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BACKGROUND: The International Trauma Questionnaire (ITQ) is used to measure posttraumatic stress disorder (PTSD) and complex posttraumatic stress disorder (CPTSD) symptoms, and the Posttraumatic Cognitions Inventory-9 (PTCI-9) is used to measure posttraumatic cognitions. Both tools have been translated for use in Brazil. However, the psychometric properties of the Brazilian versions were not investigated, and no study has verified the invariance of these tools for many traumatic event types. OBJECTIVE: This study examined the validity, reliability, and measurement invariance of the Brazilian versions of the ITQ and the PTCI-9 for trauma type, gender, race, age group, education level, and geographical region. METHODS: A total of 2,111 people (67.74% women) participated in an online survey. The scale models were tested via confirmatory factor analyses and measurement invariance through multigroup analyses. Pearson's correlation analyses were used to examine the relationships between PTSD, CPTSD, posttraumatic cognitions, and depressive symptoms. RESULTS: Except for the affective dysregulation factor, the reliabilities of the ITQ and PTCI-9 dimensions were adequate. Models with six correlated dimensions for the ITQ and three correlated dimensions for the PTCI-9 showed adequate fit to the data. The ITQ and PTCI-9 exhibited scalar invariance for gender, race, age group, education level, and geographical region. The ITQ also demonstrated full invariance for trauma type. The factors of both instruments were related to each other and to depressive symptoms, with higher effect sizes for posttraumatic cognitions and complex posttraumatic stress disorder symptoms. CONCLUSION: We recommend using the Brazilian versions of the ITQ and PTCI-9, which are crucial tools for assessing and treating trauma-related disorders.

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Following the Russian-Ukrainian conflict, the well-being of millions of Ukrainians has been jeopardised. This study aims to translate and test the psychometric features of the Ukrainian version of the General Health Questionnaire 12 (GHQ-12). The study included Ukrainian refugees housed in Verona (Italy) between November/2022 and February/2023. The Ukrainian translation was obtained through a 'forward-backward' translation. Questionnaire was completed by 141 refugees (females: 78.7%). Median age was 36 years (IQR 23-43). Individuals with a score suggestive of psychological distress were 97 (68.8%). Cronbach's coefficient was 0.84 (0.95CI 0.80-0.88). According to confirmatory factor analysis, both single- (modelB1) and two-factor (model B2) structures with bimodal scoring method fitted the data satisfactorily. The two factors of model B2 had a 0.88 correlation. Pearson coefficient showed a positive significant correlation between the GHQ-12 and International Trauma Questionnaire scores (ρ = 0.53, 0.95CI 0.40-0.64, p < 0.001). The GHQ-12 Ukrainian translation showed good psychometric features being a reliable and valid instrument to assess Ukrainian refugees' general well-being.

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BACKGROUND: The risks of oversimplification of the symptomatology of Complex PTSD (CPTSD) have been highlighted in the literature. OBJECTIVE: To re-examine 10 items representing disturbances in self-organization (DSO) that were deleted from the original 28-item version of the International Trauma Questionnaire (ITQ) when creating the current 12-item version. PARTICIPANTS AND SETTING: An online convenience sample of 1235 MTurk users. METHODS: Online survey comprising the fuller 28-item previous version of the ITQ, Adverse Childhood Experiences (ACEs) questionnaire, and PTSD Checklist for DSM-5 (PCL-5). RESULTS: First, averaged endorsement of the 10 omitted items was lower than the 6 retained DSO items (d' = 0.34). Second, the 10 omitted DSO items accounted for incremental variance over and correlated equivalently to the 6 retained items with the PCL-5. Third, only the 10 omitted DSO items (r-part = 0.12) while not the 6 retained DSO items (r-part = -0.01) independently predicted ACE scores and, eight of these ten omitted DSO items differentiated higher ACE scores even among the subset of 266 participants who endorsed all 6 of the retained DSO items, most with medium effect sizes. Fourth, exploratory principal axis factor analysis differentiated two latent variables within the fuller set of 16 DSO symptoms, with the strongest indicators of the second factor, namely uncontrollable anger, recklessness, derealization, and depersonalization, being unmeasured within the 6 retained DSO items. Moreover, scores on both factors independently predicted both PCL-5 and ACE scores. CONCLUSIONS: There are conceptual and pragmatic advantages to revisiting a more content-valid and comprehensive conceptualization of CPTSD and DSO, partially as may be measured by the recently deleted items from the original and fuller length ITQ.

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Background: The International Trauma Questionnaire (ITQ) is a standardized and validated measure aligned with the 11th version of the International Classification of Diseases (ICD-11) diagnostic criteria to assess post-traumatic stress disorder (PTSD) and complex post-traumatic stress disorder (CPTSD). It has been translated into 25 different languages, but is yet to be translated into Dari and validated for use in the Afghan population.Objective: This study aimed (1) to translate and culturally adapt the ITQ for use in Dari; (2) to assess the construct validity and composite reliability of ICD-11 PTSD and CPTSD using the Dari ITQ; and (3) to examine the concurrent, convergent, and discriminant validity of the Dari ITQ.Method: The Dari ITQ was validated through the completion of a set of standardized measures by 305 Afghan asylum seekers and refugees in Austria. Factorial analyses and psychometric properties of the Dari ITQ were assessed using confirmatory factor analysis (CFA), bivariate correlations, and multivariate regression.Results: Asylum seekers showed significantly higher levels of ICD-11 CPTSD symptomatology and probable diagnoses of ICD-11 PTSD, Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) PTSD, anxiety, depression, and psychological distress in comparison to refugees. CFA results supported the two-factor second-order model comprised of the PTSD and disturbances in self-organization (DSO) as the best fit to the data. The psychometric adequacy of this model in the Dari ITQ was evidenced by high factor loadings and excellent internal reliability. The Dari ITQ showed satisfactory concurrent, convergent, and discriminant validity.Conclusion: The current study supports the statistical validity and cultural sensitivity of the Dari ITQ in identifying symptoms of ICD-11 PTSD and CPTSD among Afghan asylum seekers and refugees.

