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1.
Rev. Flum. Odontol. (Online) ; 3(59): 43-48, set.-dez. 2022. ilus
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-1380559

RESUMO

O granuloma periférico de células gigantes (GPCG) é uma lesão hiperplásica benigna causada por trauma local ou trauma crônico. Origina-se do ligamento periodontal ou mucoperiósteo. O objetivo deste trabalho é apresentar um caso de GPCG em mandíbula tratada com sucesso através de excisão cirúrgica, curetagem e ostectomia periférica.


Peripheral giant cell granuloma (PGCG) is a benign hyperplastic lesion caused by local trauma or chronic trauma. It originates from the periodontal ligament or mucoperiosteum. The objective of this work is to present a case of PGCG in the mandible successfully treated through surgical excision, curettage and peripheral ostectomy.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Granuloma de Células Gigantes/diagnóstico , Células Gigantes , Odontologia , Granuloma/diagnóstico , Mandíbula
2.
Rev. Asoc. Odontol. Argent ; 108(2): 68-74, mayo-ago. 2020. ilus
Artigo em Espanhol | LILACS | ID: biblio-1121446

RESUMO

Objetivo: Presentar la respuesta clínica a largo plazo del tratamiento de un granuloma periférico de células gigantes en un implante oseointegrado en el maxilar inferior. Caso clínico: Un paciente de 60 años, de sexo masculino, sin antecedentes sistémicos, concurrió por una lesión con márgenes definidos, de color rojizo morado y consistencia blanda sobre los tejidos blandos en la cara vestibular de un implante colocado en zona de 46. Se realizó la escisión quirúrgica de la lesión, se procesó el tejido extirpado y se envió al laboratorio. El estudio anatomopatológico confirmó el diagnóstico de granuloma periférico de células gigantes. La lesión recidivó dos veces. En la tercera extirpación se realizó la implantoplastía de la superficie del implante. La cicatrización no presentó inconvenientes. Hasta el último control, a los 5 años, no volvió a haber recidiva. Conclusión: En este caso clínico, se logró mantener la salud periimplantaria durante 5 años luego de la eliminación de un granuloma periférico de células gigantes. No obstante, este tuvo que ser removido en tres oportunidades debido a la alta recidiva (AU)


Aim: To evaluate the long-term clinical response to the treatment of a peripheral giant cell granuloma in an osseointegrated implant in the lower jaw. Clinical case: A 60-year-old male patient, with no systemic medical problems, presented a soft tissue lesion located at the buccal aspect of an implant placed in the 46 area. The lesion had defined reddish-purple margins and soft consistency. Surgical excision of the lesion was performed, processed and sent to the laboratory. The histopathology confirmed the diagnosis of peripheral giant cell granuloma. The lesion recurred twice. During the third surgical removal an mplantoplasty of the implant surface was performed. The healing was uneventful and there was no recurrence until the last control at 5 years. Conclusion: In this clinical case, perimplantar gingival health was maintained for 5 years after the surgical removal of a giant cell peripheral granuloma. However, it had to be removed three times, demonstrating a high recurrence (AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Granuloma de Células Gigantes/cirurgia , Granuloma de Células Gigantes/etiologia , Implantes Dentários/efeitos adversos , Argentina , Recidiva , Faculdades de Odontologia , Cicatrização/fisiologia , Biópsia , Seguimentos , Procedimentos Cirúrgicos Bucais
3.
Oral Dis ; 26(2): 334-340, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31758745

RESUMO

OBJECTIVES: To investigate the molecular pathogenesis of implant-associated peripheral giant cell granuloma (IA-PGCG). METHODS: A convenience sample of 15 IA-PGCG cases was selected. Hotspot mutations of KRAS, FGFR1, and TRPV4 genes, previously reported in conventional giant cell lesions of the jaws, were investigated by Sanger sequencing. As these mutations could activate MAPK/ERK pathway, the expression of phospho-ERK1/2 was also evaluated by immunohistochemistry. RESULTS: KRAS mutations were detected in 8/15 (53.4%) samples. Similar to conventional peripheral giant cell granuloma, the KRAS mutations most frequently occurred in codon 146 (p.A146V, n = 3), followed by codon 12 (p.G12A and p.G12D, n = 1 each) and codon 14 (p.V14L, n = 1). Variants of unknown significance (VUS) were also detected in two cases, affecting codons 37 (p.E37K) and 127 (p.T127I). All samples showed wild-type (WT) sequences for FGFR1 and TRPV4 genes. Consistent with MAPK/ERK pathway activation, all mononuclear cells of the lesion showed strong staining for phospho-ERK1/2 protein in the immunohistochemical analysis. CONCLUSIONS: KRAS mutations and activation of the MAPK-ERK signaling pathway occur in IA-PGCG. This is the first study to demonstrate cancer-associated gene mutations in a non-neoplastic reactive condition associated with dental implants.


