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OBJECTIVE: This study aimed to investigate the epidemiological trends of Pediatric Sickle Cell Disease (SCD) in Brazil over the period 2008-2022, with a focus on understanding the incidence, mortality rates, and associated healthcare costs. The study explored potential associations between patient characteristics and the occurrence of crises in pediatric SCD cases. METHODS: A cross-sectional study was conducted, analyzing national annual rates of pediatric SCD hospitalizations using data from the FioCruz platform. Descriptive and inferential analyses, including time series and ARIMA regression, were employed. Economic dimensions were assessed using cost categorization. The study followed STROBE reporting guidelines. RESULTS: Data on 81,942 pediatric SCD hospitalizations were collected, with a predominance of crisis-related cases (74.08 %). Males and children under five years old were most affected. Regional disparities were observed, with the Southwest region recording the highest hospitalization rates. ICU costs were higher for crisis-related hospitalizations. Mortality rates were significantly higher for crisis-related cases (p < 0.001), with ARIMA regression indicating a significant association between hospitalizations for crisis-related cases and mortality. CONCLUSION: This study highlights the significant burden of pediatric SCD in Brazil, particularly crisis-related cases, suggesting a need for focused interventions. By prioritizing early detection, equitable access to healthcare, and evidence-based interventions, Brazil can mitigate the burden of SCD and improve patient outcomes. These findings contribute to informing public health policies and interventions aimed at addressing the challenges of pediatric SCD management in Brazil.
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During virus infection, many host proteins are redirected from their normal cellular roles to restrict and terminate infection. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are cellular RNA-binding proteins critical to host nucleic acid homeostasis, but can also be involved in the viral infection process, affecting virus replication, assembly and propagation. It has become evident that hnRNPs play important roles in modulation of host innate immunity, which provides critical initial protection against infection. These novel findings can potentially lead to the leveraging of hnRNPs in antiviral therapies. We review hnRNP involvement in antiviral innate immunity, in humans, mice and other animals, and discuss hnRNP targeting as a potential novel antiviral therapeutic.
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Ribonucleoproteínas Nucleares Heterogêneas , Imunidade Inata , Viroses , Humanos , Animais , Ribonucleoproteínas Nucleares Heterogêneas/metabolismo , Viroses/imunologia , Replicação Viral , Camundongos , Interações Hospedeiro-Patógeno/imunologiaRESUMO
Patients with end-stage heart disease who undergo a heart transplant frequently have simultaneous kidney insufficiency, therefore simultaneous heart and kidney transplantation is an option and it is necessary to understand its characteristics and long-term variables. The recipient characteristics and operative and long-term variables were assessed in a meta-analysis. A total of 781 studies were screened, and 33 were thoroughly reviewed. 15 retrospective cohort studies and 376 patients were included. The recipient's mean age was 51.1 years (95% CI 48.52-53.67) and 84% (95% CI 80-87) were male. 71% (95% CI 59-83) of the recipients were dialysis dependent. The most common indication was ischemic cardiomyopathy [47% (95% CI 41-53)] and cardiorenal syndrome [22% (95% CI 9-35)]. Also, 33% (95% CI 20-46) of the patients presented with delayed graft function. During the mean follow-up period of 67.49 months (95% CI 45.64-89.33), simultaneous rejection episodes of both organ allografts were described in 5 cases only. Overall survival was 95% (95% CI 88-100) at 30 days, 81% (95% CI 76-86) at 1 year, 79% (95% CI 71-87) at 3, and 71% (95% CI 59-83) at 5 years. Simultaneous heart and kidney transplantation is an important option for concurrent cardiac and renal dysfunction and has acceptable rejection and survival rates.
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Rejeição de Enxerto , Sobrevivência de Enxerto , Transplante de Coração , Transplante de Rim , Humanos , Masculino , Pessoa de Meia-Idade , Feminino , Síndrome Cardiorrenal/cirurgia , Função Retardada do Enxerto , Estudos Retrospectivos , Falência Renal Crônica/cirurgia , Falência Renal Crônica/complicações , Insuficiência Cardíaca/cirurgia , Insuficiência Cardíaca/mortalidade , Resultado do TratamentoRESUMO
The 35th Brazilian Congress of Surgery marked a turning point for surgical education in the country. For the first time, the Brazilian College of Surgeons included Global Surgery on the main congressional agenda, providing a unique opportunity to rethink how surgical skills are taught from a public health perspective. This discussion prompts us to consider why and how Global Surgery education should be expanded in Brazil. Although Brazilian researchers and institutions have contributed to the fields expansion since 2015, Global Surgery education initiatives are still incipient in our country. Relying on successful strategies can be a starting point to promote the area among national surgical practitioners. In this editorial, we discuss potential strategies to expand Global Surgery education opportunities and propose a series of recommendations at the national level.
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Cirurgiões , Humanos , Brasil , Universidades , Saúde PúblicaRESUMO
ABSTRACT The 35th Brazilian Congress of Surgery marked a turning point for surgical education in the country. For the first time, the Brazilian College of Surgeons included Global Surgery on the main congressional agenda, providing a unique opportunity to rethink how surgical skills are taught from a public health perspective. This discussion prompts us to consider why and how Global Surgery education should be expanded in Brazil. Although Brazilian researchers and institutions have contributed to the fields expansion since 2015, Global Surgery education initiatives are still incipient in our country. Relying on successful strategies can be a starting point to promote the area among national surgical practitioners. In this editorial, we discuss potential strategies to expand Global Surgery education opportunities and propose a series of recommendations at the national level.
RESUMO O 35º Congresso Brasileiro de Cirurgia foi marcado por discussões inovadoras para a educação cirúrgica no país. Pela primeira vez, o Colégio Brasileiro de Cirurgiões incluiu a Cirurgia Global na pauta principal do congresso, proporcionando uma oportunidade única de repensar como as habilidades cirúrgicas são ensinadas a partir de uma perspectiva de saúde pública. Essa discussão nos leva a considerar por que e como o ensino da Cirurgia Global deve ser expandido no Brasil. Embora pesquisadores e instituições brasileiras tenham contribuído para a expansão do campo desde 2015, as iniciativas de educação em Cirurgia Global ainda são incipientes em nosso país. Basear-se em estratégias bem-sucedidas pode ser um ponto de partida para promover a área entre os profissionais de cirurgia nacionais. Neste editorial, discutimos potenciais estratégias para expandir as oportunidades de educação em Cirurgia Global e propomos uma série de recomendações a nível nacional.
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BACKGROUND: Acute kidney injury has been described as a common complication in patients hospitalized with COVID-19, which may lead to the need for kidney replacement therapy (KRT) in its most severe forms. Our group developed and validated the MMCD score in Brazilian COVID-19 patients to predict KRT, which showed excellent performance using data from 2020. This study aimed to validate the MMCD score in a large cohort of patients hospitalized with COVID-19 in a different pandemic phase and assess its performance to predict in-hospital mortality. METHODS: This study is part of the "Brazilian COVID-19 Registry", a retrospective observational cohort of consecutive patients hospitalized for laboratory-confirmed COVID-19 in 25 Brazilian hospitals between March 2021 and August 2022. The primary outcome was KRT during hospitalization and the secondary was in-hospital mortality. We also searched literature for other prediction models for KRT, to assess the results in our database. Performance was assessed using area under the receiving operator characteristic curve (AUROC) and the Brier score. RESULTS: A total of 9422 patients were included, 53.8% were men, with a median age of 59 (IQR 48-70) years old. The incidence of KRT was 8.8% and in-hospital mortality was 18.1%. The MMCD score had excellent discrimination and overall performance to predict KRT (AUROC: 0.916 [95% CI 0.909-0.924]; Brier score = 0.057). Despite the excellent discrimination and overall performance (AUROC: 0.922 [95% CI 0.914-0.929]; Brier score = 0.100), the calibration was not satisfactory concerning in-hospital mortality. A random forest model was applied in the database, with inferior performance to predict KRT requirement (AUROC: 0.71 [95% CI 0.69-0.73]). CONCLUSION: The MMCD score is not appropriate for in-hospital mortality but demonstrates an excellent predictive ability to predict KRT in COVID-19 patients. The instrument is low cost, objective, fast and accurate, and can contribute to supporting clinical decisions in the efficient allocation of assistance resources in patients with COVID-19.
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COVID-19 , Masculino , Humanos , Pessoa de Meia-Idade , Idoso , Feminino , Mortalidade Hospitalar , Estudos Retrospectivos , Terapia de Substituição RenalRESUMO
OBJECTIVE: To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. METHODS: This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. RESULTS: Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). CONCLUSIONS: Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group.
