RESUMO
ABSTRACT Objective: To investigate the association between single nucleotide polymorphisms in the COX2 gene (rs689466 and rs5275) and local and systemic signs and symptoms of teething. Material and Methods: Forty-four pairs of mothers-babies/toddlers were included. Erupted primary teeth were evaluated during clinical examination. Local and systemic signs and symptoms of teething were obtained from mothers' reporting via anamnesis. Samples of buccal cells were retrieved for DNA genotyping using real-time PCR. The T-test, Chi-square test, logistic regression, and haplotype analyses were applied. Results: Almost all mothers (95.5%) reported at least one local or systemic sign and symptom of teething. The most common was increased salivation (79.5%), diarrhea (72.3 %), and fever (70.5 %). The mean number of signs and symptoms per child was higher in boys than girls (mean = 5.1; SD= 1.5; p=0.008). Sleep disturbance (p=0.03) and loss of appetite (p=0.05) were more reported in boys. The rs689466 and rs5275 were not associated with signs and symptoms of teething (p>0.05). Conclusion: The single nucleotide polymorphisms in the COX2 gene (rs689466 and rs5275) were not associated with local and systemic signs and symptoms of teething.
Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Transtornos do Sono-Vigília , Dente Decíduo/anatomia & histologia , Erupção Dentária , Polimorfismo de Nucleotídeo Único , Distribuição de Qui-Quadrado , Estudos Transversais/métodos , MãesRESUMO
OBJECTIVE: To evaluate if genetic polymorphisms in the oestrogen receptor 1 (ESR1) and oestrogen receptor 2 (ESR2) genes encoded for oestrogen receptors alpha (ERα) and beta (ERß) are involved in permanent tooth size. DESIGN: Cross-sectional study. SETTING: Orthodontic Clinic at School of Dentistry of Ribeirão Preto, University of São Paulo. PARTICIPANTS: A total of 108 orthodontic patients. MATERIALS AND METHODS: Pre-treatment orthodontic records were evaluated. Dental casts were used to determine the maximum crown measurements of fully erupted permanent teeth in the mesiodistal dimensions. Second and third molars were not included in the analysis. Genomic DNA samples were used for the genotyping of four genetic polymorphisms: ESR1 (rs9340799 and rs2234693) and ESR2 (rs1256049 and rs4986938). The associations between tooth size and sex were evaluated using t test. The associations between tooth size and genotype were analysed with linear regression and adjusted by sex at an alpha of P⩽0.05. RESULTS: Female patients presented smaller tooth size than male patients. A statistically significant difference was observed in almost all teeth (P<0.05). The genetic polymorphisms in rs9340799, rs2234693, rs1256049 and rs4986938 were associated with some tooth sizes in both the maxilla and mandible (P<0.05). CONCLUSION: This study provides evidence that genetic polymorphisms in ESR1 and ESR2 could be associated with tooth size in permanent teeth.
Assuntos
Polimorfismo de Nucleotídeo Único , Receptores de Estrogênio , Estudos Transversais , Receptor alfa de Estrogênio , Receptor beta de Estrogênio/genética , Feminino , Humanos , Masculino , Mandíbula , Polimorfismo de Nucleotídeo Único/genéticaRESUMO
OBJECTIVE: Evaluate the association between single nucleotide polymorphisms (SNPs) in Interleukin-6 (IL-6) gene (rs1800795) and in Interleukin-1-beta (IL-1ß) gene (rs1143627 and rs1143629) with dental caries and gingivitis in Brazilian children. MATERIAL AND METHODS: Three hundred and fifty-three children aged 8-11 years were included. Visible biofilm and gingival bleeding were evaluated by Community Periodontal Index. The International System for Detection and Assessment of Carious Lesions (ICDAS) was used to investigate dental caries. Real-time PCR evaluated SNPs in the DNA. Chi-square test, haplotype analysis and logistic regression were applied (alpha of 5%). RESULTS: The GG genotype in rs1800795 (IL-6) decreases the risk of gingivitis in a co-dominant model (p = .05; OR = 0.64). The GG genotype in rs1143627 (IL-1ß) reduces the risk of dental caries (Co-dominant model: ICDAS0 versus ICDAS1-6: p = .05; OR = 0.55. ICDAS0-2 versus ICDAS3-6: p = .02; OR = 0.49. Recessive model: ICDAS0 versus ICDAS1-6: p = .005; OR = 0.48. ICDAS0-2 versus ICDAS3-6: p = .004; OR = 0.45. Logistic regression: ICDAS0-2 versus ICDAS3-6: p = .05; OR = 0.24; CI 95%= 0.05-1.00). The GG genotype in rs1143629 was more frequent in ICDAS0 (p = .05; OR: 0.60). In the haplotype analysis, IL-1ß was associated with gingivitis. CONCLUSION: The rs1800795 in IL-6 gene was associated with gingivitis. The rs1143627 and rs1143629 in IL-1ß were associated with dental caries and gingivitis.
Assuntos
Cárie Dentária/genética , Gengivite/genética , Interleucina-1beta/genética , Interleucina-6/genética , Brasil , Criança , Genótipo , HumanosRESUMO
A reabilitação protética com implantes osseointegrados é uma realidade atual. Os implantes contemporâneos tiveram o seu início com Brånemark em meados dos anos 1970. A partir daí, as ligas metálicas, desenho e técnicas evoluíram muito, porém, tanto desenho quanto técnicas de uso de alguns Implantes fogem do que hoje temos como "padrão ouro" dentro da Implantodontia. No presente trabalho, foi relatado um caso clínico de fratura de um implante tipo Garbaccio na região de assoalho nasal, que possui um desenho próprio, com problemas biomecânicos nítidos apesar de ainda ser comercializado. Sendo removido o remanescente do implante fraturado e o paciente reabilitado por um implante com os padrões atuais tipo Brånemark.
Assuntos
Humanos , Masculino , Adulto , Implantação Dentária Endóssea , Falha de Restauração DentáriaRESUMO
Apesar da segurança proporcionada pelo osso autógeno para a correção de defeitos alveolares é constante a busca de alternativas que eliminem ou diminuam a morbidade de uma segunda região operada. Com o advento das técnicas de regeneração óssea guiada é também crescente o interesse pelo uso do osso alógeno. Este trabalho tem por objetivo fazer uma revisão da literatura sobre o uso do osso alógeno em bloco para a reconstrução de rebordos alveolares deficientes, associado ao tratamento com implantes dentários.
Assuntos
Aumento do Rebordo Alveolar , Transplante Ósseo , OsseointegraçãoRESUMO
PURPOSE: This retrospective study reviewed cases of fractures of the mandibular angle to identify personal data, social traits, fracture characteristics, treatment modalities, and postoperative complications. PATIENTS AND METHODS: From April 1999 until July 2004, 114 patients were treated for 115 fractures of the mandibular angle by the Division of Oral and Maxillofacial Surgery at Piracicaba Dental School-Unicamp, in Brazil. RESULTS: More angle fractures were observed in Caucasian (55%) men (89%) with some kind of drug addiction (62%). Patient mean age was 27 years. The majority of fractures in this study were sustained in altercations, including gunshot wounds (43%), followed by vehicle accidents, including bicycles and being struck by a car (39%). Open fractures were the most frequent (90%), with prevalence of the left side (57%). Only 1 patient sustained bilateral angle fractures. Ninety-seven patients (85%) underwent open reduction. Complications occurred in 19 patients (17%); 10 (9%) were infections. Of the total number of complications, 3 underwent another surgical intervention for refixation. The factors that contributed to the development of postoperative complications were social risks that included alcohol abuse, smoking, and intravenous and nonintravenous drug abuse. CONCLUSIONS: Angle fracture management outcomes are affected by many factors beyond method of fixation.
