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Resumen: OBJETIVO: Conocer la prevalencia de la deficiencia de vitamina D en adultos mayores con y sin fractura de cadera en un hospital de tercer nivel de atención. MATERIAL Y MÉTODO: Estudio observacional, descriptivo, retrospectivo y transversal efectuado en pacientes adultos mayores del 1 de agosto de 2016 al 1 de agosto de 2017. Para su análisis los pacientes se dividieron en dos grupos, uno con fractura de cadera y otro sin el antecedente de fractura. Se recolectaron los datos demográficos, concentraciones de 25-hidroxivitamina D [25(OH)D] y de hormona paratiroidea. La deficiencia de vitamina D se definió según la clasificación de Holick. RESULTADOS: Se incluyeron 58 pacientes; cada grupo (con y sin fractura de cadera) incluyó 29 pacientes. Las concentraciones de 25(OH)D fueron, en promedio, de 18.24 ± 7.8 ng/mL en todos los pacientes con diferencias entre los grupos de fracturados vs no fracturados: 14.83 ± 5.28 vs 21.66 ± 7.45 ng/mL, respectivamente (p < 0.001). La prevalencia de deficiencia de vitamina D fue de 63.7% y fue mayor en el grupo de fracturados en comparación con los que no tenían este antecedente: 86.2 vs 41.4%. CONCLUSIONES: La deficiencia de vitamina D es alta en la población de adultos mayores y su frecuencia se incrementa con la edad.

Abstract: OBJECTIVE: To know the prevalence of vitamin D deficiency in older adults with and without hip fracture in a third level hospital. MATERIAL AND METHOD: An observational, descriptive, retrospective and crosssectional study was conducted in elderly patients from August 1st 2016 to August 1st 2017. For their analysis, they were divided into two groups, one group with a hip fracture and the other without a fracture history. Demographic data, levels of 25-hydroxyvitamin-D [25(OH)D] and PTH were collected. Vitamin D deficiency was defined according to Holick's classification. RESULTS: There were included 58 patients, each group with 29. The levels of 25(OH) D were, on average, 18.24 ± 7.8 ng/mL in all patients, with differences between the groups of fractured vs non-fractured: 14.83 ± 5.28 ng/mL vs 21.66 ± 7.45 ng/ mL, respectively; p < 0.001. The prevalence of vitamin D deficiency was 63.7%, being higher in the fractured group compared to those without this background: 86.2% vs 41.4%. CONCLUSIONS: Deficiency of vitamin D is high in the population of elderly adults and its frequency is increased with age.

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Macrophage migration inhibitory factor (MIF) has been found to be involved in host resistance to several parasitic infections. To determine the mechanisms of the MIF-dependent responses to Trypanosoma cruzi, we investigated host resistance in MIF⁻/⁻ mice (on the BALB/c background) during an intraperitoneal infection. We focused on the potential involvement of MIF in dendritic cell (DC) maturation and cytokine production. Following a challenge with 5 x 10(3)T. cruzi parasites, wild type (WT) mice developed a strong IL-12 response and adequate maturation of the draining mesenteric lymph node DCs and were resistant to infection. In contrast, similarly infected MIF⁻/⁻ mice mounted a weak IL-12 response, displayed immature DCs in the early phases of infection and rapidly succumbed to T. cruzi infection. The lack of maturation and IL-12 production by the DCs in response to total T. cruzi antigen (TcAg) was confirmed by in vitro studies. These effects were reversed following treatment with recombinant MIF. Interestingly, TcAg-stimulated bone marrow-derived DCs from both WT and MIF⁻/⁻ mice had increased ERK1/2 MAPK phosphorylation. In contrast, p38 phosphorylation was only upregulated in WT DCs. Reconstitution of MIF to MIF⁻/⁻ DCs upregulated p38 phosphorylation. The MIF-p38 pathway affected MHC-II and CD86 expression as well as IL-12 production. These findings demonstrate that the MIF-induced early DC maturation and IL-12 production mediates resistance to T. cruzi infection, probably by activating the p38 pathway.

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Este trabajo presenta los resultados parciales de un estudio de carácter exploratorio y descriptivo que adoptó como supuesto básico la tesis de la transposición didáctica en la escolarización del saber. El estudio se propuso explorar las transformaciones que se producen como consecuencia de la escolarización del lenguaje escrito, focalizando el análisis en el plano de la escritura de textos, mediante el relevamiento de la distancia entre el contexto de producción y los textos de circulación social tal como son caracterizados por las disciplinas de referencia y las condiciones de producción y los textos producidos efectivamente por los alumnos en el ámbito escolar. Las unidades de análisis seleccionadas consistieron en textos escritos que proceden de cuadernos de alumnos de 2º a 7º grados de escolaridad primariade cuatro escuelas de la ciudad de Río Cuarto, Argentina, seleccionadas de acuerdo a criterios combinados de ubicación geográfica y gestión administrativa. El análisis completo de los textos escritos por los alumnos permitió observar transformaciones sustanciales que los distancian notablemente de las características y estructura esenciales respecto de los textos sociales reales

This work shows the partial results of a study of an exploratory and describer character that adopted as premise the thesis of didactic transposition of knowing. The study explores the transformations that are produced as consequence of the knowing of the written language, focalizing the analysis of writing texts, under the relay of the distance between the context of production and the texts of social circulation, as they are characterized by the disciplines of reference and the conditions of production and the texts produced by the students in school compass. The selected units of analysis consisted in written texts that proceeded of students’ notebooks of second to seventh grade of four schools in the city of Rio Quarto, Argentina, selected according to combined criterions of geographic region and directory management

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We hypothesized that Angiotensin II (Ang II), like other circulating hormones, acts exclusively intravascularly. To activate or block solely intravascular Ang II receptors, Ang II and its peptide receptor blocker saralasin (Sar) were covalently coupled to a inert polymer (POL, MW >4000 kD) forming Ang II-POL and Sar-POL. These two nonpermeable polymers, Ang II and Sar, were intracoronarily administered into the isolated, saline-perfused rat hearts. Ang II-POL and Ang II caused a dose-dependent ventricular positive inotropic (+I) and vasoconstrictor effects (+V) which were blocked by Sar. Sar-POL blocked their +I but not their +V. Thus, Ang II and Ang II-POL act on endothelial luminal receptors through paracrine mechanisms. +I were blocked solely by purinoceptor antagonists and paralleled by augmented venous release of ATP degradation products (adenosine, inosine and hypoxanthine). In contrast, +V were blocked solely by aspirin, indomethacin or a thromboxane A2 receptor antagonist. Intracoronary administration of ATP-gamma-S and U46169, a purinergic, and TXA2 agonists, respectively, mimicked +I and +V. The results indicate that ATP is the paracrine inotropic mediator while thromboxane A2 is the vasoconstrictor mediator. Thus, the +I and +V distinct effects by intracoronary Ang II indicate that its diverse mechanism of action along the coronary vascular tree may be due to a functionally heterogeneous endothelium.

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El objetivo de este trabajo es caracterizar a los arroyos de la cuenca del Río Lujan en base a sus variables físicos-químicas, biológicas y microbiológicas antes de atravesar focos contaminantes

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El objetivo de este trabajo es caracterizar a los arroyos de la cuenca del Río Lujan en base a sus variables físicos-químicas, biológicas y microbiológicas antes de atravesar focos contaminantes

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