RESUMO

The anticonvulsant activity of a homologous series of phenyl alcohol amides is described. (+-)-2-Hydroxy-2-phenylbutyramide (1), (+-)-3-hydroxy-3-phenylpentanamide (2) and (+-)-4-hydroxy-4-phenylhexanamide (3) were prepared and tested for their anticonvulsant profile and neurotoxicity. 1, 2 and 3 exhibited a broad profile of anticonvulsant activity and a similar significant activity in the seizures provoked by maximal electroshock, pentetrazol, 4-aminopyridine, bicuculline and thiosemicarbazide, but in the strychnine and picrotoxin tests, the protection was variable. The rotarod ataxia test was used to evaluate their neurotoxicity. In this test 2 possesses the lowest neurotoxicity.

Assuntos

Amidas/síntese química , Anticonvulsivantes/síntese química , Hidroxiácidos/síntese química , Fenilbutiratos/síntese química , Amidas/química , Amidas/farmacologia , Animais , Anticonvulsivantes/química , Anticonvulsivantes/farmacologia , Eletrochoque , Hidroxiácidos/química , Hidroxiácidos/farmacologia , Masculino , Camundongos , Fenilbutiratos/química , Fenilbutiratos/farmacologia , Equilíbrio Postural/efeitos dos fármacos , Convulsões/induzido quimicamente , Convulsões/prevenção & controle