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1.
Autops Case Rep ; 14: e2024471, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38476735
2.
Rev. colomb. cir ; 39(1): 155-160, 20240102. fig, tab
Artigo em Espanhol | LILACS | ID: biblio-1526867

RESUMO

Introducción. Los teratomas son neoplasias que surgen a partir de células germinales pluripotenciales y derivan de dos o más capas de células. Se clasifican en tumores maduros, que contienen tejidos bien diferenciados, o inmaduros, que contienen estructuras inmaduras y embrionarias. Su localización más frecuente son las gónadas; la ubicación mesentérica es infrecuente y se han descrito aproximadamente 40 casos en la literatura mundial. Dentro del abordaje diagnóstico y terapéutico, se emplea la tomografía computarizada y la resonancia magnética nuclear para caracterizar la lesión, evaluar la extensión intraabdominal y la relación con otras estructuras. El diagnóstico debe confirmarse mediante el examen histopatológico. Caso clínico. Paciente femenina de 56 años, con antecedente de carcinoma ductal infiltrante de mama izquierda en remisión, en estudios de seguimiento con hallazgo incidental en tomografía de abdomen de lesión abdominopélvica dependiente del mesenterio, contornos lisos y nivel grasa-líquido. Estudios de extensión con marcadores tumorales negativos. Resultados. Por la alta sospecha clínica e imagenológica de teratoma, fue llevada a resección quirúrgica de la lesión. El examen histopatológico confirmó el diagnóstico de teratoma quístico maduro del mesenterio. Conclusión. El teratoma mesentérico es una entidad clínica rara, que debe ser considerado como uno de los diagnósticos diferenciales de una masa abdominal con efecto compresivo. El diagnóstico se basa principalmente en el examen clínico y los hallazgos imagenológicos. La escisión quirúrgica temprana es el pilar del tratamiento; el abordaje laparoscópico o abierto depende de las características clínicas y la experiencia del cirujano.


Background. Teratomas are neoplasms that arise from pluripotent germ cells, derived from two or more layers of germ cells. They are classified as mature tumors (cystic or solid), which contain well-differentiated tissues, or as immature tumors, which contain immature and embryonic structures. Its most frequent location is the female and male gonads; the mesenteric location is rare and approximately 40 cases have been described in the world literature. Within the diagnostic and therapeutic approach, computed tomography and magnetic resonance imaging are used to characterize the lesion, assess intra-abdominal extension and the relationship with other structures. The diagnosis must be confirmed by histopathological examination. Clinical case. A 56-year-old female patient with a history of infiltrating ductal carcinoma of the left breast in remission. In follow-up studies, incidental abdominal tomography finding of an abdominopelvic lesion dependent on the mesentery at the level of the mesogastrium, smooth contours with fat-liquid level. Extension studies with negative tumor markers. Results. Due to high clinical and imaging suspicion of teratoma, the patient was taken to resection of the lesion. Histopathological examination confirmed the diagnosis of mature cystic teratoma of the mesentery. Conclusion. Mesenteric teratoma is a rare clinical entity and is considered one of the differential diagnoses of an abdominal mass with a compressive effect. Diagnosis is mainly based on clinical examination and imaging findings. Early surgical excision is the mainstay of treatment; laparoscopic or open approach depends on the clinical characteristics and the experience of the surgeon.


Assuntos
Humanos , Teratoma , Neoplasias Abdominais , Patologia , Células Germinativas Embrionárias , Mesentério
3.
Naunyn Schmiedebergs Arch Pharmacol ; 397(6): 3819-3827, 2024 06.
Artigo em Inglês | MEDLINE | ID: mdl-38180558

RESUMO

One-third of cancer pain patients do not experience adequate pain relief using analgesic ladder by the World Health Organization. Interventional procedures, such as epidural morphine, have been considered. This study aimed to review the literature comparing the effects of epidural administration of morphine with the oral route. This systematic review included randomized controlled trials (RCTs) conducted with patients with gastrointestinal neoplasm. A search was conducted on PubMed, EMBASE, Web of Science, Scopus, Cochrane Library, and CINAHL databases to identify studies published up to May 2023. The retrieved study was evaluated using the Risk of Bias 2 (RoB 2) tool and qualitatively synthesized. The certainty of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach (Prospero: CRD42021264728). Only one RCT, a crossover trial, was included in this systematic review. The study was conducted with ten participants (one withdrawal) and reported a statistically significant difference between both subcutaneous and epidural morphine solutions and oral morphine. The adverse events were not described. The included study presents some concerns of bias and low certainty of evidence on the effectiveness and security of epidural morphine administration. The available literature does not suffice to elucidate whether morphine administration via the epidural route is more effective than other routes. Further RCTs are necessary to improve the level of evidence on the effectiveness and risk-benefit of epidural morphine in the management of cancer pain in gastrointestinal neoplasm patients.


Assuntos
Analgesia Epidural , Analgésicos Opioides , Dor do Câncer , Neoplasias Gastrointestinais , Morfina , Ensaios Clínicos Controlados Aleatórios como Assunto , Humanos , Administração Oral , Analgesia Epidural/métodos , Analgésicos Opioides/administração & dosagem , Analgésicos Opioides/efeitos adversos , Analgésicos Opioides/uso terapêutico , Dor do Câncer/tratamento farmacológico , Neoplasias Gastrointestinais/tratamento farmacológico , Neoplasias Gastrointestinais/complicações , Morfina/administração & dosagem , Morfina/uso terapêutico , Morfina/efeitos adversos , Resultado do Tratamento
4.
Autops. Case Rep ; 14: e2024471, 2024. graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1533846
5.
Indian J Palliat Care ; 29(4): 394-406, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38058484

RESUMO

Objectives: The management of chronic pain among patients with abdominal cancer is complex; against that, the neurolysis of the celiac plexus (CPN) is the best technique at the moment to determine the efficacy and safety in the treatment of chronic pain secondary to oncological pathology of the upper abdomen. Material and Methods: This was a systematic review of controlled clinical trials between 2000 and 2021, in the sources MEDLINE/PubMed, Cochrane, Scopus, Web of Science, and Google Scholar. Three independent evaluators analysed the results of the bibliographical research. The quality of the studies was assessed with the Jadad scale and the mean difference (95% confidence interval) and heterogeneity of the studies (I2) were calculated with Review Manager 5.3. Results: Seven hundred and forty-four publications were identified, including 13 studies in the qualitative synthesis and three studies in the quantitative synthesis. No difference was found in the decrease in pain intensity between 1 and 12 weeks after the intervention, comparing the experimental group with the control (P > 0.05). The adverse effects related to neurolysis were not serious and transitory, mentioning the most frequent adverse effects and reporting a percentage between 21% and 67% (with 17% for echoendoscopic neurolysis and 49% for percutaneous neurolysis). Conclusion: Celiac plexus neurolysis for the treatment of severe chronic pain secondary to oncological pathology in the upper hemiabdomen produces similar pain relief as conventional pharmacological analgesic treatment. It is a safe analgesic technique since the complications are mild and transitory.

6.
Cambios rev. méd ; 22 (2), 2023;22(2): 925, 16 octubre 2023. ilus.
Artigo em Espanhol | LILACS | ID: biblio-1524866

RESUMO

INTRODUCCIÓN: Los quistes mesentéricos son tumores intra-abdominales definidos como cualquier quiste en el mesenterio del tracto gastrointestinal, ubicándose más frecuentemente en intestino delgado (íleon 60%) cuya incidencia es de tan solo 1 en 350.000 casos, haciendo relevante la publicación de los casos identificados para ampliar el conocimiento y conducta que se debe tener frente a los mismos. CASO CLÍNICO: Se trata de una paciente femenina de 36 años de edad, que acudió con cuadro de dolor abdominal acompañado de importante aumento del diámetro abdominal de un año de evolución, agudizado hace 4 días, por lo que se realizó ecografía abdominal donde se observó una masa quística de aproximadamente 7554ml, completando con estudio tomográfico donde no se observó aparente compromiso de grandes vasos, identificándose quirúrgicamente masa quística dependiente de mesenterio que comprometía la tercera y cuarta porción del duodeno, por lo que requirió resección de las mismas con anastomosis primaria, tras lo cual paciente mostró adecuada respuesta tras el procedimiento. DISCUSIÓN: El tratamiento de elección frente a un quiste mesentérico es la resección del mismo, debido a que otros métodos han mostrado altas tazas de recurrencia, sin embargo, el abordaje quirúrgico varía de acuerdo al cuadro clínico, teniendo como primera opción la resolución laparoscópica, no obstante, se optó por la realizar una laparotomía dado el gran volumen del quiste evidenciado en estudios de imagen. CONCLUSIONES: Los quistes mesentéricos tienen buen pronóstico una vez que son resecados completamente, sin embargo, es importante tomar en cuenta que el riesgo de compromiso vascular se vincula con el tamaño del mismo, algo que se puede confirmar solo durante el procedimiento quirúrgico, es por ello que se debe anticipar estas situaciones y tomar las medidas para reducir las consecuencias del mismo.


INTRODUCTION: Mesenteric cysts are intra-abdominal tumors defined as any cyst in the me-sentery of the gastrointestinal tract, most frequently located in the small intestine (ileum 60%) whose incidence is only 1 in 350,000 cases, making the publication of the cases relevant. iden-tified to expand the knowledge and behavior that must be followed regarding them. CLINICAL CASE: This is a 36-year-old female patient who presented with abdominal pain accompanied by a significant increase in abdominal diameter for one year, exacerbated 4 days ago, so an abdominal ultrasound was performed where a cystic mass of approximately 7554 ml, completed with a tomographic study where no apparent involvement of the great vessels was observed, surgically identifying a cystic mass dependent on the mesentery that compromised the third and fourth portions of the duodenum, which required resection of the same with primary anastomosis, after which the patient showed an adequate response after the procedure. DISCUSSION: The treatment of choice for a mesenteric cyst is its resection, because other methods have shown high rates of recurrence; however, the surgical approach varies according to the clinical picture, with laparoscopic resolution being the first option; however, it was decided to perform a laparo-tomy given the large volume of the cyst evident in imaging studies. CONCLUSION: Mesenteric cysts have a good prognosis once they are completely resected, however, it is important to take into account that the risk of vascular compromise is linked to its size, something that can be confirmed only during the surgical procedure, which is why These situations must be anticipated and measures taken to reduce their consequences


Assuntos
Humanos , Feminino , Adulto , Anastomose Cirúrgica , Trato Gastrointestinal , Duodenopatias/cirurgia , Laparotomia , Neoplasias Abdominais , Cisto Mesentérico , Cirurgia Geral , Equador
7.
Rev. colomb. cir ; 38(3): 556-567, Mayo 8, 2023. fig
Artigo em Espanhol | LILACS | ID: biblio-1438590

RESUMO

Introducción. Las neoplasias quísticas mucinosas del hígado son tumores poco frecuentes, equivalen a menos del 5 % de todas las lesiones quísticas hepáticas y se originan generalmente en la vía biliar intrahepática, con poco compromiso extrahepático. En la mayoría de los casos su diagnóstico es incidental dado que es una entidad generalmente asintomática con un curso benigno; sin embargo, hasta en el 30 % pueden ser malignas. En todos los casos se debe hacer una resección quirúrgica completa de la lesión. Caso clínico. Se presentan dos pacientes con diagnóstico de neoplasia quística mucinosa en la vía biliar intrahepática, así como sus manifestaciones clínicas, hallazgos imagenológicos y tratamiento. Discusión. Debido a su baja incidencia, esta patología constituye un reto diagnóstico, que se puede confundir con otro tipo de entidades más comunes. El diagnóstico definitivo se hace de forma histopatológica, pero en todos los casos, ante la sospecha clínica, se recomienda la resección completa. Conclusión. Se presentan dos pacientes con diagnóstico de neoplasias quísticas mucinosas del hígado, una entidad poco frecuente y de difícil diagnóstico


Introduction. Mucinous cystic neoplasms of the liver are rare tumors, accounting for less than 5% of all liver cystic lesions, and generally originate from the intrahepatic bile duct with little extrahepatic involvement. In most cases its diagnosis is incidental since it is a generally asymptomatic entity with a benign course; however, up to 30% can have a malignant course. In all cases, complete surgical resection of the lesion must be performed. Clinical case. Two patients with a diagnosis of mucinous cystic neoplasm in the intrahepatic bile duct are presented, as well as their clinical manifestations, imaging findings, and treatment. Discussion. Due to its low incidence, this pathology constitutes a diagnostic challenge, which can be confused with other types of more common entities. The definitive diagnosis is made histopathologically, but in all cases, given clinical suspicion, complete resection is recommended. Conclusion. Two patients with a diagnosis of mucinous cystic neoplasms of the liver are presented, a rare entity that is difficult to diagnose


Assuntos
Humanos , Hepatectomia , Neoplasias Abdominais , Ductos Biliares , Colestase , Fígado
8.
Rev. cir. (Impr.) ; 74(4): 339-344, ago. 2022. tab
Artigo em Espanhol | LILACS | ID: biblio-1407935

RESUMO

Resumen Introducción: Los tumores periampulares se definen como lesiones ubicadas en un radio de 2 cm alrededor de la ampolla de Vater, constituidos por 4 tipos de neoplasias con una alta tasa de malignidad que pueden originarse en páncreas, ampolla, vía biliar distal o duodeno. El manejo quirúrgico a través de la pancreatoduodenectomía sigue siendo la mejor elección en términos de resección curativa. Objetivo: Caracterizar los tumores peri-ampulares tratados en nuestra institución y que fueron llevados a pancreatoduodenectomía, asociando la relación entre tipo de tumor y complicaciones posoperatorias. Material y Método: Estudio transversal, retrospectivo y observacional con seguimiento a 45 pacientes sometidos a pancreatoduodenectomía en el Hospital Internacional de Colombia - Fundación Cardiovascular entre enero de 2011 y marzo de 2020 con diagnostico histopatológico de tumor peri-ampular. Resultados: Se realizaron 75 pancreatoduodenectomía de las cuales 45 pacientes presentaron tumor peri-ampular, siendo de origen pancreático en un 44%, seguido de ampolla 40%, vía biliar distal 8,8% y duodenal 6,6%. Las complicaciones posoperatorias más frecuentes fueron fístula pancreática y vaciamiento gástrico retardado. Falleció 1 paciente. Conclusión: La pancreatoduodenectomía es un procedimiento con alta morbilidad. Gracias al avance tecnológico, el diagnóstico de patología peri ampular es cada vez más exacto. El tipo de tumor peri-ampular puede influir no solo en su pronóstico, sino también en su morbilidad posquirúrgica.


Introduction: Periampullary tumors are defined as lesions that are located in a radius of 2 centimeters around the ampulla of Vater, constituted by 4 types of neoplasms with a high rate of malignancy originated in the pancreas, ampulla, distal bile duct or duodenum. Surgical management through the pancreatoduodenectomy remains the best choice in terms of curative resection. Objetive: To characterize periampullary tumors treated in our institution with pancreatoduodenectomy, associating the relationship between tumor type and postoperative complications. Material and Method: Cross-sectional, retrospective, observational study with a follow-up of 45 patients underwent pancreatoduodenectomy in the Hospital Internacional de Colombia - Fundación Cardiovascular between January 2011 and March 2020 with histopathological diagnosis of periampullary tumor. Results: Were performed 75 pancreatoduodenectomies, 45 patients presented with Periampullary tumor, 44% being of pancreatic origin, followed by ampulla 40%, distal bile duct 8.8% and duodenal 6.6%. Most frequent postoperative complications were pancreatic fistula and delayed gastric emptying. Mortality was of 1 patient. Conclusión: Pancreatoduodenectomy is a procedure with a high morbidity rate. Thanks to technological advances, the diagnosis of periampullary pathology is increasingly accurate. The type of periampullary tumor may influence not only in its prognosis, but also in its post-surgical morbidity.


Assuntos
Humanos , Masculino , Feminino , Neoplasias Pancreáticas/cirurgia , Laparoscopia , Neoplasias Abdominais/cirurgia , Pancreatectomia/efeitos adversos , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Complicações Pós-Operatórias/epidemiologia , Estudos Transversais , Estudos Retrospectivos , Pancreaticoduodenectomia/efeitos adversos
9.
Rev. med. (Säo Paulo) ; 101(4): e-194203, jul.-ago. 2022.
Artigo em Inglês, Português | LILACS-Express | LILACS | ID: biblio-1392162

RESUMO

O pâncreas ectópico é uma anomalia congênita rara representada por um aglomerado de tecido pancreático aberrante fora de seu lugar anatômico natural, visto em qualquer época da vida. A localização mais frequente é o duodeno ou tecido gástrico. Suas manifestações clínicas são inespecíficas e podem dificultar o diagnóstico. A ectopia pancreática pode ser vista também em outros órgãos ou regiões extra-abdominais como, por exemplo, no pulmão, mediastino e no umbigo. A incidência do pâncreas ectópico em achados de necropsias varia entre 0,6 a 5,6%. O autor relata um caso de um paciente com pâncreas ectópico localizado no antro gástrico que provocava sintomatologia gastrointestinal associado a baixo peso e faz uma breve revisão da literatura. [au]


Ectopic pancreas is a rare congenital anomaly represented by a cluster of aberrant pancreatic tissue outside its natural anatomical place seen at any time in life. The most frequent location is the duodenum or gastric tissue. Its clinical manifestations are nonspecific and can make diagnosis difficult. Pancreatic ectopy can also be seen in other organs or extra-abdominal regions, for example, in the lung, mediastinum and umbilicus. The incidence of ectopic pancreas in necropsy findings ranges from 0.6 to 5.6%. The author reports the case of a patient with ectopic pancreas located in the gastric antrum and reviews the literature. [au]

10.
J Surg Oncol ; 126(1): 48-56, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35689586

RESUMO

BACKGROUND: Malignant bowel obstruction (MBO) is a frequent complication in advanced cancer patients and especially those with abdominal tumors. The clinical management of MBO requires a specific and individualized approach based on the disease prognosis. Surgery is recommended. Less invasive approaches such as endoscopic treatments should be considered when surgery is contraindicated. The priority of care for inoperable and consolidated MBO is to control the symptoms and promote the maximum level of comfort. OBJECTIVES: This study aimed to develop recommendations for the effective management of MBO. METHODS: A questionnaire was administered to all members of the Brazilian Society of Surgical Oncology, of whom 41 surgeons participated in the survey. A literature review of studies retrieved from the National Library of Medicine database was conducted on particular topics chosen by the participants. These topics addressed questions regarding the MBO management, to define the level of evidence and strength of each recommendation, and an adapted version of the Infectious Diseases Society of America Health Service rating system was used. RESULTS: Most aspects of the medical approach and management strategies reviewed were strongly recommended by the participants. CONCLUSIONS: Guidelines outlining the strategies for management MBO were developed based on the strongest evidence available in the literature.


Assuntos
Neoplasias Abdominais , Obstrução Intestinal , Oncologia Cirúrgica , Brasil , Humanos , Obstrução Intestinal/etiologia , Obstrução Intestinal/cirurgia , Cuidados Paliativos
11.
ABCD (São Paulo, Online) ; 35: e1703, 2022. graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1419813

RESUMO

ABSTRACT BACKGROUND: Solid pseudopapillary tumor of the pancreas has been frequently reported in the past two decades. Surgery remains the treatment of choice, with the liver being the most frequent site of metastases. AIMS: The study aimed to present an option of surgical treatment for an 18-year-old female patient with a solid lesion in the body and tail of the pancreas associated with metastatic lesions in both hepatic lobes. METHODS: Two surgical procedures were scheduled. In the first procedure, body-caudal pancreatectomy with splenectomy was performed, associated with the resection of three lesions of the liver's left lobe. A right hepatectomy was performed 6 months later, progressing without complications. RESULTS: The patient continues without clinical complaints on the last return, and abdominal magnetic resonance performed 28 months after the second procedure does not show liver or abdominal cavity lesions. CONCLUSIONS: The knowledge on the biological behavior of tumors, evolution, and recurrence risks allows the indication of more rational surgical techniques that best benefit patients.


RESUMO RACIONAL: O tumor sólido pseudopapilar do pâncreas tem sido relatado na literatura com mais frequência nas últimas duas décadas. A cirurgia continua sendo o tratamento indicado, sendo o fígado o local mais frequente de metástases. OBJETIVOS: Apresentar a opção de tratamento cirúrgico de paciente feminino, 18 anos, com lesão sólida no corpo e cauda do pâncreas associada a lesões metastáticas em ambos os lobos hepáticos. MÉTODOS: Dois procedimentos cirúrgicos foram agendados. No primeiro procedimento foi realizada pancreatectomia corpo-caudal com esplenectomia, associada à ressecção de 3 lesões do lobo esquerdo do fígado. A hepatectomia direita foi realizada seis meses após, evoluindo sem complicações. RESULTADOS: O paciente continua sem queixas clínicas no último retorno, e a ressonância magnética do abdomem realizada 28 meses após o segundo procedimento não mostra lesões hepáticas ou na cavidade abdominal. CONCLUSÕES: O conhecimento do comportamento biológico dos tumores, a evolução e os riscos de recidiva, permitem a indicação de técnicas cirúrgicas mais racionais e que melhor beneficiam os pacientes.

12.
Rev. méd. Chile ; 148(11)nov. 2020.
Artigo em Espanhol | LILACS | ID: biblio-1389253

RESUMO

We report a previously healthy 34-year-old woman, presenting with a seven-month history of arterial hypertension, amenorrhea, weight gain, facial edema, acne, hirsutism and low back pain. A CT scan showed a right adrenal mass of 18 × 13 × 12.5 cm, and multiple vertebral and rib fractures. The hormonal study confirmed Cushing's Syndrome. Ketoconazole, spironolactone, cotrimoxazole, calcium / vitamin D were started. An adrenalectomy with a right nephrectomy were performed. The excised tumor measured 16 cm and weighed 1.55 kg. There was tumor embolism and a 4 mm soft tissue involvement (pT3NxMx). The right kidney was free of tumor. The patient was treated with chemotherapy (etoposide plus cisplatin). Study of vertebral fractures with magnetic resonance (MRI) showed crush fractures, without images of metastatic bone lesions. One year after surgery, a CT scan showed no signs of tumor recurrence. The patient was lost from follow-up thereafter.


Assuntos
Adulto , Feminino , Humanos , Carcinoma , Síndrome de Cushing , Imageamento por Ressonância Magnética , Tomografia Computadorizada por Raios X , Adrenalectomia , Síndrome de Cushing/etiologia
14.
Rev. bras. cancerol ; 66(4): e-11826, 2020.
Artigo em Português | LILACS | ID: biblio-1140874

RESUMO

Introdução: A neoplasia pseudopapilífera sólida de pâncreas (tumor de Frantz) é muito rara e representa menos de 1% de todos os tumores pancreáticos. Relato do caso: Paciente do sexo feminino, 48 anos, internada para investigação de massa intra-abdominal de etiologia a esclarecer. Foi submetida a tratamento cirúrgico com sucesso na ressecção tumoral e não apresentou complicações no pós-operatório. Os pacientes usualmente tornam-se sintomáticos somente após longos períodos de evolução, quando então apresentam desconforto ou dor abdominal, ou a palpação de massas abdominais no exame físico. Para o diagnóstico, são necessários exames de imagem como ultrassonografia e tomografia computadorizada, que geralmente evidenciam volumosas massas heterogêneas intra-abdominais. É necessária a confirmação com estudo anatomopatológico e comumente estas possuem características histológicas compatíveis com tumores de baixo grau de malignidade. A ressecção cirúrgica é o tratamento recomendado e mesmo os tumores de grandes dimensões possuem chances de curas consideráveis, se for possível obter margens cirúrgicas livres. Sabe-se que a ressecção tumoral completa é associada a longos períodos de sobrevida. Conclusão: A neoplasia pseudopapilífera sólida de pâncreas (tumor de Frantz), apesar de rara, deve ser considerada no diagnóstico diferencial de tumores de pâncreas, já que o tratamento cirúrgico apresenta boas chances de cura mesmo em tumores de grandes dimensões.


Introduction: The solid pseudopapillary tumor of the pancreas (Frantz's tumor) is a neoplasm extremely rare that represents less than 1% of all the pancreatic tumors. Case report: 48 years old female patient was hospitalized with intra-abdominal mass of etiology hard to define. She was submitted to surgical treatment with successful laparotomy tumor resection and there were no postoperative complications. The patients usually become symptomatic only after long time of evolution, when they have discomfort or abdominal pain or palpation of abdominal masses during physical examination. Complementary exams like ultrasound and computed tomography are necessary to diagnosis and usually they show heterogeneous large intra-abdominal masses. It is necessary the confirmation with anatomopathological study which usually has histological characteristics compatible with low-grade malignancy. The surgical resection is the recommended treatment and even large size tumors has a considerable chance of cure if free surgical margins are obtained. It is known that complete tumoral resection is associated with long-term survival. Conclusion: The solid pseudopapillary tumor of the pancreas (Frantz's tumor), although rare, should be considered in differential diagnosis of pancreatic neoplasms because surgical treatment usually has good chances of cure even in large size tumors


Introducción: La neoplasia sólida-pseudopapilar de páncreas (tumor de Frantz) es muy extraordinaria y representa menos de 1% de todos los tumores pancreáticos. Relato del caso: Paciente do sexo femenino, 48 años, internada para investigación de masa intraabdominal de etiología a esclarecer. Fue sometida al tratamiento quirúrgico con éxito en la resección tumoral y no presentó complicaciones en el postoperatorio. Los pacientes por lo general se convierten en sintomáticos solamente después de largos períodos de evolución, cuando presentan incomodidad o dolor abdominal o existe palpación de masas abdominales en el examen físico. Para el diagnóstico son necesarios exámenes de imagen como ecografía y tomografía computarizada que generalmente demuestran voluminosas masas heterogéneas intraabdominales. Es necesaria la confirmación con examen anatomopatológico y generalmente tienen características histológicas compatibles con tumores de poco grado de malignidad. La resección quirúrgica es el tratamiento indicado y mismo tumores de grandes dimensiones poseen posibilidades de curas considerables se sea posible obtener márgenes quirúrgicas libres. Se sabe que a resección tumoral completa es asociada a largos períodos de sobrevida. Conclusión: La neoplasia sólida-pseudopapilar de páncreas o tumor de Frantz: a pesar de extraordinaria, debe ser considerada en el diagnóstico diferencial de tumores de páncreas y a que el tratamiento quirúrgico presenta buenas posibilidades de cura, mismo en tumores de grandes proporciones.


Assuntos
Feminino , Pessoa de Meia-Idade , Neoplasias Pancreáticas/cirurgia , Neoplasias Pancreáticas/diagnóstico por imagem , Relatos de Casos
15.
Rev. colomb. cir ; 35(4): 689-694, 2020. fig
Artigo em Espanhol | LILACS | ID: biblio-1147986

RESUMO

Introducción. Los teratomas son masas de células totipotenciales, frecuentes en los ovarios o testículos. Su localización extragonadal es rara, siendo el epiplón aún más infrecuente. Hasta la actualidad se conocen aproximadamente 34 casos similares en la literatura. Presentación del caso. Se presenta una paciente de 61 años, con dolor en hemiabdomen inferior asociado a sensación de masa, con marcadores tumorales negativos e imágenes diagnósticas que muestran una masa encapsulada y calcificación anular interna sugestiva de necrosis grasa antigua versus tumor desmoide. Por la presentación clínica y los hallazgos imagenológicos se decide llevar a laparotomía exploratoria donde se encuentra masa quística dependiente de epiplón, con material sebáceo en su interior entremezclado con pelo y fragmentos óseos, que se reseca en bloque sin complicaciones. El informe del estudio histopatológico finalmente concluyó la presencia de un teratoma quístico maduro con cambios degenerativos. Por evolución satisfactoria se da egreso hospitalario. Discusión. El teratoma quístico extragonadal del epiplón es exótico en la literatura mundial, con escasos reportes de casos. En este caso, la resección mediante laparotomía resultó exitosa y sin complicaciones. Por su baja incidencia, la laparotomía ha sido una opción válida y segura para el manejo, no obstante conocer el caso permite plantear un abordaje con técnicas mínimamente invasivas


Introduction. Teratomas are totipotential cell masses, commonly located in the ovaries or testes. Its extragonadal location is rare, in the omentum being even rarer. To date, approximately 34 similar cases are known in the literature.Case presentation. A 61-year-old female patient is presented, with pain in the lower abdomen associated with a sensation of mass, with negative tumor markers and diagnostic images that show an encapsulated mass and internal annular calcification suggestive of old fat necrosis versus desmoid tumor. Due to the clinical presentation and the imaging findings, it was decided to carry out exploratory laparotomy where a cystic mass dependent on the omentum was found, with sebaceous material intermixed with hair and bone fragments, which was resected in bloc without complications. The histopathological study report finally concluded the presence of a mature cystic teratoma with degenerative changes. Due to satisfactory evolution, he was dis-charged from hospital.Discusion. Extragonadal cystic teratoma of the omentum is exotic in the world literature, with few case reports. In this case, the laparotomy resection was successful and uncomplicated. Due to its low incidence, laparotomy has been a valid and safe option for management, although knowing the case allows us to propose an approach with minimally invasive techniques


Assuntos
Humanos , Teratoma , Omento , Cisto Dermoide , Neoplasias Abdominais
16.
Radiol. bras ; Radiol. bras;52(6): 368-371, Nov.-Dec. 2019. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1057022

RESUMO

Abstract Objective: To evaluate the rates of success and failure of ultrasound-guided percutaneous biopsy of lesions in hollow abdominal organs, as well as the influence of contrast enhancement on those rates. Materials and Methods: This was a retrospective, single-center study evaluating patients submitted to ultrasound-guided percutaneous biopsy of abdominal lesions in hollow organs between January 2017 and June 2018. Patient records were reviewed using a standardized data collection form. Results: We included 49 procedures performed in 48 patients, of whom 18 (38%) had a prior diagnosis of cancer. Malignancy was suspected in 44 cases (90%). Among those 44 cases, the suspicion was of a new neoplasm in 28 (64%), of relapse in 11 (25%), and of a metastatic lesion in 5 (11%). The histopathological findings were sufficient to make the diagnosis in all 44 of those cases, 33 (75%) of which were found to be malignant. The diagnosis was consistent with the clinical suspicion in 33 (75%) of the cases in which there was a definitive histological result. There were no complications resulting from the procedure. Conclusion: Ultrasound-guided percutaneous biopsy is a safe procedure that demonstrates high efficacy in providing a sufficient sample for the diagnosis. The main reason to perform such a biopsy is suspicion of a new neoplasm, followed by suspicion of a metastatic lesion. The histopathological results were concordant with the suspicion in the majority of the cases evaluated here.


Resumo Objetivo: Avaliar as taxas de sucesso e insucesso das biópsias percutâneas ecoguiadas de lesões em órgãos abdominais não sólidos e a influência da realização de contraste nessa técnica. Materiais e Métodos: Estudo retrospectivo que avaliou doentes submetidos a biópsias percutâneas ecoguiadas de lesões em órgãos abdominais não sólidos, entre janeiro de 2017 e junho de 2018. Os dados clínicos dos doentes foram revistos usando um método padronizado de colheita de dados. Resultados: Foram incluídos 49 procedimentos realizados em 48 doentes, dos quais 18 (38%) tinham diagnóstico prévio de câncer. Em 44 (90%) suspeitava-se de malignidade: 28 (64%) de suspeita de diagnósticos de novo de neoplasia, 11 (25%) de recidiva neoplásica e 5 (11%) de lesões metastáticas. Os resultados histopatológicos permitiram fazer o diagnóstico em 44 casos (90%), sendo 33 (67%) malignos. O diagnóstico foi concordante com a suspeita clínica em 33 (75%) dos casos com resultado histológico definitivo. Não ocorreram complicações resultantes das biópsias. Conclusão: A realização de biópsias ecoguiadas é segura e capaz de fornecer amostra suficiente para permitir o diagnóstico definitivo. O principal motivo para realizar biópsias ecoguiadas é a suspeita de neoplasia de novo, seguida da suspeita de metástases. Os resultados histopatológicos foram concordantes com a suspeita clínica na maioria dos casos.

17.
Arch. argent. pediatr ; 117(6): 651-654, dic. 2019. tab, ilus
Artigo em Espanhol | LILACS, BINACIS | ID: biblio-1046714

RESUMO

El síndrome de opsoclonus mioclonus es un trastorno poco frecuente en pediatría. El diagnóstico es clínico y se caracteriza por la presencia de, al menos, tres de los siguientes: opsoclonus, mioclonías, ataxia, irritabilidad y trastornos del sueño. En más del 50 % de los casos, se asocia con la presencia de neuroblastoma. Es un trastorno de origen inmunitario y su tratamiento es a base de inmunosupresores, inmunomoduladores y resección tumoral en los casos secundarios a neuroblastoma. Entre el 70 % y el 80 % de los casos pueden tener secuelas neurológicas, dependiendo de la causa, la gravedad inicial de los síntomas y la velocidad de instauración del tratamiento.Se presenta el caso de un varón de 2 años con diagnóstico de síndrome de opsoclonus mioclonus secundario a un neuroblastoma suprarrenal izquierdo, en el que se realizó la resección tumoral y el tratamiento con corticoides, inmunoglobulina y rituximab.


Opsoclonus-myoclonus syndrome is a rare disorder among pediatric patients.The diagnosis is clinical and is characterized by the presence of at least three of the following: opsoclonus, myoclonus, ataxia, irritability and sleep disorders. In over 50 % of cases it is associated with the presence of Neuroblastoma. It is a disorder of immune origin and its treatment is based on immunosuppressants, immunomodulators and tumor resection in cases secondary to Neuroblastoma. Up to 70 % to 80 % of cases may present neurological sequelae, depending on the cause, the initial severity of symptoms and the delay of proper treatment. We present the case of a 2-year-old male with diagnosis of opsoclonus-myoclonus syndrome secondary to a left adrenal Neuroblastoma. Tumor resection and treatment with corticosteroids, immunoglobulin and rituximab were performed.


Assuntos
Humanos , Masculino , Pré-Escolar , Síndrome de Opsoclonia-Mioclonia , Neuroblastoma/cirurgia , Neuroblastoma/tratamento farmacológico , Pediatria , Neoplasias Abdominais
18.
Arch Argent Pediatr ; 117(6): e651-e654, 2019 12 01.
Artigo em Espanhol | MEDLINE | ID: mdl-31758904

RESUMO

Opsoclonus-myoclonus syndrome is a rare disorder among pediatric patients. The diagnosis is clinical and is characterized by the presence of at least three of the following: opsoclonus, myoclonus, ataxia, irritability and sleep disorders. In over 50 % of cases it is associated with the presence of Neuroblastoma. It is a disorder of immune origin and its treatment is based on immunosuppressants, immunomodulators and tumor resection in cases secondary to Neuroblastoma. Up to 70 % to 80 % of cases may present neurological sequelae, depending on the cause, the initial severity of symptoms and the delay of proper treatment. We present the case of a 2-year-old male with diagnosis of opsoclonus-myoclonus syndrome secondary to a left adrenal Neuroblastoma. Tumor resection and treatment with corticosteroids, immunoglobulin and rituximab were performed.


El síndrome de opsoclonus mioclonus es un trastorno poco frecuente en pediatría. El diagnóstico es clínico y se caracteriza por la presencia de, al menos, tres de los siguientes: opsoclonus, mioclonías, ataxia, irritabilidad y trastornos del sueño. En más del 50 % de los casos, se asocia con la presencia de neuroblastoma. Es un trastorno de origen inmunitario y su tratamiento es a base de inmunosupresores, inmunomoduladores y resección tumoral en los casos secundarios a neuroblastoma. Entre el 70 % y el 80 % de los casos pueden tener secuelas neurológicas, dependiendo de la causa, la gravedad inicial de los síntomas y la velocidad de instauración del tratamiento. Se presenta el caso de un varón de 2 años con diagnóstico de síndrome de opsoclonus mioclonus secundario a un neuroblastoma suprarrenal izquierdo, en el que se realizó la resección tumoral y el tratamiento con corticoides, inmunoglobulina y rituximab.


Assuntos
Neoplasias Abdominais/complicações , Neoplasias das Glândulas Suprarrenais/complicações , Neuroblastoma/complicações , Síndrome de Opsoclonia-Mioclonia/etiologia , Neoplasias Abdominais/diagnóstico , Neoplasias Abdominais/terapia , Corticosteroides/administração & dosagem , Neoplasias das Glândulas Suprarrenais/diagnóstico , Neoplasias das Glândulas Suprarrenais/terapia , Pré-Escolar , Terapia Combinada , Humanos , Imunoglobulinas/administração & dosagem , Masculino , Neuroblastoma/diagnóstico , Neuroblastoma/terapia , Síndrome de Opsoclonia-Mioclonia/diagnóstico , Rituximab/administração & dosagem
19.
Int. j. morphol ; 37(3): 1033-1037, Sept. 2019. graf
Artigo em Espanhol | LILACS | ID: biblio-1012392

RESUMO

La infección por Actinomices (actinomicosis), es una entidad poco frecuente y que puede crear dificultades diagnósticas y terapéuticas; principalmente cuando por su presentación se asemeja a neoplasias malignas. El objetivo de este estudio fue reportar un caso de actinomicosis de pared abdominal con infiltración hepática y revisar la evidencia existente. Se trata de una paciente sexo femenino, de 33 años de edad, sin antecedentes quirúrgicos ni de utilización de dispositivos intra-uterinos. Consultó por dolor abdominal y masa palpable a nivel epigástrico. Se estudió con imágenes, las que permitieron verificar una masa de pared abdominal con trayecto fistuloso al hígado. Se realizó una exéresis amplia de la lesión antes descrita. Una vez extirpado el espécimen, se fue a estudio histopatológico, que reveló gránulos de azufre consistentes con actinomices. La paciente evolució de forma satisfactoria, sin inconvenientes. Presentamos un caso poco común de actinomicosis de pared abdominal con infiltración hepática. Cuando se encuentra una gran masa intraperitoneal, la actinomicosis debe incluirse en el proceso de diagnóstico diferencial.


Actinomyces infection (actinomycosis) may create diagnostic conflicts and be confused with malignant neoplasms, especially in the abdomen. The objective of this study was to report a case of abdominal wall actinomycosis with hepatic infiltration, and review the existing evidence. Female patient, 33 years of age, with no surgical history or use of intra-uterine devices. She consulted for abdominal pain and palpable mass at the epigastrium. It was studied with images, which allowed verifying an abdominal wall mass with hepatic fistulae. A broad extirpation of the lesion was performed. The histological study revealed sulfur granules consistent with actinomyces. The patient has evolved satisfactorily, without problems; and is currently in treatment with amoxicillin. We present an unusual case of abdominal wall actinomycosis with hepatic infiltration that resulted in a difficult diagnosis. When a large intraperitoneal mass is found, actinomycosis needs to be included as a differential diagnoses.


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Actinomicose/diagnóstico , Actinomicose/cirurgia , Actinomicose/patologia , Parede Abdominal/microbiologia , Diagnóstico Diferencial , Abscesso Hepático/etiologia , Neoplasias Abdominais/diagnóstico
20.
Am J Infect Control ; 47(8): 916-921, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30850249

RESUMO

BACKGROUND: Cancer patients are at increased risk of infection. Fecal carriage of extended-spectrum ß-lactamase-producing Enterobacteriaceae (ESBL-PE) may increase this risk. There are few studies on the prevalence of ESBL-PE colonization and surgical site infections (SSIs). METHODS: This prospective cohort study included patients with gastrointestinal and gynecological malignancies who were admitted to the hospital for elective surgery. Rectal swab cultures were obtained on the day of admission and during the postoperative period every 5 days. Prevalence of ESBL-PE fecal colonization and risk factors for the development of SSI were assessed. RESULTS: We included 171 patients, 30 (17.5%) of whom were colonized with ESBL-PE at admission. This proportion increased to 21% (37 of 171) of the samples during the hospital stay. Incidence of SSI was 14.6% (n = 25). Ten of 37 (27%) patients colonized by ESBL-PE developed SSI versus 15 of 134 (11%) of the non-ESBL-PE (relative risk [RR], 2.163; 95% confidence interval [CI], 1.201-3.897; P = .016). Five patients developed a bloodstream infection, and 4 patients were colonized with ESBL-PE (RR = 4.02; 95% CI, 1.2-3.89; P = .008). CONCLUSIONS: The rate of ESBL-PE fecal colonization in surgical patients was 17.5%. Colonization of ESBL-PE duplicated the risk of SSI by the same strain and, by a factor of 4, the risk of bloodstream infections.


Assuntos
Farmacorresistência Bacteriana Múltipla , Infecções por Enterobacteriaceae/microbiologia , Enterobacteriaceae/efeitos dos fármacos , Fezes/microbiologia , Infecção da Ferida Cirúrgica/microbiologia , Adulto , Idoso , Neoplasias da Mama/cirurgia , Portador Sadio , Enterobacteriaceae/isolamento & purificação , Feminino , Neoplasias Gastrointestinais/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Ovarianas/cirurgia , Estudos Prospectivos , Fatores de Risco , Neoplasias Uterinas/cirurgia
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