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Nutrients ; 10(9)2018 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-30208590

RESUMO

BACKGROUND: Chronic kidney disease and inflammation promote loss of Klotho expression. Given the well-established anti-inflammatory effects of omega-3 fatty acids, we aimed to investigate the effect of fish oil supplementation in a model of CKD. METHODS: Male C57BL/6 mice received supplementation with an adenine-enriched diet (AD, n = 5) or standard diet (CTL, n = 5) for 10 days. Two other experimental groups were kept under the adenine diet for 10 days. Following adenine withdrawal on the 11th day, the animals returned to a standard diet supplemented with fish oil (Post AD-Fish oil, n = 9) or not (Post AD-CTL, n = 9) for an additional period of 7 days. RESULTS: Adenine mice exhibited significantly higher mean serum urea, creatinine, and renal expression of the pro-inflammatory markers Interleukin-6 (IL-6), C-X-C motif chemokine 10 (CXCL10), and Interleukin-1ß (IL-1ß), in addition to prominent renal fibrosis and reduced renal Klotho gene expression compared to the control. Post AD-Fish oil animals demonstrated a significant reduction of IL-6, C-X-C motif chemokine 9 (CXCL9), and IL-1ß compared to Post AD-CTL animals. However, serum creatinine, renal fibrosis, and Klotho were not significantly different in the fish oil-treated group. Furthermore, renal histomorphological changes such as tubular dilatation and interstitial infiltration persisted despite treatment. CONCLUSIONS: Fish oil supplementation reduced renal pro-inflammatory markers but was not able to restore renal function nor Klotho expression in an adenine-induced CKD model.


Assuntos
Adenina , Suplementos Nutricionais , Óleos de Peixe/administração & dosagem , Mediadores da Inflamação/metabolismo , Rim/metabolismo , Proteínas de Membrana/metabolismo , Nefrite/dietoterapia , Insuficiência Renal Crônica/dietoterapia , Ração Animal , Animais , Biomarcadores/metabolismo , Modelos Animais de Doenças , Regulação para Baixo , Fibrose , Rim/patologia , Rim/fisiopatologia , Proteínas Klotho , Masculino , Camundongos Endogâmicos C57BL , Nefrite/induzido quimicamente , Nefrite/metabolismo , Nefrite/fisiopatologia , Insuficiência Renal Crônica/induzido quimicamente , Insuficiência Renal Crônica/metabolismo , Insuficiência Renal Crônica/fisiopatologia
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