RESUMO
OBJECTIVE: The aim of this study was to investigate sleep quality and quality of life, sociodemographic variables that may affect sleep quality, and the relationship between sleep and quality of life in patients with atrial fibrillation (AF). MATERIALS AND METHODS: This descriptive cross sectional study had a sample of 84 individuals (AF patients from April 2019-January 2020). The Patient Description Form, the Pittsburgh Sleep Quality Index (PSQI), and the EQ-5D health-related quality of life instrument were used to collect data. RESULTS: The mean total PSQI score was 10.72 (±2.73), we found that most of the participants (90.5%) had poor sleep quality. While there was a significant difference between the sleep quality and employment status of the patients, there was no significant difference between age, gender, marital status, education level and income status, comorbidity, family history of AF, continuously used medication, non-drug AF treatment, and AF duration (P > .05). The sleep quality of those working in any job was better than of their non-working counterparts. Regarding the correlation between sleep quality and quality of life, a medium-level negative correlation was found between the patients' total mean PSQI and EQ-5D visual analogue scale scores. However, no significant correlation was found between the total mean PSQI and EQ-5D scores. CONCLUSION: We found that sleep quality in patients with AF was poor. In these patients, sleep quality should be evaluated and taken into consideration as a factor that affects quality of life.
Assuntos
Fibrilação Atrial , Humanos , Fibrilação Atrial/tratamento farmacológico , Fibrilação Atrial/epidemiologia , Qualidade de Vida , Estudos Transversais , Comorbidade , Sono , Inquéritos e QuestionáriosRESUMO
PURPOSE: To investigate the protective effects against ischemia reperfusion injury of dipyridamole in a model of induced priapism in rats. MATERIALS AND METHODS: Twenty-four male Sprague-Dawley rats were divided into four groups, control, P/R, P/R+DMSO and P/R+D. 3ml blood specimens were collected from vena cava inferior in order to determine serum MDA, IMA, TAS, TOS and OSI values, and penile tissue was taken for histopathological examination in control group. Priapism was induced in P/R group. After 1h, priapism was concluded and 30 min reperfusion was performed. In P/R+DMSO group 1ml/kg DMSO was administered intraperitoneally 30 min before reperfusion, while in P/R+D group 10mg/kg dipyridamole was administered intraperitoneally 30 min before reperfusion. Blood and penis specimens were collected after the end of 30 min reperfusion period. Sinusoidal area (µm2), tears in tunica albuginea and injury parameters in sinusoidal endothelium of penis were investigated. RESULTS: Histopathological examination revealed no significant changes in term of sinusoidal area. A decrease in tears was observed in P/R+D group compared to P/R group (p<0.05). Endothelial injury decreased in P/R+D group compared to P/R group (p>0.05). There were no significant differences in MDA and IMA values between groups. A significant increase in TOS and OSI values was observed in P/R+D group compared to P/R group. A significant decrease in TAS levels was observed in P/R+D group compared to the P/R group. CONCLUSIONS: The administration of dipyridamole before reperfusion in ischemic priapism model has a potential protective effect against histopathological injury of the penis.
Assuntos
Dipiridamol/farmacologia , Isquemia/prevenção & controle , Pênis/irrigação sanguínea , Priapismo/prevenção & controle , Traumatismo por Reperfusão/prevenção & controle , Vasodilatadores/farmacologia , Animais , Antioxidantes/análise , Biomarcadores/sangue , Modelos Animais de Doenças , Precondicionamento Isquêmico/métodos , Masculino , Malondialdeído/sangue , Oxidantes/sangue , Estresse Oxidativo , Ereção Peniana/efeitos dos fármacos , Pênis/patologia , Priapismo/patologia , Distribuição Aleatória , Ratos Sprague-Dawley , Reprodutibilidade dos Testes , Albumina Sérica , Albumina Sérica Humana , Fatores de Tempo , Resultado do TratamentoRESUMO
ABSTRACT Purpose To investigate the protective effects against ischemia reperfusion injury of dipyridamole in a model of induced priapism in rats. Materials and Methods Twenty-four male Sprague-Dawley rats were divided into four groups, control, P/R, P/R+DMSO and P/R+D. 3ml blood specimens were collected from vena cava inferior in order to determine serum MDA, IMA, TAS, TOS and OSI values, and penile tissue was taken for histopathological examination in control group. Priapism was induced in P/R group. After 1h, priapism was concluded and 30 min reperfusion was performed. In P/R+DMSO group 1ml/kg DMSO was administered intraperitoneally 30 min before reperfusion, while in P/R+D group 10mg/kg dipyridamole was administered intraperitoneally 30 min before reperfusion. Blood and penis specimens were collected after the end of 30 min reperfusion period. Sinusoidal area (µm2), tears in tunica albuginea and injury parameters in sinusoidal endothelium of penis were investigated. Results Histopathological examination revealed no significant changes in term of sinusoidal area. A decrease in tears was observed in P/R+D group compared to P/R group (p<0.05). Endothelial injury decreased in P/R+D group compared to P/R group (p>0.05). There were no significant differences in MDA and IMA values between groups. A significant increase in TOS and OSI values was observed in P/R+D group compared to P/R group. A significant decrease in TAS levels was observed in P/R+D group compared to the P/R group. Conclusions The administration of dipyridamole before reperfusion in ischemic priapism model has a potential protective effect against histopathological injury of the penis.