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A Retrospective, Observational Analysis of Tumor Infiltrating Lymphocytes and Tumor Regression in Melanoma.
Zaladonis, Angela; Farma, Jeffrey; Hill, Maureen; Hotz, Meghan; Meller, Karli; Board, Tamsin; Deng, Mengying; Wu, Hong; Reddy, Sanjay; O'Halloran, Eileen.
Afiliação
  • Zaladonis A; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA; Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
  • Farma J; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA. Electronic address: Jeffrey.Farma@fccc.edu.
  • Hill M; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA.
  • Hotz M; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA; Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
  • Meller K; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA.
  • Board T; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA; Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
  • Deng M; Department of Statistics, Fox Chase Cancer Center, Philadelphia, PA.
  • Wu H; Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA.
  • Reddy S; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA.
  • O'Halloran E; Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA.
J Surg Res ; 267: 203-208, 2021 11.
Article em En | MEDLINE | ID: mdl-34153563
BACKGROUND: Tumor infiltrating lymphocytes (TILs) and regression are thought to be distinct markers of the immune response to melanoma. OBJECTIVE: This study sought to analyze the relationship of TIL grade and presence of regression to each other and to other prognostic histopathologic and clinical values in melanoma. MATERIALS AND METHODS: A retrospective analysis was conducted using patients diagnosed with melanoma between 2013 and 2019 whose complete histopathologic reports were available. RESULTS: Regression was seen in 48.9%, 30.1% and 37.9% of patients with brisk, non-brisk, and absent TILs respectively (P=0.019). Melanoma tumors with brisk TILs were found to have a lower Breslow thickness than those with non-brisk or absent (P= 0.001). Tumors with regression were also found to have lower Breslow thickness (P<0.001). Neither TIL grade nor regression were protective of nodal metastasis or associated with improved survival. CONCLUSION: Brisk TILs have a positive association with thinner tumors and the presence of tumor regression relative to non-brisk or absent TILs. This may suggest a more robust immune response in tumors with brisk TILs. Further exploration of the interplay between TIL grade, lymphocyte cell subtype and lymphocyte density may help explain this finding.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Melanoma Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Surg Res Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Melanoma Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: J Surg Res Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos