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J Inorg Biochem ; 105(4): 497-508, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21329647

RESUMO

The stability of cubane-type [Fe4S4(SR)4](2-) clusters in mixed organic/aqueous solvents was examined as an initial step in the development of stable water-soluble cluster compounds possibly suitable for reconstitution of scaffold proteins in protein biosynthesis. The research involves primarily spectrophotometric assessment of stability in 20-80% Me2SO/aqueous media (v/v), from which it was found that conventional clusters tend to be stable for up to 12h in 60% Me2SO but are much less stable at higher aqueous content. α-Cyclodextrin mono- and dithioesters and thiols were prepared as ligand precursors for cluster binding, which was demonstrated by spectroscopic methods. A potentially bidentate cyclodextrin dithiolate was found to be relatively effective for cluster stabilization in 40% Me2SO, suggesting (together with earlier results) that other exceptionally large thiolate ligands may promote cluster stability in aqueous media.


Assuntos
Complexos de Coordenação/química , Ferro/química , Enxofre/química , Materiais Biomiméticos/síntese química , Materiais Biomiméticos/química , Dimetil Sulfóxido/química , Interações Hidrofóbicas e Hidrofílicas , Proteínas Ferro-Enxofre/síntese química , Proteínas Ferro-Enxofre/química , Ligantes , Modelos Moleculares , Estrôncio/química , alfa-Ciclodextrinas/química
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