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Among the vegetables that stand out for their high concentration of anthocyanins, red cabbage appears as one of the most-used sources of these pigments in food production and it is considered a suitable raw material for the extraction of natural dye. Therefore, the objective was to carry out the production of natural extracts from red cabbage, under different conditions, varying the solvent, type of pre-treatment, pH range, and processing temperature during the concentration of the extracts. The anthocyanins were extracted from red cabbage using the following solvents: distilled water, 25% ethyl alcohol, and 70% ethyl alcohol. The raw material was divided into two groups, the first was subjected to a drying pre-treatment at 70 °C for 1 h and for the second group, the extraction was performed with the raw material in natura. Two pH ranges of 4.0 and 6.0 and extraction temperatures of 25 °C and 75 °C were used in the extracts, resulting in 24 formulations. The extracts obtained were analyzed for colorimetric parameters and anthocyanins. The results of anthocyanins show that the methodology that uses 25% alcohol, pH 4.0, and processing temperature of 25 °C produces a reddish extract and better results in the extraction, presenting average values of 191.37 mg/100 g of anthocyanins, being 74% higher compared to the highest values obtained in the other extracts where the same raw material was used and the solvents differed.
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Antocianinas , Brassica , Solventes , Etanol , Extratos VegetaisRESUMO
BACKGROUND: Scorpions are a leading cause of envenomation in Brazil. The species Tityus serrulatus is associated with the most severe cases, especially in children. Despite not being endemic to the state of Santa Catarina, such occurrences have increased more than 500% in the state recently. Therefore, this study aimed to analyze the occurrence of envenomation by T. serrulatus, attended by the Center for Toxicological Information and Assistance of Santa Catarina. METHODS: This was a retrospective and descriptive study of the occurrence of T. serrulatus, identified by the agency, from 2014 to 2021 in Santa Catarina, using data obtained by the BI-DATATOX system. RESULTS: A total of 112 occurrences were classified as envenomation. Of these cases, 48.2% were recorded in the Itajaí Valley region and 33% in Greater Florianópolis. Men were involved in 59.8% of these, and the most common age group was 20-39 years (39.3%). Most envenomation occurred in urban areas (89.3%) under non-occupational circumstances (83%). Stings were more frequent on the hands (50.9%). Care was sought within 1 h after the event in 75.9% of the cases, and 94.6% were classified as mild. CONCLUSIONS: Occurrence of envenomation involving T. serrulatus in Santa Catarina increased significantly during the study period. Most cases occurred in urbanized areas, which suggests that they might have been transported from other states, and it must be considered that, in the urban environment, scorpions find a large supply of food and shelter and a reduced number of specific predators, allied to parthenogenesis.
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Picadas de Escorpião , Venenos de Escorpião , Masculino , Criança , Animais , Humanos , Adulto Jovem , Adulto , Escorpiões , Brasil/epidemiologia , Estudos Retrospectivos , Picadas de Escorpião/epidemiologia , Picadas de Escorpião/complicações , Meio AmbienteRESUMO
BACKGROUND: Fibromyalgia (FM) is a rheumatic syndrome that causes musculoskeletal disorders and is associated with several problems that affect quality of life. As the musculoskeletal system is affected, it can have an impact on the pelvic floor muscles, leading to pelvic floor dysfunction (PFD). OBJECTIVE: Investigate the occurrence of PFD, such as urinary incontinence (UI) and anal incontinence (AI), sexual problems, and pelvic organ prolapse (POP), in women with FM compared to a control group composed of women without FM; and investigate the association between FM and PFD. STUDY DESIGN: This was an online cross-sectional survey. Demographic and anthropometric data, the description of PFD (UI, nocturia, AI, genital-pelvic pain/penetration disorder, and POP), and previous obstetric history were collected through a web-based questionnaire. The groups were compared using the independent t-test for quantitative variables and the chi-square test for categorical variables. The association between FM and PFD was tested using logistic regression analysis. RESULTS: A total of 175 women answered the questionnaire (97 with FM and 78 healthy controls). The women with FM reported significantly more UI, mixed urinary incontinence, AI, POP, and vaginismus than the healthy controls (p ≤ 0.05). FM was associated with mixed urinary incontinence (OR: 2.6; 95 % CI: 1.1-6.4; p = 0.04), anal incontinence (OR: 2.9; 95 % CI: 1.3-6.1; p = 0.01), and flatus incontinence (OR: 2.6; 95 % CI: 1.2-5.4; p = 0.01). CONCLUSION: The prevalence of PFD was significantly higher in women with FM compared to healthy women. Indeed, the women with FM were 2.6-fold to 2.9-fold more likely to report mixed urinary incontinence, anal and flatus incontinence than those in the control group. The present findings show possible impairment of the pelvic floor musculature in women with FM.
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Incontinência Fecal , Fibromialgia , Distúrbios do Assoalho Pélvico , Prolapso de Órgão Pélvico , Incontinência Urinária por Estresse , Incontinência Urinária , Gravidez , Feminino , Humanos , Estudos Transversais , Fibromialgia/complicações , Fibromialgia/epidemiologia , Distúrbios do Assoalho Pélvico/complicações , Distúrbios do Assoalho Pélvico/epidemiologia , Diafragma da Pelve , Qualidade de Vida , Flatulência/complicações , Incontinência Urinária/epidemiologia , Incontinência Urinária/etiologia , Incontinência Urinária por Estresse/etiologia , Incontinência Urinária de Urgência/complicações , Inquéritos e Questionários , Incontinência Fecal/epidemiologia , Incontinência Fecal/etiologia , Prolapso de Órgão Pélvico/complicações , Prolapso de Órgão Pélvico/epidemiologiaRESUMO
INTRODUCTION AND HYPOTHESIS: As a result of the impairment of the musculoskeletal system, the pelvic floor muscles are likely compromised in women with systemic lupus erythematosus (SLE). We hypothesized that women with SLE would report more symptoms of pelvic floor dysfunction (PFD) and there will be an association between SLE and PFD. METHODS: An online cross-sectional survey was conducted. Data were collected on demographic and anthropometric characteristics, PFD (urinary incontinence, nocturia, anal incontinence, genital-pelvic pain/penetration disorder and pelvic organ prolapse) and obstetric history using a web-based questionnaire. The groups were compared using the Mann-Whitney test for quantitative variables and the chi-squared test for categorical variables. The association between SLE and PFD was tested using logistic regression analysis. RESULTS: A total of 196 women answered the questionnaire (102 with SLE and 94 healthy controls). Women with SLE reported significantly more urinary incontinence, nocturia, anal incontinence, pelvic organ prolapse and genital-pelvic pain/penetration disorder than the healthy controls (p ≤ 0.05). Women with SLE were 2.8- to 3.0-fold more likely to report genital-pelvic pain/penetration disorder than healthy women. CONCLUSIONS: The prevalence of PFD was significantly higher in women with SLE compared to healthy women. Thus, PFD seems to be an important problem in women with this disease. An in-depth investigation of these disorders could contribute to the understanding of how SLE impacts pelvic floor function.
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Incontinência Fecal , Lúpus Eritematoso Sistêmico , Distúrbios do Assoalho Pélvico , Incontinência Urinária , Feminino , Humanos , Gravidez , Estudos Transversais , Incontinência Fecal/epidemiologia , Incontinência Fecal/etiologia , Lúpus Eritematoso Sistêmico/complicações , Lúpus Eritematoso Sistêmico/epidemiologia , Noctúria , Distúrbios do Assoalho Pélvico/epidemiologia , Distúrbios do Assoalho Pélvico/etiologia , Prolapso de Órgão Pélvico/complicações , Prolapso de Órgão Pélvico/epidemiologia , Inquéritos e Questionários , Incontinência Urinária/epidemiologia , Incontinência Urinária/etiologiaRESUMO
ABSTRACT Background: Scorpions are a leading cause of envenomation in Brazil. The species Tityus serrulatus is associated with the most severe cases, especially in children. Despite not being endemic to the state of Santa Catarina, such occurrences have increased more than 500% in the state recently. Therefore, this study aimed to analyze the occurrence of envenomation by T. serrulatus, attended by the Center for Toxicological Information and Assistance of Santa Catarina. Methods: This was a retrospective and descriptive study of the occurrence of T. serrulatus, identified by the agency, from 2014 to 2021 in Santa Catarina, using data obtained by the BI-DATATOX system. Results: A total of 112 occurrences were classified as envenomation. Of these cases, 48.2% were recorded in the Itajaí Valley region and 33% in Greater Florianópolis. Men were involved in 59.8% of these, and the most common age group was 20-39 years (39.3%). Most envenomation occurred in urban areas (89.3%) under non-occupational circumstances (83%). Stings were more frequent on the hands (50.9%). Care was sought within 1 h after the event in 75.9% of the cases, and 94.6% were classified as mild. Conclusions: Occurrence of envenomation involving T. serrulatus in Santa Catarina increased significantly during the study period. Most cases occurred in urbanized areas, which suggests that they might have been transported from other states, and it must be considered that, in the urban environment, scorpions find a large supply of food and shelter and a reduced number of specific predators, allied to parthenogenesis.
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The highly nutritional caja fruit (Spondias mombin L.) is an accessible source of vitamins and antioxidants that are indispensable for the human diet. The objective of the present work was to study the production of a probiotic caja pulp using Bifidobacterium animalis ssp. lactis B94. Firstly, a kinetic study was performed on the fermentation of the caja pulp with Bifidobacterium animalis ssp. lactis B94 to determine the optimum conditions of the process. Growth kinetics revealed that the ideal time for ending the fermentation would be at 22 h because it corresponds to the end of the exponential phase. Both the whole pulp and the probiotic pulp were characterized for pH, acidity, total soluble solids, water content, phenolic content, reducing carbohydrates, ascorbic acid, and total carotenoids. Physicochemical characterization revealed similar results between the whole and the probiotic pulp. The stability test demonstrated that the probiotic pulp is stable and preserved the probiotic attributes of the final product. In conclusion, our results reveal that caja pulp can be considered a favorable medium for the Bifidobacterium animalis ssp. lactis B94 growth and consequently can be explored biotechnologically for new food products.
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INTRODUCTION AND HYPOTHESIS: The use of valid patient-reported outcome measurements is essential in clinical and research settings. The structure of the Brazilian version of the King's Health Questionnaire (Br-KHQ) has not been evaluated. Thus, this study sought to evaluate the structural validity and internal consistency of the multi-item domains of the Br-KHQ in women with urinary incontinence (UI). METHODS: A total of 462 Brazilian Portuguese speakers with UI aged 18 years or older were included in this study. Participants answered the Br-KHQ, and a questionnaire containing demographic and personal information. The structure of the Br-KHQ was examined through Exploratory Factor Analysis (EFA) with the implementation of parallel analysis and evaluated using confirmatory factor analysis (CFA). For the latter, several goodness-of-fit indices were considered to evaluate the model fit of the structures tested in this study. Internal consistency was assessed using Cronbach's alpha, composite reliability, and coefficient omega. RESULTS: The EFA showed that the questionnaire has a five-factor structure, i.e., limitations of daily life, personal relationship, emotions, sleep/energy, and severity measures. The CFA demonstrated that this structure presented the most adequate goodness-of-fit indices and the lowest values of Akaike information criterion and Bayesian information criterion, compared with the original and Portuguese structure. High values (>0.70) of internal consistency were found. CONCLUSIONS: The Brazilian version of the KHQ is composed of a five-factor structure. Further studies should evaluate other measurement properties of the Br-KHQ to ensure reliable interpretation of this patient-reported outcome measure in clinical practice.
