RESUMO

This study examines the impact of G × E interaction effects on non-alcoholic fatty liver disease (NAFLD) among Mexican Americans in the Rio Grande Valley (RGV) of South Texas. We examined potential G × E interaction using variance components models and likelihood-based statistical inference in the phenotypic expression of NAFLD, including hepatic steatosis and hepatic fibrosis (identified using vibration controlled transient elastography and controlled attenuation parameter measured by the FibroScan Device). We screened for depression using the Beck Depression Inventory-II (BDI-II). We identified significant G × E interactions for hepatic fibrosis × BDI-II. These findings provide evidence that genetic factors interact with depression to influence the expression of hepatic fibrosis.

RESUMO

Family, twin, and adoption studies have suggested that genetic factors might be involved in suicidal behavior. Corticotropin-releasing receptor type 1 (CRHR1) and 2 (CRHR2) genes play a key role in the activation and modulation of the hypothalamic-pituitary-adrenal (HPA) axis, which is considered a major stress regulator. Childhood trauma is an environmental risk factor associated with suicide attempt (SA) and it has been related to HPA axis dysregulation. This study aimed at analyzing the relationship of CRHR1 and CRHR2 genes with childhood trauma concerning the development of SA. In this study, we included 366 affective disorder patients. Among them, 183 patients had SA at least once and 183 had not SA. Information regarding SA and childhood trauma was obtained from medical records. Multifactor Dimensionality Reduction program was used to detect gene-environment interactions between CRHR1 (rs110402, rs242924, and rs16940665) and CRHR2 (rs2190242, rs2284217, and rs2014663) with childhood trauma in SA. The analysis showed an interaction of CRHR1 and CRHR2 with childhood trauma, thus conferring increased risk of having presented at least one SA (OR 7.44; 95% CI 4.58-12.07; p < 0.0001). In addition, we observed the following in the trauma subtypes analysis: physical negligence (OR 4.72; 95% CI 3.01-7.40; p < 0.0001), emotional abuse (OR 5.76; 95% CI 3.67-9.05; p < 0.0001), and sexual abuse (OR 5.70; 95% CI 3.62-8.97; p < 0.0001). Our results suggested that genetic variants of CRHR1 and CRHR2 genes in addition to physical negligence, and emotional and sexual abuse, contribute to increase risk of presented at least one SA.

Assuntos

Trauma Psicológico/psicologia , Receptores de Hormônio Liberador da Corticotropina/genética , Tentativa de Suicídio , Adolescente , Adulto , Criança , Feminino , Predisposição Genética para Doença/genética , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único , Adulto Jovem

RESUMO

Knowledge on genetic and environmental (G × E) interaction effects on cardiometabolic risk factors (CMRFs) in children is limited.  The purpose of this study was to examine the impact of G × E interaction effects on CMRFs in Mexican American (MA) children (n = 617, ages 6-17 years). The environments examined were sedentary activity (SA), assessed by recalls from "yesterday" (SAy) and "usually" (SAu) and physical fitness (PF) assessed by Harvard PF scores (HPFS). CMRF data included body mass index (BMI), waist circumference (WC), fat mass (FM), fasting insulin (FI), homeostasis model of assessment-insulin resistance (HOMA-IR), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), systolic (SBP) and diastolic (DBP) blood pressure, and number of metabolic syndrome components (MSC). We examined potential G × E interaction in the phenotypic expression of CMRFs using variance component models and likelihood-based statistical inference. Significant G × SA interactions were identified for six CMRFs: BMI, WC, FI, HOMA-IR, MSC, and HDL, and significant G × HPFS interactions were observed for four CMRFs: BMI, WC, FM, and HOMA-IR. However, after correcting for multiple hypothesis testing, only WC × SAy, FM × SAy, and FI × SAu interactions became marginally significant. After correcting for multiple testing, most of CMRFs exhibited significant G × E interactions (Reduced G × E model vs. Constrained model). These findings provide evidence that genetic factors interact with SA and PF to influence variation in CMRFs, and underscore the need for better understanding of these relationships to develop strategies and interventions to effectively reduce or prevent cardiometabolic risk in children.