This study provides the first translation and validation of the ITQ in Dari with an Afghan refugee population in Austria.The two-factor second-order model was supported as the best fit to the data.Additional support for the composite reliability, and concurrent, convergent, and discriminant validity was provided, suggesting the statistical validity and cultural sensitivity of the Dari ITQ in identifying symptoms of ICD-11 PTSD and CPTSD among Afghan asylum seekers and refugees.

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Background: The ICD-11 post-traumatic stress disorder (PTSD) and complex PTSD diagnoses have been examined in several studies using the International Trauma Questionnaire (ITQ). The cross-cultural validity of the ITQ has not previously been studied using item responses theory methods focused on the issue of equal item functioning and thus comparability of scores across language groups.Objective: To investigate the cross-cultural validity of the ITQ scales considering specifically local independence of items and differential item functioning (DIF) in a cross-cultural sample of refugees.Method: Data from 490 treatment-seeking refugees were included, covering Danish, Arabic, and Bosnian languages and different levels of interpreter-assisted administration. Rasch and graphical log-linear Rasch models were used.Results: There was strong local dependence among items from the same symptom clusters in the PTSD and disorders in self-organization (DSO) scales, except between affective dysregulation items. Weak local dependence was discovered between an item from the affective dysregulation cluster and an item from the disturbed relationship cluster. There was no evidence of DIF related to language or interpreter assistance. There was evidence of DIF for two PTSD items relative to gender and time since the traumatic event. The targeting of the scales to the study population was not optimal. Reliability varied from 0.55 to 0.78 for subgroups.Conclusions: The PTSD and the DSO scales have stable psychometric properties across the Danish, Arabic, and Bosnian language versions and different levels of assisted administration. Scores are comparable across these groups. However, DIF relative to gender and time since trauma introduces considerable measurement bias. DIF-adjusted summed scale scores or estimated person parameters should be used to avoid measurement bias. Future research should investigate whether scales including more and/or alternative items that require higher levels of PTSD and DSO to be endorsed will improve targeting and measurement precision for refugee populations.

A first cross-cultural validity study of the ITQ using IRT.PTSD and DSO subscales functioned invariantly across Danish, Arabic, and Bosnian, and also across degrees of interpreter assistance. Two PTSD items did not function invariantly across gender and time since trauma.The Danish, Arabic, and Bosnian ITQ can be used for screening treatment-seeking refugees, taking into account the item bias in the PTSD subscale, and suboptimal targeting and reliability, which require extensions or modification of items.

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Amino transaminases (ATAs) have been supported on a 2D ITQ-2 zeolite through electrostatic interactions, resulting in a highly stable active biocatalyst to obtain a variety of valuable chiral amines starting from prochiral ketones derived from biomass. We have extended the biocatalyst applications by designing a chemo-enzymatic process that allows, as the first step, prochiral ketones to be obtained from biomass-derived compounds through an aldol condensation-reduction step using a bifunctional metal/base catalyst. The prochiral ketone is subsequently converted into the chiral amine using the immobilized ATA. We show that it is feasible to couple both steps in a semi-continuous process to produce industrially relevant chiral amines with yields of >95% and ∼100% enantiomer excess.

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BACKGROUND: The International Trauma Questionnaire-Child and Adolescent version (ITQ-CA) is a self-report measure that assesses posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD) based on the diagnostic formulation of the 11th version of the International Classification of Diseases (ICD-11). This study aimed to provide a Chinese translation and psychometric evaluation of the ITQ-CA using a sample of mental-health service seeking adolescents in Mainland China. METHODS: The ITQ-CA was translated and back-translated from English to simplified Chinese and finalized with consensus from an expert panel. Adolescents ages 12-17 were recruited via convenience sampling from an outpatient psychiatric clinic in Mainland China. Participants completed the ITQ-CA; measures of four criterion variables (depression, anxiety, stress, adverse childhood experiences); and the PTSD Checklist for DSM-5 (PCL-5). Construct validity, concurrent validity, and comparison of PTSD caseness between ICD-11 and DSM-5 measures were assessed. RESULTS: The final sample consisted of 111 Chinese adolescents (78% female; mean age of 15.23), all diagnosed with a major depressive disorder. Confirmatory factor analysis indicated the two-factor second-order model provided optimal fit. All criterion variables were positively and significant correlated with the six ITQ-CA symptom cluster summed scores. In the present sample, 69 participants (62.16%) met symptom criteria for ICD-PTSD or CPTSD using the ITQ-CA, and 73 participants (65.77%) met caseness for DSM-5 PTSD using the PCL-5. Rates of PTSD symptom cluster endorsement and caseness deriving from both diagnostic systems were comparable. CONCLUSIONS: The Chinese ITQ-CA has acceptable psychometric properties and confers additional benefits in identifying complex presentations of trauma-related responses in younger people seeking mental health services.

