RESUMO
The cerebral arteries (common carotid, internal carotid, vertebral, middle cerebral, and basilar arteries) were examined from 1547 autopsied persons in five countries (Norway, Guatemala, United States, Jamaica, and Chile). Subgroups comparisons were made using a basal group of cases from which were excluded all persons with coronary heart disease, peripheral arterial disease, other atherosclerotic complication, hypertension, and diabetes. The prevalence and mean extent of atherosclerotic lesions increase in each succeeding age group. Lesions appear to develop later in life in the cerebral arteries than in the aorta and the cerebral arteries than in the aorta and the coronary arteries. Men have more raised atherosclerotic lesions than women. The mean extent of fatty streaks in the cartoid arteries does not differ among age groups from 35 to 69 years of age, nor does it differ among location-race groups. The mean extent of raised atherosclerotic lesions in the carotid arteries increases in each succeeding age group after 35 years of age, and differs among location-race groups.The pattern of development of atherosclerosis in the carotid arteries follows that of the aorta. Fatty streaks appear in the intracranial and vertebral arteries much later in life than they do in the carotid arteries.The mean extent of both fatty streaks and raised lesions increases in each succeeding age group after 35 years of age, and the average involvement of both types of lesions differs among location-race groups. The pattern of development of atherosclerosis in the vertebral and intracranial arteries follows that of the coronary arteries. When location-race groups are ranked by extent of cerebral atherosclerosis, they rank in approximately the same order as when they are ranked by aortic and coronary atherosclerosis. (AU)
Assuntos
Humanos , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Masculino , Feminino , Arteriosclerose Intracraniana/epidemiologia , Arteriosclerose/epidemiologia , Arteriosclerose/patologia , Artéria Basilar/patologia , Negro ou Afro-Americano , Artérias Carótidas/patologia , Artérias Cerebrais/patologia , Arteriosclerose Intracraniana/patologia , Chile , Etnicidade , Geografia , Guatemala , Jamaica , Louisiana , Noruega , Fatores Sexuais , Artéria Vertebral/patologiaRESUMO
Comparison has been made of measures of coronary and aortic atherosclerosis in autopsied persons having five selected diseases (lung cancer,stomach cancer, other cancer, cirrhosis of the liver, and tuberculosis) with similar measures in control cases. There appears to be a slight but not significant tendency for lung cancer to be associated with more severe atherosclerosis within age-location-race subgroups. The tendency is strongest in the abdominal aorta. None of the other four diseases appears to be associated with increased or decreased severity of atherosclerosis in comparison with the control groups.(AU)
Assuntos
Humanos , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Masculino , Feminino , Aorta Abdominal/patologia , Arteriosclerose/complicações , Arteriosclerose/epidemiologia , Vasos Coronários/patologia , Cirrose Hepática/complicações , Neoplasias/complicações , Tuberculose/complicações , Fatores Etários , Arteriosclerose/etiologia , Arteriosclerose/patologia , Negro ou Afro-Americano , Etnicidade , Guatemala , Jamaica , Louisiana , Neoplasias Pulmonares/complicações , México , Noruega , Filipinas , Porto Rico , Fatores Sexuais , África do Sul , América do Sul , Neoplasias Gástricas/complicaçõesRESUMO
Cooperating pathologists in different countries collected 23,207 sets of coronary arteries and aortae, according to a standard protocol. A central laboratry staff stained the arteries with Sudan IV, and a team of pathologists graded the atherosclerotic lesions. A basal group of cases which died from accidents, infections, cancer, and selected miscellaneous causes was extracted in order to compare atherosclerosis among the different geographic, racial, and sex subgroups. Even the most homogeneous subgroups (same location, sex, age, and race) vary greatly in extent of advanced atherosclerotic lesions. The 19 location-race groups differ significantly in extent of raised lesions. The abdominal aorta and the left anterior descending coronary artery have more atherosclerosis than other arteries. Within most location-race groups, coronary arteries of men have more raised lesions than the coronary arteries of women. Aortae of men in some groups have slightly more, and in other groups slightly less raised lesions than the aortae of women. Negro groups show little or no sex difference in either the coronary arteries or the aorta. Ranking of the 19 location-race groups by raised atherosclerotic lesions is similar, regardless of lesion measure (fatty streaks excepted), sex, artery, or age group. New Orleans white and the Oslo group rank highest; Bogota, Sao Paulo Negro, Guatemala, and Durban Bantu groups rank lowest. With few exceptions, ranking these groups by raised lesions corresponds closely with ranking them by coronary heart disease mortality rate. (AU)