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Background/Objectives: Misophonia, characterized by strong emotional reactions to specific sounds, poses significant challenges, particularly in academic settings. This study aimed to examine the psychometric properties of the Brazilian version of the MisoQuest in a sample of high school and university students. The primary objective was to assess its reliability and structural validity to enhance understanding of misophonia in young adults. Methods: A total of 549 students (Mean age = 23.2 years, SD = 9.3; 285 females, 260 males, 4 individuals who did not disclose their gender) participated. Both exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were employed to evaluate the MisoQuest. Fit indices for unifactorial and trifactorial models were compared. Internal consistency was assessed using Cronbach's alpha. Results: The EFA suggested a dominant single-factor structure with high factor loadings (ranging from 0.60 to 0.79). However, the CFA revealed excellent fit for both unifactorial (CFI and TLI = 1.00, RMSEA close to zero) and trifactorial models (CFI and TLI = 1.00, RMSEA = 0.037). The MisoQuest demonstrated high internal consistency (Cronbach's alpha = 0.93). Additionally, 4.5% of participants were identified as positive for misophonia based on a predefined cutoff score of 61. Conclusions: The Brazilian version of the MisoQuest is a reliable and valid tool for assessing misophonia. These findings suggest that the instrument may capture multiple dimensions of the disorder. Given the observed prevalence of misophonia and its impact on students, early identification and tailored interventions are crucial for providing adequate support. Further research is needed to refine the tool and expand its clinical utility.

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PURPOSE: The COVID-19 pandemic has resulted in significant global morbidity and mortality. The disease presents a broad clinical spectrum, significantly influenced by underlying comorbidities. While certain conditions are known to exacerbate COVID-19 outcomes, the role of chronic inflammatory airway diseases such as asthma and rhinitis in influencing disease severity remains controversial. This study investigates the association between asthma and allergic rhinitis and the severity of COVID-19 outcomes in a specific geographical region prior to widespread vaccine deployment. METHODS: We conducted a case-control study with unvaccinated adult patients who had laboratory-confirmed COVID-19 by polymerase chain reaction (PCR). Cases were defined as severe or critical COVID-19 patients requiring intensive care unit (ICU) admission, and controls were non-severe patients without signs of viral pneumonia or hypoxia. We utilized the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire to assess the presence of asthma and allergic rhinitis. The association between these chronic inflammatory airway diseases and the severity of COVID-19 was evaluated using multivariate logistic regression analysis. RESULTS: A total of 122 patients were analyzed, with 61 in each group. The presence of asthma (9 patients) was associated with an increased likelihood of severe COVID-19 (OR = 13.0; 95% CI 1.27-133.74), while rhinitis (39 patients) was associated with a protective effect against severe outcomes (OR = 0.36; 95% CI 0.13-0.99). No significant association was found between the frequency of asthmatic episodes or the severity of rhinitis and the severity of COVID-19 outcomes. CONCLUSION: This study underscores the divergent effects of chronic inflammatory airway diseases on COVID-19 severity, with asthma associated with a higher likelihood of severe outcomes and rhinitis potentially offering protective effects. These findings enhance our understanding of the complex interactions between respiratory allergies and COVID-19, emphasizing the importance of targeted clinical management and public health strategies.

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PURPOSE: The aim of this systematic review and meta-analysis was to systematically review and perform a meta-analysis on the anatomical variations of the RLN. METHODS: We performed online research for studies that addressed anatomical variations of the RLN and laterality, published between 2015 and 2021. We found 230 articles, and nine were included. RESULTS: Eight variations were found, with Type I prevailing (41.17%; 95% CI 19.44-64.88), extra laryngeal divergence of the RLN. The other types were: II-fan shape; III-distance greater than 5 mm to the cricothyroid joint; IV-thickening and adipopexy in the elderly; V-non-recurrent laryngeal nerve; VI-intracranial branch; VII-tortuous ascending RLN; and VIII-combination between the inferior branch of the NV and the ascending trunk of the RLN. Types I (p = 0) and III (p < 0.01) prevailed on the left and types II (p < 0.01) and V (p < 0.01) on the right. CONCLUSIONS: It was observed that variations occurred due to the path of the RLN to the entrance to the larynx, its shape, and the age of the evaluated individual. The most frequent variation and side were, respectively, Type I, extra laryngeal divergence and left.

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Although most of the diversity of true bugs (Hemiptera: Heteroptera) is terrestrial, over 550 species of water bugs (Heteroptera: Gerromorpha, Leptopodomorpha & Nepomorpha) have been recorded from Brazil alone. Southeastern Brazil, composed of the states of Esprito Santo, Minas Gerais, Rio de Janeiro and So Paulo, is the best studied region of the country, but there are still knowledge gaps in the area. Here, two new species are described from Esprito Santo: Hydrometra ruschii Cordeiro, Rodrigues & Moreira, sp. nov. and H. tuberculata Cordeiro, Rodrigues & Moreira, sp. nov. (Gerromorpha: Hydrometridae). Furthermore, new records from southeastern Brazil are provided for 78 species of water bugs, of which 19 are firstly recorded from Esprito Santo, four from Minas Gerais, eight from Rio de Janeiro, and seven from So Paulo.

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Objetivo: avaliar a capacidade funcional dos idosos longevos da zona urbana de um município do Estado do Amazonas.Método: Estudo descritivo, transversal e quantitativo, realizado com 135 idosos longevos cadastrados nas Unidades Básicas de Saúde em um município do Amazonas, no período de dezembro de 2019 a fevereiro de 2020. Resultados: Os resultados demonstraram predominância do sexo feminino (61,5%) e a faixa etária entre 80 a 89 (79,3%). Com relação as Atividades Básicas, verificou-se um maior frequência de independência nas eliminações intestinais (88, 1 %) e menor para dependência para escada (38,5%). Quanto às atividades instrumentais, houve uma alta independência por parte dos idosos na administração do consumo de remédios (51, 1 %), enquanto a dependência total foi maior para lavar e passar roupas (44,4%). Conclusão: avaliar a capacidade funcional dos idosos permite um conhecimento sobre seus impasses na realização de suas necessidades básicas e mostra as dificuldades enfrentadas por eles.(AU)

Objective: to evaluate the functional capacity of older elderly people in the urban area of a municipality in theState of Amazonas. Method: Descriptive, cross-sectional and quantitative study, conducted with 135 long-lived elderly registered in Basic Health Units in a municipality in Amazonas, from December 2019 to February 2020. Results: The results showed a predominance of females (61.5 %) and the age group between 80 and 89 (79.3%). Regarding the Basic Activities, there was a higher frequency of independence in intestinal eliminations (88.1 %) and a lower frequency for dependence on stairs (38.5%). As for instrumental activities, there was a high degree of independence on the part of the elderly in administering medication consumption (51.1 %), while total dependence was greater for washing and ironing clothes (44.4%). Conclusion: evaluating the functional capacity of the elderly allows a better understanding of their impasses in meeting their basic needs and shows the difficulties faced them.(AU)

Objetivo: evaluar la capacidad funcional de adultos mayores longevos en el área urbana de un município dei Estadode Amazonas. Método: Estudio descriptivo, transversal y cuantitativo, realizado con 135 adultos mayores longevos registrados en Unidades Básicas de Salud de un município de Amazonas, de diciembre de 2019 a febrero de 2020. Resultados: Los resultados mostraron un predomínio dei sexo femenino (61,5%) y el grupo de edad entre 80 y 89 (79,3%). Con respecto a las Actividades Básicas, hubo mayor frecuencia de independencia en las eliminaciones intestinales (88, 1 %) y menor frecuencia por dependencia de escalera (38,5%). En cuanto a las actividades instrumentales, hubo un alto grado de independencia por parte de los ancianos en la administración dei consumo de medicamentos (51, 1 %), mientras que la dependencia total fue mayor para el lavado y planchado de rapa (44,4%). Conclusión: evaluar la capacidad funcional de los ancianos permite conocer sus impasses en la satisfacción de sus necesidades básicas y muestra las dificultades que enfrentan(AU)

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The rearrangement distance is a method to compare genomes of different species. Such distance is the number of rearrangement events necessary to transform one genome into another. Two commonly studied events are the transposition, which exchanges two consecutive blocks of the genome, and the reversal, which reverts a block of the genome. When dealing with such problems, seminal works represented genomes as sequences of genes without repetition. More realistic models started to consider gene repetition or the presence of intergenic regions, sequences of nucleotides between genes and in the extremities of the genome. This work explores the transposition and reversal events applied in a genome representation considering both gene repetition and intergenic regions. We define two problems called Minimum Common Intergenic String Partition and Reverse Minimum Common Intergenic String Partition. Using a relation with these two problems, we show a [Formula: see text]-approximation for the Intergenic Transposition Distance, the Intergenic Reversal Distance, and the Intergenic Reversal and Transposition Distance problems, where k is the maximum number of copies of a gene in the genomes. Our practical experiments on simulated genomes show that the use of partitions improves the estimates for the distances.

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O goalball diferentemente de outros esportes paralímpicos foi criado exclusivamente para a pessoa com deficiência visual. Os estudos a respeito desse são relativamente escassos no que se refere a análise de sistema ofensivo de jogo. Nesse sentido, o objetivo desse ensaio foi apresentar modelos de sistemas de jogo ofensivo em que a estratégia e a tática se aplicam no goalball como estratégia facilitadora da aprendizagem e de comunicação. A proposta foi padronizada de maneira ilustrativa e sistematizando as estruturas de posicionamento tático do goalball com foco nas estratégias de ataque e tem por finalidade a organização e qualidade técnica do jogo. O principal apontamento desse ensaio foi auxiliar o entendimento do atleta com deficiência visual através da sistematização do ataque afim de incrementar a organização ofensiva de uma equipe de goalball.

Goalball, unlike other adapted sports, was created exclusively for the persons with visual impairment. Studies of analysis of systematic observation of gambling in the sport are relatively scarce. The aim of this essay is to present models of offensive systems in which strategy and tactics are applied in goalball for a better learning, facilitating and simplifying communication between coach and athletes. Corroborating this essay, authors demonstrate that in order to obtain efficient offensive actions, it is necessary that athletes present a high tactical understanding. This essay standardizes in an illustrative and systematic way the systems of tactical positioning of goalball focusing on attack strategies and aims at the organization and technical quality of the game. The main point of this essay was to help the understanding of the visually impaired athlete in the construction of the attack in order to increase the offensive organization of a goalball team.

El golbol a diferencia de otros deportes paralímpicos, fue creado exclusivamente para personas con discapacidad visual. Los estudios a respecto son relativamente escasos en lo que respecta al análisis del sistema de juego ofensivo. En este sentido, el objetivo de este ensayo fue presentar modelos de sistemas de juego ofensivos en los que se aplica la estrategia y la táctica en el golbol como estrategia que facilita el aprendizaje y la comunicación. La propuesta se estandarizó de forma ilustrativa y sistematizó las estructuras de posicionamento táctico de golbol con un enfoque en las estrategias de ataque y apunta a la organización e calidad técnica del juego. El objetivo principal de este ensayo fue ayudar a la comprensión del atleta con discapacidad visual mediante la sistematización del ataque para aumentar la organización ofensiva de un equipo de golbol.

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OBJECTIVE: To evaluate the hydration of obese and non-obese adolescents by vectorial bioimpedance analysis, in addition to verifying the associations between obesity and bioelectrical impedance vectorial analysis (BIVA) parameters. METHODS: A cross-sectional study with adolescents between 14 and 18 years old (n=489, 300 boys and 189 girls). Electric bioimpedance (BIA; Quantum_II, RJL system, Rome, Italy) provided resistance and reactance parameters to calculate phase angle (PA), fat-free mass (FFM) and body fat (%BF). The confidence ellipses were compared, and the construction of the tolerance ellipses allowed individual and qualitative evaluation of the vectors and classification in dehydrated, normohydrated and hyperhydrated. RESULTS: 78 obese and 411 eutrophic adolescents participated. Resistance (p<0.001) and reactance (p<0.001) and their normalization by stature (p<0.001) were reduced in the obese, whereas the PA was higher (p=0.003). %BF was 11.3% higher in obese adolescents. The main vector of the obese, both male (D=1.38; p<0.001) and female (D=1.49; p<0.001), indicated greater hydration. The ellipse of tolerance of the total sample showed that 25 (32.1%) were hyperhydrated and 02 (2.6%) vectors positioned in the sense of dehydration. A total of 17 (53.2%) girls and 16 (34.8%) boys were hyperhydrated. Logistic regression showed an inverse relation of BMI with resistance (p<0.001), reactance (p<0.001) and both normalized by stature. Adolescents with increased PA (p<0.001) were twice as likely to present obesity. CONCLUSIONS: Obese adolescents were hyperhydrated and there was an inverse relationship of BMI with resistance and direct with PA.

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Abstract Rationale: Disuse colitis is frequent in our country and the most effective treatment is high cost and there is a need for effective and low cost therapy. Objective: To evaluate the efficacy of Baccharis dracunculifolia (field rosemary) in the treatment of exclusion colitis in rats. Method: Eighteen Wistar rats were anesthetized and submitted to colostomy; they were then distributed into two groups: Control Group, receiving intrarectal saline infusion (n = 8) and Group BD receiving intrarectal infusion ofBaccharis dracunculifolia extract (n = 10); after 21 days of treatment they were euthanized, the intestinal segment excluded from intestinal transit was resected and submitted to histopathological study, classifying the degree of inflammation and degree of vascular congestion from 0 to 3. Results: Mean inflammation was 2.7 in Control Group versus 2.1 in BD Group (p = 0.049), while mean vascular congestion was 2.3 and 2, respectively, in Control and BD groups (p = 0.1642). Conclusion: Intra-rectal infusion ofBaccharis dracunculifolia extract significantly minimized the inflammatory process in the exclusion colitis of rats submitted to colostomy, without altering the degree of vascular congestion.

Resumo Racional A colite de desuso é frequente em nosso meio e o tratamento de maior eficácia é de alto custo, havendo necessidade de se encontrar uma terapêutica eficaz e de baixo custo. Objetivo Avaliar a eficácia da Baccharis dracunculifolia (alecrim-do-campo) no tratamento da colite de exclusão em ratos. Método Utilizou-se 18 ratos Wistar, os quais foram anestesiados e submetidos à colostomia; em seguida distribuídos em 2 grupos: Grupo Controle, recebendo infusão intrarretal de solução salina (n = 8) e Grupo BD, recebendo infusão intrarretal de extrato de Baccharis dracunculifolia (n = 10); após 21 dias de tratamento foram submetidos a eutanásia, o segmento intesinal excluso de trânsito intestinal foi ressecado e submetido a estudo histopatológico classificando-se o grau de inflamação e grau de congestão vascular de 0 a 3. Resultados Verificou-se média de inflamação 2,7 no Grupo Controle vs. 2,1 no Grupo BD (p = 0,049), enquanto as médias de congestão vascular foram 2,3 e 2, respectivamente, nos grupos controle e BD (p = 0,1642). Conclusão A infusão intrarretal do extrato de Baccharis dracunculifolia minimizou significantemente o processo inflamatório na colite de exclusão de ratos submetidos à colostomia, sem alterar o grau de congestão vascular.

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ABSTRACT Objective: To evaluate the hydration of obese and non-obese adolescents by vectorial bioimpedance analysis, in addition to verifying the associations between obesity and bioelectrical impedance vectorial analysis (BIVA) parameters. Methods: A cross-sectional study with adolescents between 14 and 18 years old (n=489, 300 boys and 189 girls). Electric bioimpedance (BIA; Quantum_II, RJL system, Rome, Italy) provided resistance and reactance parameters to calculate phase angle (PA), fat-free mass (FFM) and body fat (%BF). The confidence ellipses were compared, and the construction of the tolerance ellipses allowed individual and qualitative evaluation of the vectors and classification in dehydrated, normohydrated and hyperhydrated. Results: 78 obese and 411 eutrophic adolescents participated. Resistance (p<0.001) and reactance (p<0.001) and their normalization by stature (p<0.001) were reduced in the obese, whereas the PA was higher (p=0.003). %BF was 11.3% higher in obese adolescents. The main vector of the obese, both male (D=1.38; p<0.001) and female (D=1.49; p<0.001), indicated greater hydration. The ellipse of tolerance of the total sample showed that 25 (32.1%) were hyperhydrated and 02 (2.6%) vectors positioned in the sense of dehydration. A total of 17 (53.2%) girls and 16 (34.8%) boys were hyperhydrated. Logistic regression showed an inverse relation of BMI with resistance (p<0.001), reactance (p<0.001) and both normalized by stature. Adolescents with increased PA (p<0.001) were twice as likely to present obesity. Conclusions: Obese adolescents were hyperhydrated and there was an inverse relationship of BMI with resistance and direct with PA.

RESUMO Objetivo: Avaliar a hidratação de adolescentes obesos e não obesos por meio dos gráficos da análise vetorial por bioimpedância (BIVA), além de verificar as associações entre a obesidade e os parâmetros da BIVA. Métodos: Estudo transversal realizado com adolescentes entre 14 e 18 anos (n=489, 300 meninos e 189 meninas). A bioimpedância elétrica (BIA; Quantum_II, RJL system, Roma, Itália) ofereceu os parâmetros de resistência e reactância para calcular o ângulo de fase (AF), a massa livre de gordura (MLG) e a gordura corporal (GC). As elipses de confiança foram comparadas e a construção das elipses de tolerância permitiu a avaliação individual e a qualitativa dos vetores e, ainda, a classificação em desidratados, normohidratados e hiper-hidratados. Resultados: Participaram do estudo 78 adolescentes obesos e 411 eutróficos. A resistência (p<0,001), a reactância (p<0,001) e a normalização desses pela estatura (p<0,001) estavam reduzidas nos obesos, enquanto o AF foi superior (p=0,003). O percentual de gordura corporal (%GC) foi 11,3% maior nos adolescentes obesos. O vetor principal dos obesos, tanto masculino (Distância de Mahalanobis (D)=1,38; p<0,001) quanto feminino (D=1,49; p<0,001), indicou maior hidratação. A elipse de tolerância da amostra total mostrou que 25 adolescentes (32,1%) estavam hiper-hidratados e dois (2,6%) vetores posicionados no sentido de desidratação. Dezessete (53,2%) meninas e 16 (34,8%) meninos estavam hiper-hidratados. A regressão logística mostrou relação inversa do índice de massa corpórea (IMC) com a resistência (p<0,001) e a reactância (p<0,001), ambas normalizadas pela estatura. Os adolescentes com aumento do AF (p<0,001) apresentaram duas vezes mais chances de serem classificados como obesos. Conclusões: Os adolescentes obesos estavam hiper-hidratados e houve relação inversa do IMC com a resistência e direta com o AF.

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BACKGROUND: Diversion colitis is still very common in our country, since the stoma creation is a common practice especially in situations of trauma. needing treatment for this condition. AIM: To evaluate the therapeutic effect of rectal infusion of Curcuma longa (turmeric) in the excluded intestinal segment of rats. METHOD: Eighteen Wistar rats were used and submitted to colostomy: control group (n=8) under rectal saline infusion and group CL, receiving intra-rectal infusion of Curcuma longa extract (n=10). After 21 days of treatment they were submitted to euthanasia; the intestinal segment excluded from intestinal transit was resected and sent to histopathological evaluation, classifying the degree of inflammation and of vascular congestion. RESULTS: The average of inflammation was 2.7 in the control group vs. 2.6 in the CL group (p=0.3125), while the mean vascular congestion was 2.3 and 2.1, respectively, in the control and CL groups (p=0.1642). CONCLUSION: Intra-rectal infusion of Curcuma longa extract was not able to minimize the inflammatory process or vascular congestion in the diversion colitis of rats subjected to colostomy.

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The aim of this study was to evaluate the reliability and agreement between the test and retest of the 10-repetition maximum (10-RM) test for leg press and bench press in breast cancer survivors (BCS). Thirty-one BCS participated in this study, age 54.87 ± 5.7 years. All performed 10-RM tests and retests for the leg press 45° and the bench press. For reliability analyses, an intraclass coefficient correlation (ICC) and coefficient of variation (CV) were performed. The limits of agreement were calculated using a Bland-Altman plot with 95% CIs. For absolute and relative error of measurement, we used standard error of measurement and minimally detectable change. The result showed a high reliability for the bench press and leg press; ICC of 0.94 and 0.98, respectively. CV was <10% for both exercises. The systematic error were 1.5 kg (10%) and 6.1 (8%) for the bench press and leg press, respectively. The standard errors of measurements were 0.96 kg (6.08%) and 4.11 kg (5.27%) for the bench press and leg press, respectively. The minimally detectable changes were 2.72 kg (17.20%) and 5.62 kg (7.21%) for the bench press and leg press, respectively. In breast cancer survivors, the muscular strength measurement for the 10-RM test showed a high to very high rate of reliability and agreement, with acceptable error of measurement.

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Goalball is a Paralympic sport involving people with visual impairment. Little is known about the physical fitness of elite players of this sport, as previous studies only evaluated body composition and aerobic capacity. Thus, the aim of this study was to describe the performance of elite goalball players in different physical tests and to look for relationships between them. Eleven elite Brazilian goalball players, seven males and four females, were evaluated for body composition, maximal handgrip isometric force (MHGF), countermovement jump (CMJ), throwing velocity (TV) and the Yo-Yo intermittent recovery test level 1 (Yo-Yo IR1). Players produced 41.54 ± 8.41 kgf in MHGF, 34.81 ± 7.2 cm in CMJ, 14.21 ± 1.89 m∙s-1 in TV, and 505 ± 313 m in Yo-Yo IR1, with an estimated maximum oxygen consumption (VO2max) of 40.64 ± 2.63 mL∙kg-1∙min-1. Most performance tests exhibited moderate to high correlations among them, while the percentage of body fat correlated with both the CMJ and Yo-Yo IR1 results. The current study reveals that CMJ could be a valuable monitoring tool as it was correlated with all other performance tests. The highest correlation observed was with TV (r = 0.754; p < 0.05), which is a key capacity in goalball. Moreover, high levels of body fat could be detrimental to anaerobic performance.