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Qualidade de Vida , Incontinência Urinária , Teorema de Bayes , Brasil , Feminino , Humanos , Psicometria , Reprodutibilidade dos Testes , Inquéritos e Questionários , Incontinência Urinária/diagnóstico , Incontinência Urinária/psicologiaRESUMO
BACKGROUND: Deposition of Schistosoma mansoni eggs in the brain of patients with hepatosplenic schistosomiasis (HS-SM) is frequent and usually asymptomatic. However, it is questioned whether it could cause seizures. Thus, we investigated the occurrence of seizures in these patients and also searched for parameters associated with this disorder. METHODS: In a cross-sectional survey, we compared 128 patients with HS-SM with 102 patients with portal hypertension due to compensated chronic hepatic disease of other etiologies. A standardized questionnaire, emphasizing epilepsy-related parameters, was applied to all participants. RESULTS: Eight (6.3%) patients with HS-SM had a history of seizures, whereas this condition was reported by three (2.9%) individuals from the comparison group (p=0.354). None of the variables were associated with the occurrence of seizures, either in univariate or in multivariate analysis. CONCLUSIONS: The frequency of seizures was similar in both study groups. However, it was higher than that described in population-based studies. Thus, we hypothesize that HS-SM individuals may have a higher frequency of seizure. The lack of difference between the two study groups may be explained by the inclusion of cases of HS-MS overlapping other chronic liver diseases in the comparison group, because this finding is relatively common in schistosome-endemic areas.
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Hepatopatias , Neuroesquistossomose , Esquistossomose mansoni , Esquistossomose , Animais , Brasil/epidemiologia , Estudos Transversais , Humanos , Neuroesquistossomose/complicações , Schistosoma mansoni , Esquistossomose/complicações , Esquistossomose mansoni/complicações , Esquistossomose mansoni/epidemiologia , Convulsões/epidemiologia , Convulsões/etiologia , Inquéritos e QuestionáriosRESUMO
Fagopyrum esculentum is highly nutritious due to its proteins of high biological value and high fiber content. Its most relevant property is nonetheless its antioxidant activity, provided by the presence of flavonoids. It is an important pseudocereal in agriculture, animal production, and human food. The objective of study was to evaluate the grain yield and flavonoid production of Fagopyrum esculentum cultivars as a function of base saturation. The experiment was carried out in a greenhouse, in a completely randomized design with four replicates. Treatments were represented by cultivars IPR 91 and IPR 92 and five base saturation levels (9, 31, 53, 75, and 97 %), in a factorial arrangement (2 × 5). Agronomic attributes and total-flavonoid and rutin contents and production were evaluated. Subsequently, the data were subjected to statistical analysis. Base saturation does not affect flavonoid production. However, base saturation influences shoot dry matter yield (maximum at 62.0% base saturation) and grain yield (maximum at 9.00%) in IPR 92. The higher-yielding cultivar is IPR 92. This is the first scientific report of base saturation in the species.(AU)
Fagopyrum esculentum é muito nutritivo por conter proteínas com alto valor biológico e alto teor de fibras, a propriedade mais relevante dele é a atividade antioxidante, devido à presença de flavonoides. É um pseudocereal importante na agricultura, produção animal e alimentação humana. O objetivo desse trabalho foi avaliar a produção de grãos e de flavonoides em cultivares de Fagopyrum esculentum em função da saturação por bases. O experimento foi realizado em casa de vegetação em delineamento inteiramente casualizado, com quatro repetições. Os tratamentos foram as cultivares IPR 91 e IPR 92 e cinco saturações por bases (9, 31, 53, 75 e 97 %), em esquema fatorial (2 × 5). Foram avaliados atributos agronômicos e teor e produção de flavonoides totais e de rutina. Posteriormente os dados foram submetidos a análises estatísticas. Para a produção de flavonoides, a saturação por bases não influencia nos resultados. Porém, para a produção de matéria seca da parte aérea (produção máxima aos 62,0 % de saturação por bases) e para a produção de grãos da IPR 92 (produção máxima aos 9,00 %), a saturação por bases influencia. A cultivar de maior produção é a IPR 92. Esse é o primeiro relato científico de saturação por bases da espécie.(AU)