Assuntos

Doenças Cardiovasculares/genética , Interação Gene-Ambiente , Síndrome Metabólica/genética , Americanos Mexicanos/genética , Aptidão Física , Comportamento Sedentário , Adolescente , Glicemia/metabolismo , Índice de Massa Corporal , Criança , Feminino , Variação Genética , Humanos , Funções Verossimilhança , Masculino , Modelos Genéticos , Herança Multifatorial/genética , Fatores de Risco , Circunferência da Cintura/genética

RESUMO

Sugarcane (Saccharum sp.) is one of the most important crops in Brazil. The high demand for sugarcane-derived products has stimulated the expansion of sugarcane cultivation in recent years, exploring different environments. The adaptability and the phenotypic stability of sugarcane genotypes in the Minas Gerais state, Brazil, were evaluated based on the additive main effects and multiplicative interaction (AMMI) method. We evaluated 15 genotypes (13 clones and two checks: RB867515 and RB72454) in nine environments. The average of two cuttings for the variable tons of pol per hectare (TPH) measure was used to discriminate genotypes. Besides the check RB867515 (20.44 t ha-1), the genotype RB987935 showed a high average TPH (20.71 t ha-1), general adaptability and phenotypic stability, and should be suitable for cultivation in the target region. The AMMI method allowed for easy visual identification of superior genotypes for each set of environments.

RESUMO

Adjustment of seeding schemes is one of the crop management techniques that most influences grain yield components. This work aimed to characterize the potential grain yield and its components in wheat (Triticum aestivum L.) genotypes with contrasting tillering ability under different seeding densities and environments. Five experiments were conducted in split-plot design, each with ten cultivars (main plot), sown in five distinct seeding densities (subplots). Experiments were sown in three locations in southern Brazil in the years 2005, 2006 and 2007. The grain yield per plot and its yield components: number of fertile tillers, weight of 1,000 grains, ear weight and number of grains per ear were evaluated. Genotypes with reduced tillering ability expressed an increase in grain yield with an increase in seeding densities, however showing a reduction in ear weight. The number of grains per ear did not affect grain yield but was highly influenced by seeding densities. The compensatory effect was expressed by the weight of a thousand grains as a function of the experimental conditions in which the genotypes were evaluated, regardless of seeding densities used. Results pointed to differences among cultivars tested in specific locations and years.

RESUMO

Adjustment of seeding schemes is one of the crop management techniques that most influences grain yield components. This work aimed to characterize the potential grain yield and its components in wheat (Triticum aestivum L.) genotypes with contrasting tillering ability under different seeding densities and environments. Five experiments were conducted in split-plot design, each with ten cultivars (main plot), sown in five distinct seeding densities (subplots). Experiments were sown in three locations in southern Brazil in the years 2005, 2006 and 2007. The grain yield per plot and its yield components: number of fertile tillers, weight of 1,000 grains, ear weight and number of grains per ear were evaluated. Genotypes with reduced tillering ability expressed an increase in grain yield with an increase in seeding densities, however showing a reduction in ear weight. The number of grains per ear did not affect grain yield but was highly influenced by seeding densities. The compensatory effect was expressed by the weight of a thousand grains as a function of the experimental conditions in which the genotypes were evaluated, regardless of seeding densities used. Results pointed to differences among cultivars tested in specific locations and years.

RESUMO

Sugarcane (Saccharum sp.) is one of the most important crops in Brazil. The high demand for sugarcane-derived products has stimulated the expansion of sugarcane cultivation in recent years, exploring different environments. The adaptability and the phenotypic stability of sugarcane genotypes in the Minas Gerais state, Brazil, were evaluated based on the additive main effects and multiplicative interaction (AMMI) method. We evaluated 15 genotypes (13 clones and two checks: RB867515 and RB72454) in nine environments. The average of two cuttings for the variable tons of pol per hectare (TPH) measure was used to discriminate genotypes. Besides the check RB867515 (20.44 t ha-1), the genotype RB987935 showed a high average TPH (20.71 t ha-1), general adaptability and phenotypic stability, and should be suitable for cultivation in the target region. The AMMI method allowed for easy visual identification of superior genotypes for each set of environments.