RESUMO
Substance P content was determined by radioimmunoassay in rectal mucosa of 17 children with idiopathic constipation and 9 with normal bowel movements who were used as controls. In children with chronic idiopathic constipation, rectal mucosa substance P levels were lower than levels in the control group: 47.6 +/- 11 vs. 79.4 +/- 11 pg/mg net weight respectively (differences not statistically significant). Substance P levels in rectal mucosa of children with soiling (11/17) did not differ from those of chronically constipated children without soiling (46.0 +/- 16 vs. 50.5 +/- 19 pg/mg net weight). In children with constipation, substance P levels did not correlate either with age or duration of symptoms. Substance P levels in normal controls were similar to levels previously observed in non-constipated adults, whereas levels in constipated children were intermediate between levels observed in healthy subjects and levels in adults with chronic constipation. These findings may point to a motility derangement as a possible factor in the pathogenesis of chronic constipation in childhood.
Assuntos
Constipação Intestinal/metabolismo , Mucosa Intestinal/química , Substância P/análise , Estudos de Casos e Controles , Criança , Pré-Escolar , Doença Crônica , Constipação Intestinal/etiologia , Constipação Intestinal/terapia , Feminino , Seguimentos , Humanos , Lactente , Masculino , RadioimunoensaioRESUMO
Niveles de Substancia P fueron determinados por radioinmunoassay en la mucosa rectal de 17 niños con constipación, idiopática crónica y comparados con la de 9 nin÷s sin constipación. En el grupo de niños con constipación, los niveles de Sustancia P fueron menores que aquellos de los controles: 47,6+-11 vs. 79,4+-11 pg/mg de peso húmero de tejido respectivamente (la diferencia no obtuvo significación estadística). Niveles de Sustancia P en la mucosa rectal de niños con soiling (11/17) no fueron diferentes de los niveles en niños constipados sin soiling (46,0+-13 vs. 50,5+-19). En niños con constipación, los niveles de Sustancia P no varían de acuerdo a la edad o la duración de síntomas. Los niveles de Sustancia P en la mucosa rectal de niños controles (sin constipación) fueron similares a aquellos que previamente observamos en adultos normales, y los niveles en niños constipados fueron intermediarios entre estos niveles normales y los de adultos constipados. Estas observaciones sugieren un problema de motilidad como factor importante en la patogenesis de la constipación crónica en niños. (AU)
Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Substância P/análise , Mucosa Intestinal/química , Constipação Intestinal/metabolismo , Doença Crônica , Radioimunoensaio , Estudos de Casos e Controles , Seguimentos , Constipação Intestinal/terapia , Constipação Intestinal/etiologiaRESUMO
Niveles de Substancia P fueron determinados por radioinmunoassay en la mucosa rectal de 17 niños con constipación, idiopática crónica y comparados con la de 9 ninõs sin constipación. En el grupo de niños con constipación, los niveles de Sustancia P fueron menores que aquellos de los controles: 47,6+-11 vs. 79,4+-11 pg/mg de peso húmero de tejido respectivamente (la diferencia no obtuvo significación estadística). Niveles de Sustancia P en la mucosa rectal de niños con soiling (11/17) no fueron diferentes de los niveles en niños constipados sin soiling (46,0+-13 vs. 50,5+-19). En niños con constipación, los niveles de Sustancia P no varían de acuerdo a la edad o la duración de síntomas. Los niveles de Sustancia P en la mucosa rectal de niños controles (sin constipación) fueron similares a aquellos que previamente observamos en adultos normales, y los niveles en niños constipados fueron intermediarios entre estos niveles normales y los de adultos constipados. Estas observaciones sugieren un problema de motilidad como factor importante en la patogenesis de la constipación crónica en niños.
Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Constipação Intestinal/metabolismo , Mucosa Intestinal/química , Substância P/análise , Estudos de Casos e Controles , Doença Crônica , Constipação Intestinal/etiologia , Constipação Intestinal/terapia , Seguimentos , RadioimunoensaioRESUMO
Substance P content was determined by radioimmunoassay in rectal mucosa of 17 children with idiopathic constipation and 9 with normal bowel movements who were used as controls. In children with chronic idiopathic constipation, rectal mucosa substance P levels were lower than levels in the control group: 47.6 +/- 11 vs. 79.4 +/- 11 pg/mg net weight respectively (differences not statistically significant). Substance P levels in rectal mucosa of children with soiling (11/17) did not differ from those of chronically constipated children without soiling (46.0 +/- 16 vs. 50.5 +/- 19 pg/mg net weight). In children with constipation, substance P levels did not correlate either with age or duration of symptoms. Substance P levels in normal controls were similar to levels previously observed in non-constipated adults, whereas levels in constipated children were intermediate between levels observed in healthy subjects and levels in adults with chronic constipation. These findings may point to a motility derangement as a possible factor in the pathogenesis of chronic constipation in childhood.
