A new homologous series of anticonvulsants: phenyl alcohol amides. Synthesis and pharmacological evaluation.
Arzneimittelforschung
; 40(12): 1289-91, 1990 Dec.
Article
em En
| MEDLINE
| ID: mdl-2095124
The anticonvulsant activity of a homologous series of phenyl alcohol amides is described. (+-)-2-Hydroxy-2-phenylbutyramide (1), (+-)-3-hydroxy-3-phenylpentanamide (2) and (+-)-4-hydroxy-4-phenylhexanamide (3) were prepared and tested for their anticonvulsant profile and neurotoxicity. 1, 2 and 3 exhibited a broad profile of anticonvulsant activity and a similar significant activity in the seizures provoked by maximal electroshock, pentetrazol, 4-aminopyridine, bicuculline and thiosemicarbazide, but in the strychnine and picrotoxin tests, the protection was variable. The rotarod ataxia test was used to evaluate their neurotoxicity. In this test 2 possesses the lowest neurotoxicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilbutiratos
/
Amidas
/
Hidroxiácidos
/
Anticonvulsivantes
Limite:
Animals
Idioma:
En
Revista:
Arzneimittelforschung
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Alemanha