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Governments have introduced local individual transferable quotas (ITQs) to maintain fishery resource sustainability. However, quota rent-seeking activities by fishermen may weaken ITQ's resource conservation effect in countries with immature private property systems. This method is developed to analyse how opening-up trade impacts resource management and welfare under quota rent-seeking activities by applying rent-seeking for emission permits to rent-seeking for ITQ in a two-country model to investigate the policy effect of opening-up trade on renewable resources. The method helps analyse ITQ's welfare effect in an open economy with quota rent-seeking activities and the welfare effect of opening-up trade via quota lobbying, comparing an autarky with an open economy. Quota changes in the foreign country specialising in fishery production influence quota prices in both the foreign country and the home country, diversifying away from fishery to manufacturing production, thereby affecting fishery and manufacturing goods production in the home country. Thus, fishery policy indirectly affects welfare in the home country. The method can be applied to investigate fisheries disputes under international resource management. In sum, this method facilitates:•Analysing the welfare effect of quotas with quota lobbying in a two-country model;•Examining the policy effect of opening-up trade on quota rent-seeking and fisheries production, comparing an autarky with an open economy; and•Investigating fisheries disputes under the international management of fishery resources.

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Many adult dual users of e-cigarettes and cigarettes in the United States report using e-cigarettes with the intention to quit (ITQ) smoking. This study examined transition outcomes among adult dual users of e-cigarettes and cigarettes with the ITQ compared to mono cigarette smokers with ITQ. We conducted a longitudinal analysis of 3,542 adults aged ≥ 18 years with data from Waves 1 and 4 of the United States Population Assessment of Tobacco and Health study (2013-2018) between May 2021 and January 2022. Current dual users (e-cigarettes and cigarettes use on ≥ 20 days in the past month) with the ITQ were compared to current mono cigarette smokers with the ITQ for transition outcomes (cessation, mono e-cigarette, mono cigarette and dual use) three years later. We conducted multinomial logistic regression modeling adjusting for potential confounders and reported the adjusted relative risk ratios (aRRR) with 95% confidence intervals (CI) for the transition outcomes. Approximately 10.7% (7.8-14.3) of dual users with the ITQ (in 2013) reported cessation (no past-month use of any tobacco) three years later, compared to 16.1% (14.6-17.7) of mono cigarette smokers. Dual users were 83% and 79% less likely to transition to cessation (aRRR: 0.17, 95% CI:0.09-0.32) or mono cigarette use (0.21, 0.14-0.32), respectively, compared to mono cigarette smokers. Our findings show that in a real-world scenario, dual e-cigarette and cigarette use may hinder rather than facilitate smoking cessation among those interested in quitting. This needs consideration when assessing the population impact of e-cigarettes and their role in harm reduction.

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Gastrointestinal Stromal Sarcomas (GIST) are mesenchymal neoplasms whose incidence accounts for 1-2% of digestive tumors, being located in the stomach (55-60%) and small intestine (30%). The advances in its knowledge and management succeeded in the last years have being spectacular. This review aims to summarize the most important of them for surgeons. We identified four areas of interest: molecular oncology, laparoscopic approach, management of GIST located at unusual locations, and management of advanced GIST. Advances in the field of molecular oncology lead to the discovery of new oncogenic mutations making the term Wil Type GIST obsolete. Moreover, these advances allow for the development of 2 new drugs: Avapritinib and Ripretinib, that added to the previous 3 commercially available drugs (imatinib, sunitinib and regorafenib) make possible the management of GIST with resistant mutations. The principles of the surgical management of primary GIST are well stablished which laparoscopic approach must accomplish. This approach is limited by 2 main factors: location and size. The diagnosis of GIST in unusual locations as esophagus, duodenum, rectum of out of the gastrointestinal tract (EGIST), implies an extraordinary therapeutic challenge, being imperative to manage them by surgeons and oncologist among others in the setting of a multidisciplinary team. The management of advanced/metastatic GIST has changed in a revolutionary fashion because surgery is now part of its treatment as adjuvant to tyrosine kinase inhibitors.

Los tumores del estroma gastrointestinal (GIST) suponen el 1-2% de los tumores digestivos, siendo su localización más frecuente el estómago (55-60%) y el intestino delgado (30%). Los avances más importantes sucedidos en los últimos años se centran en cuatro áreas: biología molecular, abordaje quirúrgico laparoscópico, manejo técnico del GIST en localizaciones inusuales y tratamiento e integración de la cirugía en el manejo del GIST avanzado. Los avances en el conocimiento de la biología molecular del GIST han dado lugar a la progresiva identificación de nueva mutaciones oncogénicas que hacen del concepto wild type obsoleto. Estos avances han permitido el desarrollo de dos nuevos fármacos, avapritinib y ripretinib, lo que permite el tratamiento de pacientes con mutaciones resistentes a las tres líneas terapéuticas clásicas. El tratamiento quirúrgico del GIST se rige por unos principios técnicos bien establecidos que el abordaje laparoscópico debe cumplir, abordaje que queda limitado por dos factores clave: localización y tamaño. El GIST de localización infrecuente (esófago, duodeno o recto, o extradigestivo) supone un reto terapéutico. Estos pacientes deben ser manejados en un contexto multidisciplinario. La cirugía queda integrada en el manejo del GIST avanzado, considerándose como adyuvante a los inhibidores de la tirosina cinasa.

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Adsorption is a superior method for removing and recycling high concentration of mercury from nonferrous metal smelting flue gas, especially adsorbents with good sulfur resistance and large adsorption capacity. In this study, Co and Mn oxide-modified layered ITQ-2 zeolites were designed to capture and recycle elemental mercury (Hg0). The physicochemical characteristics of the adsorbents were characterized using BET, XRD, FESEM, TEM, and XPS, and the results showed that Mn/ITQ-2 zeolite has a large specific surface area, and MnOx was highly dispersed on ITQ-2 zeolite. The Hg0 removal efficiency and adsorption capacity of the 5%Mn/ITQ-2 zeolite at 300 °C were 97% and 2.04 mg/g in 600 min, respectively, much higher than those of the previously reported 5%Mn/MCM-22 zeolite. The 2%Co-2%Mn/ITQ-2 zeolite exhibited a higher SO2 resistance performance. The mechanism of Hg0 removal was concluded to be driven by the primary catalytic oxidation of MnOx, secondary oxidation of active chlorine, and concurrent chemisorption. However, the Hg0 adsorption capacity was determined by the specific surface area and pore structure of ITQ-2. The 2%Co-2%Mn/ITQ-2 zeolite exhibited a high SO2 resistance performance. The Mn/ITQ-2 and Co-Mn/ITQ-2 zeolites have excellent regenerability and reusability, which can realize mercury recycling from flue gas.

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Background: The International Trauma Questionnaire (ITQ) is a validated measure that assesses ICD-11 posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD). An important task is to determine whether the ITQ is an appropriate evaluative measure for clinical trials. Objective: To assess the psychometric properties of the ITQ in the context of treatment and determine if the ITQ measures reliable and clinically significant change over the course of a psychosocial intervention. Method: Analyses were based on data from an online skills training programme delivered to 254 U.S. Veterans. Reliability and validity of the ITQ scores were assessed at baseline. Changes in symptom scores and probable diagnostic rates were compared at pre-, mid- and post-treatment. A reliable change index (RCI) score was computed to classify participants as improved, unchanged, or worsened. The PCL-5 was used as a comparison measure. Results: Baseline concurrent and factorial validity was similar to previous studies. Internal consistency at each assessment was excellent and comparable to the PCL-5. Decline in symptoms from pre-to-post-treatment was significant for PTSD and CPTSD symptom profiles. Rate of probable disorder (PTSD or CPTSD) declined significantly from pre-treatment to post-treatment. Pre-to-post treatment declines exceeded the critical RCI values for the ITQ. Clinically significant changes were observed where most participants improved, some stayed the same, and few worsened. The performance of the ITQ was consistent with the PCL-5 regarding sensitivity to change. Conclusion: This study provides the first demonstration that the ITQ measures reliable and clinically significant treatment-related change of ICD-11 PTSD and CPTSD symptoms.

Antecedentes: el Cuestionario Internacional de Trauma (ITQ por su sigla en inglés) es una medida validada que evalúa el trastorno por estrés postraumático (TEPT) y el TEPT complejo (TEPT-C) según la CIE-11. Una tarea importante es determinar si la ITQ es una medida de evaluación adecuada para los ensayos clínicos.Objetivo: Evaluar las propiedades psicométricas de la ITQ en el contexto del tratamiento y determinar si la ITQ mide un cambio confiable y clínicamente significativo durante el transcurso de una intervención psicosocial.Método: Los análisis se basaron en datos de un programa de entrenamiento de habilidades en línea entregado a 254 veteranos estadounidenses. La confiabilidad y la validez de las puntuaciones de ITQ se evaluaron al inicio del estudio. Se compararon los cambios en las puntuaciones de los síntomas y las tasas de diagnóstico probables antes, en la mitad y después del tratamiento. Se calculó una puntuación de índice de cambio confiable (RCI) para clasificar a los participantes como mejorados, sin cambios o empeorados. El PCL-5 se utilizó como medida de comparación.Resultados: La validez basal concurrente y factorial fue similar a estudios previos. La consistencia interna en cada evaluación fue excelente y comparable a la del PCL-5. La disminución de los síntomas de antes a después del tratamiento fue significativa para los perfiles de síntomas de TEPT TEPT-C. La tasa de trastorno probable (TEPT o TEPT-C) disminuyó significativamente desde el pretratamiento hasta el postratamiento. Las disminuciones antes-después del tratamiento excedieron los valores críticos de RCI para la ITQ. Se observaron cambios clínicamente significativos en los que la mayoría de los participantes mejoraron, algunos permanecieron igual y pocos empeoraron. El desempeño de la ITQ fue consistente con el PCL-5 con respecto a la sensibilidad al cambio.Conclusión: Este estudio proporciona la primera demostración de que la ITQ mide cambios confiables y clínicamente significativos relacionados con el tratamiento de los síntomas de TEPT y TEPT-C de la CIE-11.

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Background: In the 11th revision of the International Classification of Diseases (ICD-11) posttraumatic stress disorder (PTSD) and the complex variant (CPTSD) were newly conceptualised. The International Trauma Questionnaire (ITQ) was developed as a brief self-report measure to screen for both disorders. The English original version has been rigorously tested and presents convincing psychometric properties. The aim of the current study was to validate the German version by means of item response theory (IRT). Method: This is a secondary analysis of a representative, trauma-exposed adult sample from the German general population (N = 500). 1- and 2-parameter logistic IRT models (i.e. examination on an item level), diagnostic rates and confirmatory factor analyses were calculated. Results: All items showed good model fit and acceptable to good performance aligning with the items of the English original except for item C1 (Long time to calm down) which had a high endorsement rate and a low discriminatory power yielding low information gain. CPTSD diagnostic rate of 3.2% was lower than in comparable literature. Confirmatory factor analysis deemed the six first-order, two second-order factors model superior. Conclusion: Measurement and factorial validity of the German version of the ITQ was confirmed. The German translation matches the English original in most psychometric properties and can thus be used for research and clinical practice.