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Flavonoides , Produtos Biológicos , Fagopyrum , AntioxidantesRESUMO
INTRODUCTION: Pelvic floor muscle training (PFMT) exercises and neuromuscular electrical stimulation (NMES) are described as conservative interventions to prevent or treat female stress urinary incontinence (SUI). However, it has not been described yet the effect of PFMT associated to intravaginal NMES which evaluated the cost-effectiveness and cost-utility of treating. AIMS: To evaluate the effects of intravaginal NMES associated with the PFMT protocol on urinary loss and quality of life in women with SUI and to evaluate the cost-effectiveness and cost-utility and pelvic floor muscle in women with SUI. METHODS: Randomized controlled trial study with economic evaluation. Inclusion criteria are woman (biological), aged ≥ 18 years old and with a report of SUI ≥ once/week. Exclusion criteria are presence of vaginal or urinary infection, virginity, being in the gestational or puerperium period, or neurological disease. Participants will undergo physical therapy assessment and intervention: anamnesis, pelvic floor muscle assessment by vaginal palpation and manometry (PeritronTM), questionnaires (Short-Form 6 Dimensions-Brazil (SF-6D), King's Health Questionnaire (KHQ) and King´s Health Questionnaire for Scoring Algorithm), health costs, and voiding diary. Participants will be randomly allocated into 3 groups: CG (control group), IG 1 (intervention group 1, PFMT), and IG2 (intervention group 2, PFMT + NMES). The statistical analysis will be performed by intention to treat, and multivariate analysis of mixed effects will be used to compare outcomes. Effect size measurements will be calculated and will be provided by Cohen's d test. A significance level of 5% will be adopted. Additionally, the incremental cost-effectiveness and incremental cost-utility ratios will be used. DISCUSSION: This protocol can corroborate with the literature in order to identify the effect of techniques, based on the possibility of confirming the hypothesis that the NMES associated with PFMT performed concurrently will be the best treatment option; considering the effectiveness, cost-effectiveness, and cost-utility analysis, it will be used as an option for optimization of the treatment of SUI. TRIAL REGISTRATION: Brazilian Registry of Clinical Trials (ReBEC) ID: RBR-6gtzg4 . Registered on September 3, 2019.
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Incontinência Urinária por Estresse , Adolescente , Análise Custo-Benefício , Estimulação Elétrica , Terapia por Exercício , Feminino , Humanos , Diafragma da Pelve , Qualidade de Vida , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento , Incontinência Urinária por Estresse/diagnóstico , Incontinência Urinária por Estresse/terapiaRESUMO
Rhipicephalus microplus, known as the cattle tick, is a cause of great economic losses for dairy cattle farming because of its high frequency of occurrence and the difficulty in controlling it. This research characterized the chemical profile and evaluated the in vitro toxicity of crude Lithraea brasiliensis extract and its isolated compound against acaricide-resistant and acaricide-susceptible R. microplus strains. Acaricidal activity was evaluated using a larval immersion test and the selectivity against non-target organisms was assessed on Artemia salina assay. The chemical investigation by high-performance liquid chromatography coupled with mass spectrometry (i.e., HPLC-MS) analysis showed the presence of hydrolysable tannins as well as urushiol derivatives. Column chromatography (CC) was carried out on the extract to obtain fractions and an isolated compound. The extract exhibited significant activity against acaricide-resistant (LC50 0.64 mg/mL) and acaricide-susceptible (LC50 0.76 mg/mL) strains of R. microplus larvae. The isolated compound from the extract (urushiol II), exhibited LC50 of 1.11 mg/mL for acaricide-resistant larvae. For acute toxicity in A. salina, the extract showed LC50>100 µg/mL. Thus, our findings represent the first effort to demonstrate the potential of L. brasiliensis extract and urushiol II as potential natural acaricides to replace or to be integrated into the conventional control of R. microplus larvae.
