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Involvement of endogenous central hydrogen sulfide (H2S) in hypoxia-induced hypothermia in spontaneously hypertensive rats.
Sabino, João Paulo J; Soriano, Renato N; Donatti, Alberto F; Fernandez, Rodrigo Restrepo; Kwiatkoski, Marcelo; Francescato, Heloísa D C; Coimbra, Terezila M; Branco, Luiz G S.
Afiliação
  • Sabino JP; a Dental School of Ribeirão Preto, 14040-904, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Soriano RN; b Division of Physiology and Biophysics, Department of Basic Life Sciences, Federal University of Juiz de Fora, 35020-220, Governador Valadares, MG, Brazil.
  • Donatti AF; a Dental School of Ribeirão Preto, 14040-904, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Fernandez RR; a Dental School of Ribeirão Preto, 14040-904, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Kwiatkoski M; a Dental School of Ribeirão Preto, 14040-904, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Francescato HD; c School of Medicine of Ribeirão Preto, 14040-904, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Coimbra TM; c School of Medicine of Ribeirão Preto, 14040-904, University of São Paulo, Ribeirão Preto, SP, Brazil.
  • Branco LG; a Dental School of Ribeirão Preto, 14040-904, University of São Paulo, Ribeirão Preto, SP, Brazil.
Can J Physiol Pharmacol ; 95(2): 157-162, 2017 Feb.
Article em En | MEDLINE | ID: mdl-27901369
Spontaneously hypertensive rats (SHR) display autonomic imbalance and abnormal body temperature (Tb) adjustments. Hydrogen sulfide (H2S) modulates hypoxia-induced hypothermia, but its role in SHR thermoregulation is unknown. We tested the hypothesis that SHR display peculiar thermoregulatory response to hypoxia and that endogenous H2S overproduced in the caudal nucleus of the solitary tract (NTS) of SHR modulates this response. SHR and Wistar rats were microinjected into the fourth ventricle with aminooxyacetate (AOA, H2S-synthezing enzyme inhibitor) or sodium sulfide (Na2S, H2S donor) and exposed to normoxia (21% inspired O2) or hypoxia (10% inspired O2, 30 min). Tb was continuously measured, and H2S production rate was assessed in caudal NTS homogenates. In both groups, AOA, Na2S, or saline (i.e., control; 1 µL) did not affect euthermia. Hypoxia caused similar decreases in Tb in both groups. AOA presented a longer latency to potentiate hypoxic hypothermia in SHR. Caudal NTS H2S production rate was higher in SHR. We suggest that increased bioavailability of H2S in the caudal NTS of SHR enables the adequate modulation of excitability of peripheral chemoreceptor-activated NTS neurons that ultimately induce suppression of brown adipose tissue thermogenesis, thus accounting for the normal hypoxic hypothermia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Temperatura Corporal / Sulfeto de Hidrogênio / Hipotermia Induzida / Hipóxia Limite: Animals Idioma: En Revista: Can J Physiol Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Temperatura Corporal / Sulfeto de Hidrogênio / Hipotermia Induzida / Hipóxia Limite: Animals Idioma: En Revista: Can J Physiol Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá