RESUMO
OBJECTIVE: Childhood standing height has been estimated from arm span-related (heightAS) models. The authors aimed to develop and cross-validate a heightAS model in individuals with spina bifida (SB) and examine the accuracy of existing heightAS models. METHODS: Participants were individuals with sacral and low-lumbar SB (n = 14) and non-SB (n = 83), 7-16 years old. Arm span, age, sex, and group (SB vs. non-SB) were candidate height predictors. Sequential regression and leave-one-out cross-validation approaches were used for the model development (M1) and cross-validation (M1-M5). Existing models were: an SB-specific model from Polfuss et al. (M2) and non-SB specific models from Gauld et al. (M3), Mulu et al. (M4), and Zverev et al. (M5) studies. RESULTS: Arm span and group explained 95 % of the variance in height (R2 = 0.95; p < 0.001; SEE = 3.666 cm) and were included in the M1. Mean differences between actual and estimated height were 0.0 cm (M1), 0.4 cm (M2), and 0.5 cm (M5), all not significant (p > 0.05). However, Bland-Altman analysis revealed some variability in the predictability of the models across participants with limits of agreement ranging from 7.4 to 10.9 cm. Considerable errors were observed with M3 (mean diff: -5.58 cm, 95 % CI: -1.6, -20.2 cm), and M4 (mean diff: 10.5 cm, 95 % CI: -13.8, -27.3 cm). CONCLUSIONS: Models (M1, M2 and M5) may accurately estimate standing height in groups of children with SB. However, due to the wide limits of agreement, caution is recommended when applying these models for individual height estimations.
Assuntos
Estatura , Disrafismo Espinal , Humanos , Estatura/fisiologia , Criança , Feminino , Masculino , Adolescente , Braço/anatomia & histologia , Reprodutibilidade dos TestesRESUMO
ABSTRACT BACKGROUND: Knowledge of clinical and laboratory differences between chromosomal and undefined causes aids etiological research on non-obstructive azoospermia. OBJECTIVE: Compare clinical and laboratory differences between men with non-obstructive azoospermia due to chromosomal anomalies versus undefined causes DESIGN AND SETTING: A cross-sectional retrospective study conducted at a public university hospital in Campinas (Brazil) METHODS: All men aged 20-40 years with non-obstructive azoospermia were included in the analysis. RESULTS: The 107 cases included 14 with Klinefelter syndrome (KS) (13%), 1 with mosaic KS, 4 with sex development disorders (2 testicular XX, 1 NR5A1 gene mutation, and 1 mild androgen insensitivity syndrome) (4%), 9 with other non-obstructive azoospermia etiologies (8%), and 79 with undefined causes. The 22 chromosomal anomaly cases (14 KS, 1 mosaic KS, 2 testicular XX, 4 sex chromosome anomalies, and 1 autosomal anomaly) were compared with the 79 undefined cause cases. The KS group had lower average testicular volume, shorter penile length, and lower total testosterone levels but greater height, arm span, serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels, and gynecomastia frequency (absent in the undefined group and affecting more than half of the KS group). Patients with testicular XX DSD had LH, FSH, and penile length data intermediate between the KS and undefined cause groups, testicular volume similar to the KS group, and other data similar to the undefined group. CONCLUSION: Clinical and laboratory data differentiate men with non-obstructive azoospermia and chromosomal anomalies, particularly KS and testicular XX, from those with undefined causes or other chromosomal anomalies.
RESUMO
The purpose of this research is to examine stature in both Albanian sexes as well as its association with arm span, as an alternative to estimating stature. A total of 445 individuals (266 boys and 179 girls) participated in this research. The anthropometric measurements were taken according to the protocol of ISAK. The relationships between stature and arm span were determined using simple correlation coefficients at a 95 % confidence interval. Then a linear regression analysis was carried out to examine extent to which arm span can reliably predict stature. Results displayed that Albanian boys are 176.57±7.36 cm tall and have an arm span of 179.98±9.41 cm, while Albanian girls are 166.84±9.28 cm tall and have an arm span of 167.53±10.34 cm. The results have shown that both sexes made Albanians a tall nation but not even close to their male compatriots from Kosovo that are almost 3 centimeters taller, while the results in female population are opposite. Moreover, the arm span reliably predicts stature in both sexes, which confirms a high R-square (%) for the boys (73.4) as well as for the girls (78.8).
El objetivo de esta investigación fue examinar la estatura en individuos de ambos sexos albaneses, además de su asociación con la extensión del brazo, como una alternativa a la estimación de la estatura. Un total de 445 individuos (266 niños y 179 niñas) participaron en esta investigación. Las medidas antropométricas se tomaron de acuerdo con el protocolo de ISAK. Las relaciones entre la estatura y el brazo se determinaron utilizando coeficientes de correlación simples en un intervalo de confianza del 95 %. Luego se realizó un análisis de regresión lineal para examinar en qué medida el brazo puede predecir de manera confiable la estatura. Los resultados muestran que los niños albaneses miden 176,57 ± 7,36 cm de alto y tienen una medida del brazo de 179,98 ± 9,41 cm, mientras que las niñas albanesas miden 166,84 ± 9,28 cm de alto y tienen una medida del brazo de 167,53 ± 10,34 cm. Los resultados han demostrado una altura importante en ambos sexos de la población albanesa. Sin embargo, se observó que respecto de la altura los varones de Kosovo miden casi 3 centímetros más, mientras que en la población femenina se observó lo contrario. Además, la extensión del brazo predice de manera confiable la estatura en ambos sexos, lo que confirma un alto Rcuadrado (%) para los varones (73,4) y para las mujeres (78,8).
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Adulto Jovem , Braço/anatomia & histologia , Estatura , Prognóstico , Modelos Lineares , Antropometria , AlbâniaRESUMO
The purpose of this research is to examine stature in both Kosovan sexes as well as its association with arm span, as an alternative to estimating stature. A total of 1623 individuals (830 boys and 793 girls) participated in this research. The anthropometric measurements were taken according to the protocol of ISAK. The relationships between stature and arm span were determined using simple correlation coefficients at a ninety-five percent confidence interval. Then a linear regression analysis was carried out to examine extent to which arm span can reliably predict stature. Results displayed that Kosovan boys are 179.52±5.96 cm tall and have an arm span of 181.29±7.02 cm, while Kosovan girls are 165.72±4.93 cm tall and have an arm span of 165.60±5.87 cm. The results have shown that both sexes made Kosovans a tall nation but not even close to be in the top tallest nations. Moreover, the arm span reliably predicts stature in both sexes.
El propósito de esta investigación fue examinar la talla en individuos kosovares de ambos sexos, así como su asociación con la extensión de brazo como una alternativa para la estimación de estatura. En la investigación participaron 1623 personas (830 hombres y 793 mujeres) . Las mediciones antropométricas se tomaron de acuerdo con el protocolo de ISAK. Las relaciones entre la talla y la extensión del brazo se determinó utilizando coeficientes de correlación simple con un 95 % de confianza. Se llevó a cabo un análisis de regresión lineal para examinar hasta qué punto la extensión de brazo puede predecir la estatura. Los resultados mostraron que los varones kosovares tienen 179.52 ± 5.96 cm de altura y tienen una extensión de brazo de 181.29 ± 7.02 cm, mientras que las mujeres kosovares tienen 165.72 ± 4.93 cm de altura y extensión de brazo de 165.60 ± 5.87 cm. Los resultados indicaron que los individuos kosovares de ambos sexos son una población alta, sin embargo las mediciones no se acercaron a poblaciones en las naciones de mayor altura. Además, la extensión de brazo fue predecible en cuanto a la estatura en ambos sexos.