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Vitamin D and skeletal muscle: A narrative review focusing on chronic kidney disease and dialysis.
Vogt, Barbara Perez; Caramori, Jacqueline Costa Teixeira.
Afiliação
  • Vogt BP; Graduate Program in Health Sciences, Medicine Faculty, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil.
  • Caramori JCT; Department of Internal Medicine, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Hemodial Int ; 2021 Mar 10.
Article em En | MEDLINE | ID: mdl-33694274
Morphological, molecular, and physiological effects of vitamin D on skeletal muscle have been analyzed both in animals and humans. Vitamin D may be a potential therapeutic for increasing muscle mass and function. The presence of vitamin D receptors in skeletal muscle cells is already established. However, there is still need for more evidence about the effect of vitamin D on muscle. Some studies have associated vitamin D and skeletal muscle in chronic kidney disease (CKD) patients; most of these studies enrolled hemodialysis patients. FGF-23 and Klotho were recently described in mineral and bone disorders in CKD, resulting in reductions in calcitriol levels. Therefore, both Klotho and FGF-23 may play a role in muscle loss in CKD, which is related to morbidity and mortality risk. Therefore, this article presents a narrative review, aiming to discuss the available information associating skeletal muscle and vitamin D, highlighting the results in CKD and dialysis patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Hemodial Int Assunto da revista: NEFROLOGIA / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Hemodial Int Assunto da revista: NEFROLOGIA / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá