Substance P in rectal mucosa of children with chronic constipation.
Acta Gastroenterol Latinoam
; 31(1): 41-5, 2001 Mar.
Article
em En
| MEDLINE
| ID: mdl-11370180
Substance P content was determined by radioimmunoassay in rectal mucosa of 17 children with idiopathic constipation and 9 with normal bowel movements who were used as controls. In children with chronic idiopathic constipation, rectal mucosa substance P levels were lower than levels in the control group: 47.6 +/- 11 vs. 79.4 +/- 11 pg/mg net weight respectively (differences not statistically significant). Substance P levels in rectal mucosa of children with soiling (11/17) did not differ from those of chronically constipated children without soiling (46.0 +/- 16 vs. 50.5 +/- 19 pg/mg net weight). In children with constipation, substance P levels did not correlate either with age or duration of symptoms. Substance P levels in normal controls were similar to levels previously observed in non-constipated adults, whereas levels in constipated children were intermediate between levels observed in healthy subjects and levels in adults with chronic constipation. These findings may point to a motility derangement as a possible factor in the pathogenesis of chronic constipation in childhood.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Substância P
/
Constipação Intestinal
/
Mucosa Intestinal
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Acta Gastroenterol Latinoam
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Israel
País de publicação:
Argentina