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A new homologous series of anticonvulsants: phenyl alcohol amides. Synthesis and pharmacological evaluation.
Meza-Toledo, S E; Zenteno-García, M T; Juárez-Carvajal, E; Martínez-Muñoz, D; Carvajal-Sandoval, G.
Afiliação
  • Meza-Toledo SE; Departamento de Bioquímica, Escuela Nacional de Ciencias Biológica, Instituto Politécnico Nacional (IPN), Mexico City, Mexico.
Arzneimittelforschung ; 40(12): 1289-91, 1990 Dec.
Article em En | MEDLINE | ID: mdl-2095124
The anticonvulsant activity of a homologous series of phenyl alcohol amides is described. (+-)-2-Hydroxy-2-phenylbutyramide (1), (+-)-3-hydroxy-3-phenylpentanamide (2) and (+-)-4-hydroxy-4-phenylhexanamide (3) were prepared and tested for their anticonvulsant profile and neurotoxicity. 1, 2 and 3 exhibited a broad profile of anticonvulsant activity and a similar significant activity in the seizures provoked by maximal electroshock, pentetrazol, 4-aminopyridine, bicuculline and thiosemicarbazide, but in the strychnine and picrotoxin tests, the protection was variable. The rotarod ataxia test was used to evaluate their neurotoxicity. In this test 2 possesses the lowest neurotoxicity.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenilbutiratos / Amidas / Hidroxiácidos / Anticonvulsivantes Limite: Animals Idioma: En Revista: Arzneimittelforschung Ano de publicação: 1990 Tipo de documento: Article País de afiliação: México País de publicação: Alemanha
Buscar no Google
Adicionar na Minha BVS
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PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenilbutiratos / Amidas / Hidroxiácidos / Anticonvulsivantes Limite: Animals Idioma: En Revista: Arzneimittelforschung Ano de publicação: 1990 Tipo de documento: Article País de afiliação: México País de publicação: Alemanha