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Background: Both post-traumatic stress disorder (PTSD) and complex post-traumatic stress disorder (CPTSD) have been included in the 11th edition of the International Classification of Diseases (ICD-11). Although the validity of CPTSD has been controversial, a growing number of studies support the distinction between PTSD and CPTSD. However, the majority of this research has originated in high-income countries (HICs), whereas the prevalence of trauma experience associated with PTSD/CPTSD diagnosis is significantly higher in low- and middle-income countries (LMICs). Objective: This study assessed whether a sample from an LMIC setting produced distinct classes that reflect ICD-11 criteria for PTSD and CPTSD. Furthermore, this study investigated whether childhood trauma distinguished between PTSD and CPTSD. Method: International Trauma Questionnaire responses from a sample of South African university undergraduates were used as indicator variables in a latent class analysis (LCA). Chi-squared tests of independence and Kruskal-Wallis H tests were used to assess between-class differences. Results: The LCA identified four distinct classes: a PTSD class with elevated symptoms of PTSD, but low endorsement of disturbances in self-organization (DSO; symptoms that are specific to CPTSD); a CPTSD class with elevated symptoms of PTSD and DSO; a DSO class with low symptoms of PTSD, but elevated symptoms of DSO; and a Low class with low endorsements on all symptoms. Regarding childhood trauma, participants in the CPTSD class had more severe childhood abuse and neglect, specifically emotional abuse and neglect, than participants in the PTSD class. Conclusions: Findings were consistent with the distinction between PTSD and CPTSD symptom profiles in the ICD-11. Our findings support a similar qualitative distinction between PTSD and CPTSD in our LMIC context, as previously reported in HICs. This distinction is especially relevant in LMICs because of the significant number of individuals vulnerable to these disorders.

Antecedentes: Tanto el trastorno de estrés postraumático (TEPT) como el trastorno de estrés postraumático complejo (TEPT-C) se han incluido en la 11ª edición de la Clasificación Internacional de Enfermedades (CIE-11). Aunque la validez del TEPT-C ha sido controvertida, un número creciente de estudios apoyan la distinción entre TEPT y TEPT-C. Sin embargo, la mayor parte de esta investigación se ha originado en países de ingresos altos (HIC en su sigla en inglés), mientras que la prevalencia de experiencias traumáticas asociadas con el diagnóstico de TEPT/TEPT-C es significativamente mayor en países de ingresos bajos y medios (LMIC en su sigla en inglés).Objetivo: Este estudio evaluó si una muestra de un entorno de LMIC produjo clases distintas que reflejan los criterios de la CIE-11 para TEPT y TEPT-C. Además, este estudio investigó si el trauma infantil distinguía entre TEPT y TEPT-C.Método: Las respuestas del Cuestionario Internacional de Trauma (ITQ en su sigla en inglés) de una muestra de estudiantes universitarios de Sudáfrica se utilizaron como variables indicadoras en un análisis de clase latente (LCA en su sigla en inglés). Se utilizaron pruebas de independencia de chi-cuadrado y pruebas H de Kruskal-Wallis para evaluar las diferencias entre clases.Resultados: El LCA identificó cuatro clases distintas: una clase de trastorno de estrés postraumático con síntomas elevados de trastorno de estrés postraumático, pero baja validación de las alteraciones en la autoorganización (DSO en su sigla en inglés; síntomas que son específicos de TEPT-C); una clase de TEPT-C con síntomas elevados de TEPT y DSO; una clase de DSO con síntomas bajos de TEPT, pero síntomas elevados de DSO; y una clase baja con baja validación de todos los síntomas. Con respecto al trauma infantil, los participantes en la clase de TEPT-C tuvieron abuso y negligencia infantil más severos, específicamente abuso y negligencia emocional, que los participantes en la clase de TEPT.Conclusiones: Los hallazgos fueron consistentes con la distinción entre los perfiles de síntomas de TEPT y TEPT-C según la CIE-11. Nuestros hallazgos apoyan una distinción cualitativa similar entre TEPT y TEPT-C en nuestro contexto de LMIC a lo reportado anteriormente en los HIC. Esta distinción es especialmente relevante en los países de ingresos bajos y medios debido al número significativo de personas vulnerables a estos trastornos.

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Ferrierites and their delaminated forms (ITQ-6), containing aluminum or titanium in the zeolite framework, were synthetized and modified with copper by an ion-exchange method. The obtained samples were characterized with respect to their chemical composition (ICP-OES), structure (XRD, UV-Vis DRS), textural parameters (N2-sorption), surface acidity (NH3-TPD), form and reducibility of deposited copper species (UV-Vis DRS and H2-TPR). Ferrierites and delaminated ITQ-6 zeolites modified with copper were studied as catalysts for the selective catalytic oxidation of ammonia to dinitrogen (NH3-SCO). It was shown that aggregated copper oxide species, which were preferentially formed on Ti-zeolites, were catalytically active in direct low-temperature ammonia oxidation to NO, while copper introduced into Al-zeolites was present mainly in the form of monomeric copper cations catalytically active in selective reduction of NO by ammonia to dinitrogen. It was postulated that ammonia oxidation in the presence of the studied catalysts proceeds according to the internal-selective catalytic reduction mechanism (i-SCR) and therefore the suitable ratio between aggregated copper oxide species and monomeric copper cations is necessary to obtain active and selective catalysts for the NH3-SCO process. Cu/Al-ITQ-6 presented the best catalytic properties possibly due to the most optimal ratio of these copper species.

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Background: The 11th edition of the International Classification of Diseases (ICD-11) introduces Posttraumatic Stress Disorder (PTSD) and Complex Posttraumatic Stress Disorder (CPTSD) as two distinct trauma-related disorders. Numerous studies support the proposed symptom structure of ICD-11 CPTSD in adults, but only a few studies have examined CPTSD symptom structure in children, reporting diverging results. To assess ICD-11 CPTSD in children, the International Trauma Questionnaire (ITQ) was recently adapted for children and adolescents (ITQ-CA), with no validated German version available yet. Objective: This study aimed (1) to test the symptom structure of ICD-11 CPTSD in a sample of trauma-exposed foster children using the ITQ-CA, and (2) to examine the concurrent, convergent and discriminant validity of the German ITQ-CA. Method: Altogether, 161 Austrian foster children completed a set of standardized measures, resulting in a final sample of 135 trauma-exposed foster children meeting the inclusion criteria. Psychometric properties of the ITQ-CA were assessed using confirmatory factor analysis (CFA), bivariate correlations and multivariate regression. Results: CFA supported ICD-11 CPTSD symptom structure in children as a two-factor higher-order model with PTSD and Disturbances in Self-Organization (DSO) as correlated factors with very good model fit, while a one-factor higher-order model also fitted the data very well. High factor loadings and excellent levels of internal reliability evidenced the psychometric adequacy of the ITQ-CA. Concurrent and convergent validity were evidenced by high correlations between ITQ-CA scales and criterion variables (PTSD symptoms, depression, anxiety, dissociation, lifetime traumatization). Discriminant validity was partly supported by PTSD and DSO being differently predicted by exogenous criterion variables. Conclusions: CPTSD symptom structure in children is in support of the ICD-11 conceptualization. The reliability and validity of the German ITQ-CA are evidenced for the first time, identifying it as an easy-to-use screening instrument to assess ICD-11 PTSD and CPTSD in children. Further implications and areas for upcoming studies are discussed.

Antecedentes: La CIE-11 recientemente publicada presenta el trastorno de estrés postraumático (TEPT) y el trastorno de estrés postraumático complejo (TEPT-C) como dos trastornos distintos relacionados con trauma. Numerosos estudios apoyaron la estructura de síntomas propuesta de TEPT-C en adultos de la CIE-11, pero solo unos pocos estudios examinaron la estructura de síntomas de TEPT-C en niños, reportando resultados divergentes. Para evaluar TEPT-C en niños según la CIE-11, el Cuestionario Internacional de Trauma (ITQ) fue adaptado recientemente para niños y adolescentes (ITQ-CA), sin una versión alemana validada disponible todavía.Objetivo: El estudio actual se estableció para (1) probar la estructura de síntomas de TEPT-C según la CIE-11 en una muestra de niños de crianza temporal expuestos a traumas utilizando el ITQ-CA y para (2) examinar la validez concurrente, convergente y discriminante de la versión en alemán del ITQ-CA.Método: Ciento sesenta y un niños de crianza temporal austriacos completaron un conjunto de medidas estandarizadas, lo que resultó en una muestra final de 135 niños de crianza temporal expuestos a traumas que cumplieron con los criterios de inclusión. Las propiedades psicométricas del ITQ-CA se evaluaron mediante análisis factorial confirmatorio (AFC), correlaciones bivariadas y regresión de objetivos multivariados.Resultados: AFC respaldó la estructura de síntomas de TEPT-C según CIE-11 en niños como modelo de dos factores de orden superior con TEPT y DSO (Perturbaciones en la organización del sí mismo) como factores correlacionados con muy buen ajuste del modelo, mientras que un modelo de un factor de orden superior también se ajustó muy bien a los datos. Las altas cargas factoriales y los excelentes niveles de confiabilidad interna evidenciaron la adecuación psicométrica del ITQ-CA. La validez concurrente y convergente se evidenció por las altas correlaciones entre las escalas ITQ-CA y las variables de criterio (síntomas de TEPT, depresión, ansiedad, disociación, traumatismo de por vida). La validez discriminante fue apoyada en parte por el TEPT y DSO siendo diferenciadamente predicho por variables de criterio exógenas.Conclusiones: La estructura de los síntomas del TEPT-C en los niños respalda la conceptualización de la CIE-11. La confiabilidad y validez de la ITQ-CA alemana se evidencia por primera vez, identificándola como un instrumento de cribado fácil de usar para evaluar el TEPT y TEPT-C de la CIE-11 en niños. Se discuten más implicaciones y áreas para futuros estudios.

