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Genet Mol Res ; 13(3): 6804-12, 2014 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-25177959

RESUMO

The study aimed to investigate the bio-distribution and radio-immuno-imaging features of [(131)I]-herceptin in nude mice with BT-474 breast carcinoma. [(131)I]-Herceptin was administrated by tail intravenous injection to the nude mice with BT-474 breast carcinoma. Radiocounting was performed at 4, 12, 24, 48, and 96 h after administration. The activity ratio in the tumor tissue and non-tumor tissue (T/NT) and the radiocounting percentage per gram tissue to the injected dose (%ID/g) were calculated. The nude mice with BT-474 breast carcinoma were also visualized continuously by single photon emission computed tomography at 2, 4, 8, 12, 24, 48, and 96 h after the injection of [(131)I]-herceptin. Nude mice with MDA-MB-231 used as the control group were subjected to the same analyses. Clear tumor images were obtained after the injection of [(131)I]-herceptin in nude mice with BT-474 breast carcinoma. The images were the clearest at 24 h after the injection and remained clear even at 96 h. The T/NT ratio and %ID/g in the tumor tissues of nude mice with BT-474 were both significantly higher than those of the control group (P < 0.01). [(131)I]-Herceptin displays tumors clearly in the nude mice with BT-474 and accumulates well in the tumor tissues.


Assuntos
Anticorpos Monoclonais Humanizados/farmacocinética , Radioisótopos do Iodo/farmacocinética , Neoplasias Mamárias Experimentais/metabolismo , Animais , Antineoplásicos/farmacocinética , Linhagem Celular Tumoral , Feminino , Humanos , Neoplasias Mamárias Experimentais/diagnóstico , Neoplasias Mamárias Experimentais/diagnóstico por imagem , Camundongos Endogâmicos BALB C , Camundongos Nus , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Fatores de Tempo , Distribuição Tecidual , Tomografia Computadorizada de Emissão de Fóton Único , Transplante Heterólogo , Trastuzumab
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