Assuntos
Implantes Dentários/efeitos adversos , Granuloma de Células Gigantes/etiologia , Granuloma de Células Gigantes/genética , Proteínas Proto-Oncogênicas p21(ras)/genética , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Quinases de Proteína Quinase Ativadas por Mitógeno/metabolismo , Mutação , Transdução de Sinais
4.
BMC Oral Health ; 19(1): 283, 2019 12 16.
Artigo em Inglês | MEDLINE | ID: mdl-31842866

RESUMO

BACKGROUND: Peripheral giant cell granuloma (PGCG) is an uncommon pathology that affects gingival or alveolar mucosa. Although PGCG can be associated with dental implants, little is known about this lesion and implant osseointegration as well as its etiopathogenesis and the treatments available. This study sought to report a rare case of PGCG associated with dental implant, emphasizing its clinical and histopathological aspects. CASE PRESENTATION: A 53-year-old man had an exophytic, reddish lesion, around a crown attached to a dental implant located in the left mandible. Radiographically, there was bone loss around the implant. After excisional biopsy, histological examination revealed a submucosal proliferation of multinucleated giant cells rendering the diagnosis of peripheral giant cell granuloma. Patient has been under follow-up for 6 months with no recurrence. CONCLUSIONS: Peri-implant lesions must be completely removed to prevent recurrence of PGCG and implant failure, even in cases suspected to be reactive. Besides, histological examination must be performed on all peri-implant reactions to achieve the appropriate diagnosis and, consequently, the best treatment and follow up.


Assuntos
Implantes Dentários , Granuloma de Células Gigantes , Células Gigantes , Gengiva , Humanos , Masculino , Mandíbula , Pessoa de Meia-Idade
5.
Rev. ADM ; 73(4): 175-182, jul.-ago. 2016. ilus, tab
Artigo em Espanhol | LILACS | ID: biblio-835291

RESUMO

El granuloma periférico de células gigantes (GPCG) es una hiperplasiareactiva que se presenta sólo en la encía como respuesta a una irritación local o trauma crónico, sin predilección de género y edad variable. Objetivo: Identifi car las características demográfi cas e histopatológicas de 87 casos de GPCG en un servicio privado de patología bucal. Metodología: Se obtuvieron los datos de edad, género y diagnóstico clínico de 87 casos de GPCG. Se analizó la distribución por género y edad. Los cortes histológicos fueron examinados para confirmar el diagnóstico en 84 casos, ya que tres no presentaron las características del GPCG. Las características histopatológicas que se evaluaron fueron la presencia de estroma hipercelular, infi ltrado infl amatorio crónico, hemorragia, hemosiderina, tejidos mineralizados y úlcera. Resultados: De los 87 casos, tres fueron descartados por no corresponder al diagnóstico. En un periodo de 10 años se recibieron 6,696 biopsias, de las cuales 84 (1.2 por ciento) correspondieron a GPCG. Se presentó en un rango de edad de cinco a 90 años, con una media de edad de 42 años (± 19.9), siendomás frecuente en la quinta década de la vida y mostró predilección por el género femenino (58.5 por ciento). En los cortes histológicos se observó un estroma hipercelular con células de forma ovoide o fusiforme y células gigantes multinucleadas tipo osteoclasto, infi ltrado inflamatorio(66 por ciento), hemorragia (85 por ciento), hemosiderina (20 por ciento), tejidos mineralizados (11.9 por ciento) y úlcera (25 por ciento). Conclusión: El GPCG es una lesión exofítica reactiva de la encía que presenta características demográficas variables y que al examen microscópico se distingue por tener células gigantes multinucleadas tipo osteoclasto, además de otros componentes como tejidos mineralizados.


