RESUMO
Objective: In view of the side effects of voiding cystourethrography (VCUG), identification of noninvasive markers predicting the presence of vesicoureteral reflux (VUR) is important. This study was conducted to determine the predictive value of serum interleukin-8 (IL-8) in diagnosis of VUR in children with first febrile urinary tract infection (UTI). Materials and Methods: Eighty children with first febrile UTI were divided into two groups, with and without VUR, based on the results of VCUG. The sensitivity, specificity, positive and negative predictive value positive and negative likelihood ratio, and accuracy of IL-8 for prediction of VUR were investigated. Results: Of the 80 children with febrile UTI, 30 (37.5%) had VUR. There was no significant difference between the children with and without VUR and also between low and high-grade VUR groups in terms of serum concentration of IL-8 (P>0.05). Based on ROC curve, the sensitivity, specificity, likelihood ratio positive, and accuracy of serum IL-8 was lower than those of erythrocyte sedimentation rate and C-reactive protein. Multivariate logistic regression analysis showed significant positive correlation only between erythrocyte sedimentation rate and VUR. Conclusions: This study showed no significant difference between the children with and without VUR in terms of the serum concentration of IL-8. Therefore, it seems that serum IL-8 is not a reliable marker for prediction of VUR.
Assuntos
Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Febre/sangue , /sangue , Infecções Urinárias/sangue , Refluxo Vesicoureteral/sangue , Biomarcadores/sangue , Proteína C-Reativa/análise , Métodos Epidemiológicos , Febre/diagnóstico , Valor Preditivo dos Testes , Valores de Referência , Curva ROC , Infecções Urinárias/diagnóstico , Refluxo Vesicoureteral/diagnósticoRESUMO
OBJECTIVE: In view of the side effects of voiding cystourethrography (VCUG), identification of noninvasive markers predicting the presence of vesicoureteral reflux (VUR) is important. This study was conducted to determine the predictive value of serum interleukin-8 (IL-8) in diagnosis of VUR in children with first febrile urinary tract infection (UTI). MATERIALS AND METHODS: Eighty children with first febrile UTI were divided into two groups, with and without VUR, based on the results of VCUG .The sensitivity, specificity, positive and negative predictive value positive and negative likelihood ratio, and accuracy of IL-8 for prediction of VUR were investigated. RESULTS: Of the 80 children with febrile UTI, 30 (37.5%) had VUR. There was no significant difference between the children with and without VUR and also between low and high-grade VUR groups in terms of serum concentration of IL-8 (P>0.05). Based on ROC curve, the sensitivity, specificity, likelihood ratio positive, and accuracy of serum IL-8 was lower than those of erythrocyte sedimentation rate and C-reactive protein. Multivariate logistic regression analysis showed significant positive correlation only between erythrocyte sedimentation rate and VUR. CONCLUSIONS: This study showed no significant difference between the children with and without VUR in terms of the serum concentration of IL-8. Therefore, it seems that serum IL-8 is not a reliable marker for prediction of VUR.
Assuntos
Febre/sangue , Interleucina-8/sangue , Infecções Urinárias/sangue , Refluxo Vesicoureteral/sangue , Biomarcadores/sangue , Proteína C-Reativa/análise , Criança , Pré-Escolar , Métodos Epidemiológicos , Feminino , Febre/diagnóstico , Humanos , Lactente , Masculino , Valor Preditivo dos Testes , Curva ROC , Valores de Referência , Infecções Urinárias/diagnóstico , Refluxo Vesicoureteral/diagnósticoRESUMO
Possible relationships between renal scars and P blood group have been recently emphasized. Urinary tract infections, an important factor in the production of renal scar, are mainly caused by specific types of E. coli, which has the ability to adhere through fimbriae, to receptors of the urinary tract epithelium that are structurally related to antigens detected in people with blood group P1. We looked for P1 sub-group in 30 children with vesicoureteral reflux and renal scar and 30 patients with equivalent degrees of reflux but without evidence of renal scar. Sex and age were unmatched. The frequency of P1 blood sub-group was similar in both kinds of patients (56.7% vs. 66.7, n.s.) so we could not demonstrate that P1 sub-group can be a useful indirect risk marker for renal scar formation.