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Can J Physiol Pharmacol ; 95(2): 157-162, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27901369

RESUMO

Spontaneously hypertensive rats (SHR) display autonomic imbalance and abnormal body temperature (Tb) adjustments. Hydrogen sulfide (H2S) modulates hypoxia-induced hypothermia, but its role in SHR thermoregulation is unknown. We tested the hypothesis that SHR display peculiar thermoregulatory response to hypoxia and that endogenous H2S overproduced in the caudal nucleus of the solitary tract (NTS) of SHR modulates this response. SHR and Wistar rats were microinjected into the fourth ventricle with aminooxyacetate (AOA, H2S-synthezing enzyme inhibitor) or sodium sulfide (Na2S, H2S donor) and exposed to normoxia (21% inspired O2) or hypoxia (10% inspired O2, 30 min). Tb was continuously measured, and H2S production rate was assessed in caudal NTS homogenates. In both groups, AOA, Na2S, or saline (i.e., control; 1 µL) did not affect euthermia. Hypoxia caused similar decreases in Tb in both groups. AOA presented a longer latency to potentiate hypoxic hypothermia in SHR. Caudal NTS H2S production rate was higher in SHR. We suggest that increased bioavailability of H2S in the caudal NTS of SHR enables the adequate modulation of excitability of peripheral chemoreceptor-activated NTS neurons that ultimately induce suppression of brown adipose tissue thermogenesis, thus accounting for the normal hypoxic hypothermia.


Assuntos
Regulação da Temperatura Corporal , Sulfeto de Hidrogênio/metabolismo , Hipotermia Induzida , Hipóxia/fisiopatologia , Ácido Amino-Oxiacético/administração & dosagem , Ácido Amino-Oxiacético/farmacologia , Animais , Temperatura Corporal/efeitos dos fármacos , Hipóxia/complicações , Masculino , Microinjeções , Ratos , Ratos Endogâmicos SHR , Núcleo Solitário/metabolismo , Núcleo Solitário/fisiopatologia , Sulfetos/administração & dosagem , Sulfetos/farmacologia
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