RESUMO
1. Water-soluble compounds showed an antiseptic effect, whereas the fat solvents such as benzol, toluol, xylol, carbon trichloride, and carbon tetrachloride wich have a strong hypnotic effect were found to be only slinghtly antiseptic or not at all.2. Sodium, copper, and nickel salts of fatty acids were found about equally efective whereas zinc, strontium, lead, and uranium salts showed no effect.3. The double-bond-containing compounds all showed antiseptic effect, the double bond being more effective on the side chain than on the ring in aromatic compounds.4. Unsaturated alcohols showed an antiseptic effect, particularly when containing the phenyl group which proved to be the most powerful toxic group.5. High alcohols approaching waxes showed no effect. Secondary alcohols were eually or less effective than primary alcohols.6. Hydroxy compounds are highly antiseptic toward acid-fast organisms, as they are toward other bacteira.7. Tha antiseptic effect of phenols increase with the number of hydroxyl groups, the position of these groups being of importance, as the ortho compounds are more antiseptic than the para or meta compounds.8. Alkylation on the ring increases the antiseptic effect of phenols, whereas alkylation on the OH group of polyhydroxyphenols has no noteworthy effect, provided at least one hydroxyl is preserved free.9. The amino group (NH2) has a reverse effect on the antiseptic power of the aromatic compounds, in as much as it has no effect when located on the ring but is strongly antiseptic when linked to the ring directly on the side chain. It acts as a haptophore group and the strong effect of benzylamine is no doubt due to the function of the phenyl group.10. Open-chain terpenes are more effective than their cyclic isomers.11. In the cyclic hydrocarbons the double bond in the ring seems to be of importance in the presence of other groups on the ring, but not in itself.
Assuntos
Chaulmoogra/efeitos adversos , Chaulmoogra/farmacologia , Chaulmoogra/toxicidade , Chaulmoogra/uso terapêutico , Hanseníase/complicações , Hanseníase/diagnóstico , Hanseníase/fisiopatologia , Hanseníase/história , Hanseníase/transmissãoRESUMO
The choline ester of chaulmoogric acid has a small but definite muscarine-like activity, slightly greater than that of molescularly equivalent amounts of choline. In addition it has direct harmful effects upon tissues. A fraction of the ester may be rapidly hydrolized to form choline chaulmoograte. Chaulmoogrylcholine is unsuited for antileprosy use since its toxicity precludes administration of significant amounts of chaulmoogric acid in this form.
Assuntos
Animais , Chaulmoogra/farmacologia , Chaulmoogra/uso terapêutico , Hansenostáticos/farmacologia , Hanseníase/tratamento farmacológicoRESUMO
Os novos methodos de luta contra a lepra com os oleos de "chaulmoogra" e seus derivados, em particular nas Indias, nas Ilhas Hawaii e em Molokai (trabalhos da Irmn Marie Susane) provaram que uma porcentagem notavel de hansenianos em estado adiantado, podia ser curada e que, em inicio, "eram curados cento por cento".
Assuntos
Chaulmoogra/análise , Chaulmoogra/farmacologia , Chaulmoogra/história , Chaulmoogra/toxicidade , Chaulmoogra/uso terapêuticoRESUMO
Wahrend man sich fruher darauf beschrankte, die in den verschiedenen Flacourtiaceenolen enthaltenen therapeutisch wirksamen Cyclofettsauren in Form ihrer Salze oder Ester wie Athyl und Benzylester klinisch zu verwenden, wird seit Jahren von einigen 1)2)3) versucht, durch chemische Modellierung der Chaulmoogra- und der Hydnocarpussaure sowie durch Synthese ahnlich gebauter Verbindungen zu maximal wirksamen Heilmitteln gegen die Lepra zu gelangen.