RESUMO
BACKGROUND: We evaluated the impact of completion intraoperative venography on clinical outcomes for axillosubclavian vein (AxSCV) thrombosis owing to venous thoracic outlet syndrome (vTOS). METHODS: We performed a retrospective, single-center review of all patients with vTOS treated with first rib resection (FRR) and intraoperative venography from 2011 to 2023. We reviewed intraoperative venographic films to classify findings and collected demographics, clinical and perioperative variables, and clinical outcomes. Primary end points were symptomatic relief and primary patency at 3 months and 1 year. Secondary end points were time free from symptoms, reintervention rate, perioperative complications, and mortality. RESULTS: Fifty-one AxSCVs (49 patients; mean age, 31.3 ± 12.6 years; 52.9% female) were treated for vTOS with FRR and external venolysis followed by completion intraoperative venography with a mean follow up of 15.5 ± 13.5 months. Before FRR, 32 underwent catheter-directed thrombolysis (62.7%). Completion intraoperative venography identified 16 patients with no stenosis (group 1, 31.3%), 17 with no stenosis after angioplasty (group 2, 33.3%), 10 with residual stenosis after angioplasty (group 3, 19.7%), and 8 with complete occlusion (group 4, 15.7%). The overall symptomatic relief was 44 of 51 (86.3%) and did not differ between venographic classifications (group 1, 14 of 16; group 2, 13 of 17; group 3, 10 of 10; and group 4, 7 of 8; log-rank test, P = .5). The overall 3-month and 1-year primary patency was 42 of 43 (97.7%) and 32 of 33 (97.0%), respectively (group 1, 16 of 16 and 9 of 9; group 2, 16 of 17 and 12 of 13; group 3, 10 of 10, 5 of 5; group 4, primary patency not obtained). There was one asymptomatic rethrombosis that resolved with anticoagulation, and three patients underwent reintervention with venous angioplasty for significant symptom recurrence an average 2.89 ± 1.7 months after FRR. CONCLUSIONS: Our single-center retrospective study demonstrates that FRR with completion intraoperative venography has excellent symptomatic relief and short- and mid-term patency despite residual venous stenosis and complete occlusion. Although completion intraoperative venographic classification did not correlate with adverse outcomes, this protocol yielded excellent results and provides important clinical data for postoperative management. Our results also support a conservative approach to AxSCV occlusion identified after FRR.
Assuntos
Flebografia , Costelas , Síndrome do Desfiladeiro Torácico , Grau de Desobstrução Vascular , Humanos , Síndrome do Desfiladeiro Torácico/diagnóstico por imagem , Síndrome do Desfiladeiro Torácico/cirurgia , Síndrome do Desfiladeiro Torácico/fisiopatologia , Feminino , Masculino , Estudos Retrospectivos , Adulto , Costelas/cirurgia , Costelas/diagnóstico por imagem , Adulto Jovem , Resultado do Tratamento , Pessoa de Meia-Idade , Osteotomia/efeitos adversos , Fatores de Tempo , Veia Subclávia/diagnóstico por imagem , Veia Subclávia/cirurgia , Veia Axilar/diagnóstico por imagem , Veia Axilar/cirurgia , Cuidados Intraoperatórios , Valor Preditivo dos Testes , Terapia Trombolítica/efeitos adversosRESUMO
OBJECTIVE: Intravascular ultrasound (IVUS) examination is increasingly used in the treatment of iliofemoral venous disease and provides more sensitive and specific detection of stenotic lesions when compared with traditional multiplanar venography alone. Correlations with deep venous stent patency, however, have not yet been investigated. The objective of the study was to evaluate the impact of the use of IVUS examination in addition to multiplanar venography on iliofemoral venous patency. METHODS: Consecutive patients who underwent stenting for symptomatic thrombotic or nonthrombotic iliofemoral venous lesions (NIVLs) between 2014 and 2020 at a single institution were identified and divided into two groups based on whether IVUS examination was used before stent deployment in addition to multiplanar venography compared with venography alone. A retrospective review of demographic, operative, and follow-up data was performed. Thirty-day and 2-year stent patency were measured as primary end points. χ2 analysis, logistic regression models, and Kaplan-Meier survival analysis were used to determine outcomes. Technical details and outcomes were additionally examined among patients treated for acute deep venous thrombosis, post-thrombotic syndrome, or NIVLs separately on subgroup analysis. RESULTS: We identified 150 patients (173 limbs, 23 bilateral) who underwent iliofemoral stenting during the study period at our institution (mean age: 48.8 ± 16.8 years, 61% female). Adjunctive IVUS utilization before stent deployment was reported in 69 of 173 (39.9%) treated limbs. IVUS examination was more likely to be used in patients who underwent stenting for NIVLs compared with thrombotic disease (41.0% vs 11.2%, P < .01). There was no difference in the number of stents deployed between IVUS and non-IVUS cohorts. However, IVUS examination was associated with the increased total length of the stent deployed (126 ± 56 vs 112 ± 48 mm, P = .04) and a higher rate of infrainguinal stent extension (17.4% vs 6.7%, P = .03). In addition, mean stent diameter was significantly higher when IVUS examination was performed before stent placement (16.3 ± 3.7 vs 15.2 ± 1.9 mm, P < .01). Both 30-day (98.5% vs 89.4%, P = .02) and 2-year (90.3% vs 78.7%, P = .03) primary patency were significantly higher in the IVUS cohort. Adjunctive IVUS use was found to significantly protect against stent reintervention at 2 years on adjusted Cox regression analysis (hazard ratio: 0.22, 95% confidence interval: 0.07-0.71, P = .01). CONCLUSIONS: Adjunctive IVUS utilization is associated with differences in stent diameter and length selections as well as landing segments in the treatment of thrombotic and nonthrombotic iliofemoral venous disease. IVUS examination before stent deployment significantly protects against 30-day and 2-year stent reintervention when compared with the use of multiplanar venography alone. These data provide stronger evidence for routine IVUS use in addition to venography before iliofemoral venous stenting.
Assuntos
Veia Ilíaca , Doenças Vasculares , Adulto , Idoso , Feminino , Humanos , Veia Ilíaca/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Stents , Resultado do Tratamento , Ultrassonografia de Intervenção , Grau de Desobstrução VascularRESUMO
OBJECTIVE: To determine the prevalence of and risk factors for cerebral sinus venous thrombosis (CSVT) in neonates undergoing congenital heart disease (CHD) repair. STUDY DESIGN: Neonates who had CHD repair with cardiopulmonary bypass and postoperative brain magnetic resonance imaging (MRI) between 2013 and 2019 at a single tertiary care center were identified from institutional databases. Demographic, clinical, and surgical data were abstracted from these databases and from the medical record; 278 neonates with CHD had cardiopulmonary bypass, 184 of whom had a postoperative brain MRI. RESULTS: Eight patients (4.3%) had a CSVT. Transposition of the great arteries with an intact ventricular septum (P < .01) and interrupted aortic arch (P = .02) were associated with an increased risk for CSVT. Other risk factors for CSVT included cross-clamp time (98 [IQR, 77.5-120] minutes vs 67 [IQR, 44-102] minutes; P = .03), units of platelets (3.63 [IQR, 3-4] vs 2.17 [IQR, 1-4]; P < .01) and packed red blood cells (0.81 [IQR, 0.25-1] vs 1.21 [IQR, 1-1]; P = .03) transfused intraoperatively, and time between surgery and MRI (10 [IQR, 7-12.5] days vs 20 [IQR, 12-35] days; P < .01). Five patients (62.5%) were treated with anticoagulation. All patients had complete or partial resolution of their CSVT, regardless of treatment. CONCLUSIONS: Brain MRI after cardiopulmonary bypass in neonates revealed a low prevalence of CSVT (4.3%). Further studies are needed to establish best practices for surveillance, prevention, and treatment of CSVT in this population.
Assuntos
Cardiopatias Congênitas , Trombose dos Seios Intracranianos , Transposição dos Grandes Vasos , Trombose Venosa , Anticoagulantes/uso terapêutico , Cardiopatias Congênitas/complicações , Humanos , Lactente , Recém-Nascido , Trombose dos Seios Intracranianos/epidemiologia , Trombose dos Seios Intracranianos/etiologia , Transposição dos Grandes Vasos/complicações , Trombose Venosa/complicaçõesRESUMO
Background: Equine cutaneous habronemiasis is common in the distal regions of the limbs. Organophosphates, appliedsystemically, one previously used treatment, which is highly effective, but currently in disuse, due to the risks of intoxication. Regional perfusion is a potential technique for distal limb wounds, since, in addition to being used in low doses, itprevents systemic circulation of the drug and possible intoxication, and has a lower treatment cost. The current work aimedto perform clinical, laboratory, and venography evaluations of the use of trichlorfon in regional intravenous perfusion, asa possible form of treatment for cutaneous habronemosis in the distal region of equine limbs.Materials, Methods & Results: Twelve equines were used, divided into 2 groups, with the left thoracic limb (LTL) beingthe test limb, and the right thoracic limb (RTL) the control limb. At moment zero (M0), distal radiography and venographywere performed. The tourniquet was then loosened and after 5 min, at moment one (M1), the tourniquet was repositionedfor 1.25 mg/kg (G1) and 5.5 mg/kg (G2) trichlorfon injections into the left thoracic limb, diluted in 20 mL of Ringers lactate solution, and 20 mL of Ringers lactate solution was applied to the right thoracic limb. The tourniquet was maintainedfor 30 min after infusion in both groups. At moment 2 (M2), 4 days later, blood tests, radiography, and venography wererepeated. Every day between M0 and M2, physical examinations were performed, including measurement of the pastern,fetlock, and coronet band, and a lameness examination. There were no significant alterations in clinical parameters, behavior, and appetite. In the blood cell count, there was an increase in leukocytes on D4 in G2, although remaining withinthe reference values for the species. The biochemical tests showed no alterations. There were no changes in the circumferences evaluated and 4 equines from G2 presented lameness in the LTL and...
Assuntos
Animais , Cavalos , Infecções por Spirurida/terapia , Infecções por Spirurida/veterinária , Perfusão/veterinária , Triclorfon/administração & dosagem , Triclorfon/uso terapêutico , Flebografia/veterináriaRESUMO
Although pharmacokinetic studies of drugs administered by intravenous regional limb perfusion (IRLP) to treat equine orthopedic infections suggest efficient drug distribution in the limbs, it remains unclear whether drug perfusion is affected by the position of the horse during the procedure. This study compared the perfusion of a radiopaque contrast into tissues of the extremities of horses maintained in standing and recumbent positions during an IRLP. Radiopaque contrast was administered through IRLP into the cephalic vein of 10 healthy adult horses under general anesthesia and right lateral recumbency (RG) or under sedation and standing (SG). The same animals were used in both groups, respecting a two-week washout period. Sequential radiographic images were performed immediately at the beginning of contrast administration (T0) and after 10, 20, 30, 40, and 50 minutes. Tourniquets were removed after 30 minutes. The time required for the contrast to reach the hooves was compared between groups. Contrast reached the hooves faster in SG (114 ± 15 seconds) compared with RG (236 ± 29 seconds) (P < 0.5). SG showed more uniform perfusion of the limb vessels, whereas RG showed more deposition of the contrast in the lateral digital vein, with smaller amounts reaching the hooves. From T10 onward, soft tissue radiopacity increased, albeit more markedly in standing than in recumbent animals, remaining until T50. Contrast radiography evidenced that IRLP performed in standing position leads to a quicker and more uniform perfusion of the vasculature and a more noticeable diffusion to the tissues than in recumbent horses.
Assuntos
Casco e Garras , Posição Ortostática , Administração Intravenosa/veterinária , Animais , Cavalos , Perfusão/veterinária , TorniquetesRESUMO
Background Pelvic congestion syndrome is among the causes of pelvic pain. One of the diagnostic tools is pelvic venography using Beard's criteria, which are 91% sensitive and 80% specific for this syndrome. Objective To assess the diagnostic performance of the clinical findings in women diagnosed with pelvic congestion syndrome coming to a Level III institution. Methods Descriptive retrospective study in women with chronic pelvic pain taken to transuterine pelvic venography at the Advanced Gynecological Laparoscopy and Pelvic Pain Unit of Clinica Comfamiliar, between August 2008 and December 2011, analyzing social, demographic, and clinical variables. Results A total of 132 patients with a mean age of 33.9 years. Dysmenorrhea, ovarian points, and vulvar varices have a sensitivity greater than 80%, and the presence of leukorrhea, vaginal mass sensation, the finding of an abdominal mass, abdominal trigger points, and positive pinprick test have a specificity greater than 80% when compared with venography. Conclusion This study may be considered as the first to evaluate the diagnostic performance of the clinical findings associated with pelvic congestion syndrome in a sample of the Colombian population. In the future, these findings may be used to create a clinical score for the diagnosis of this condition.
Assuntos
Doenças dos Anexos/complicações , Doenças dos Anexos/diagnóstico , Medição da Dor/métodos , Dor Pélvica/complicações , Síndrome , Vulva/irrigação sanguínea , Adulto , Dor Crônica , Estudos Transversais , Feminino , Ginecologia , Humanos , Pelve , Flebografia , Reprodutibilidade dos Testes , Estudos Retrospectivos , Sensibilidade e Especificidade , Varizes/diagnóstico , Varizes/cirurgiaRESUMO
Objetivos. Determinar el rol de la venografía por tomografía computada e identificar variables que determinen el diagnóstico de trombosis venosa profunda de extremidades inferiores en pacientes con sospecha clínica de TEP y sometidos a angiografía de tórax por tomografía computada. Diseño. Cohorte retrospectiva que evaluó 151 pacientes en los que se realizó venografía de extremidades inferiores - angiografía de tórax mediante tomografía computada. Se tabularon factores de riesgo como la edad, sexo, servicio de proveniencia, riesgo para TEP (según score de Wells), ecotomografía Doppler de EEII previa y sus resultados, diagnóstico y lugar anatómico de TEP y diagnóstico y lugar anatómico de TVP según los resultados obtenidos con la venografía. Resultados. Se dispuso de información completa para 151 pacientes. 40 fueron positivo para TEP (26,5%) y 13 venografías resultaron positivas (8.6% del total). Los casos provenían en un 41,7% de Urgencia; 31,1% de UPC; 19,8% hospitalizados (no crítico); y 7,2% de consultas ambulatorias. De las variables estudiadas, ninguna resultó estadísticamente significativa para predecir el hallazgo de trombosis venosa profunda en concomitancia con la angiografía pulmonar mediante TC. En aquellos pacientes con ultrasonido Doppler contemporáneo, la venografía por tomografía computada no aportó nueva información de aquella ya disponible. Conclusiones. En este estudio no se encontraron variables que a priori apoyen la realización de una fase venográfica en concomitancia con una angiografía de tórax mediante tomografía computada cuando existe la sospecha clínica de tromboe-mbolismo pulmonar. No se justificaría realizar venografía por TC en pacientes con hemodinamia estable y sospecha de TEP.
Objectives. To determine the role of CT venography and identify variables that determine the diagnosis of deep venous thrombosis (DVT) of lower extremities in patients with clinical suspicion of PE, and who underwent chest CT angiography. Design. Retrospective group study that evaluated hundred fifty-one patients in whom lower extremity venography- chest CT angiography was performed. Risk factors were tabulated - such as age, sex, department origin, risk of PE (according to Wells Criteria), previous Doppler ultraso-nography of lower extremities and their results, diagnosis and anatomical site of PE, and diagnosis and anatomical site of DVT according to the results obtained with the venography. Results. Complete data was available for 151 patients. 40 were positive for PE (26.5 percent) and 13 venographs were positive (8.6percent of the total). The case origins were 41.7 percent from Emergency Department, 31.1 percent from ICU, 19.8 percent hospitalized (non-critical) and 7.2 percent from outpatient consultations. Of the variables studied, none resulted statistically significant for predicting the discovery of deep vein thrombosis in conjunction with CT pulmonary angio-graphy. In those patients with contemporary Doppler ultrasound, the CT venography did not provide new information from that already available. Conclusions. In this study we did not find variables that support a priori the realization of a venography phase in conjunction with chest CT angiogram when there is clinical suspicion of pulmonary embolism. Performing CT venography in patients with stable hemodynamics and suspected PE, would not be justified.
Assuntos
Humanos , Masculino , Adolescente , Adulto , Feminino , Adulto Jovem , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Embolia Pulmonar , Flebografia/métodos , Tomografia Computadorizada por Raios X/métodos , Estudos Retrospectivos , Modelos Logísticos , Valor Preditivo dos TestesRESUMO
OBJECTIVE: To investigate Port-A-Cath (PAC)-related thrombosis and postthrombotic syndrome (PTS) in children with cancer. STUDY DESIGN: The study population was a consecutive cohort of children diagnosed with cancer and a PAC implanted at diagnosis. Children were evaluated for the presence of PAC-related thrombosis by magnetic resonance venography and the presence of congenital prothrombotic risk factors and PTS. RESULTS: A total of 114 children (median age, 6.04 years) were included. Of these children, 48 (42%) were treated for solid tumors and 66 (58%) were treated for hematopoietic tumors, including 38 for acute lymphoblastic leukemia. At the time of magnetic resonance venography, 42 children (37%) had the PAC still in place, and 72 (63%) had the PAC removed. Overall, PACs were in place for a total of 324.92 PAC-years. PAC-related thrombosis was detected in 45 children (39.5%) with a current or previous PAC. Of these, 21 (47%) had a solid tumor, 14 (31%) had acute lymphoblastic leukemia, and 10 (22%) had another hematopoietic tumor. Younger age at diagnosis, female sex, duration of PAC use, and left-side PAC placement were independently associated with an increased risk of thrombosis, whereas asparaginase therapy and the presence of inherited prothrombotic risk factors were not. Mild PTS (ie, presence of prominent collateral vessels in the skin) was present in 5.6% of the children. CONCLUSION: PAC-related thrombosis is common in pediatric oncology patients. In some children, thrombotic complications can lead to the development of PTS.