RESUMEN

BACKGROUND: The diagnostic criteria for Posttraumatic Stress Disorder (PTSD) differ between the DSM-5 and the ICD-11, affecting prevalence and associated metrics of PTSD. OBJECTIVE: Investigating the effects of the diverging DSM-5 and ICD-11 PTSD conceptualizations on prevalence and comorbidity rates, as well as predictor impact in a sample of foster children and adolescents using manual-specific measures. METHOD: The sample consisted of n = 145 foster children and adolescents. PTSD rates were assessed and compared utilizing the International Trauma Questionnaire - Child and Adolescent Version (ICD-11) and the Child and Adolescent Trauma Screen (DSM-5). PTSD comorbidities with Generalized Anxiety Disorder (GAD) and Major Depressive Disorder (MDD) were assessed. The predictive value of age, gender and cumulative trauma for PTSD was determined. RESULTS: A non-significant trend for higher DSM-5 (21.4%) vs. ICD-11 (16.7%) PTSD prevalence was observed. Significantly elevated DSM-5 vs. ICD-11 diagnostic rates were recorded in the re-experience (diff. = 18.3%) and hyperarousal (diff. = 10.1%) clusters. DSM-5 PTSD showed a non-significant trend for higher comorbidities with GAD and MDD. Gender and cumulative trauma predicted PTSD significantly and approximately equally according to both taxonomies. CONCLUSION: The study supports the assumption that utilizing manual-specific PTSD measures in children and adolescents leads to higher rates of DSM-5 PTSD compared to ICD-11 PTSD. The exact methodological reasons for diverging diagnostic rates need to be analysed.

Antecedentes: Los criterios de diagnóstico para el trastorno de estrés postraumático (TEPT) difieren entre el DSM-5 y el CIE-11, lo cual afecta la prevalencia y las métricas asociadas al TEPT.Objetivo: Investigar los efectos de las conceptualizaciones divergentes del TEPT entre el DSM-5 y el CIE-11, utilizando medidas específicas del manual, en las tasas de prevalencia y comorbilidad, así como el impacto predictor en una muestra de niños y adolescentes en condición de acogida familiar temporal.Método: La muestra consistió en un n = 145 niños y adolescentes en condición de acogida familiar temporal. Las tasas de TEPT se evaluaron y compararon utilizando el Cuestionario Internacional de Trauma - Versión para Niños y Adolescentes (CIE-11) y la Prueba de Detección del Trauma para Niños y Adolescentes (DSM-5). Se evaluaron las comorbilidades del TEPT, trastorno de ansiedad generalizada (TAG) y trastorno depresivo mayor (TDM). Se determinó el valor predictivo para TEPT de las variables edad, género y trauma acumulativo.Resultados: Se observó una tendencia, no-significativa, de una mayor prevalencia de TEPT para el DSM-5 (21.4%) comparado con el CIE-11 (16.7%). Se registraron tasas de diagnóstico significativamente elevadas en los grupos de re-experimentación (dif. = 18.3%) e hiperactivación (dif. = 10.1%) para el DSM-5 versus el CIE-11. El TEPT en el DSM-5 mostró una tendencia mayor, no-significativa, para las comorbilidades TAG y TDM. El género y el trauma acumulativo predijeron el TEPT de manera significativa, y aproximadamente equivalente en ambas taxonomías.Conclusión: El estudio apoya el supuesto de que la utilización de medidas TEPT específicas para el manual en niños y adolescentes conlleva tasas más altas de TEPT para el DSM-5 en comparación con el CIE-11. Es necesario analizar las razones metodológicas precisas para estas tasas de diagnóstico divergentes.

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BACKGROUND: Complex PTSD (CPTSD) has been incorporated in the 11th edition of the International Classification of Diseases (ICD-11) as a mental health condition distinct from PTSD. OBJECTIVE: The objective of the current study is to determine whether individuals classified as having CPTSD can benefit from an intensive trauma-focused treatment, resulting in decreased PTSD and CPTSD symptoms, and loss of diagnoses. METHOD: Patients diagnosed with PTSD (N = 308) took part in an intensive 8-day treatment programme combining prolonged exposure, EMDR therapy, psycho-education, and physical activity. The treatment was not phase-based in that it did not contain a stabilization phase or skill training prior to therapy. CPTSD diagnosis was assessed by means of the International Trauma Questionnaire (ITQ) and PTSD diagnosis was assessed with both the ITQ and CAPS-5. Treatment response was measured with the CAPS-5, PCL-5, and ITQ. RESULTS: Symptoms of both PTSD and CPTSD significantly decreased from pre- to post-treatment resulting in a significant loss of CAPS-5 based PTSD (74.0%) and ITQ-based PTSD and CPTSD diagnoses (85.0% and 87.7%, respectively). No adverse events occurred in terms of suicides, suicide attempts, or hospital admissions. CONCLUSIONS: The results are supportive of the notion that the majority of patients classified as having CPTSD strongly benefit from an intensive trauma-focused treatment for their PTSD.