The peripheral giant-cell granuloma (PGCG) is a reactive hyperplasiathat occurs only in the gum, in response to local irritation orchronic trauma, with no predilection for either age or sex. Objective:To identify the demographic and histopathological characteristics of87 cases of PGCG in a private oral pathology service. Methodology:Data on the age, gender, and clinical diagnosis of 87 cases of PGCGwere obtained, which were analyzed to determine the distributionby sex and age. Histological sections were examined to confirm thediagnosis in 84 of the cases (three did not present any characteristicsof PGCG). The histopathologic features were evaluated for the presence of hypercellular stroma, chronic infl ammatory infi ltrate,hemorrhaging, hemosiderin, mineralized tissues, and ulcers. Results: of the 87 cases, 3 were eliminated as they did not match the requireddiagnosis. Over a 10-year period, 6,696 biopsies were received bythe pathology service, of which 84 (1.2%) were of PGCG. This was presented in patients ranging from 5 to 90 years old, the mean agebeing 42 years (± 19.9); it occurred most frequently in the 5th decadeof life and showed a predilection for females (58.5%). In the histologicsections, a hypercellular stroma with ovoid or fusiform cellsand multinucleated osteoclast-like giant cells was observed, as wellas infl ammatory infi ltrate (66%), hemorrhaging (85%), hemosiderin(20%), mineralized tissues (11.9%), and ulcers (25%). Conclusion:The PGCG is a reactive exophytic lesion of the gingiva that presentsvariable demographic features and which, under microscopic examination, is distinguished by multinucleated osteoclast-like giant cells, and other components as mineralized tissues.


Assuntos
Humanos , Masculino , Feminino , Granuloma de Células Gigantes/cirurgia , Granuloma de Células Gigantes/diagnóstico , Granuloma de Células Gigantes/epidemiologia , Granuloma de Células Gigantes/patologia , Distribuição por Idade e Sexo , Biópsia/métodos , Diagnóstico Diferencial , México , Estudo Observacional , Procedimentos Cirúrgicos Bucais/métodos , Interpretação Estatística de Dados
6.
CCH, Correo cient. Holguín ; 19(2): 378-384, abr.-jun. 2015. ilus
Artigo em Espanhol | LILACS | ID: lil-749568

RESUMO

Se presentó una paciente femenina de 37 años de edad, sin antecedentes generales de interés, con hábito de onicofagia desde la niñez, que presentaba aumento de volumen localizado en la papila interdentaria entre incisivo lateral y canino maxilar derecho, de aproximadamente dos años de evolución, que le ocasionaba molestias y sangramiento durante el cepillado dentogingival. La lesión se presentó con aspecto de una pieza dentaria, de coloración rosa a rojo, superficie lisa, base sésil, no doloroso a la palpación, rebasaba el borde incisal, sin interferir con la oclusión y sobrepasaba el ancho vestíbulo lingual de los dientes contiguos en aproximadamente dos milímetros. Radiográficamente se observó reabsorción superficial de la cresta del tabique interdentario entre ambos dientes y espaciamiento del trabeculado óseo. Se realizó la escisión quirúrgica y posterior examen anatomopatológico, el cual confirmó la presencia de granuloma periférico gigante celular completamente resecado, lo cual corroboró el diagnóstico presuntivo. Se apreció una satisfactoria evolución postquirúrgica.


A female patient of 37 years old with no history of general interest, nail biting habit from childhood, which had increased volume within the interdental papilla between lateral incisor and maxillary right canine about two years of evolution was presented, which caused discomfort and bleeding during dentogingival brushing. The lesion appeared with appearance of a tooth, pink color to red, smooth, sessile base, not painful on palpation, exceeded the incisal margin, without interfering with the occlusion and surpassing the broad lingual hall of the contiguous teeth in approximately two millimeters. The radiographic exam evidenced superficial reabsorption of the crest of the interdental partition between both teeth and bone-like spacing of the trabeculate. The lesion was eliminated by surgical excision. The histologic test confirmed the presence of peripheral giant cell granuloma completely eliminated. A satisfactory post-surgical evolution was observed.

7.
J. res. dent ; 3(1): [606-610], jan.-feb2015.
Artigo em Inglês | LILACS | ID: biblio-1363318

RESUMO

Peripheral giant cell granuloma (PGCG) is a non neoplastic reactive lesion of the gingiva, originating from the periosteum or periodontal membrane following local irritation or chronic trauma. PGCG manifests as a red-purple growth located in the gingiva or edentulous alveolar margins. The lesion can develop at any age, shows a slight female predilection. Usually, they cause one or the other problem in eruption or alignment of teeth, but may also present without disturbing the normal occlusion or eruption pattern. Management of these teeth depends on the symptoms. Presented here is a case of PGCG in relation to the lower right first premolar in a 10 year old child.


Assuntos
Humanos , Masculino , Feminino , Criança , Granuloma de Células Gigantes , Doenças da Gengiva , Hiperplasia
8.
Rev. Fac. Odontol. Univ. Antioq ; 22(1): 117-121, dic. 2010.
Artigo em Espanhol | LILACS | ID: lil-575825

RESUMO

El granuloma periférico de células gigantes (GPCG) es una lesión pseudotumoral exofítica poco frecuente en cavidad oral, localizado principalmente en el maxilar inferior en zona de premolares y molares, sangrante y de crecimiento rápido, asociado a factores irritativos o agresión (extracción, traumatismo, placa, sarro, obturación desbordante, infección crónica, impactación alimentaria, etc.). Su tratamiento es la excisión quirúrgica, retirando los factores irritativos. Dentro de sus diagnósticos diferenciales se encuentran el tumor pardo del hiperparatiroidismo, el querubismo y el quiste óseo aneurismático, que tienen el mismo patrón histológico del granuloma periférico de células gigantes. Se reporta caso clínico de paciente femenino de 52 años de edad que acudió a consulta odontológica en la Facultad de Odontología de la Universidad de Cartagena, por presentar una lesión tumoral ubicada en encía vestibular y lingual zona de anteroinferiores asociada con abundante placa bacteriana y cálculos subgingivales. Se le realizó la escisión quirúrgica de la lesión, exodoncia de los dientes involucrados por la marcada pérdida ósea, curetaje y se envió a patología donde se confirmó diagnóstico de granuloma periférico de células gigantes.


The peripheral giant cell granuloma (PGCG) is a pseudotumoral exophytic lesion, very rare in oral cavity, it is primarily located in the premolar and molar area of the mandible, it usually presents bleeding and rapid growth, also, is associated with aggression or irritating factors (extraction, trauma, plaque, tartar, faulty restorations, chronic infection, food impaction, among others). Its treatment consists of surgical excision, removing the irritating factors. Within its differential diagnosis are the hyperparathyroidism brown tumor, cherubism and aneurysmal bone cyst, which have the same histological pattern as the peripheral giant cell granuloma. This is a description of a clinical case of a female patient, age 52 who attended the College of Dentistry of the University of Cartagena because she presented a tumor located in the vestibular and lingual gingival area of anterior and lower zone associated with abundant bacterial plaque and subgingival calculus. The surgeon made the surgical excision of the lesion, extraction of teeth affected by the marked bone loss, and curettage. The sample was sent to the pathology lab which confirmed the diagnosis of peripheral giant cell granuloma.


Assuntos
Humanos , Hiperplasia Gengival , Granuloma de Células Gigantes
9.
Rev. Salusvita (Online) ; 26(1): 99-104, 2007. ilus
Artigo em Português | LILACS | ID: lil-559704

RESUMO

A lesão periférica de células gigantes é um processo proliferativo não neoplásico. Considerada uma lesão reacional, parece ter origem no periósteo ou ligamento periodontal, relacionada a trauma, irritação local e mais recentemente aos implantes dentais. Neste trabalho apresentamos as principais características clínicas, radiográficas e microscópicas da lesão fundamentados em recente revisão de literatura.


Peripheral giant cell granuloma is a non-neoplasic tumorous proliferationthat occurs in all age groups, and this condition can be more aggressive in child. The etiological factors it is not exactly known, althogh local irritating factors, trauma, and actually dentalimplants are related. There is a high predilection for the mandible anda slight one for women. After surgical treatment the tissue must besubmitted for histopathological evaluation to a correct diagnosis.


Assuntos
Humanos , Masculino , Feminino , Boca/cirurgia , Ferimentos e Lesões , Granuloma de Células Gigantes , Implantes Dentários
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