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1.
Acta Gastroenterol Latinoam ; 20(2): 81-8, 1990.
Artigo em Espanhol | MEDLINE | ID: mdl-2275312

RESUMO

To evaluate quali-quantitatively ischemic liver injury due to acute cardiocirculatory failure (ischemic hepatitis), and its real clinical signification, 200 out of 1165 autopsy records with ACF clinical diagnosis were selected; 33/200 (16.5%) shown centrilobular necrosis without inflammatory component, accompanied or not by midzonal compromise. Grade IV centrilobular necrosis (50-100% involved lobules) was present in 96.9%, with 15.5% associated midzonal pattern, and 21.2% of confluent type; 2 additional cases with isolated midzonal necrosis (5.7%) were seen. Only six patients (3.0% of ACF patients, and 18.2% of those with histological injury) shown overt clinical liver disease, one of them with a fulminant hepatitis picture (0.5% of ACF, and 3.0% of patients with ischemic necrosis). Bilirubin levels were 3.4-10.2 mg%, and aminotransferases rose up to 540 times over their seric superior normal limits. Centrilobular necrosis involved 100% of lobules in all cases.


Assuntos
Parada Cardíaca/complicações , Isquemia/patologia , Hepatopatias/patologia , Fígado/irrigação sanguínea , Adulto , Idoso , Feminino , Humanos , Isquemia/etiologia , Hepatopatias/etiologia , Masculino , Microcirculação , Pessoa de Meia-Idade , Necrose/patologia , Estudos Retrospectivos
2.
Acta gastroenterol. latinoam ; Acta gastroenterol. latinoam;20(2): 81-8, 1990.
Artigo em Espanhol | BINACIS | ID: bin-51725

RESUMO

To evaluate quali-quantitatively ischemic liver injury due to acute cardiocirculatory failure (ischemic hepatitis), and its real clinical signification, 200 out of 1165 autopsy records with ACF clinical diagnosis were selected; 33/200 (16.5


) shown centrilobular necrosis without inflammatory component, accompanied or not by midzonal compromise. Grade IV centrilobular necrosis (50-100


involved lobules) was present in 96.9


, with 15.5


associated midzonal pattern, and 21.2


of confluent type; 2 additional cases with isolated midzonal necrosis (5.7


) were seen. Only six patients (3.0


of ACF patients, and 18.2


of those with histological injury) shown overt clinical liver disease, one of them with a fulminant hepatitis picture (0.5


of ACF, and 3.0


of patients with ischemic necrosis). Bilirubin levels were 3.4-10.2 mg


, and aminotransferases rose up to 540 times over their seric superior normal limits. Centrilobular necrosis involved 100


of lobules in all cases.

3.
Acta gastroenterol. latinoam ; 19(1): 21-30, jan.-mar. 1989. Tab
Artigo em Espanhol | BINACIS | ID: bin-28797

RESUMO

Data provided by 51 voluntaru blood donnors identified as asymptomatic HBsAg carriers five to ten years (x = 7.5 years) before their inclusion in the study are analysed towards their long-term evolution. HBsAg clearance was estimated 2.5% yearly and 83.9% of those remaining positive showed the classical non-replicative serological pattern,; another 12.9% were negative for both HBeAg - Anti HBe (serovonversion window?), one of them presenting raised ASATALAT levels and enhanced histological activity (lobular chronic hepatitis). Neither alpha-fetoprotein seric levels (RIA) nor liver ultrasonography demonstrated hepato cellular carcinoma suspicion signs in 35 HBsAg positive cases to this methods; ASAT-ALAT levels raised over two fold the normal superior limit ion only 11.4%, and neither agressive chronic liver disease nor hepatocyte dissplasia was showed in 17 biopsed cases (70.6% normal; 23.6% chronic reactive or chronic persistent hepatitis; 5.8% chronic liobular hepatitis). One out of five patients biopsed with a seven years interval showed histologic worsening (AU)


Assuntos
Humanos , Vírus da Hepatite B/patogenicidade , Carcinoma Hepatocelular/imunologia , Hepatite B/imunologia , Neoplasias Hepáticas/imunologia , Antígenos de Superfície da Hepatite B/análise
4.
Acta gastroenterol. latinoam ; Acta gastroenterol. latinoam;19(1): 21-30, jan.-mar. 1989. tab
Artigo em Espanhol | LILACS | ID: lil-76189

RESUMO

Data provided by 51 voluntaru blood donnors identified as asymptomatic HBsAg carriers five to ten years (x = 7.5 years) before their inclusion in the study are analysed towards their long-term evolution. HBsAg clearance was estimated 2.5% yearly and 83.9% of those remaining positive showed the classical non-replicative serological pattern,; another 12.9% were negative for both HBeAg - Anti HBe (serovonversion window?), one of them presenting raised ASATALAT levels and enhanced histological activity (lobular chronic hepatitis). Neither alpha-fetoprotein seric levels (RIA) nor liver ultrasonography demonstrated hepato cellular carcinoma suspicion signs in 35 HBsAg positive cases to this methods; ASAT-ALAT levels raised over two fold the normal superior limit ion only 11.4%, and neither agressive chronic liver disease nor hepatocyte dissplasia was showed in 17 biopsed cases (70.6% normal; 23.6% chronic reactive or chronic persistent hepatitis; 5.8% chronic liobular hepatitis). One out of five patients biopsed with a seven years interval showed histologic worsening


Assuntos
Humanos , Antígenos de Superfície da Hepatite B/análise , Carcinoma Hepatocelular/imunologia , Vírus da Hepatite B/patogenicidade , Hepatite B/imunologia , Neoplasias Hepáticas/imunologia
5.
Acta Gastroenterol Latinoam ; 19(1): 21-30, 1989.
Artigo em Espanhol | MEDLINE | ID: mdl-2481374

RESUMO

Data provided by 51 voluntary blood donors identified as asymptomatic HBsAg carriers five to ten years (mean = 7.5 years) before their inclusion in the study are analysed towards their long-term evolution. HBsAg clearance was estimated 2.5% yearly and 83.9% of those remaining positive showed the classical non-replicative serological pattern; another 12.9% were negative for both HBeAg-Anti HBe (seroconversion window?), one of them presenting raised ASAT-ALAT levels and enhanced histological activity (lobular chronic hepatitis). Neither alpha-fetoprotein seric levels (RIA) nor liver ultrasonography demonstrated hepatocellular carcinoma suspicion signs in 35 HBsAg positive cases to this methods; ASAT-ALAT levels raised over two fold the normal superior limit in only 11.4%, and neither aggressive chronic liver disease nor hepatocyte dysplasia was showed in 17 biopsied cases (70.6% normal; 23.6% chronic reactive or chronic persistent hepatitis; 5.8% chronic lobular hepatitis). One out of five patients biopsied with a seven years interval showed histologic worsening.


Assuntos
Carcinoma Hepatocelular/etiologia , Portador Sadio/imunologia , Antígenos de Superfície da Hepatite B/análise , Hepatite B/imunologia , Neoplasias Hepáticas/etiologia , Doadores de Sangue , Anticorpos Anti-Hepatite B/análise , Antígenos E da Hepatite B/análise , Humanos , Estudos Prospectivos , Transaminases/sangue , alfa-Fetoproteínas/análise
6.
Acta gastroenterol. latinoam ; Acta gastroenterol. latinoam;19(1): 21-30, 1989.
Artigo em Espanhol | BINACIS | ID: bin-52018

RESUMO

Data provided by 51 voluntary blood donors identified as asymptomatic HBsAg carriers five to ten years (mean = 7.5 years) before their inclusion in the study are analysed towards their long-term evolution. HBsAg clearance was estimated 2.5


yearly and 83.9


of those remaining positive showed the classical non-replicative serological pattern; another 12.9


were negative for both HBeAg-Anti HBe (seroconversion window?), one of them presenting raised ASAT-ALAT levels and enhanced histological activity (lobular chronic hepatitis). Neither alpha-fetoprotein seric levels (RIA) nor liver ultrasonography demonstrated hepatocellular carcinoma suspicion signs in 35 HBsAg positive cases to this methods; ASAT-ALAT levels raised over two fold the normal superior limit in only 11.4


, and neither aggressive chronic liver disease nor hepatocyte dysplasia was showed in 17 biopsied cases (70.6


normal; 23.6


chronic reactive or chronic persistent hepatitis; 5.8


chronic lobular hepatitis). One out of five patients biopsied with a seven years interval showed histologic worsening.

7.
Acta Gastroenterol Latinoam ; 13(2): 155-61, 1983.
Artigo em Espanhol | MEDLINE | ID: mdl-6239495

RESUMO

Data from 1035 laparoscopic examinations were evaluated with 1% general morbidity and 0.1% death rate - Comparative diagnostic sensibility, specificity and predictive value between endoscopic and histologic findings from 748 cases (408 diffusse - parenchimatous liver diseases, 246 focal - nodular lesions, and 94 normal liver) were calculated. General sensibility (s) was similar for both laparoscopy and histology (s = 93) with different behavior for diffusse liver disease (DLD) and focal-nodular disease (FND) as follows: DLD: Laparoscopy s = 90 +/- 3 Vs. Histology s = 100. FND: Laparoscopy s = 98 +/- 1.8 Vs. Histology s = 85 +/- 4.8 Laparoscopic specificity (Sp) for FND was high (Sp = 100), but 10.6% false positive was diagnosed as DLD (Sp = 90 +/- 6.5). Non histologic false positive were found. High positive predictive value (p.p.v.) was found all cases: DLD: Laparoscopy ppv = 0.97 Vs. Histology p.p.v. = 1. FND: Laparoscopy ppv = 1 Vs. Histology p p.p.v. = 1. On the other hand, negative predictive value (npv) evidences well diferentiated results: DLD Laparoscopy n.p.v. = 0.69 Vs. Histology n.p.v. = 1. FND Laparoscopy n.p.v. = 0.94 Vs. Histology n.p.v. = 0.68. Histologic findings can not replace high fiability of macroscopic ones for FND diagnosis; then, blind liver biopsy is not recommended for this cases, but it could be very useful for DLD diagnosis.