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Acaricidas , Rhipicephalus , Acaricidas/farmacologia , Animais , Larva , Dose Letal Mediana , Extratos Vegetais/farmacologiaRESUMO
OBJECTIVE: The aim of the present study was to analyze the effects of dance practice on body composition, metabolic profile, functional fitness, and self-image/self-esteem in postmenopausal women. METHODS: A total of 36 postmenopausal participants (mean age 57âyears) danced three times per week for 90 minutes each day and were evaluated before and after 16âweeks. The parameters evaluated were body composition (body fat and lean mass), blood lipids, functional fitness, self-image, and self-esteem. RESULTS: Statistical analysis was done using Student t test for paired samples and the Wilcoxon test with P values less than 0.05 considered statistically significant. Lower triglycerides (baselineâ=â156.5â±â17.0âmg/dL; after 16-weeksâ=â131.5â±â12.9âmg/dL; Pâ<â0.01), higher high-density lipoprotein cholesterol (baselineâ=â55.4â±â15.9âmg/dL; after 16 weeksâ=â60.0â±â15.4âmg/dL; Pâ<â0.001), and higher total cholesterol (baselineâ=â199.5â±â26.8âmg/dL; after 16 weeksâ=â211.8â±â35.7âmg/dL; Pâ<â0.01) levels were observed in postmenopausal women. Dance intervention improved coordination (baselineâ=â8.6â±â2.6; after 16 weeksâ=â6.7â±â1.6; Pâ<â0.001), agility (baselineâ=â55.9â±â8.8; after 16 weeksâ=â64.1â±â8.3; Pâ<â0.001), and aerobic capability (baselineâ=â446.8â±â63.4; after 16 weeksâ=â377.4â±â53.8; Pâ<â0.001). Classification of general function fitness index (GFFI) was considered regular at baseline (GFFI of 200-299), but improved after 16âweeks of dance practice (GFFI of 300-399, Pâ<â0.001). CONCLUSION: The 16-week dance intervention was effective in improving not only the lipid profile and functional fitness of postmenopausal women, but also self-image and self-esteem.
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Dança , Composição Corporal , Exercício Físico , Feminino , Humanos , Lipídeos , Pessoa de Meia-Idade , Aptidão Física , Pós-MenopausaRESUMO
INTRODUCTION AND HYPOTHESIS: The International Continence Society recommends vaginal palpation as a method for assessing pelvic floor muscle (PFM) function. Our aim was to analyze the agreement between preferences of examiner and participants according to unidigital and bidigital vaginal palpation during PFM assessment. The second aim was to investigate qualitatively women's perception of vaginal palpation. METHODS: Maximal voluntary contractions (MVCs) were requested during both types of vaginal palpation and were classified by the Modified Oxford Scale (MOS). Examiner and participants answered if they had preferences regarding vaginal palpation. Women answered qualitatively what they felt during the assessment. Cohen's linear kappa (κ) evaluated the agreement after allocation of the women with a weaker and stronger MVC and qualitative analysis was performed by transcription considering age range (18-35; 36-59; ≥60 years). RESULTS: Agreement was almost zero for women with weaker and stronger MVC at unidigital (κ = 0.06 and κ = -0.12) and bidigital vaginal palpation (κ = 0.008 and κ = 0.005). Participants associated bidigital palpation with more perception and an easier way of contracting the PFMs. Women between 36 and 59 years associated unidigital palpation with a harder but comfortable way of contracting the PFMs. Subjects aged ≥60 years associated bidigital palpation with an uncomfortable, harder way of contracting PFM, with less space into the vagina. CONCLUSIONS: Agreement between preferences was almost zero neither between women with a weaker and stronger PFM contraction, nor between the types of vaginal palpation. Bidigital palpation increased women's perception, made the contraction easier, and was associated with less space in the vaginal canal and less comfort.
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Contração Muscular , Diafragma da Pelve , Adolescente , Adulto , Feminino , Humanos , Palpação , Pesquisa Qualitativa , Vagina , Adulto JovemRESUMO
The residue generated from the processing of Tacinga inamoena (cumbeba) fruit pulp represents a large amount of material that is discarded without proper application. Despite that, it is a raw material that is source of ascorbic acid, carotenoids and phenolic compounds, which are valued in nutraceutical diets for allegedly combating free radicals generated in metabolism. This research paper presents a study focused on the mathematical modeling of drying kinetics and the effect of the process on the level of bioactive of cumbeba residue. The experiments of cumbeba residue drying (untreated or whole residue (WR), crushed residue (CR) and residue in the form of foam (FR)) were carried out in a fixed-bed dryer at four air temperatures (50, 60, 70 and 80 °C). Effective water diffusivity (Deff) was determined by the inverse method and its dependence on temperature was described by an Arrhenius-type equation. It was observed that, regardless of the type of pretreatment, the increase in air temperature resulted in higher rate of water removal. The Midilli model showed better simulation of cumbeba residue drying kinetics than the other models tested within the experimental temperature range studied. Effective water diffusivity (Deff) ranged from 6.4890 to 11.1900 × 10-6 m2/s, 2.9285 to 12.754 × 10-9 m2/s and 1.5393 × 10-8 to 12.4270 × 10-6 m2/s with activation energy of 22.3078, 46.7115 and 58.0736 kJ/mol within the temperature range of 50-80 °C obtained for the whole cumbeba, crushed cumbeba and cumbeba residue in the form of foam, respectively. In relation to bioactive compounds, it was observed that for a fixed temperature the whole residue had higher retention of bioactive compounds, especially phenolic compounds, whereas the crushed residue and the residue in the form of foam had intermediate and lower levels, respectively. This study provides evidence that cumbeba residue in its whole form can be used for the recovery of natural antioxidant bioactive compounds, mainly phenolic compounds, with the possibility of application in the food and pharmaceutical industries.
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O O silêncio é um tema que não quer calar. Por isso, vamos falar sobre ele uma vez mais. Esse artigo traz como proposta fazer uma análise sucinta do silêncio enquanto meio de comunicação, introduzindo as noções de silêncio silencioso e silêncio silenciado. Para, depois, apresentar e comentar o silêncio na clínica psicanalítica, tanto o do paciente quanto o do analista, e seus possíveis manejos. Por fim, deixa-nos a mensagem do quão importante é hoje saber ouvir os sons do silêncio na clínica, nas ruas, em nossas vidas pessoais e dentro de nós mesmos especialmente quando vivemos em uma sociedade marcada pela presença de tantos ruídos perturbadores.(AU)
Silence is a topic that does not want to shut up. So lets talk about it one more time. This paper intends to make a succinct analysis of silence as a means of communication, introducing the notions of silent silence and silenced silence. And then present and comment on the silence in the psychoanalytic clinic, both the patient and the analyst, and their possible managements. Finally, it leaves us with the message of how important it is today to know how to listen to the sounds of silence in the clinic, on the streets, in our personal lives and within ourselves especially when we live in a society marked by the presence of so many disturbing noises.(AU)
El silencio es un tema que no quiere calar. Así que hablemos de ello una vez más. Este artículo propone hacer un análisis sucinto del silencio como medio de comunicación, introduciendo las nociones de silencio silencioso y silencio silenciado. Luego, presentar y comentar el silencio en la clínica psicoanalítica, tanto del paciente como del analista, y sus posibles manejos. Finalmente, nos deja el mensaje de lo importante que es hoy en día saber escuchar los sonidos del silencio en la clínica, en la calle, en nuestra vida personal y dentro de nosotros mismos especialmente cuando vivimos en una sociedad marcada por la presencia de tantos ruídos perturbadores.(AU)
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This is a case report of a lactating woman in her twenties diagnosed with a breast pseudoaneurysm following a 14-gauge ultrasound-guided core needle biopsy detected by a Color Doppler exam, and treated with surgery. Further discussion concerning the patient's symptoms, useful imaging modalities, and treatment options are included. Knowledge on this complication is crucial for the correct diagnosis and best management and treatment.
