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Visualization and body distribution of [¹³¹I]-herceptin in nude mice with BT-474 breast carcinoma.
Yang, Z X; Cao, H; Xing, C G; Wei, S H; Jiang, G Q; Liu, Z L.
Afiliação
  • Yang ZX; Department of Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
  • Cao H; Department of Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
  • Xing CG; Department of Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
  • Wei SH; Department of Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
  • Jiang GQ; Department of Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China guoqinjiangcn@126.com.
  • Liu ZL; Department of Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Genet Mol Res ; 13(3): 6804-12, 2014 Aug 29.
Article em En | MEDLINE | ID: mdl-25177959
The study aimed to investigate the bio-distribution and radio-immuno-imaging features of [(131)I]-herceptin in nude mice with BT-474 breast carcinoma. [(131)I]-Herceptin was administrated by tail intravenous injection to the nude mice with BT-474 breast carcinoma. Radiocounting was performed at 4, 12, 24, 48, and 96 h after administration. The activity ratio in the tumor tissue and non-tumor tissue (T/NT) and the radiocounting percentage per gram tissue to the injected dose (%ID/g) were calculated. The nude mice with BT-474 breast carcinoma were also visualized continuously by single photon emission computed tomography at 2, 4, 8, 12, 24, 48, and 96 h after the injection of [(131)I]-herceptin. Nude mice with MDA-MB-231 used as the control group were subjected to the same analyses. Clear tumor images were obtained after the injection of [(131)I]-herceptin in nude mice with BT-474 breast carcinoma. The images were the clearest at 24 h after the injection and remained clear even at 96 h. The T/NT ratio and %ID/g in the tumor tissues of nude mice with BT-474 were both significantly higher than those of the control group (P < 0.01). [(131)I]-Herceptin displays tumors clearly in the nude mice with BT-474 and accumulates well in the tumor tissues.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Monoclonais Humanizados / Radioisótopos do Iodo / Neoplasias Mamárias Experimentais Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Monoclonais Humanizados / Radioisótopos do Iodo / Neoplasias Mamárias Experimentais Tipo de estudo: Diagnostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: China País de publicação: Brasil