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[Hepatic lesions in acute cardiovascular failure in necropsy specimens]. / Valoración del daño hepático en el fallo agudo cardiocirculatorio en material de necropsias.
Jmelnitzky, A; Castelletto, R; Rondina, A; Sidoti, A; Apraiz, M; Mincarelli, J C; Toledo, C; Albuquerque, M M; Viñas, D.
Afiliação
  • Jmelnitzky A; Cátedra de Gastroenterología de Post-grado, Universidad Nacional de la Plata.
Acta Gastroenterol Latinoam ; 20(2): 81-8, 1990.
Article em Es | MEDLINE | ID: mdl-2275312
To evaluate quali-quantitatively ischemic liver injury due to acute cardiocirculatory failure (ischemic hepatitis), and its real clinical signification, 200 out of 1165 autopsy records with ACF clinical diagnosis were selected; 33/200 (16.5%) shown centrilobular necrosis without inflammatory component, accompanied or not by midzonal compromise. Grade IV centrilobular necrosis (50-100% involved lobules) was present in 96.9%, with 15.5% associated midzonal pattern, and 21.2% of confluent type; 2 additional cases with isolated midzonal necrosis (5.7%) were seen. Only six patients (3.0% of ACF patients, and 18.2% of those with histological injury) shown overt clinical liver disease, one of them with a fulminant hepatitis picture (0.5% of ACF, and 3.0% of patients with ischemic necrosis). Bilirubin levels were 3.4-10.2 mg%, and aminotransferases rose up to 540 times over their seric superior normal limits. Centrilobular necrosis involved 100% of lobules in all cases.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Parada Cardíaca / Isquemia / Fígado / Hepatopatias Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: Es Revista: Acta Gastroenterol Latinoam Ano de publicação: 1990 Tipo de documento: Article País de publicação: Argentina
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Parada Cardíaca / Isquemia / Fígado / Hepatopatias Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: Es Revista: Acta Gastroenterol Latinoam Ano de publicação: 1990 Tipo de documento: Article País de publicação: Argentina