Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
1.
Chem Pharm Bull (Tokyo) ; 38(10): 2733-6, 1990 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-2127556

RESUMO

For several years we have screened natural products having aldose reductase (AR) inhibitory activity. 3,3',4-Tri-O-methylellagic acid 4'-sulfate potassium salt (2) was isolated from a Mexican herb "Sinfito" (Potentilla candicans) as a potent AR inhibitory active constituent. 2 was more potent (IC50 = 8.0 x 10(-8)M) than ellagic acid, which is one of the natural inhibitors of AR. So we examined the synthesis of ellagic acid derivatives and found that the sulfate group is one of the important function.


Assuntos
Aldeído Redutase/antagonistas & inibidores , Plantas Medicinais/análise , Aldeído Redutase/metabolismo , Animais , Técnicas In Vitro , Cristalino/enzimologia , México , Ratos
2.
Chem Pharm Bull (Tokyo) ; 37(9): 2531-2, 1989 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-2514047

RESUMO

Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mí, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the highest inhibitory activity, being about 6 times more potent than quercitrin, which is a known natural inhibitor of AR.


Assuntos
Aldeído Redutase/antagonistas & inibidores , Plantas Medicinais/análise , Desidrogenase do Álcool de Açúcar/antagonistas & inibidores , Animais , Técnicas In Vitro , Paraguai , Ratos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA