Chemotherapeutic experiments with chaulmoogra and allied preparations. IV.: A survey of certain organic copounds as to their growth-inhibiting activity toward acid-fast bacilli in vitro
São Paulo; s.n; 1942. 23 p. tab.
Non-conventional
em En
| SES-SP, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1242784
Biblioteca responsável:
BR191.1
Localização: [{"text": "01044/d.a"}]
ABSTRACT
1. Water-soluble compounds showed an antiseptic effect, whereas the fat solvents such as benzol, toluol, xylol, carbon trichloride, and carbon tetrachloride wich have a strong hypnotic effect were found to be only slinghtly antiseptic or not at all.2. Sodium, copper, and nickel salts of fatty acids were found about equally efective whereas zinc, strontium, lead, and uranium salts showed no effect.3. The double-bond-containing compounds all showed antiseptic effect, the double bond being more effective on the side chain than on the ring in aromatic compounds.4. Unsaturated alcohols showed an antiseptic effect, particularly when containing the phenyl group which proved to be the most powerful toxic group.5. High alcohols approaching waxes showed no effect. Secondary alcohols were eually or less effective than primary alcohols.6. Hydroxy compounds are highly antiseptic toward acid-fast organisms, as they are toward other bacteira.7. Tha antiseptic effect of phenols increase with the number of hydroxyl groups, the position of these groups being of importance, as the ortho compounds are more antiseptic than the para or meta compounds.8. Alkylation on the ring increases the antiseptic effect of phenols, whereas alkylation on the OH group of polyhydroxyphenols has no noteworthy effect, provided at least one hydroxyl is preserved free.9. The amino group (NH2) has a reverse effect on the antiseptic power of the aromatic compounds, in as much as it has no effect when located on the ring but is strongly antiseptic when linked to the ring directly on the side chain. It acts as a haptophore group and the strong effect of benzylamine is no doubt due to the function of the phenyl group.10. Open-chain terpenes are more effective than their cyclic isomers.11. In the cyclic hydrocarbons the double bond in the ring seems to be of importance in the presence of other groups on the ring, but not in itself.
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Coleções:
06-national
/
BR
Base de dados:
SES-SP
/
SESSP-ILSLACERVO
Assunto principal:
Chaulmoogra
/
Hanseníase
Idioma:
En
Ano de publicação:
1942
Tipo de documento:
Non-conventional
País de publicação:
Brasil