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Falso Aneurisma , Neoplasias da Mama , Falso Aneurisma/diagnóstico por imagem , Falso Aneurisma/etiologia , Falso Aneurisma/terapia , Biópsia com Agulha de Grande Calibre/efeitos adversos , Mama/diagnóstico por imagem , Mama/patologia , Neoplasias da Mama/patologia , Feminino , Humanos , Lactação , Ultrassonografia de Intervenção/efeitos adversos , Ultrassonografia de Intervenção/métodosRESUMO
It is well known that intake of probiotic brings health benefits. Lactic bacteria with probiotic potential have aroused the interest of the industry in developing food products that incorporate such benefits. However, incorporating probiotic bacteria into food is a challenge for the industry, given the sensitivity of probiotic cultures to process conditions. Therefore, the objective of this study is to evaluate gelatin- and inulin-based filmogenic solutions as a potential vehicle for incorporating probiotics into food products and to model the fermentation kinetics. L. salivarius (Lactobacillus salivarius) growth in filmogenic solutions was analyzed under the influence of a variety gelatin concentrations (1.0-3.0%) and inulin concentrations (4.0-6.0%) and fermented under the effect of different temperatures (25-45 °C). A full 23 factorial plan with three replicates at the central point was used to optimize the process. The impacts of process conditions on cell development are fundamental to optimize the process and make it applicable by the industry. The present study showed that the optimal conditions for the development of probiotic cells in filmogenic solutions are a combination of 1.0% gelatin with 4.0% inulin and fermentation temperature of 45 °C. It was observed that the maximum cell growth occurred in an estimated time of about 4 h of fermentation. L. salivarius cell production and substrate consumption during the fermentation of the filmogenic solution were well simulated by a model proposed in this article, with coefficients of determination of 0.981 (cell growth) and 0.991 (substrate consumption).
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OBJECTIVES: Obesity is considered a risk factor for the development of non-alcoholic fatty liver disease (NAFLD). The hydroalcoholic extract obtained from the açai seed (ASE), rich in proanthocyanidins, has been shown a potential body weight regulator with antioxidant properties. This study aimed to investigate the therapeutic effect of ASE in obesity-associated NAFLD and compare it with Rosuvastatin. METHODS: Male C57BL/6 mice received a high-fat diet or standard diet for 12 weeks. The treatments with ASE (300 mg/kg per day) or rosuvastatin (20 mg/kg per day) began in the eighth week until the 12th week. KEY FINDINGS: Our data show that the treatments with ASE and rosuvastatin reduced body weight and hyperglycaemia, improved lipid profile and attenuated hepatic steatosis in HFD mice. ASE and Rosuvastatin reduced HMGCoA-Reductase and SREBP-1C and increased ABGC8 and pAMPK expressions in the liver. Additionally, ASE, but not Rosuvastatin, reduced NPC1L1 and increased ABCG5 and PPAR-α expressions. ASE and rosuvastatin increased SIRT-1 expression and antioxidant defence, although only ASE was able to decrease the oxidative damage in hepatic tissue. CONCLUSIONS: The therapeutic effect of ASE was similar to that of rosuvastatin in reducing dyslipidemia and hepatic steatosis but was better in reducing oxidative damage and hyperglycaemia.