RESUMO
BACKGROUND: Tumor infiltrating lymphocytes (TILs) and regression are thought to be distinct markers of the immune response to melanoma. OBJECTIVE: This study sought to analyze the relationship of TIL grade and presence of regression to each other and to other prognostic histopathologic and clinical values in melanoma. MATERIALS AND METHODS: A retrospective analysis was conducted using patients diagnosed with melanoma between 2013 and 2019 whose complete histopathologic reports were available. RESULTS: Regression was seen in 48.9%, 30.1% and 37.9% of patients with brisk, non-brisk, and absent TILs respectively (P=0.019). Melanoma tumors with brisk TILs were found to have a lower Breslow thickness than those with non-brisk or absent (P= 0.001). Tumors with regression were also found to have lower Breslow thickness (P<0.001). Neither TIL grade nor regression were protective of nodal metastasis or associated with improved survival. CONCLUSION: Brisk TILs have a positive association with thinner tumors and the presence of tumor regression relative to non-brisk or absent TILs. This may suggest a more robust immune response in tumors with brisk TILs. Further exploration of the interplay between TIL grade, lymphocyte cell subtype and lymphocyte density may help explain this finding.
Assuntos
Melanoma , Neoplasias Cutâneas , Humanos , Linfócitos do Interstício Tumoral , Melanoma/patologia , Prognóstico , Estudos Retrospectivos , Neoplasias Cutâneas/patologiaRESUMO
A 73-year-old man presented with fatigue and weight loss. He had CT-proven splenic mass with fistulous connection to the greater curvature of the stomach, which suggested abscess. FDG PET/CT confirmed gastrosplenic fistula in addition to active lymph nodes in the gastrohepatic ligament and epigastric region. Pathological examination after the biopsy of the spleen was consistent with diffuse large B-cell lymphoma. Chemotherapy was administered with close clinical follow-up and resulted in the resolution of fistula without requirement for surgery.
Assuntos
Fístula/diagnóstico por imagem , Fístula/etiologia , Fluordesoxiglucose F18 , Linfoma/complicações , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Baço , Estômago , Idoso , Humanos , MasculinoAssuntos
Linfonodos/transplante , Linfedema/cirurgia , Mamoplastia/métodos , Complicações Pós-Operatórias/cirurgia , Músculos Superficiais do Dorso/transplante , Retalhos Cirúrgicos/transplante , Tromboembolia Venosa/complicações , Adulto , Axila , Feminino , Humanos , Excisão de Linfonodo , Linfedema/etiologia , Reoperação , TóraxRESUMO
It is now possible to model thermal relaxation of neutron stars after bouts of accretion during which the star is heated out of equilibrium by nuclear reactions in its crust. Major uncertainties in these models can be encapsulated in modest variations of a handful of control parameters that change the fiducial crustal thermal conductivity, specific heat, and heating rates. Observations of thermal relaxation constrain these parameters and allow us to predict longer term variability in terms of the neutron star core temperature. We demonstrate this explicitly by modeling ongoing thermal relaxation in the neutron star XTE J1701-462. Its future cooling, over the next 5 to 30 years, is strongly constrained and depends mostly on its core temperature, uncertainties in crust physics having essentially been pinned down by fitting to the first three years of observations.
RESUMO
We report on a new mechanism for heat conduction in the neutron star crust. We find that collective modes of superfluid neutron matter, called superfluid phonons, can influence heat conduction in magnetized neutron stars. They can dominate the heat conduction transverse to the magnetic field when the magnetic field B> approximately 10(13) G. At a density of rho approximately 10(12)-10(14) g/cm3, the conductivity due to superfluid phonons is significantly larger than that due to lattice phonons and is comparable to electron conductivity when the temperature approximately 10(8) K. This new mode of heat conduction can limit the surface anisotropy in highly magnetized neutron stars. Cooling curves of magnetized neutron stars with and without superfluid heat conduction could show observationally discernible differences.
RESUMO
The first description of avian influenza (AI) dates back to 1878 in northern Italy, when Perroncito [Perroncito E. Epizoozia tifoide nei gallinacei. Annali Accad Agri Torino 1878;21:87-126] described a contagious disease of poultry associated with high mortality. The disease, termed "fowl plague", was initially confused with the acute septicemic form of fowl cholera. However, in 1880, soon after its first description, Rivolta and Delprato [as reported by Stubs EL. Fowl pest, In: Biester HE, Devries L, editors. Diseases of poultry. 1st ed. Ames, IO: Iowa State College Press; 1943. p. 493-502] showed it to be different from fowl cholera, based on clinical and pathological properties, and called it Typhus exudatious gallinarum. In 1901, Centanni and Savunzzi [Centanni E, Savonuzzi E, La peste aviaria I & II, Communicazione fatta all'accademia delle scienze mediche e naturali de Ferrara, 1901] determined that fowl plague was caused by a filterable virus; however, it was not until 1955 that the classical fowl plague virus was shown to be a type A influenza virus based on the presence of type A influenza virus type-specific ribonucleoprotein [Schäfer W. Vergleichender sero-immunologische Untersuchungen über die Viren der Influenza und klassischen Geflügelpest. Z Naturf 1955;10b:81-91]. The term fowl plague was substituted by the more appropriate term highly pathogenic avian influenza (HPAI) at the First International Symposium on Avian Influenza [Proceedings of the First International Symposium on Avian Influenza. Beltsville, MD. 1981, Avian Dis 47 (Special Issue) 2003.] and will be used throughout this review when referring to any previously described fowl plague virus.