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Stabilities of cubane type [Fe4S4(SR)4](2-) clusters in partially aqueous media.
Lo, Wayne; Scott, Thomas A; Zhang, Ping; Ling, Chang-Chun; Holm, R H.
Afiliação
  • Lo W; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
J Inorg Biochem ; 105(4): 497-508, 2011 Apr.
Article em En | MEDLINE | ID: mdl-21329647
The stability of cubane-type [Fe4S4(SR)4](2-) clusters in mixed organic/aqueous solvents was examined as an initial step in the development of stable water-soluble cluster compounds possibly suitable for reconstitution of scaffold proteins in protein biosynthesis. The research involves primarily spectrophotometric assessment of stability in 20-80% Me2SO/aqueous media (v/v), from which it was found that conventional clusters tend to be stable for up to 12h in 60% Me2SO but are much less stable at higher aqueous content. α-Cyclodextrin mono- and dithioesters and thiols were prepared as ligand precursors for cluster binding, which was demonstrated by spectroscopic methods. A potentially bidentate cyclodextrin dithiolate was found to be relatively effective for cluster stabilization in 40% Me2SO, suggesting (together with earlier results) that other exceptionally large thiolate ligands may promote cluster stability in aqueous media.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Enxofre / Complexos de Coordenação / Ferro País/Região como assunto: Cuba Idioma: En Revista: J Inorg Biochem Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Enxofre / Complexos de Coordenação / Ferro País/Região como assunto: Cuba Idioma: En Revista: J Inorg Biochem Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos