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Fundamento: el trastorno del espectro autista es una entidad de origen neurobiológico, caracterizada por una variedad de signos y síntomas. Objetivo: elevar el nivel de conocimiento en familiares de educandos con trastorno del espectro de autismo. Métodos: se realizó un estudio cuasiexperimental, de intervención educativa en los nueve Servicios de Rehabilitación de las áreas de salud del municipio de Camagüey, durante los meses enero-diciembre de 2022. La muestra quedó constituida por 25 familiares que cumplieron con los criterios de elegibilidad. Para evaluar los resultados de la intervención se aplicó un cuestionario antes y después de desarrollada la intervención. Resultados: existió predominio del sexo femenino 23 (92 %), un rango de edad de 30-39 años 11 (44 %) y un nivel escolar de bachiller 13 (52 %). Antes de la intervención fue insuficiente el nivel de conocimiento general sobre el trastorno del espectro autista en un 68 %. En lo referente a la competencia emocional, alcanzó el 84 %, el tratamiento indicado el 84 %, y los métodos educativos el 60 %. Posterior a la estrategia se logró elevar el nivel de conocimiento general en el 100 %, el 92 % alcanzó el objetivo de la competencia emocional, el 100 % logró suficiencia sobre el tratamiento indicado y en el 92 % obtuvo mejoría en el conocimiento sobre los estilos educativos. Conclusiones: se logró elevar el nivel de conocimientos generales sobre el trastorno del espectro autista, la competencia emocional, cumplimiento del tratamiento neurosensorial y estilos educativos.

Background: autism spectrum disorder" is an entity of neurobiological origin, characterized by a variety of signs and symptoms. Objective: raise the knowledge level in relatives of students with autism spectrum disorder. Methods: a quasi-experimental study of educational intervention was carried out in the nine Rehabilitation Services of the Camagüey municipality health areas, from January to December 2022. The sample consisted of 25 family members who met the eligibility criteria. To evaluate the results of the intervention, a questionnaire was applied before and after the intervention was developed. Results: there was a predominance of the female sex 23 (92%), an age range of 30-39 years 11 (44%) and a high school level 13 (52%). Before the intervention, the level of general knowledge about autism spectrum disorder was insufficient by 68%. Regarding emotional competence, it reached 84%, the indicated treatment 84%, and educational methods 60%. After the strategy, it was possible to raise the level of general knowledge by 100%, 92% achieved the objective of emotional competence, 100% achieved sufficiency regarding the indicated treatment and 92% obtained improvement in educational styles knowledge. Conclusions: it was possible to raise the level of general knowledge about autism spectrum disorder, emotional competence, compliance with neurosensory treatment and educational styles.

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BACKGROUND: In Brazil, human visceral leishmaniasis (HVL) is caused by the protozoan parasite Leishmania infantum, primarily transmitted by the sand fly Lutzomyia longipalpis, with dogs acting as the main urban reservoir. This study aims to evaluate the effectiveness of 4% deltamethrin-impregnated dog collars (DMC) on HVL incidence. METHODS: This is a community intervention study carried out from 2012 to 2015 in the municipalities of Araguaína, State of Tocantins, and Montes Claros, State of Minas Gerais, Brazil. Two areas in each were randomly allocated to either (1) culling seropositive dogs + residual insecticide spraying (control area-CA) or (2) culling seropositive dogs + residual insecticide spraying + DMC fitted to dogs every six months for two years (intervention area-IA). Cases of HVL (n = 1202) occurring from 2008 to 2020 were identified from the Brazilian Reportable Diseases Information System and georeferenced to the control and intervention areas. The HVL cases from 2008 to 2012 were considered as occurring in the "pre-intervention" period. Those cases from 2013 to 2016 and from 2017 to 2020 were regarded as occurring in the "intervention" and "post-intervention" periods, respectively. We used a mixed-effects Poisson regression model to estimate the effectiveness of the intervention, comparing the changes from the pre-intervention period to the intervention and post-intervention periods in the control and intervention areas. RESULTS: In Araguaína, there was a statistically significant reduction in the incidence of HVL in both the control and intervention areas, comparing both the intervention and post-intervention periods with the pre-intervention period. The intervention with DMC was significantly associated with a reduction in HVL when comparing the intervention and pre-intervention periods, yielding an effectiveness estimate of the DMC of 27% (IC95% 1-46%, p = 0.045). No differences were observed when comparing the pre- and post-intervention periods (p = 0.827). In Montes Claros, cases reduced in both the control and intervention areas from the pre-intervention period to the intervention period (p = 0.913). In the post-intervention period, the incidence increased in the control area, while cases continued to decrease in the DMC area (p = 0.188). CONCLUSIONS: The use of DMC was associated with a reduction of 27% in the incidence of HVL during the period of DMC delivery, indicating that DMC is effective as an additional strategy for controlling visceral leishmaniasis in Brazil. However, no significant reduction associated with DMC was detected after the intervention period, suggesting that a control program based on the large-scale deployment of DMC might have to be maintained for more extended periods without interruption.

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ABSTRACT Objective: to evaluate the effectiveness of an educational manual on the support provided by companions during the labor process in an obstetric center. Method: a Randomized Clinical Trial conducted with 248 participants, comprising 124 companions and 124 puerperal women. The study took place between November 2018 and October 2019 at an obstetric center in Fortaleza, Ceará, Brazil. The Companion Characterization Form, the Support Evaluation Form, and the Postpartum Woman's Labor Experience and Satisfaction Evaluation Form were used. The data were analyzed using the Statistical Package for the Social Sciences statistical program. Chi-square and Fisher tests were employed, as well as the Mann-Whitney test. The Relative Risk (RR) and the 95% Confidence Interval (CI) were calculated for the main dependent variables. Results: it was evident that the companions from the Intervention Group were more likely to engage in physical, emotional, informational and advocacy/intermediation support actions, with a statistically significant difference observed in all support dimensions when comparing both groups. The companions from the Intervention Group performed more support actions (20 vs 6; p:0.001) and rated the experience of accompanying the birth more favorably (100.0 vs 74.2; p:0.001). It was identified that the puerperal women accompanied by participants from the Intervention Group were more likely to express satisfaction with how the labor process took place. Conclusion: the intervention applied in the maternity unit using an educational manual aimed at parturients' companions is effective and contributes to providing support during childbirth.

