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[Effect of a high glucose load on serum concentrations of C-reactive protein and alpha1-antitrypsin in obese women]. / Evaluación del efecto de la ingesta de una sobrecarga de glucosa sobre los niveles séricos de la proteína C reactiva y de la alpha1-antitripsina en mujeres obesas.
Ramírez A, Ma M; Andreína Medina, M; Querales C, M; Millán, B E; Sánchez R, C O.
Afiliação
  • Ramírez A MM; Departamento de Bioquímica, Escuela de Medicina-Valencia. Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Estado Carabobo, Venezuela. mmramirez@uc.edu.ve
Nutr Hosp ; 23(4): 340-7, 2008.
Article em Es | MEDLINE | ID: mdl-18604320
UNLABELLED: Obesity is associated with increased inflammation. C-reactive protein (CRP) is a proinflammatory molecule, and alpha1-antitrypsin is an inflammation-sensitive plasma protein. Proinflammatory process may be influenced by postprandial hyperglycemia. OBJECTIVE: The aim of the present study was to evaluate the role of high-glucose load on postprandial circulating levels of PCR and alpha1-antitrypsin in obese women with normal glucose tolerance. DESIGN: A total of 15 obese women (age=34.4+/-4.3 years, BMI=35.5+/-5.3 kg/m2) and 15 lean controls women (age=33.9+/-2.9 years, BMI=21.8+/-1.9 kg/m2) were recruited for this study. After and overnight fast subjects underwent a 2 h-75 g oral glucose tolerance test. Preprandial and postprandial CRP and alpha1-antitrypsin were measured. Anthropometry and blood biochemical parameters were measured in both groups. RESULTS: The obese women had fasting serum PCR levels higher (P=or<0.001) than those of control women. There weren't differences in fasting serum alpha1-antitrypsin levels in obese group in comparison to lean control group (P=0.26). Serum PCR and alpha1-antitrypsin did not change postprandially (P=or>0.05 difference to fasting levels). Serum CRP levels was positively related to body mass index (BMI) in obese group. Serum alpha1-antitrypsin was not related to BMI in both groups. CONCLUSION: A high glucose load is not associated with serum PCR and alpha1-antitrypsin levels increase. Serum alpha1-antitripsin levels are not increased in obese women. Serum PCR levels are increased in obese women, and are positively related to BMI.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Alfa 1-Antitripsina / Glucose / Obesidade Limite: Adult / Female / Humans Idioma: Es Revista: Nutr Hosp Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Venezuela País de publicação: Espanha
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Alfa 1-Antitripsina / Glucose / Obesidade Limite: Adult / Female / Humans Idioma: Es Revista: Nutr Hosp Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Venezuela País de publicação: Espanha