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COVID-19 , Infecções por HIV , Feminino , Humanos , Pessoa de Meia-Idade , Masculino , Infecções por HIV/complicações , Infecções por HIV/epidemiologia , SARS-CoV-2 , Estudos Retrospectivos , Unidades de Terapia IntensivaRESUMO
Abstract Objective To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group.
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OBJECTIVES: COVID-19 has been associated with long-term consequences to patient wellness and quality of life. Data on post-COVID-19 conditions are scarce in developing countries. This study aimed to investigate long COVID in a cohort of hospitalized patients in Brazil. METHODS: Surviving patients discharged from the hospital between July 1, 2020 and March 31, 2021 were assessed between 2 and 12 months after acute onset of COVID-19. The outcomes were the prevalence of persistent symptoms, risk factors associated with long COVID, and quality of life as assessed by the EuroQol 5D-3L questionnaire. RESULTS: Of 439 participants, most (84%) reported at least one long COVID symptom, at a median of 138 days (interquartile range [IQR] 90-201) after disease onset. Fatigue (63.1%), dyspnea (53.7%), arthralgia (56.1%), and depression/anxiety (55.1%) were the most prevalent symptoms. In multivariate analysis, dysgeusia (odds ratio [OR] 2.0, 95% confidence interval [CI] 1.18-3.44, P <0.001) and intensive care unit (ICU) admission (OR 2.6, 95% CI 1.19-6.56, P = 0.03) were independently associated with long COVID. Fifty percent of patients reported a worsened clinical condition and quality of life. CONCLUSION: Long-term outcomes of SARS-CoV-2 infection in a low- to middle-income country were relevant. Fatigue was the most common persistent symptom. ICU admission was an independent factor associated with long COVID. Dysgeusia could be a potential predictor of long COVID.
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COVID-19 , Brasil/epidemiologia , COVID-19/complicações , COVID-19/epidemiologia , Estudos Transversais , Disgeusia , Fadiga/epidemiologia , Fadiga/etiologia , Humanos , Qualidade de Vida , Fatores de Risco , SARS-CoV-2 , Síndrome de COVID-19 Pós-AgudaRESUMO
Previous studies that assessed risk factors for venous thromboembolism (VTE) in COVID-19 patients have shown inconsistent results. Our aim was to investigate VTE predictors by both logistic regression (LR) and machine learning (ML) approaches, due to their potential complementarity. This cohort study of a large Brazilian COVID-19 Registry included 4120 COVID-19 adult patients from 16 hospitals. Symptomatic VTE was confirmed by objective imaging. LR analysis, tree-based boosting, and bagging were used to investigate the association of variables upon hospital presentation with VTE. Among 4,120 patients (55.5% men, 39.3% critical patients), VTE was confirmed in 6.7%. In multivariate LR analysis, obesity (OR 1.50, 95% CI 1.11-2.02); being an ex-smoker (OR 1.44, 95% CI 1.03-2.01); surgery ≤ 90 days (OR 2.20, 95% CI 1.14-4.23); axillary temperature (OR 1.41, 95% CI 1.22-1.63); D-dimer ≥ 4 times above the upper limit of reference value (OR 2.16, 95% CI 1.26-3.67), lactate (OR 1.10, 95% CI 1.02-1.19), C-reactive protein levels (CRP, OR 1.09, 95% CI 1.01-1.18); and neutrophil count (OR 1.04, 95% CI 1.005-1.075) were independent predictors of VTE. Atrial fibrillation, peripheral oxygen saturation/inspired oxygen fraction (SF) ratio and prophylactic use of anticoagulants were protective. Temperature at admission, SF ratio, neutrophil count, D-dimer, CRP and lactate levels were also identified as predictors by ML methods. By using ML and LR analyses, we showed that D-dimer, axillary temperature, neutrophil count, CRP and lactate levels are risk factors for VTE in COVID-19 patients.
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COVID-19 , Tromboembolia Venosa , Adulto , Anticoagulantes , Brasil/epidemiologia , Proteína C-Reativa , COVID-19/complicações , COVID-19/epidemiologia , Estudos de Coortes , Feminino , Humanos , Lactatos , Masculino , Oxigênio , Sistema de Registros , Fatores de Risco , Tromboembolia Venosa/epidemiologia , Tromboembolia Venosa/etiologia , Tromboembolia Venosa/prevenção & controleRESUMO
BACKGROUND: It is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19. METHODS: The study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number of comorbidities, and hospital was performed for the paired analysis. RESULTS: Of 7,762 patients with COVID-19, 526 had previously diagnosed hypothyroidism and 526 were matched controls. The median age was 70 years, and 68.3% were females. The prevalence of comorbidities was similar, except for coronary and chronic kidney diseases that were higher in the hypothyroidism group (p=0.015 and p=0.001). D-dimer levels were lower in patients with hypothyroid (p=0.037). In-hospital management was similar, but hospital length-of-stay (p=0.029) and mechanical ventilation requirement (p=0.006) were lower for patients with hypothyroidism. There was a trend of lower in-hospital mortality in patients with hypothyroidism (22.1% vs 27.0%; p=0.062). CONCLUSION: Patients with hypothyroidism had a lower requirement of mechanical ventilation and showed a trend of lower in-hospital mortality. Therefore, hypothyroidism does not seem to be associated with a worse prognosis.
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COVID-19 , Hipotireoidismo , Idoso , Teste para COVID-19 , Feminino , Mortalidade Hospitalar , Humanos , Hipotireoidismo/complicações , Hipotireoidismo/epidemiologia , Prognóstico , Sistema de Registros , SARS-CoV-2RESUMO
Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecutive patients with confirmed COVID-19 were included from March to September 2020. Genetic matching for sex, age, hypertension, diabetes mellitus and hospital was performed in a 4:1 ratio. Of the 7018 patients who had confirmed COVID-19, 31 patients with CD and 124 matched controls were included (median age 72 (64-80) years-old, 44.5% were male). At baseline, heart failure (25.8% vs. 9.7%) and atrial fibrillation (29.0% vs. 5.6%) were more frequent in CD patients than in the controls (p < 0.05). C-reactive protein levels were lower in CD patients compared with the controls (55.5 [35.7, 85.0] vs. 94.3 [50.7, 167.5] mg/dL). In-hospital management, outcomes and complications were similar between the groups. In this large Brazilian COVID-19 Registry, CD patients had a higher prevalence of atrial fibrillation and chronic heart failure compared with non-CD controls, with no differences in-hospital outcomes. The lower C-reactive protein levels in CD patients require further investigation.
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COVID-19/complicações , Doença de Chagas/patologia , Hospitalização/tendências , Idoso , Fibrilação Atrial , Brasil , Proteína C-Reativa/análise , COVID-19/patologia , Doença de Chagas/complicações , Doença de Chagas/virologia , Coinfecção , Diabetes Mellitus , Feminino , Mortalidade Hospitalar/tendências , Hospitalização/estatística & dados numéricos , Hospitais , Humanos , Hipertensão , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , SARS-CoV-2/patogenicidadeRESUMO
Resumo Historicamente nota-se que a domesticação e a normatização do corpo feminino podem ser reconhecidas como uma estratégia consideravelmente durável e flexível de controle social, cumprindo também com uma função ideológica que pode vir a se desdobrar em inúmeras formas de violência. Nesse contexto, o presente artigo teve como objetivo compreender como o corpo feminino e a violência de gênero são abordados no documentário brasileiro de 2018 Chega de Fiu Fiu. A partir de uma análise de conteúdo temática os principais resultados destacam a objetificação e a submissão das mulheres por parte dos homens que, naturalizados, reforçam e reiteram os assédios morais e violências sexuais que vitimam as mulheres na nossa sociedade.
Resumen Históricamente, se ha señalado que la domesticación y normalización del cuerpo femenino pueden ser reconocidas como una estrategia de control social considerablemente duradera y flexible, cumpliendo además una función ideológica que puede desplegarse en innumerables formas de violencia. En este contexto, este artículo tuvo como objetivo comprender cómo se abordan el cuerpo femenino y la violencia de género en el documental brasileño Chega de Fiu Fiu 2018. A partir de un análisis de contenido temático, los principales resultados destacan la cosificación y sometimiento de las mujeres por parte de los hombres que, naturalizados, refuerzan y reiteran los hostigamientos morales y la violencia sexual que victimizan a las mujeres en nuestra sociedad.
Abstract Historically, it has been noted that the domestication and standardization of the female body can be recognized as a considerably long-lasting and flexible strategy of social control, also fulfilling an ideological function that can unfold into several forms of violence. In this context, this article aimed to comprehend how the female body and gender violence are addressed in the 2018 Brazilian documentary Chega de Fiu Fiu. From a thematic content analysis, the main results highlight the objectification and submission of women by men, which, when naturalized, reinforce and reiterate the moral harassment and sexual violence that victimize women in our society.
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Humanos , Feminino , Mulheres , Assédio Sexual , Aparência Física , Violência de Gênero , Normas Sociais/história , Exposição à Violência/históriaRESUMO
INTRODUÇÃO: Ozonioterapia é uma ferramenta terapêutica utilizada para o tratamento de dor lombar associada a hérnia de disco lombar. Objetivo: o objetivo dessa revisão sistemática foi ratificar a relevância desse tratamento na prática clínica e enfatizar sua possível utilização na fisioterapia. MATERIAIS AND MÉTODOS: PRISMA e PICOS foram utilizados para analisar o desenho dos manuscritos. A seleção dos manuscritos foi realizada através de busca nas bases de dados PUBMED, Periódicos CAPES e Scielo. Quatro ensaios clínicos foram selecionados de acordo com os critérios de inclusão criado para essa estudo. RESULTADOS: Todos os autores confirmaram a eficiência da ozonioterapia como método terapêutico na reversão da sintomatologia álgica de pacientes com hérnia de disco lombar. Ozonioterapia associada ao tratamento fisioterapêutico pode contribuir no alívio da dor associada a dor lombar influenciando na qualidade de vida dos pacientes. CONCLUSÃO: Ozonioterapia é uma opção terapêutica efetiva para pacientes com dor lombar associada a hérnia de disco lombar. [AU]
INTRODUCTION: Ozonetherapy is a therapeutic tool used in the treatment of low back pain associated to herniation of lumbar disks. OBJECTIVE: The objective of this systematic review was to ratify the relevance of this treatment in clinical practice, besides emphasizing its possible utilization on physiotherapy. MATERIALS AND METHODS: PRISMA and PICOS were used to analyze the manuscripts design. Manuscripts selection was made by a research in the PUBMED, Periódicos CAPES and Scielo databases. Four clinical trials were selected according to the inclusion criterias designer for the study. RESULTS: All the authors confirmed the efficiency of ozonetherapy as a therapeutic method in reversing the algic symptomatology of pacients whit lumbar disc herniation. Ozonetherapy associated to the physiotherapeutic treatment can contribute pain relief related to low back pain by influencing the improvement in patients quality of life. CONCLUSION: Ozonetherapy is an effective therapeutic option for patients whit low back pain associated whit lumbar disk herniation. [AU]
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Humanos , Ozônio/uso terapêutico , Modalidades de Fisioterapia , Dor Lombar/terapia , Degeneração do Disco Intervertebral/complicações , Hérnia/complicações , Vértebras Lombares , Dor Lombar/etiologiaRESUMO
ABSTRACT Background Low back pain (LBP) is a common musculoskeletal condition among elders and is associated with falls. However, the underlying biological risk factors for falling among elders with LBP has been poorly investigated. The Physiological Profile Assessment (PPA) is a validated fall-risk assessment tool that involves the direct assessment of sensorimotor abilities and may contribute to the understanding of risk factors for falls among elders with LBP. Objective To assess fall risk using the PPA in elders with and without LBP. Method This is an observational, comparative, cross-sectional study with elders aged ≥65 years. The present study was conducted with a subsample of participants from the Back Complaints in the Elders (BACE) - Brazil study. Fall risk was assessed using the PPA, which contains five tests: visual contrast sensitivity, hand reaction time, quadriceps strength, lower limb proprioception, and postural sway. Results Study participants included 104 individuals with average age of 72.3 (SD=4.0) years, divided into two groups: GI) 52 participants with LBP; GII) 52 participants without LBP. The participants with LBP had a significantly higher fall risk (1.10 95% CI 0.72 to 1.48), greater postural sway (49.78 95% CI 13.54 to 86.01), longer reaction time (58.95 95% CI 33.24 to 84.65), and lower quadriceps strength (–4.42 95% CI –8.24 to –0.59) compared to asymptomatic participants. There was no significant difference for vision and proprioception tests between LBP and non-LBP participants. Conclusion Elders with LBP have greater risk for falls than those without LBP. Our results suggest fall-risk screening may be sensible in elders with LBP.