Assuntos
Técnicas de Fixação da Arcada Osseodentária , Fraturas Mandibulares , Adolescente , Adulto , Feminino , Fixação de Fratura/classificação , Fixação de Fratura/métodos , Humanos , Masculino , Fraturas Mandibulares/epidemiologia , Fraturas Mandibulares/etiologia , Fraturas Mandibulares/cirurgia , Pessoa de Meia-Idade , Estudos Retrospectivos , Distribuição por Sexo , Transtornos Relacionados ao Uso de Substâncias/complicaçõesRESUMO
Este trabalho tem por objetivo determinar a prevalência da xerostomia nos pacientes que procuraram atendimento na Área de Odontologia da UNIVILLE e sua relação com medicamentos utilizados no tratamento de doenças como hipertensão, convulsão, depressão e outros. A metodologia consistiu em fornecer aos pacientes um questionário sobre as condições de saúde geral, sintoma de xerostomia e uso de medicamentos. Os pacientes foram separados e analisados de acordo com o medicamento utilizado no tratamento das doenças, bem como o sintoma isoladamente. De todos os pacientes atendidos, 24,8% relataram xerostomia. Dos que fazem uso de medicamentos o sintoma esteve associado a 35,9%. Os principais medicamentos relacionados ao sintoma nesse estudo foram anti-hipertensivos, antidepressivos e anticonvulsivantes. A xerostomia tem maior prevalência nos pacientes que fazem uso dos medicamentos mencionados
The aim of this research was to know the xerostomy prevalence on patients who have been assisted by the Dentistry Area of the Univille and its relation with some drugs for the following treatments: arterial hypertension disease, seizure, depression and other diseases which require medication. The methodology consists of bringing a questionnaire referent to patients' health conditions, xerostomy symptoms and medications use. Patients were separated and analyzed depending on the medication drug used for their disease treatment and patients presenting isolated xerostomy. From all studied patients,24.8% of them were related with xerostomy. Patients who were relatedto drug medication use presented a 35.9% of this symptom. The main medications related to this xerostomy on this research were: antidepressives, antihypertensives and antiseizure. Xerostomy has a greater prevalence on patients who use the mentioned medications
Assuntos
Inquéritos e Questionários , Preparações Farmacêuticas , XerostomiaRESUMO
Schwannoma is a relatively uncommon, slowly growing lesion that is most commonly encountered in the nerve sheath. The mobile portion of the tongue is the most common site, followed by the palate, floor of mouth, buccal mucosa, lips, and jaws. The present case report refere a 13-year-old boy with a tongue mass that did not interfere with the speech. The histopathology and immunohistochemistry study of the excised lesion showed a Schwannoma of the tongue
Assuntos
Adolescente , Masculino , Humanos , Boca/patologia , Neurilemoma , Imuno-Histoquímica , Doenças da LínguaRESUMO
A extraçäo de terceiros molares é o procedimento mais comum na prática da cirurgia bucomaxilofacial. A classificaçäo das alteraçöes de posiçäo dos terceiros molares facilita tanto a comunicaçäo entre profissionais como o planejamento cirúrgico das exodontias desses dentes. O objetivo deste trabalho foi classificar, radiograficamente, terceiros molares inferiores de pacientes submetidos à exodontia no Centro Cirúrgico da FOP - Unicampo. Foram examinadas 277 radiografias panorâmicas constantes dos prontuários analisados. Na amostra de 507 terceiros molares inferiores, encontrou-se maior prevalência na posiçäo mesioangular, classe II - B. Os autores enfantizam a necessidade do planejamento pré-cirúrgico com o objetivo de diminuir o risco de acidentes e complicaçöes
Assuntos
Dente Serotino , Radiografia Dentária , Radiografia Panorâmica , Cirurgia Bucal , Extração DentáriaRESUMO
A displasia cemento-óssea florida afeta preferencialmente os ossos maxilares de mulheres negras, acima dos quarenta anos. Esta patologia é caracterizada por ser assintomática e radiograficamente apresentar-se como uma massa radiopaca difusa, geralmente bilateral, podendo estar presente tanto na maxila quanto na mandíbula. Quando infectada, apresenta-se sintomática e necessita de tratamento cirúrgico. O objetivo deste trabalho é discutir as características clínicas, radiográficas, histológicas e a conduta cirúrgica adotada