RESUMO
The disorders of the central nervous system associated with cancer by remote immune-mediated mechanisms are a heterogeneous group. These disorders encompass the classic paraneoplastic disorders and the recently recognized autoimmune encephalitis associated with antibodies against neuronal cell surface or synaptic proteins that occur with or without cancer association. In the last decade, the new surge of interest in neuronal diseases associated with anti-neuronal antibodies led to the rapid discovery of new forms of disease that have different manifestations and were not previously suspected to be immune mediated. The recognition of these syndromes is important because it may lead to early detection of an underlying malignancy and prompt initiation of treatment, improving chances for a better outcome.
Assuntos
Doenças do Sistema Nervoso Central/sangue , Encefalite/sangue , Doença de Hashimoto/sangue , Síndromes Paraneoplásicas do Sistema Nervoso/sangue , Anticorpos/sangue , Doenças do Sistema Nervoso Central/complicações , Doenças do Sistema Nervoso Central/patologia , Doenças do Sistema Nervoso Central/terapia , Detecção Precoce de Câncer , Encefalite/complicações , Encefalite/patologia , Encefalite/terapia , Doença de Hashimoto/complicações , Doença de Hashimoto/patologia , Doença de Hashimoto/terapia , Humanos , Neurônios/metabolismo , Neurônios/patologia , Síndromes Paraneoplásicas do Sistema Nervoso/complicações , Síndromes Paraneoplásicas do Sistema Nervoso/patologia , Síndromes Paraneoplásicas do Sistema Nervoso/terapia , Sinapses/metabolismo , Sinapses/patologiaRESUMO
El cáncer de mama triple negativo es un tumor agresivo que, muy pocas veces en la clínica, se presenta con un síndrome neurológico paraneoplásico asociado a un carcinoma metastásico de origen desconocido. Este artículo reporta una paciente con tal asociación y que su caso fue discutida en Clínica Patológica Institucional(AU)
Triple negative breast cancer is an aggressive tumor that, in the clinic, rarely presents with a paraneoplastic neurological syndrome associated with a metastatic carcinoma of unknown origin. This article reports a patient with such an association and that was discussed in Institutional Pathological Clinic(AU)