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Epidemiological profile trends and cost of pediatric sickle cell disease in Brazil from 2008 to 2022.
Telles, Luiza; Melo, Paulo Henrique Moreira; Dornelas, Luana Baptistele; Lech, Gabriele Eckerdt; Sampaio, Natália Zaneti; Gerk, Ayla; Carroll, Madeleine; Camargo, Cristina Pires.
Afiliação
  • Telles L; Instituto de Educação Médica (IDOMED/Estácio, Campus Vista Carioca), Rio de Janeiro, RJ, Brazil. Electronic address: lulustelles21@gmail.com.
  • Melo PHM; Universidade Federal de Minas Gerais, Faculdade de Medicina, Belo Horizonte, MG, Brazil.
  • Dornelas LB; Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brazil.
  • Lech GE; Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Sampaio NZ; Universidade de Araraquara, Araraquara, SP, Brazil.
  • Gerk A; Harvard Medical School, Program in Global Surgery and Social Change, Boston, United States; McGill University, Department of Surgical and Interventional Sciences, Quebec, Canada; Montreal Children's Hospital, Harvey E. Beardmore Division of Pediatric Surgery, Quebec, Canada.
  • Carroll M; Harvard Medical School, Program in Global Surgery and Social Change, Boston, United States.
  • Camargo CP; Faculdade de Medicina, Universidade de São Paulo, Microcirurgia Laboratorial e Cirurgia Plástica, São Paulo, SP, Brazil.
J Pediatr (Rio J) ; 2024 Sep 07.
Article em En | MEDLINE | ID: mdl-39251065
ABSTRACT

OBJECTIVE:

This study aimed to investigate the epidemiological trends of Pediatric Sickle Cell Disease (SCD) in Brazil over the period 2008-2022, with a focus on understanding the incidence, mortality rates, and associated healthcare costs. The study explored potential associations between patient characteristics and the occurrence of crises in pediatric SCD cases.

METHODS:

A cross-sectional study was conducted, analyzing national annual rates of pediatric SCD hospitalizations using data from the FioCruz platform. Descriptive and inferential analyses, including time series and ARIMA regression, were employed. Economic dimensions were assessed using cost categorization. The study followed STROBE reporting guidelines.

RESULTS:

Data on 81,942 pediatric SCD hospitalizations were collected, with a predominance of crisis-related cases (74.08 %). Males and children under five years old were most affected. Regional disparities were observed, with the Southwest region recording the highest hospitalization rates. ICU costs were higher for crisis-related hospitalizations. Mortality rates were significantly higher for crisis-related cases (p < 0.001), with ARIMA regression indicating a significant association between hospitalizations for crisis-related cases and mortality.

CONCLUSION:

This study highlights the significant burden of pediatric SCD in Brazil, particularly crisis-related cases, suggesting a need for focused interventions. By prioritizing early detection, equitable access to healthcare, and evidence-based interventions, Brazil can mitigate the burden of SCD and improve patient outcomes. These findings contribute to informing public health policies and interventions aimed at addressing the challenges of pediatric SCD management in Brazil.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2024 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Pediatr (Rio J) Ano de publicação: 2024 Tipo de documento: Article País de publicação: Brasil