RESUMO
We report 72 years old woman, with adenoacamthoma of the upper osophagus who was admitted in Hospital israelita "EZRAH" in April of 1991. We performed a review of the literature on this rare tumour, that is the reason of presenting this case (AU)
Assuntos
Humanos , Feminino , Idoso , Neoplasias Esofágicas/patologia , Adenocarcinoma/patologiaRESUMO
We report 72 years old woman, with adenoacamthoma of the upper osophagus who was admitted in Hospital israelita "EZRAH" in April of 1991. We performed a review of the literature on this rare tumour, that is the reason of presenting this case
Assuntos
Humanos , Feminino , Idoso , Adenocarcinoma/patologia , Neoplasias Esofágicas/patologiaRESUMO
We report a 72 year-old woman, with adenoacanthoma of the upper esophagus who was admitted in Hospital Israelita "EZRAH" in April of 1991. We performed a review of the literature on this rare tumour, that is the reason of presenting this case.
Assuntos
Adenocarcinoma/patologia , Neoplasias Esofágicas/patologia , Idoso , Feminino , HumanosRESUMO
We report a 72 year-old woman, with adenoacanthoma of the upper esophagus who was admitted in Hospital Israelita [quot ]EZRAH[quot ] in April of 1991. We performed a review of the literature on this rare tumour, that is the reason of presenting this case.
RESUMO
We report a 72 year-old woman, with adenoacanthoma of the upper esophagus who was admitted in Hospital Israelita [quot ]EZRAH[quot ] in April of 1991. We performed a review of the literature on this rare tumour, that is the reason of presenting this case.
RESUMO
We intended to estimate D.G.R. in patients suffering from GU, and CG, comparing them with healthy controls. 70 patients, divided in 3 groups, were studied; Group A (Control): 14 cases, Group B (GU) type I Johnson: 11 cases, type III Johnson: 20 cases; Group C (CG): 25 cases (11 antral and 14 antral and fundic). The following studies were performed in all of them upper digestive tract X-ray and fibro-endoscopy with multiple antral and fundic biopsies. Tc 99 HIDA 2 ml. Cu. I.V. was used as radioactive compound, and in the first hour 0.3 ml Cu. in 100 cc of water was administered orally, so as to confirm gastric topography. All patients were studied for 2 hour. Quantitative assessment of D.G.R. was expressed in % related to the hepatobiliary area. D.G.R. was detected in 7.1% of patients in Group A: 54.5% of GU type I and 70% in GU type III. In antral CG a 72.7% of D.G.R. was observed and in antral and fundic CG a 87.6% was found. The differences were significant in all the cases. D.G.R. MAGNITUDE, expressed as geometric mean, was: for Group A: 0.73%; for Group B: Ulcer type I: 6.26% and type III: 6.26%, for Group C: 6.78% in antral gastritis and 11.41% in antral and fundic gastritis.
Assuntos
Refluxo Duodenogástrico/diagnóstico por imagem , Gastrite/fisiopatologia , Úlcera Gástrica/fisiopatologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Doença Crônica , Refluxo Duodenogástrico/complicações , Feminino , Gastrite/complicações , Humanos , Iminoácidos , Masculino , Pessoa de Meia-Idade , Compostos Organometálicos , Cintilografia , Úlcera Gástrica/complicações , Lidofenina Tecnécio Tc 99mRESUMO
We intended to estimate D.G.R. in patients suffering from GU, and CG, comparing them with healthy controls. 70 patients, divided in 3 groups, were studied; Group A (Control): 14 cases, Group B (GU) type I Johnson: 11 cases, type III Johnson: 20 cases; Group C (CG): 25 cases (11 antral and 14 antral and fundic). The following studies were performed in all of them upper digestive tract X-ray and fibro-endoscopy with multiple antral and fundic biopsies. Tc 99 HIDA 2 ml. Cu. I.V. was used as radioactive compound, and in the first hour 0.3 ml Cu. in 100 cc of water was administered orally, so as to confirm gastric topography. All patients were studied for 2 hour. Quantitative assessment of D.G.R. was expressed in
related to the hepatobiliary area. D.G.R. was detected in 7.1
of patients in Group A: 54.5
of GU type I and 70
in GU type III. In antral CG a 72.7
of D.G.R. was observed and in antral and fundic CG a 87.6
was found. The differences were significant in all the cases. D.G.R. MAGNITUDE, expressed as geometric mean, was: for Group A: 0.73
; for Group B: Ulcer type I: 6.26
and type III: 6.26
, for Group C: 6.78
in antral gastritis and 11.41
in antral and fundic gastritis.