RESUMO

Successful treatment of a patient with myelokathexis, a rare form of chronic neutropenia associated with recurrent infections, is described. Rapid mobilization of bone marrow neutrophils and improved myeloid morphologic features were observed after treatment with human granulocyte colony stimulating factor. Transient thrombocytopenia and bone pain were observed during treatment. Although neutrophil chemotaxis, superoxide production, and FcRIII surface expression were reduced, the patient improved clinically after restoration of a normal neutrophil count.

Assuntos

Fator Estimulador de Colônias de Granulócitos/uso terapêutico , Neutropenia/terapia , Antígenos CD/análise , Quimiotaxia de Leucócito , Criança , Doença Crônica , Feminino , Gengivite/imunologia , Gengivite/terapia , Fator Estimulador de Colônias de Granulócitos/efeitos adversos , Humanos , Neutropenia/imunologia , Neutrófilos/metabolismo , Neutrófilos/fisiologia , Contagem de Plaquetas , Proteínas Recombinantes/efeitos adversos , Proteínas Recombinantes/uso terapêutico , Estomatite/imunologia , Estomatite/terapia