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Non-alcoholic Fatty Liver Disease and Depression: Evidence for Genotype × Environment Interaction in Mexican Americans.
Manusov, Eron Grant; Diego, Vincent P; Sheikh, Khalid; Laston, Sandra; Blangero, John; Williams-Blangero, Sarah.
Afiliação
  • Manusov EG; Department of Human Genetics, The University of Texas Rio Grande Valley, Brownsville, TX, United States.
  • Diego VP; School of Medicine, South Texas Diabetes and Obesity Institute, The University of Texas Rio Grande Valley, Brownsville, TX, United States.
  • Sheikh K; Department of Human Genetics, The University of Texas Rio Grande Valley, Brownsville, TX, United States.
  • Laston S; School of Medicine, South Texas Diabetes and Obesity Institute, The University of Texas Rio Grande Valley, Brownsville, TX, United States.
  • Blangero J; School of Medicine, The University of Texas Rio Grande Valley, Edinburg, TX, United States.
  • Williams-Blangero S; Department of Human Genetics, The University of Texas Rio Grande Valley, Brownsville, TX, United States.
Front Psychiatry ; 13: 936052, 2022.
Article em En | MEDLINE | ID: mdl-35845438
This study examines the impact of G × E interaction effects on non-alcoholic fatty liver disease (NAFLD) among Mexican Americans in the Rio Grande Valley (RGV) of South Texas. We examined potential G × E interaction using variance components models and likelihood-based statistical inference in the phenotypic expression of NAFLD, including hepatic steatosis and hepatic fibrosis (identified using vibration controlled transient elastography and controlled attenuation parameter measured by the FibroScan Device). We screened for depression using the Beck Depression Inventory-II (BDI-II). We identified significant G × E interactions for hepatic fibrosis × BDI-II. These findings provide evidence that genetic factors interact with depression to influence the expression of hepatic fibrosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies País/Região como assunto: Mexico Idioma: En Revista: Front Psychiatry Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies País/Região como assunto: Mexico Idioma: En Revista: Front Psychiatry Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Suíça