Assuntos
Biópsia por Agulha , Laparoscopia , Hepatopatias/patologia , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Humanos , Hepatopatias/diagnóstico , Masculino , Matemática , Pessoa de Meia-Idade , Estudos Prospectivos
8.
Acta gastroenterol. latinoam ; Acta gastroenterol. latinoam;13(2): 155-61, 1983.
Artigo em Espanhol | BINACIS | ID: bin-49776

RESUMO

Data from 1035 laparoscopic examinations were evaluated with 1


general morbidity and 0.1


death rate - Comparative diagnostic sensibility, specificity and predictive value between endoscopic and histologic findings from 748 cases (408 diffusse - parenchimatous liver diseases, 246 focal - nodular lesions, and 94 normal liver) were calculated. General sensibility (s) was similar for both laparoscopy and histology (s = 93) with different behavior for diffusse liver disease (DLD) and focal-nodular disease (FND) as follows: DLD: Laparoscopy s = 90 +/- 3 Vs. Histology s = 100. FND: Laparoscopy s = 98 +/- 1.8 Vs. Histology s = 85 +/- 4.8 Laparoscopic specificity (Sp) for FND was high (Sp = 100), but 10.6


false positive was diagnosed as DLD (Sp = 90 +/- 6.5). Non histologic false positive were found. High positive predictive value (p.p.v.) was found all cases: DLD: Laparoscopy ppv = 0.97 Vs. Histology p.p.v. = 1. FND: Laparoscopy ppv = 1 Vs. Histology p p.p.v. = 1. On the other hand, negative predictive value (npv) evidences well diferentiated results: DLD Laparoscopy n.p.v. = 0.69 Vs. Histology n.p.v. = 1. FND Laparoscopy n.p.v. = 0.94 Vs. Histology n.p.v. = 0.68. Histologic findings can not replace high fiability of macroscopic ones for FND diagnosis; then, blind liver biopsy is not recommended for this cases, but it could be very useful for DLD diagnosis.

11.
Acta Gastroenterol Latinoam ; 9(3): 153-8, 1979.
Artigo em Espanhol | MEDLINE | ID: mdl-532530

RESUMO

207 cases of oesopha-gastric endoscopic exfoliative citology was realized during 1976-1977, 126 was malignant and 81 non-malignant. The high general diagnosis posivity in oesophagus (96,9% without erroneous posivity, and a posivity of 88,8% en stomach, with 4,2% erroneous posivity are remarked. The quick diagnosis, the easy technique and the unexpensive process, both the needed of high professional capacity, are realized. The incidence of tumoral localization, macroscopic and histologic characters on diagnosis security are comented.


Assuntos
Citodiagnóstico , Neoplasias Esofágicas/diagnóstico , Esofagoscopia , Gastroscopia , Neoplasias Gástricas/diagnóstico , Biópsia , Neoplasias Esofágicas/patologia , Humanos , Neoplasias Gástricas/patologia
12.
Acta gastroenterol. latinoam ; Acta gastroenterol. latinoam;9(3): 153-8, 1979.
Artigo em Espanhol | LILACS-Express | BINACIS | ID: biblio-1157589

RESUMO

207 cases of oesopha-gastric endoscopic exfoliative citology was realized during 1976-1977, 126 was malignant and 81 non-malignant. The high general diagnosis posivity in oesophagus (96,9


without erroneous posivity, and a posivity of 88,8


en stomach, with 4,2


erroneous posivity are remarked. The quick diagnosis, the easy technique and the unexpensive process, both the needed of high professional capacity, are realized. The incidence of tumoral localization, macroscopic and histologic characters on diagnosis security are comented.

13.
Acta gastroenterol. latinoam ; Acta gastroenterol. latinoam;9(3): 153-8, 1979.
Artigo em Espanhol | BINACIS | ID: bin-47229

RESUMO

207 cases of oesopha-gastric endoscopic exfoliative citology was realized during 1976-1977, 126 was malignant and 81 non-malignant. The high general diagnosis posivity in oesophagus (96,9


without erroneous posivity, and a posivity of 88,8


en stomach, with 4,2


erroneous posivity are remarked. The quick diagnosis, the easy technique and the unexpensive process, both the needed of high professional capacity, are realized. The incidence of tumoral localization, macroscopic and histologic characters on diagnosis security are comented.

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