RESUMEN Objetivo: evaluar la efectividad de un manual educativo en el apoyo proporcionado por acompañantes durante el proceso de parto en un centro obstétrico. Método: Ensayo Clínico Aleatorizado realizado con 248 participantes: 124 acompañantes y 124 puérperas. El estudio se llevó a cabo entre noviembre de 2018 y octubre de 2019 en un centro obstétrico de Fortaleza, Ceará, Brasil. Se utilizó un Formulario de caracterización del acompañante; un Formulario para evaluar el apoyo proporcionado y un Formulario para evaluar la experiencia y satisfacción de las puérperas con el trabajo de parto. Los datos se analizaron en el programa estadístico Statistical Package for the Social Sciences. Se emplearon las pruebas de chi-cuadrado y Fisher y la de Mann-Whitney. Se calculó el Riesgo Relativo (RR) y el Intervalo de Confianza (IC) del 95% para las principales variables dependientes Resultados: se evidenció que los acompañantes del Grupo Intervención fueron más propensos a desarrollar acciones de apoyo físico, emocional, informativo y de soporte/intermediación, verificándose una diferencia estadística significativa en todas las dimensiones de apoyo al comparar ambos grupos. Los acompañantes del Grupo Intervención realizaron más acciones de apoyo (20 vs 6; p:0,001) y evaluaron de mejor manera la experiencia de estar presentes en el parto (100,0 vs 74,2; p:0,001). Se determinó que las puérperas acompañadas por participantes del Grupo Intervención fueron más propensas a mostrarse satisfechas con la forma en la que se desarrolló el trabajo de parto. Conclusión: la intervención que se aplicó en la maternidad empleando el manual educativo y direccionada a acompañantes de parturientas es efectiva y ayuda a proporcionar apoyo durante el parto.

RESUMO Objetivo: Avaliar a efetividade de um manual educativo no apoio prestado por acompanhantes durante o processo parturitivo em um centro obstétrico. Método: Ensaio Clínico Randomizado realizado com 248 participantes, sendo 124 acompanhantes e 124 puérperas. O estudo foi realizado em centro obstétrico em Fortaleza, Ceará, Brasil, entre os meses de novembro de 2018 a outubro de 2019. Utilizou-se o Formulário de caracterização do acompanhante; Formulário de avaliação do apoio prestado; e Formulário de avaliação da experiência e satisfação da puérpera com o trabalho de parto. Os dados foram analisados no programa estatístico Statistical Package for the Social Sciences. Foram utilizados os testes qui-quadrado e Fisher e o teste de Mann-Whitney. O Risco Relativo (RR) e o Intervalo de Confiança (IC) de 95% foram calculados para as principais variáveis dependentes Resultados: Evidenciou-se que acompanhantes do grupo intervenção tiveram mais probabilidade de desenvolver ações de apoio físico, emocional, informacional e advocacia/intermediação, verificando-se diferença estatística significativa em todas as dimensões de apoio quando comparados os dois grupos. Acompanhantes do grupo intervenção realizaram um maior número de ações de apoio (20 vs 6; p:0,001) e melhor avaliaram a experiência de acompanhar o parto (100,0 vs 74,2; p:0,001). Identificou-se que puérperas acompanhadas por participantes do grupo intervenção foram mais propícias a demonstrar satisfação com a forma como ocorreu o trabalho de parto. Conclusão: A intervenção aplicada na maternidade com uso de manual educativo direcionada a acompanhantes de parturientes é efetiva e contribui para a prestação de apoio durante o parto.

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Introducción: En el contexto de la pandemia por COVID-19 surgen las secuelas discapacitantes, aún por dimensionar, que acompañarán los próximos años. En relación con esta temática deben dirigirse acciones con enfoque multidisciplinario, donde la salud pública y el sistema educativo aporten el conocimiento y la metodología para su enfrentamiento. Objetivo: Elevar el nivel de conocimiento sobre las secuelas discapacitantes pos-COVID-19 en estudiantes de medicina. Métodos: Se realizó un estudio cuasi-experimental de intervención educativa en estudiantes de quinto año de medicina de la Universidad de Ciencias Médicas de Camagüey, desde la asignatura Salud Pública, durante el período abril-mayo de 2023. Del universo de 23 estudiantes se seleccionó una muestra de 20. Fueron estudiadas las variables grupos de edades, sexo, nivel de conocimiento sobre la epidemiología de las secuelas discapacitantes pos-COVID-19, clasificación por sistemas, identificación, seguimiento, tratamiento y nivel de conocimiento global acerca de estas. Resultados: Predominaron el grupo de 21-25 años (50 por ciento) y el sexo femenino (65 por ciento). En el tema sobre la epidemiología de las secuelas discapacitantes pos-COVID-19 el nivel de conocimiento aumentó entre 5-95 por ciento; mientras, en lo referente a la clasificación por sistemas alcanzó 20-90 por ciento. En cuanto a la identificación, el seguimiento y el tratamiento, el nivel de conocimiento suficiente fue de un 15-75 por ciento. La evaluación global suficiente transitó de un 5 por ciento a un 90 por ciento. Conclusiones: Se logró elevar el nivel de conocimiento sobre las secuelas discapacitantes pos-COVID-19 en estudiantes de medicina. Esto permitirá identificar, conducir y seguir los casos durante la educación en el trabajo(AU)

Introduction: In the context of the COVID-19 pandemic, the disabling sequelae emerge, still to be measured, which will accompany the coming years. With respect to this issue, actions with a multidisciplinary approach should be targeted, in which public health and the educational system provide the knowledge and methodology for their confrontation. Objective: To raise the level of knowledge about post-COVID-19 disabling sequelae in medical students. Methods: A quasiexperimental study of educational intervention was carried out with fifth-year medical students from Universidad de Ciencias Médicas de Camagüey, as part of the Public Health course, during the period April-May 2023. From the study universe of 23 students, a sample of 20 was selected. The following variables were studied: age groups, sex, level of knowledge about the epidemiology of post-COVID-19 disabling sequelae, classification by systems, identification, follow-up, treatment and overall level of knowledge about these. Results: The group aged 21-25 years (50 percent) and the female sex (65 percent) predominated. The level of knowledge about the epidemiology of post-COVID-19 disabling sequelae increased between 5 percent and 95 percent, while it reached 20 percent -90 percent regarding the classification by systems. With respect to identification, follow-up and treatment, the level of sufficient knowledge was 15 percent -75 percent. The overall sufficient assessment moved from 5 percent to 90 percent. Conclusions: The level of knowledge about post-COVID-19 disabling sequelae was managed to be raised in medical students. This will allow identifying, conducting and following up cases during education at work(AU)

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Resumen Objetivo: Evaluar el impacto de una intervención educativa individualizada en los conocimientos, autocuidado de los pies, control glucémico, riesgo de ulceración e incidencia de úlceras en pacientes con diabetes tipo 2. Material y Métodos: Estudio de intervención realizado en 65 pacientes ambulatorios, mayores de 35 años, con diabetes tipo 2, distribuidos aleatoriamente en dos grupos: grupo control (35) quien recibió un manual de cuidado de los pies, y grupo intervención (30) quien recibió la intervención, un kit de cuidado de los pies y un manual. El seguimiento se realizó a los tres y seis meses después de la intervención. El análisis estadístico incluyó la prueba de Chi-cuadrado, prueba de Wilcoxon y prueba ANOVA de mediciones repetidas. Resultados: La intervención mejoró los conocimientos y el autocuidado de pies en el grupo de intervención, con diferencias significativas entre grupos (p=.001), pero no mejoró el control glucémico ni el riesgo de ulceración. Conclusiones: El programa "tus pies te llaman" fue efectivo parcialmente, este estudio puede ser replicado en instituciones de primer nivel de forma ordinaria para mejorar el autocuidado y prevenir la ulceración del pie a mediano plazo.

Abstract Objective: To evaluate the impact of an individualized educational intervention on knowledge, self-care of the feet, glycemic control, risk of ulceration and incidence of ulcers in patients with type 2 diabetes. Material and Methods: The intervention study, was carried out on 65 outpatients, over 35 years of age, with type 2 diabetes, patients were randomly distributed into two groups: the control group (35), who received a manual on foot care, and the intervention group (30), who received the intervention, a foot care kit, and manual. Follow-up was done at three and six months after the intervention. Statistical analysis included the Chi-square test, Wilcoxon test and the ANOVA test of repeated measures. Results: The intervention improved knowledge and foot self-care in the intervention group with significant differences between groups (p=.001), but not the glycemic control or the ulceration risk. Conclusions: The program "Your Feet Call You" was partially effective, and this study can be ordinarily replicated in first-level institutions to improve self-care and prevent foot ulceration in the medium term.

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Objective: to investigate the influence of physical exercise in the context of cognitive compromise of the elderly, and the exercise programmes of greater impact in the motor response and neuromuscular adaptations. Method: a systematic review was developed in the Pubmed/MEDLINE, Scopus, LILACS, SPORTDiscus and Embase databases. The PRISMA 2020 checklist and bias risk analysis were applied using the Cochrane handbook scale for the systematic review of interventions (Version 5.1.0). Domains in table 8.5.d. Results: 21 studies were included in the qualitative analysis. The regular practice of physical exercise causes a series of positive neuromuscular adaptations in the elderly. These adaptations are related to increases in muscle mass, strength and power, favouring cognitive and motor capacity. The change in lifestyle of the elderly has a significant impact, and 30% of the ageing process is considered natural and caused by sensory, mental and physical factors and a loss of self-control, but 70% depends absolutely on the individual lifestyle. Conclusion: The present study suggests a programme composed of combined strength, resistance and aerobic exercises. Such exercises cause increases in neurotrophic, vascular and growth factors, as well as promoting cognitive, mood and quality of life improvements during ageing. Thus, the implementation of an exercise programme involving plyometrics and greater intensities of resistance training (equal or greater to 60% of 1-MR) and an adequate and progressive volume (equal or greater to three 30-40-minute sessions per week), appears to promise improved cognitive and psychomotor outcomes in old age (AU).

Objetivo: investigar a influência do exercício físico no comportamento cognitivo dos idosos e os programas de exercícios de maior impacto na resposta motora e adaptações neuromusculares. Método: desenvolveu-se uma revisão sistemática nas bases de dados Pubmed/MEDLINE, Scopus, LILACS, SPORTDiscus e Embase. Utilizou-se o PRISMA 2020 e análise de risco de viés através da escala Cochrane handbook para revisões sistemáticas de inter-venções (Versão 5.1.0). Domínios da tabela 8.5.d Resultados: 21 estudos foram incluídos para análise qualitativa. A prática regular de exercício físico desencadeia uma série de adaptações neuromusculares positivas em pessoas idosas. Essas adaptações estão relacionadas ao aumento da massa, força e potência muscular, favorecendo a capa-cidade cognitiva e motora. A mudança no estilo de vida do idoso apontou impacto significativo, e 30% do processo de envelhecimento é considerado natural e causado por fatores sensoriais, mentais, físicos e perda do autocontrole. No entanto, 70% dependem impreterivelmente do estilo de vida individual. Conclusão: O presente estudo sugere um programa composto por exercícios combinados de força, resistência e aeróbicos. Tais exercícios promovem o aumento dos fatores neurotróficos, vascular e de crescimento, além de promover melhorias cognitivas, de humor e qualidade de vida ao envelhecer. Para tanto, a implementação de um programa de exercícios que envolva a plio-metria e um treinamento resistido com intensidades mais altas (igual ou superior a 60% de 1-RM) e um volume adequado e progressivo (igual ou superior a 3 sessões de 30-40 minutos por semana), parece ser promissor aos melhores desfechos cognitivos e psicomotores na terceira idade (AU).

El objetivo: investigar la influencia del ejercicio físico en el comportamiento cognitivo de las personas mayores y los programas de ejercicio con mayor impacto en la respuesta motora y adaptaciones neuromusculares. Método: se realizó una revisión sistemática en las bases de datos Pubmed/MEDLINE, Scopus, LILACS, SPORTDiscus y Embase. Se utilizó el PRISMA 2020 y el análisis de riesgo de sesgo mediante la escala del manual Cochrane para revisiones sistemáticas de intervenciones (Versión 5.1.0). Dominios en la tabla 8.5.d Resultados: Se incluyeron 21 estudios para el análisis cualitativo. La práctica regular de ejercicio físico desencadena una serie de adaptaciones neuro-musculares positivas en las personas mayores. Estas adaptaciones están relacionadas con el aumento de la masa muscular, la fuerza y la potencia, favoreciendo la capacidad cognitiva y motora. El cambio en el estilo de vida de los ancianos mostró un impacto significativo, y el 30% del proceso de envejecimiento se considera natural y causado por factores sensoriales, mentales, físicos y pérdida de autocontrol. Sin embargo, el 70% depende absolutamen-te del estilo de vida individual. Conclusión: El presente estudio sugiere un programa compuesto por ejercicios combinados de fuerza, resistencia y aeróbicos. Dichos ejercicios promueven el aumento de factores neurotróficos, vasculares y de crecimiento, además de promover mejoras cognitivas, anímicas y de calidad de vida en el enveje-cimiento. Por lo tanto, la implementación de un programa de ejercicios que involucre ejercicios pliométricos y de fuerza con intensidades más altas (igual o mayor al 60% de 1-RM) y un volumen adecuado y progresivo (igual o mayor a 3 sesiones de 30-40 minutos a la semana) ), parece ser prometedor para mejores resultados cognitivos y psicomotores en la vejez (AU).

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Objetivo: compreender o excesso de judicialização no Brasil e buscar algumas justificativas que levaram ao estado da arte. Metodologia: utilizou-se o método de pesquisa indutivo, realizando um levantamento bibliográfico e análise documental, com base em dados divulgados pelo Conselho Nacional de Justiça e, de forma complementar, em dados extraídos do sítio institucional da Agência Nacional de Saúde Suplementar. Resultados: a judicialização da saúde tem apresentado um caráter predominantemente individual, o que agrava o alcance da macrojustiça e do atendimento da coletividade. Além disso, as dificuldades estruturais do Sistema Único de Saúde tornam-se cada vez mais evidentes. Observa-se que a judicialização da saúde pode ser perversa do ponto de vista do excesso de concessão de tutelas de urgência, da prioridade da justiça individualizada e do destaque da microjustiça; elementos que prejudicam o funcionamento do sistema de saúde como um todo. Conclusão: a indústria farmacêutica apresenta intensa participação no processo de incorporação de medicamentos. No entanto, a complexidade e demora das etapas procedimentais da incorporação dessas novas tecnologias, não raro, resultam em demandas judiciais que derivam decisões polêmicas e nem sempre acertadas. Todo esse desenho acaba por desencadear pressão no órgão competente de incorporação, incompreensões sobre o funcionamento do SUS e fortalecimento da microjustiça.

Objective: to understand the excess of judicialization in Brazil and seek some justifications that led to the state of the art. Methods: an inductive research method was used, which involved conducting a bibliographic survey and documentary analysis of data released by the National Council of Justice and, in addition, data extracted from the institutional website of the National Supplementary Health Agency. Results: the judicialization of health has presented a predominantly individual aspect, which aggravates the reach of macrojustice and community care. In addition, the structural difficulties of the Unified Health System become increasingly evident. The judicialization of health can be perverse from the point of view of the excess of granting emergency guardianships, the priority of individualized justice, the prominence of microjustice; elements that undermine the functioning of the health system as a whole. Conclusion: the pharmaceutical industry plays an intense role in the drug incorporation process. However, the complexity and delay in the procedural stages of incorporating these new technologies often result in legal demands that result in controversial decisions that are not always correct. This entire design ends up triggering pressure on the competent incorporation body, misunderstandings about the functioning of the SUS and strengthening microjustice.

Objetivo: comprender el exceso de judicialización en Brasil y buscar algunas justificaciones que han llevado al estado del arte. Metodología: se utilizó el método de investigación inductivo, realizando un levantamiento bibliográfico y análisis documental, con base en datos divulgados por el Consejo Nacional de Justicia y, de forma complementaria, en datos extraídos del sitio web institucional de la Agencia Nacional de Salud Complementaria. Resultados: la judicialización de la salud ha presentado un carácter predominantemente individual, lo que agrava el alcance de la macrojusticia y de la atención de la colectividad. Además, las dificultades estructurales del Sistema Único de Salud son cada vez más evidentes. Se observa que la judicialización de la salud puede ser perversa desde el punto de vista de la concesión excesiva de tutelas de urgencia, de la prioridad de la justicia individualizada y del énfasis en la microjusticia; elementos que perjudican el funcionamiento del sistema de salud em su conjunto. Conclusión: la industria farmacéutica juega un papel intenso en el proceso de incorporación de medicamentos. Sin embargo, la complejidad y demora en las etapas procesales de incorporación de estas nuevas tecnologías derivan muchas veces en exigencias legales que derivan en decisiones controvertidas y no siempre correctas. Todo este diseño termina provocando presiones sobre el órgano constitutivo competente, malentendidos sobre el funcionamiento del SUS y fortalecimiento de la microjusticia.

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Women in the US Virgin Islands (USVI) experience intimate partner violence (IPV) and human immunodeficiency virus (HIV) at disproportionate rates compared to women on the US mainland. Women in violent relationships report experiencing controlling behaviours that decrease their ability to negotiate for sex using condoms or to prevent unwanted pregnancies. Though several evidence-based interventions exist to prevent either IPV or HIV, few address them through an integrated health promotion approach or attend to particular USVI cultural mores. This article describes the systematic development of a theory based, culturally tailored, integrated health promotion intervention that addresses IPV and HIV among USVI women experiencing abuse. The process included: (i) identifying and integrating evidence-based health promotion interventions, (ii) conducting formative research using focus groups, (iii) synthesizing focus group data to inform intervention development and (iv) developing a culturally and linguistically appropriate intervention specific to the needs and concerns of USVI women. The Empowered Sisters Project: Making Choices Reducing Risks (ESP) was developed through this research. ESP is a three-session health promotion curriculum focussed on enhancing sexual health and safety among women experiencing abuse. The ESP intervention components included promoting condom use, increasing IPV and HIV knowledge and developing a personalized safety plan. Health professionals facilitated individual intervention sessions using culturally tailored visual media and scripts. This program focussed on experiences of women living in the USVI and has implications for utility across the Caribbean diaspora.

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Lipids represent one out of three major macronutrient classes in the human diet. It is estimated to account for about 15-20% of the total dietary intake. Triacylglycerides comprise the majority of them, estimated 90-95%. Other lipid classes include free fatty acids, phospholipids, cholesterol, and plant sterols as minor components. Various methods are used for the characterization of nutritional lipids, however, lipidomics approaches become increasingly attractive for this purpose due to their wide coverage, comprehensiveness and holistic view on composition. In this chapter, analytical methodologies and workflows utilized for lipidomics profiling of food samples are outlined with focus on mass spectrometry-based assays. The chapter describes common lipid extraction protocols, the distinct instrumental mass-spectrometry based analytical platforms for data acquisition, chromatographic and ion-mobility spectrometry methods for lipid separation, briefly mentions alternative methods such as gas chromatography for fatty acid profiling and mass spectrometry imaging. Critical issues of important steps of lipidomics workflows such as structural annotation and identification, quantification and quality assurance are discussed as well. Applications reported over the period of the last 5years are summarized covering the discovery of new lipids in foodstuff, differential profiling approaches for comparing samples from different origin, species, varieties, cultivars and breeds, and for food processing quality control. Lipidomics as a powerful tool for personalized nutrition and nutritional intervention studies is briefly discussed as well. It is expected that this field is significantly growing in the near future and this chapter gives a short insight into the power of nutritional lipidomics approaches.

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Introducción: Actualmente, se ha expuesto el papel que desempeñan las habilidades cognitivo-emocionales en el desarrollo de la resiliencia. En consecuencia, estudios realizados hasta el momento indican que un buen nivel de inteligencia emocional tiene una influencia beneficiosa en el funcionamiento psicológico y social, al mejorar los procesos cognitivos, sociales, emocionales y conductuales. Se realizó una revisión sistemática mediante 2 búsquedas en distintas bases de datos, tales como PsycINFO, Scopus, Web of Science, Psicodoc y PubMed Central. De este modo, se obtuvieron un total de 472 documentos que, tras aplicar los criterios de inclusión y exclusión quedaron 5 estudios para revisión. Objetivo: Identificar la influencia que ejercen los programas de intervención en la promoción de la resiliencia y la inteligencia emocional en militares. Desarrollo: Se mostró la relación que ejercen los programas de intervención en el desarrollo de la resiliencia e inteligencia emocional en el bienestar personal de los miembros de las fuerzas armadas. Conclusiones: Los militares que poseen mayores niveles en resiliencia e inteligencia emocional presentan mayor bienestar psicológico y físico, así como mayor capacidad para adaptarse y recuperarse con mayor éxito ante situaciones difíciles y mostrar mejor preparación para el combate. Por tanto, se considera que futuros estudios de intervención tengan en cuenta los resultados del presente trabajo, de modo que les permita corroborar estos hallazgos(AU)

Introduction: Currently, the role of cognitive-emotional skills in the development of resilience has been exposed. Consequently, studies conducted so far indicate that a good level of emotional intelligence has a beneficial influence on psychological and social functioning by improving cognitive, social, emotional and behavioral processes. A systematic review was carried out through 2 searches in different databases, such as PsycINFO, Scopus, Web of Science, Psicodoc and PubMed Central. Objective: To identify the influence of intervention programs in the promotion of resilience and emotional intelligence in the military. Development: A total of 472 documents were obtained and, after applying the inclusion and exclusion criteria, 5 studies were left for review. The existing relationship between the intervention programs in the development of resilience and emotional intelligence in the personal well-being of the members of the Armed Forces was shown. Conclusions: Military personnel with higher levels of resilience and emotional intelligence have greater psychological and physical well-being, as well as a greater capacity to adapt and recover more successfully in difficult situations and show better combat readiness. Therefore, it is considered that future intervention studies should take into account the results found in the present work, in order to corroborate these findings(AU)

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Introducción: El paludismo o malaria es una enfermedad producida por el parásito Plasmodium, se transmite por la picadura del mosquito Anopheles hembra. En la actualidad la malaria está considerada como una enfermedad de gran impacto, hay poblaciones que residen en áreas donde es común encontrarla, por lo que constituye un problema de salud pública a nivel mundial. Objetivo: Evaluar la intervención de autocuidado del adulto con malaria en la comunidad. Métodos: Se realizó un estudio de intervención, desarrollo contextualizado en el Centro de Salud del Barrio Piloto del municipio Cuito Provincia Bie, país Angola durante el periodo de 2022 a 2023. Variables de estudio: nivel de información, autocuidado y estado de salud. Se utilizó entrevista estructurada para conocer la información y el autocuidado brindado por el personal de enfermería, para la mejoría del estado de salud. Después de aplicada de la estrategia se compararon las proporciones poblacionales mediante Prueba de McNemar. Resultados: La información de las enfermeras, al finalizar el programa de capacitación obtuvo 72,09 %. El del estado de salud de los adultos con malaria fue bueno 86,66 %; el autocuidado de los adultos se pudo constatar que recibieron un cuidado aceptable, el 68,57 % obedeció a cambios de conductas. Conclusiones: Se logró el diseño de la intervención de autocuidado del adulto con malaria en la comunidad, que favorecen la relación adulto con malaria, enfermera, familia y comunidad.

Introduction: Malaria is a disease caused by the Plasmodium parasite, and is transmitted by the bite of the female Anopheles mosquito. Malaria is currently considered a high-impact disease, there are populations residing in areas where it is common to find it, this being a public health problem worldwide. Objective: To evaluate the self-care intervention of adults with malaria in the community. Methods: An intervention study was carried out, which was develop contextualized in the Health Center of the Pilot Neighborhood of the Cuito Municipality, Bie Province, from 2022 to 2023. Study variables, level of information, self-care, state of health. A structured interview was used to know the information and self-care provided by the Nursing staff, for the improvement of the state of health. After applying the strategy, the population proportions were compared using the McNemar Test. Results: The information of the nurses, at the end of the training program, obtained 72.09%. The health status of adults with malaria was good 86.66%; self-care of adults it was possible to verify that they received acceptable care, 68.57% were due to behavioral changes. Conclusions: The design of the self-care intervention of the adult with malaria in the community was achieved, which favors the adult relationship with malaria, nurse, family and community.

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Introducción: La COVID-19 es una enfermedad que se ha propagado por todo el mundo con comportamiento de pandemia. Objetivo: Determinar el nivel de conocimiento sobre COVID-19 en los residentes de la especialidad de Higiene y Epidemiología en la provincia Camagüey. Métodos: Se realizó un estudio cuasi-experimental de intervención educativa para determinar el nivel de conocimiento sobre COVID-19 en los residentes de la especialidad de Higiene y Epidemiología, en el período comprendido del 1ro de enero al 31 de marzo de 2021. El universo estuvo constituido por 57 residentes y se tomó una muestra de 42 a través de un muestreo aleatorio simple, a los que se les aplicó un cuestionario el cual constituyó la fuente primaria de obtención de los datos de la investigación. Para la ejecución del estudio en una primera etapa se estableció la comunicación con los estudiantes con el objetivo de lograr la participación de los mismos en dicha investigación. Resultados: Se encontró bajos conocimientos sobre qué es la COVID-19, su sintomatología, modo de transmisión, cómo se diagnóstica y las medidas o formas de prevención. Conclusiones: Se considera efectiva la intervención educativa ya que se elevó el número de residentes de la especialidad que adquirieron los conocimientos sobre el tema investigado.

Introduction: COVID-19 is a disease that has spread rapidly throughout the world with a pandemic behavior. Objective: To determine the level of knowledge about COVID-19 in residents of the Hygiene and Epidemiology specialty in Camagüey. Methods: A quasi-experimental study on educational intervention was carried out to determine the level of knowledge about COVID-19 in residents of the Hygiene and Epidemiology specialty, in the period from January 1st to March 31st, 2021. The universe was made up of 57 residents and a sample of 42 was taken through simple random sampling, to whom a questionnaire was applied which was the primary source of obtaining the research data. To carry out the study in a first stage, communication with the students was established with the objective of achieving their participation in above-mentioned research. Results: Low knowledge was found about what COVID-19 is, its symptoms, transmission mode, how it is diagnosed and measures or forms of prevention. Conclusions: The educational intervention is considered effective since the number of residents of the specialty who acquired knowledge about the topic investigated increased.

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Introducción: Son innumerables los beneficios de la lactancia materna, ya que proporciona los nutrientes y la energía necesaria para un crecimiento y desarrollo saludable en los lactantes durante sus primeros seis meses de vida, sin embargo, todavía existe desconocimiento sobre este tema. Objetivo: Elevar el nivel de conocimientos sobre la lactancia materna en gestantes ingresadas en el Hogar Materno Justo Legón Padilla, pertenecientes al municipio y provincia Pinar del Río, durante el año 2022. Métodos: Se realizó un estudio cuasi experimental de intervención educativa, con pre y post test. El universo estuvo conformado por 150 embarazadas que estuvieran en el último trimestre de embarazo, ingresadas en dicha institución en el período señalado, de la cual se seleccionó una muestra de 90 embarazadas según muestreo probabilístico al azar simple, previo consentimiento informado. Se aplicó un programa educativo. Los resultados fueron procesados y presentados a través de tablas. Se aplicaron medidas estadísticas de distribución de frecuencias absolutas y relativas. Resultados: El 97 % de las embarazadas se encontraron con buena calificación posterior a la intervención educativa, en temas relacionados con la lactancia materna. Conclusiones: La estrategia de intervención educativa sobre lactancia materna resultó efectiva en las gestantes estudiadas.

Introduction : There are innumerable benefits of breastfeeding, since it provides the necessary nutrients and energy for healthy growth and development in infants during their first six months of life; however, there is still a lack of knowledge on this subject. Objective: To increase the level of knowledge about breastfeeding in pregnant women admitted to the Justo Legón Padilla Maternity Home, belonging to the municipality and province of Pinar del Rio, during the year 2022. Methods: A quasi-experimental study of educational intervention was carried out, with pre-test and post-test. The universe was made up of 150 pregnant women who were in the last trimester of pregnancy, admitted to said institution in the indicated period, from which a sample of 90 pregnant women was selected according to simple random probabilistic sampling, with prior informed consent. An educational program was applied. The results were processed and presented through tables. Statistical measures of absolute and relative frequency distribution were applied. Results: 97% of the pregnant women were found with a good qualification after the educational intervention, in issues related to breastfeeding. Conclusions: The educational intervention strategy on breastfeeding was effective in the pregnant women studied.

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OBJECTIVES: This study evaluates, in the medium and long term (12, 36, and 48 mo), the effect of an intervention to promote consumption of fruit and vegetables on the body weight of Brazilian primary health care users. METHODS: A follow-up with participants (n = 3414) in a controlled randomized trial was performed in a primary health care service. Those in the control group performed the service's usual intervention (guided physical exercise 3 times/wk), and those in the intervention group additionally participated for 7 mo in collective activities to promote consumption of fruit and vegetables. Sociodemographic, health, and body weight data were collected by face-to-face interview at baseline and after 12 mo. At 36 and 48 mo, weight was obtained by telephone interview and was validated. Adherence to the intervention was assessed by the presence of the actions. Weight change (Δ) was measured by subtracting the weight at each follow-up time from the baseline measurement. RESULTS: Participants in both groups had a minor weight loss of about 0.1 kg over 12, 36, and 48 mo. The addition of an intervention for consumption of fruit and vegetables did not enhance this effect. Higher weight loss was observed in individuals with obesity classes II and III with low adherence in the intervention and after 36 mo (Δ = -27.1 kg; P = 0.024). CONCLUSIONS: Participating in the primary health care service contributed to a small reduction in weight, and the intervention for consumption of fruit and vegetables did not enhance this effect. However, greater weight loss was observed in participants with obesity and those who adhered to the intervention.

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Mais de um terço dos familiares de pacientes internados em Unidades de Terapia Intensiva Pediátricas (UTIP) evoluem com ansiedade, depressão e Transtorno de Estresse Pós- Traumático (TEPT), com consequente diminuição da qualidade de vida e grande impacto social. A estas complicações, alcunhou-se o termo Síndrome Pós-Terapia Intensiva Familiar (PICS- F), com o objetivo de aumentar a conscientização sobre o assunto visto que os dados disponíveis na literatura são ainda escassos e de baixa qualidade. Estratégias que minimizem estes desfechos negativos após a alta vêm sendo adotadas em UTIP de diferentes países. O objetivo desta tese foi avaliar o impacto de um programa de diários hospitalares na incidência de TEPT e de sofrimento psíquico em familiares de pacientes pediátricos criticamente doentes. Entre dezembro de 2019 e dezembro de 2021, realizamos um estudo de intervenção randomizado por clusters e alocado em crossover, com dois braços e dois períodos em quatro UTIP do estado do Rio de Janeiro. Foram elegíveis os familiares de crianças de 29 dias a 12 anos que estiveram internadas na UTIP por mais de 36 horas por motivos clínicos ou cirúrgicos. O uso de diários de UTIP foi comparado com a prática padrão. Os diários foram preenchidos pela equipe de saúde e familiares, tiveram fotografias inseridas e foram entregues aos familiares na alta da UTIP. Os desfechos primários foram: (a) a incidência de TEPT aferida com o instrumento PCL- 5 (Posttraumatic Stress Disorder Checklist for DSM-5 - Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition); e (b) a incidência de sofrimento psíquico aferida com o instrumento Hospital Anxiety and Depression Score (HADS). Ambos os desfechos foram aferidos em familiares de crianças graves, 45 a 60 dias após sua alta da UTIP. Também foi realizada uma análise de sensibilidade para avaliar o impacto de níveis diferentes de adesão ao diário nos desfechos. Um total de 339 participantes foi analisado, 170 no grupo que fez uso do diário e 169 no grupo controle. As características dos participantes foram semelhantes nos dois grupos de estudo. O uso de diários diminuiu em média 2,57 pontos no escore total do PCL 5 dos familiares (IC 95% -2,58 a -2,57; p<0,001) e foi encontrada razão de taxa de incidência (IRR) de 0,60 (IC 95% 0,57 a 0,64; p<0,001), significando uma redução de 40% na incidência de TEPT no grupo intervenção quando comparado ao controle. Com relação ao sofrimento psíquico, o uso de diários resultou em um IRR de 0,78 (IC 95% 0,77 a 0,78). A análise de conteúdo dos diários mostrou que a adesão total foi ainda mais impactante do que a adesão parcial aos diários. Os resultados apresentados nesta tese corroboram a hipótese de que diários têm efeito protetor sobre a incidência de TEPT e de sofrimento psíquico em familiares de crianças criticamente doentes, sendo, portanto, benéficos na prevenção de PICS-F.

More than a third of family members of critically ill children in Pediatric Intensive Care Units (PICU) develop anxiety, depression, and Post Traumatic Stress Disorder (PTSD), with a consequent decrease in quality of life and great social impact. Hence, the term Post- Intensive Family Therapy Syndrome (PICS-F) was created to raise awareness of these complications and define a global research agenda. Data on this theme available in the literature are still scarce and of low quality. After discharge, strategies that minimize these negative outcomes have been adopted in PICUs in different countries. This thesis aimed to evaluate the impact of a hospital diary program on PTSD and psychological distress incidence in family members of critically ill pediatric patients. Between December 2019 and December 2021, we conducted a cluster-randomized, crossover, two-arm, two-period intervention study in four PICUs. Relatives of children aged 29 days to 12 years who were hospitalized in the PICU for more than 36 hours for clinical or surgical reasons were eligible. The use of PICU diaries was compared with standard practice. The diaries were filled in by the health professionals and family members, had photographs inserted, and were handed to family members upon PICU discharge. The primary outcomes were: (a) the incidence of PTSD measured with the PCL-5 instrument (Posttraumatic Stress Disorder Checklist for DSM-5 - Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition); and (b) the incidence of psychological distress measured with the Hospital Anxiety and Depression Score (HADS) instrument. Both outcomes were measured in family members of critically ill children 45 to 60 days after discharge from the PICU. A sensitivity analysis was also performed on adherence to the diary by evaluating its content. A total of 339 participants were analyzed, 170 in the diary group and 169 in the control group. Participant characteristics were similar in the two study groups. The use of diaries decreased an average of 2.57 points in the total PCL-5 score of family members (95% CI -2.58 to -2.57; p<0.001) and an incidence rate ratio (IRR) of 0.60 (95% CI 0.57 to 0.64; p< 0.001), resulting in a 40% reduction in PTSD incidence. Regarding psychological distress, the use of diaries resulted in an IRR of 0.78 (95% CI 0.77 to 0.78). The content analysis of the diaries showed that full adherence was even more impactful than partial adherence to the diaries (IRR 0.68 [CI 95% 0.57 to 0.81] and IRR 0.77 [CI 95% 0. 70 to 0.86], respectively). Therefore, the more complete the diaries, the greater their effect on reducing psychological distress incidence. The results presented in this thesis support the hypothesis that diaries have a protective effect on PTSD and psychological distress in family members of critically ill children and are beneficial in preventing PICS-F.

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O objetivo do estudo é verificar o agrupamento dos fatores de risco cardiometabólicos e as possíveis mudanças deste, após um programa de intervenção interdisciplinar realizado com adolescentes com sobrepeso/obesidade. Os sujeitos foram alocados em dois grupos: grupo intervenção e grupo controle. O grupo intervenção participou de um programa com a duração de seis meses, com sessões três vezes por semana, que incluiu sessões com exercícios físicos, orientações nutricionais e psicológicas. Foram realizadas avaliações antropométricas, pressão arterial, aptidão cardiorrespiratória e coleta sanguínea para avaliação da glicose e perfil lipídico, antes e após o período de intervenção. Análise de componentes principais foi realizada para verificar o agrupamento dos fatores de risco nos períodos pré e pós-intervenção. A análise fatorial agrupou os componentes em três fatores no momento pré-intervenção, no grupo intervenção, que representou 83,88% da variância total do modelo. Já, no grupo controle, no período pré e pós-intervenção, e na avaliação pós-intervenção do grupo intervenção, os componentes foram agrupados em dois fatores centrais, que explicam, respectivamente, 68,38%, 71,23%, 75,19% da variância total do modelo. O grupo intervenção apresentou mudanças no agrupamento das variáveis nos resultados pós-intervenção, em comparação com o pré-teste. Nenhum componente central, que inter-relacionasse todos os demais fatores, nas quatro análises realizadas, foi encontrado. Entretanto, as variáveis antropométricas aparecem como os componentes de maior carga fatorial, agrupadas no fator 1, em todas as análises realizadas, fator que explica a maior variância total em torno das variáveis iniciais. (AU)

The objective of the study is to verify the grouping of cardiometabolic risk factors and their possible changes after an interdisciplinary intervention program performed with overweight/obese adolescents. The subjects were allocated in two groups: the intervention group and the control group. The intervention group participated in a program lasting six months, with sessions three times a week, which included sessions with physical exercises, nutritional and psychological orientations. Anthropometric evaluations, blood pressure, cardiorespiratory fitness, and blood collection were performed for evaluation of glucose and lipid profile before and after the intervention period. Main component analysis was performed to verify the grouping of risk factors in the pre-and post-intervention periods. The factorial analysis grouped the components into three factors at the pre-intervention time, in the intervention group, which represented 83.88% of the total variance of the model. In the control group, in the pre-and post-intervention period, and in the post-intervention evaluation of the intervention group, the components were grouped into two central factors, which explain, respectively, 68.38%, 71.23%, 75, 19% of the total variance of the model. The intervention group presented changes in the grouping of the variables in the post-intervention results, compared to the pre-test. No central component, which interrelated all the other factors, was found in the four analyzes. However, the anthropometric variables appear as the components of higher factor load, grouped in factor 1, in all the analyzes performed, a factor that explains the largest total variance around the initial variables. (AU)

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BACKGROUND: The first 2 years of life are the window of opportunity to promote healthy feeding practices. Thus, the present study aimed to assess the impact of a health workers training in infant dietary guidelines on energy intake and anthropometric measurement into childhood. METHODS: Cluster randomised field trial (NCT00635453) was conducted in Porto Alegre, Brazil. Healthcare centres were randomised into intervention (n = 9) and control (n = 11) groups. In intervention sites, health workers were trained to promote healthy feeding practices based on the Brazilian guideline for children's nutrition. Pregnant women who were in the last trimester of pregnancy were registered as potential mothers who would receive dietary counselling from the health workers. Energy and macronutrient intake and anthropometric measurements were obtained from children at ages 6 months, 12 months, 3 years and 6 years from low-income families. RESULTS: At age 3 years, intervention group had lower consumption of energy [-92.5 kcal; 95% confidence interval (CI) = -153.5 to -31.5], carbohydrates (-11.9 g; 95% CI = -19.9 to -2.3), and total fat (-3.9 g; 95% CI = -6.2 to -1.2), compared to the control group. At 6 years of age, children in the intervention group had lower waist circumference (-1.3 cm; 95% CI = -2.7 to -0.0), triceps (-1.3 mm; 95% CI = -2.5 to -0.0) and subscapular skinfolds (-1.3 mm; 16 95% CI = -2.6 to -0.0) thickness measurements compared to those in the control group. CONCLUSIONS: The health workers training to promote infant healthy feeding practices resulted in lower energy, carbohydrates and fat intake at 3 years and lower waist circumference, triceps and subscapular skinfolds measurements at 6 years.

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INTRODUCTION: Overweight children and adolescents are more susceptible to metabolic disorders. However, changes in lifestyle can prevent or delay the appearance of risk factors, highlighting the importance of intervening early in this populationOBJECTIVE: To analyze the effects of a six months interdisciplinary intervention program on the indicators of insulin resistance and uric acid levels in overweight and obese studentsMETHODS: This is an interventional study in overweight adolescents, composed of a control group (n=19) and an intervention group (n=20). The group participated in a six-month program with nutritional, psychological and physical exercise intervention, three times a week. The values of waist circumference, glucose, insulin, uric acid assessment and HOMA-IR index, were evaluated before and after the programRESULTS: After 6 months, the intervention group had a significant reduction in waist circumference (p=0.007), HOMA-IR index (p=0.048) and uric acid (p=0.036); the control group did not present differences in the pre and post evaluationCONCLUSION: The intervention program was effective in reducing waist circumference, HOMA-IR and uric acid levels in overweight adolescents

INTRODUÇÃO: Crianças e adolescentes com excesso de peso são mais suscetíveis a apresentarem disfunções metabólicas. No entanto, mudanças no estilo de vida podem prevenir ou retardar o surgimento de fatores de risco, destacando a importância de intervir precocemente nesta populaçãoOBJETIVO: Analisar os efeitos de seis meses de um programa de intervenção interdisciplinar sobre os indicadores de resistência à insulina e os níveis de ácido úrico em escolares com sobrepeso e obesidadeMÉTODO: Estudo de intervenção, realizado com adolescentes com excesso de peso, composto por grupo controle (n=19) e grupo intervenção (n=20), que participou de programa de seis meses com intervenção nutricional, psicológica e de exercícios físicos, três vezes por semana. Foi avaliada a circunferência da cintura (CC), realizada coleta sanguínea para avaliação da glicose, insulina e ácido úrico e calculado o índice HOMA-IR, antes e após o programaRESULTADOS: O grupo intervenção apresentou redução significante da circunferência da cintura (p=0,007), índice HOMA-IR (p=0,048) e ácido úrico (p=0,036), após os seis meses do programa; já o grupo controle não apresentou diferenças na pré e pós avaliaçãoCONCLUSÃO: O programa de intervenção mostrou-se eficiente na redução da circunferência da cintura, HOMA-IR e níveis de ácido úrico em adolescentes com excesso de peso

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BACKGROUND: Given the current worldwide epidemic of obesity, there is a demand for interventions with higher impact, such as those carried out in the primary health care (PHC) setting. Here we evaluate the effect of intervention performed according to the stages of change of the transtheoretical model (TTM) for weight management. METHODS: This randomized controlled trial in Brazilian PHC offered free physical exercise and nutrition education. The participants were women, aged 20 years or older who were obese or overweight, users in PHC service. The intervention group (IG, n = 51) received the same orientation as the comparison group (CG, n = 35) plus individual health counseling based on the TTM aimed at weight loss, which lasted 6 months. The outcome measures were anthropometric, food, and nutrient profiles. Inflammatory parameters were evaluated in a random subsample. The inter-group and intra-group differences were evaluated using interntion-to-treat analysis, and analysis of covariance (ANCOVA) used to assess intervention effectiveness. RESULTS: There was a difference between groups of - 1.4 kg (CI95%: - 2.5; - 0.3) in body weight after the intervention. About 97% of women in the IG reported benefits of the intervention and presented positive changes in diet, biochemical markers, and anthropometry. The IG showed better body mass index, resistine, and blood glucose results compared to the CG during follow-up. CONCLUSION: The individualized TTM-based intervention, combined with usual care, was an effective strategy in PHC. These results should encourage the use of interdisciplinary practices; nevertheless, research to identify additional strategies is needed to address barriers to weight maintenance among obese low-income women. TRIAL REGISTRATION: The trial is registered with Brazilian clinical trials under the code: RBR-8t7ssv, Registration date: 12/12/2017 (retrospectively registered).

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OBJECTIVES: To assess if improvement of working conditions related to heat stress was associated with improved kidney health outcomes among sugarcane harvest workers in Chichigalpa, Nicaragua, a region heavily affected by the epidemic of chronic kidney disease of non-traditional origin. METHODS: Based on our findings during the 2017-2018 harvest (harvest 1), recommendations that enhanced the rest schedule and improved access to hydration and shade were given before the 2018-2019 harvest (harvest 2). Actual work conditions during harvest 2 were then observed. Serum creatinine (SCr) was measured before and at end-harvest, and cross-harvest changes in estimated glomerular filtration rate (eGFR) and incident kidney injury (IKI, ie, SCr increase by ≥0.30 mg/dL or ≥1.5 times the baseline value) were compared between harvest 1 and harvest 2 for three jobs with different physical workloads using regression modelling. Workers who left during harvest were contacted at home, to address the healthy worker selection effect. RESULTS: In burned cane cutters, mean cross-harvest eGFR decreased 6 mL/min/1.73 m2 (95% CI 2 to 9 mL/min/1.73 m2) less and IKI was 70% (95% CI 90% to 50%) lower in harvest 2 as compared with harvest 1 data. No such improvements were seen among seed cutters groups with less successful intervention implementation. CONCLUSION: Kidney injury risk was again elevated in workers with strenuous jobs. The results support further efforts to prevent kidney injury among sugarcane workers, and other heat-stressed workers, by improving access to water, rest and shade. The distinction between design and implementation of such interventions should be recognised.

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