RESUMO
UNLABELLED: Obesity is associated with increased inflammation. C-reactive protein (CRP) is a proinflammatory molecule, and alpha1-antitrypsin is an inflammation-sensitive plasma protein. Proinflammatory process may be influenced by postprandial hyperglycemia. OBJECTIVE: The aim of the present study was to evaluate the role of high-glucose load on postprandial circulating levels of PCR and alpha1-antitrypsin in obese women with normal glucose tolerance. DESIGN: A total of 15 obese women (age=34.4+/-4.3 years, BMI=35.5+/-5.3 kg/m2) and 15 lean controls women (age=33.9+/-2.9 years, BMI=21.8+/-1.9 kg/m2) were recruited for this study. After and overnight fast subjects underwent a 2 h-75 g oral glucose tolerance test. Preprandial and postprandial CRP and alpha1-antitrypsin were measured. Anthropometry and blood biochemical parameters were measured in both groups. RESULTS: The obese women had fasting serum PCR levels higher (P=or<0.001) than those of control women. There weren't differences in fasting serum alpha1-antitrypsin levels in obese group in comparison to lean control group (P=0.26). Serum PCR and alpha1-antitrypsin did not change postprandially (P=or>0.05 difference to fasting levels). Serum CRP levels was positively related to body mass index (BMI) in obese group. Serum alpha1-antitrypsin was not related to BMI in both groups. CONCLUSION: A high glucose load is not associated with serum PCR and alpha1-antitrypsin levels increase. Serum alpha1-antitripsin levels are not increased in obese women. Serum PCR levels are increased in obese women, and are positively related to BMI.
Assuntos
Proteína C-Reativa/análise , Glucose/administração & dosagem , Obesidade/sangue , alfa 1-Antitripsina/sangue , Adulto , Feminino , Teste de Tolerância a Glucose , HumanosRESUMO
Paciente masculino de 75 anos, presenta linfadenopatia generalizada gammapatia policlonal, aumento de linfocitos B y linfocitos T disminuidos. La biopsia de ganglio linfatico demuestra proliferacion inmunoblastica difusa secundaria a la estimulacion antigenica constante por picadura de abeja. La prueba cutanea con veneno purificado de abeja fue positiva. Se hace un llamado de atencion sobre esta alteracion ganglionar linfatica, ya que es frecuente su confusion con linfoma