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Human permanent tooth sizes are associated with genes encoding oestrogen receptors.
Cunha, Arthur S; Vertuan Dos Santos, Luiza; Schaffer Pugsley Baratto, Samantha; Abbasoglu, Zerrin; Gerber, Jennifer Tsi; Paza, Aleysson; Matsumoto, Mírian Aiko Nakane; Scariot, Rafaela; Stuani, Maria Bernadete; Küchler, Erika Calvano.
Afiliação
  • Cunha AS; Department of Orthodontics, School of Dentistry, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Vertuan Dos Santos L; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Schaffer Pugsley Baratto S; School of Health and Biological Sciences, Universidade Positivo, Curitiba, Brazil.
  • Abbasoglu Z; Department of Pediatric Dentistry, Yeditepe University, Istanbul, Turkey.
  • Gerber JT; School of Health and Biological Sciences, Universidade Positivo, Curitiba, Brazil.
  • Paza A; School of Dentistry, Univille University, Joinville, Brazil.
  • Matsumoto MAN; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Scariot R; School of Health and Biological Sciences, Universidade Positivo, Curitiba, Brazil.
  • Stuani MB; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Küchler EC; School of Health and Biological Sciences, Universidade Positivo, Curitiba, Brazil.
J Orthod ; 48(1): 24-32, 2021 03.
Article em En | MEDLINE | ID: mdl-32985343
OBJECTIVE: To evaluate if genetic polymorphisms in the oestrogen receptor 1 (ESR1) and oestrogen receptor 2 (ESR2) genes encoded for oestrogen receptors alpha (ERα) and beta (ERß) are involved in permanent tooth size. DESIGN: Cross-sectional study. SETTING: Orthodontic Clinic at School of Dentistry of Ribeirão Preto, University of São Paulo. PARTICIPANTS: A total of 108 orthodontic patients. MATERIALS AND METHODS: Pre-treatment orthodontic records were evaluated. Dental casts were used to determine the maximum crown measurements of fully erupted permanent teeth in the mesiodistal dimensions. Second and third molars were not included in the analysis. Genomic DNA samples were used for the genotyping of four genetic polymorphisms: ESR1 (rs9340799 and rs2234693) and ESR2 (rs1256049 and rs4986938). The associations between tooth size and sex were evaluated using t test. The associations between tooth size and genotype were analysed with linear regression and adjusted by sex at an alpha of P⩽0.05. RESULTS: Female patients presented smaller tooth size than male patients. A statistically significant difference was observed in almost all teeth (P<0.05). The genetic polymorphisms in rs9340799, rs2234693, rs1256049 and rs4986938 were associated with some tooth sizes in both the maxilla and mandible (P<0.05). CONCLUSION: This study provides evidence that genetic polymorphisms in ESR1 and ESR2 could be associated with tooth size in permanent teeth.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Estrogênio / Polimorfismo de Nucleotídeo Único Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: J Orthod Assunto da revista: ODONTOLOGIA / ORTODONTIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Estrogênio / Polimorfismo de Nucleotídeo Único Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: J Orthod Assunto da revista: ODONTOLOGIA / ORTODONTIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido