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Substance P in rectal mucosa of children with chronic constipation.
Granot, E; Wengrower, D; Lysy, J; Waldbaum, C; Karmeli, F; Goldin, E.
Afiliação
  • Granot E; Department of Pediatrics, Hadassah University Hospital, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Acta Gastroenterol Latinoam ; 31(1): 41-5, 2001 Mar.
Article em En | MEDLINE | ID: mdl-11370180
Substance P content was determined by radioimmunoassay in rectal mucosa of 17 children with idiopathic constipation and 9 with normal bowel movements who were used as controls. In children with chronic idiopathic constipation, rectal mucosa substance P levels were lower than levels in the control group: 47.6 +/- 11 vs. 79.4 +/- 11 pg/mg net weight respectively (differences not statistically significant). Substance P levels in rectal mucosa of children with soiling (11/17) did not differ from those of chronically constipated children without soiling (46.0 +/- 16 vs. 50.5 +/- 19 pg/mg net weight). In children with constipation, substance P levels did not correlate either with age or duration of symptoms. Substance P levels in normal controls were similar to levels previously observed in non-constipated adults, whereas levels in constipated children were intermediate between levels observed in healthy subjects and levels in adults with chronic constipation. These findings may point to a motility derangement as a possible factor in the pathogenesis of chronic constipation in childhood.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Substância P / Constipação Intestinal / Mucosa Intestinal Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies Limite: Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Acta Gastroenterol Latinoam Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Israel País de publicação: Argentina
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Substância P / Constipação Intestinal / Mucosa Intestinal Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies Limite: Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Acta Gastroenterol Latinoam Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Israel País de publicação: Argentina