Antecedentes: El TEPT complejo (TEPT-C) se ha incorporado en la 11ª edición de la Clasificación Internacional de Enfermedades (CIE-11) como una condición de salud mental distinta del TEPT.Objetivo: El objetivo del presente estudio es determinar si las personas clasificadas como con TEPT-C pueden beneficiarse de un tratamiento intensivo centrado en el trauma, lo que resulta en una disminución de los síntomas de TEPT y TEPT-C y la pérdida de diagnóstico de TEPT.Método: Los pacientes diagnosticados con TEPT (N = 308) participaron en un programa de tratamiento intensivo de 8 días que combina exposición prolongada, terapia EMDR, psicoeducación y actividad física. El tratamiento no se dividió en fases, ya que no contenía una fase de estabilización o entrenamiento de habilidades antes de la terapia. El diagnóstico de TEPT-C se evaluó mediante el Cuestionario Internacional de Trauma (ITQ por sus siglas en ingles) y el diagnóstico de TEPT se evaluó tanto con el ITQ como con CAPS-5. La respuesta al tratamiento se midió con CAPS-5, PCL-5 e ITQ.Resultados: los síntomas de TEPT y TEPT-C disminuyeron significativamente del pretratamiento al postratamiento, lo que resultó en una pérdida significativa del diagnóstico de TEPT basado en CAPS-5 (74.0%) y diagnósticos de TEPT y TEPT-C basados en ITQ (85.0 y 87.7%, respectivamente). No se produjeron eventos adversos en términos de suicidios, intentos de suicidio o ingresos hospitalarios.Conclusiones: Los resultados apoyan la noción de que la mayoría de los pacientes clasificados con TEPT-C se benefician significativamente de un tratamiento intensivo centrado en el trauma para su TEPT.

RESUMEN

BACKGROUND: The International Trauma Questionnaire (ITQ) is a self-report measure for post-traumatic stress disorder (PTSD) and complex post-traumatic stress disorder (CPTSD), corresponding to the diagnostic criteria in the International Classification of Diseases, 11th Revision (ICD-11). A 12-item version of the ITQ based on samples from English-speaking countries has been presented, and the wider generalizability to other languages needs to be examined. OBJECTIVE: The current study examines the psychometric properties of scores from a longer, preliminary 22-item version of the ITQ and the current reduced 12-item version by means of generalizability theory (G-theory) and confirmatory factor analysis (CFA). METHOD: The 22-item version of the ITQ was translated into Norwegian and administered to patients in two trauma treatment trials (total N = 202). A generalizability study was used to investigate the psychometric properties of scores reflecting CPTSD. G-theory was also used to investigate alternative measurement designs to optimize the sufficient number of items that provide acceptable generalizability and dependability of scores. Model fit to the theoretical factor structure was then examined by CFA, both for the 22-item version and for the 12-item version of the ITQ. RESULTS: The two subscales negative self-concept and relational disturbances had acceptable generalizability coefficients. We found substantial measurement error related to affective dysregulation, mainly attributable to affective hyperactivation. A latent factor structure model with two separate affective dysregulation factors: hyperactivation and deactivation, represented the data well in the 22-item version. The proposed confirmatory structure model for the 12-item short form did not converge in the CFA. CONCLUSION: This study supports the applicability of the ITQ in a non-English-speaking country and provides support for the validity of the Norwegian translation. Further research is needed to improve the psychometric properties of the affective dysregulation subscale.

Antecedentes: El Cuestionario Internacional de Trauma (ITQ en su sigla en inglés) es una medida de autoreporte para el trastorno de estrés postraumático (TEPT) y el trastorno de estrés postraumático complejo (TEPT-C), que corresponde a los criterios de diagnóstico de la CIE-11. Recientemente, se presentó una versión de ITQ de 12 ítems basada en muestras de países de habla inglesa, y es necesario examinar la posibilidad de generalización a otros idiomas.Objetivo: El presente estudio examina las propiedades psicométricas de los puntajes de una versión preliminar más larga de 22 ítems del ITQ y la versión reducida actual de 12 ítems por medio de la Teoría de la Generalización (TG) y el Análisis Factorial Confirmatorio (AFC).Método: La versión de 22 ítems de ITQ fue traducida al noruego y fue administrada a los pacientes en dos ensayos de tratamiento de trauma (total N = 202). Se usó un estudio de Generalización para investigar las propiedades psicométricas de las puntuaciones que reflejan el TEPT-C. La TG también se usó para investigar los diseños de medición alternativos para optimizar el número de ítems suficientes para proporcionar una generalización y confiabilidad aceptables de los puntajes. El ajuste del modelo a la estructura factorial teórica se examinó mediante un análisis factorial confirmatorio, tanto para la versión de 22 ítems como para la versión de 12 ítems del ITQ.Resultados: Las dos subescalas de autoconcepto negativo y la de perturbación en las relaciones tenían coeficientes de generalización aceptables. Encontramos un error de medición sustancial relacionado con la desregulación afectiva, principalmente atribuible a la hiperactivación afectiva. Un modelo de estructura factorial latente con dos factores de desregulación afectiva separados, hiperactivación y desactivación, representó bien los datos en la versión de 22 ítems. El modelo de estructura confirmatoria propuesto para el formato corto de 12 ítems no convergió en el análisis AFC.Conclusión: El presente estudio respalda la aplicabilidad de ITQ en un país de habla no inglesa, y brinda soporte para la validez de la traducción al noruego. Se necesita más investigación para mejorar las propiedades psicométricas de la subescala de desregulación afectiva.

RESUMEN

The preparation of continuous layers of highly hydrophobic pure silica ITQ-29 zeolite, potentially applicable as hydrophobic membranes for separation of molecules based on their polarity, has been investigated. Continuous layers of intergrown ITQ-29 zeolite crystals were successfully grown on porous alumina supports by optimization of the synthesis conditions, such as the appropriate selection of the seeds, the procedure for the gel preparation, and the calcination conditions. This resulted in the formation of all silica ITQ-29 zeolite layers without the presence of germanium required in previously reported ITQ-29 membranes, with the subsequent improvement in quality and stability, as verified by the absence of cracks after calcination. We have proved that the incorporation of aluminum from the support into the zeolite layer does not occur, neither during the secondary growth nor through migration of aluminum species during calcination.

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