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Background: Low back pain (LBP) is a common musculoskeletal condition among elders and is associated with falls. However, the underlying biological risk factors for falling among elders with LBP has been poorly investigated. The Physiological Profile Assessment (PPA) is a validated fall-risk assessment tool that involves the direct assessment of sensorimotor abilities and may contribute to the understanding of risk factors for falls among elders with LBP. Objective: To assess fall risk using the PPA in elders with and without LBP. Method: This is an observational, comparative, cross-sectional study with elders aged ≥65 years. The present study was conducted with a subsample of participants from the Back Complaints in the Elders (BACE) - Brazil study. Fall risk was assessed using the PPA, which contains five tests: visual contrast sensitivity, hand reaction time, quadriceps strength, lower limb proprioception, and postural sway. Results: Study participants included 104 individuals with average age of 72.3 (SD=4.0) years, divided into two groups: GI) 52 participants with LBP; GII) 52 participants without LBP. The participants with LBP had a significantly higher fall risk (1.10 95% CI 0.72 to 1.48), greater postural sway (49.78 95% CI 13.54 to 86.01), longer reaction time (58.95 95% CI 33.24 to 84.65), and lower quadriceps strength (-4.42 95% CI -8.24 to -0.59) compared to asymptomatic participants. There was no significant difference for vision and proprioception tests between LBP and non-LBP participants. Conclusion: Elders with LBP have greater risk for falls than those without LBP. Our results suggest fall-risk screening may be sensible in elders with LBP.
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The purpose of this study was to compare physical capacity in elderly with and without acute low back pain (LBP). The Back Complaints in the Elders (BACE) consortium is a prospective study conducted in Brazil, Australia, and Netherlands. This subsample consists of elderly BACE Brazil study volunteers. This is an observational, cross-sectional, and comparative study with older adults aged ≥ 65 years who had a new episode (an agudization of symptoms) of LBP. Physical capacity was assessed using the Timed Up and Go test, Sit to Stand test, and normal Walking Speed test. Continuous variables were compared using a nonparametric Mann Whitney U test. A chi squared test was used for categorical variables. Significance level of α = 5%. The study included 104 elderly with mean age of 72.3 ± 4.2 years, classified into two groups: 52 elderly with LBP (GI) and 52 elderly without LBP (GII). The GI group showed worse performance in the Timed Up and Go (p = 0.000), Sit to Stand (p = 0.000) and normal Walking Speed (p = 0.002) tests than the GII group. Finally, the results of this study show the negative impact of LBP exacerbation on physical capacity in the elderly. Thus, it is important that health professionals involved in elderly care are attentive in the assessment and interpretation of clinical conditions regarding LBP to prevent negative impacts on physical function.
O objetivo deste estudo foi comparar a capacidade física em idosos com e sem dor lombar (DL) aguda. O consórcio Back Complaints in the Elders (BACE) é um estudo prospectivo conduzido no Brasil, Austrália e Holanda. Esta subamostra consiste de idosos voluntários do estudo BACE Brasil. Este é um estudo observacional, transversal e comparativo com idosos de idade ≥ 65 anos que apresentaram um novo episódio (uma agudização dos sintomas) de DL. A capacidade física foi avaliada usando o Timed Up and Go teste, o teste de sentar e levantar da cadeira e velocidade da marcha. As variáveis contínuas foram comparadas usando o teste não paramétrico Mann Whitney U. O teste do qui-quadrado foi usado para variáveis categóricas. O nível de significância considerado foi α = 5%. O estudo incluiu 104 idosos com idade média de 72,3 ± 4,2 anos, classificados em dois grupos: 52 idosos com DL (GI) e 52 idosos sem DL (GII). O grupo GI apresentou pior desempenho nos testes Timed Up and Go (p = 0,000), sentar e levantar da cadeira (p = 0,000) e velocidade da marcha (p = 0,002), do que o grupo GII. Os resultados deste estudo mostram o impacto negativo da exacerbação da DL na capacidade física em idosos. Assim, é importante que os profissionais de saúde envolvidos no cuidado ao idoso estejam atentos à avaliação e interpretação das condições clínicas que envolvam a DL para prevenir impactos negativos na função física.