of relations in the institution at a time of such uncertainty, suffering and challenges.


Assuntos
Humanos , Educação Médica/métodos , Educação em Enfermagem/métodos , Tutoria , COVID-19/psicologia , Faculdades de Medicina , Escolas de Enfermagem , Estudantes de Medicina/psicologia , Estudantes de Enfermagem/psicologia
18.
Blood Purif ; 49(6): 652-657, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32146464

RESUMO

Chronic kidney disease is a significant problem of public health worldwide, and up to 60% of patients start dialysis in an unplanned manner without a definitive dialysis access. Recently, peritoneal dialysis (PD) has emerged as an alternative to unplanned chronic dialytic method, and the world collective experience shows that PD can be an efficient, safe, and cost-effective alternative with comparable outcomes to the planned PD and urgent-start hemodialysis (HD). More importantly, as compared to urgent-start HD using a central venous catheter, urgent-start PD has significantly fewer incidences of catheter-related bloodstream infections, dialysis-related mechanical complications, and need for dialysis catheter reinsertions during the initial time of the therapy. An integrative review was conducted on PD urgent start compared to HD urgent start and to planned PD, identifying its potential advantages and limitations. Literature search was performed within multiple databases, and observational studies on clinical experience with urgent PD were reviewed and appraised.


Assuntos
Serviços Médicos de Emergência , Achados Incidentais , Diálise Peritoneal , Terapia de Substituição Renal , Brasil , Tomada de Decisão Clínica , Países em Desenvolvimento , Gerenciamento Clínico , Humanos , Falência Renal Crônica/diagnóstico , Falência Renal Crônica/terapia , Diálise Peritoneal/métodos , Insuficiência Renal Crônica/diagnóstico , Insuficiência Renal Crônica/terapia , Terapia de Substituição Renal/métodos
19.
Ren Fail ; 42(1): 225-233, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32126885

RESUMO

Introduction: Low vitamin D levels are associated with mortality in hemodialysis (HD) patients; however, the serum vitamin D thresholds are unclear. This study aimed to identify the vitamin D level below which mortality increases in HD patients.Methods: A cohort of HD patients enrolled from January 2014 to January 2017 was evaluated. The variables were analyzed according to the season, namely, summer, winter, and annual average, mortality was the primary outcome. The patients were assigned to vitamin D quintiles, and multivariate Cox regression analysis adjusted for age, ethnicity, gender, body mass index (BMI), inhibitors of the renin-angiotensin system, statin, calcitriol, and antiplatelet drugs use, hemodialysis vintage, hypertension, diabetes mellitus, atherosclerotic disease, and C-reactive protein was performed.Results: There were studied 306 patients. Vitamin D levels of 18.0-23.6 ng/mL (hazard ratio [HR] = 4.30; 95% confidence interval [CI] 1.60-11.54, p = 0.004) and <18.0 ng/mL (HR = 3.83; 95% CI: 1.42-10.35, p = 0.008) in summer and vitamin D levels of 21.5-27.1 ng/mL (HR = 3.70; 95% CI: 1.50-9.11, p = 0.004) and ≤17.5 ng/mL (HR = 2.84; 95% CI: 1.13-7.13, p = 0.026) in winter were associated with mortality. The average annual values of vitamin D associated with all-cause mortality were <17.7 ng/dL (adjusted HR = 4.25, 95% CI: 1.57-11.48, p = 0.004), and between >17.7 ng/dL and ≤23.1 ng/dL (adjusted HR = 3.91, 95% CI: 1.47-10.42, p = 0.006).Conclusions: Annual average vitamin D levels <23.1 ng/mL were associated with higher all-cause mortality, regardless of the confounding variables evaluated.


Assuntos
Falência Renal Crônica/sangue , Diálise Renal/mortalidade , Deficiência de Vitamina D/sangue , Vitamina D/sangue , Adulto , Idoso , Brasil/epidemiologia , Causas de Morte , Estudos de Coortes , Feminino , Humanos , Falência Renal Crônica/complicações , Masculino , Pessoa de Meia-Idade , Estações do Ano , Análise de Sobrevida , Deficiência de Vitamina D/mortalidade
20.
Eur J Clin Nutr ; 74(2): 357-358, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31831841

RESUMO

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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