RESUMO
The disorders of the central nervous system associated with cancer by remote immune-mediated mechanisms are a heterogeneous group. These disorders encompass the classic paraneoplastic disorders and the recently recognized autoimmune encephalitis associated with antibodies against neuronal cell surface or synaptic proteins that occur with or without cancer association. In the last decade, the new surge of interest in neuronal diseases associated with anti-neuronal antibodies led to the rapid discovery of new forms of disease that have different manifestations and were not previously suspected to be immune mediated. The recognition of these syndromes is important because it may lead to early detection of an underlying malignancy and prompt initiation of treatment, improving chances for a better outcome.
Assuntos
Doenças do Sistema Nervoso Central/sangue , Encefalite/sangue , Doença de Hashimoto/sangue , Síndromes Paraneoplásicas do Sistema Nervoso/sangue , Anticorpos/sangue , Doenças do Sistema Nervoso Central/complicações , Doenças do Sistema Nervoso Central/patologia , Doenças do Sistema Nervoso Central/terapia , Detecção Precoce de Câncer , Encefalite/complicações , Encefalite/patologia , Encefalite/terapia , Doença de Hashimoto/complicações , Doença de Hashimoto/patologia , Doença de Hashimoto/terapia , Humanos , Neurônios/metabolismo , Neurônios/patologia , Síndromes Paraneoplásicas do Sistema Nervoso/complicações , Síndromes Paraneoplásicas do Sistema Nervoso/patologia , Síndromes Paraneoplásicas do Sistema Nervoso/terapia , Sinapses/metabolismo , Sinapses/patologiaRESUMO
Morvan's syndrome is a rare autoimmune channelopathy. A case of Morvan's syndrome is presented as a paraneoplastic syndrome associated to the recurrence of a well-differentiated thymic carcinoma, which showed a good clinical response to treatment with intravenous immunoglobulin.
El síndrome de Morvan es una canalopatía rara de origen autoinmune. Se presenta el caso de un síndrome de Morvan como una entidad paraneoplásica asociada a la recurrencia de un carcinoma tímico bien diferenciado, el cual presentó una buena respuesta clínica al tratamiento con inmunoglobulina intravenosa.