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The possible protective effects of dipyridamole on ischemic reperfusion injury of priapism.
Karaguzel, Ersagun; Bayraktar, Cemil; Kutlu, Omer; Yulug, Esin; Mentese, Ahmet; Okatan, Ali Ertan; Colak, Fatih; Ozer, Serap; Kazaz, Ilke O.
Afiliação
  • Karaguzel E; Department of Urology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
  • Bayraktar C; Department of Urology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
  • Kutlu O; Department of Urology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
  • Yulug E; Department of Histology and Embryology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
  • Mentese A; Department of Medical Biochemistry, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
  • Okatan AE; Department of Urology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
  • Colak F; Department of Urology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
  • Ozer S; Department of Medical Biochemistry, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
  • Kazaz IO; Department of Urology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Int Braz J Urol ; 42(1): 146-53, 2016.
Article em En | MEDLINE | ID: mdl-27136481
PURPOSE: To investigate the protective effects against ischemia reperfusion injury of dipyridamole in a model of induced priapism in rats. MATERIALS AND METHODS: Twenty-four male Sprague-Dawley rats were divided into four groups, control, P/R, P/R+DMSO and P/R+D. 3ml blood specimens were collected from vena cava inferior in order to determine serum MDA, IMA, TAS, TOS and OSI values, and penile tissue was taken for histopathological examination in control group. Priapism was induced in P/R group. After 1h, priapism was concluded and 30 min reperfusion was performed. In P/R+DMSO group 1ml/kg DMSO was administered intraperitoneally 30 min before reperfusion, while in P/R+D group 10mg/kg dipyridamole was administered intraperitoneally 30 min before reperfusion. Blood and penis specimens were collected after the end of 30 min reperfusion period. Sinusoidal area (µm2), tears in tunica albuginea and injury parameters in sinusoidal endothelium of penis were investigated. RESULTS: Histopathological examination revealed no significant changes in term of sinusoidal area. A decrease in tears was observed in P/R+D group compared to P/R group (p<0.05). Endothelial injury decreased in P/R+D group compared to P/R group (p>0.05). There were no significant differences in MDA and IMA values between groups. A significant increase in TOS and OSI values was observed in P/R+D group compared to P/R group. A significant decrease in TAS levels was observed in P/R+D group compared to the P/R group. CONCLUSIONS: The administration of dipyridamole before reperfusion in ischemic priapism model has a potential protective effect against histopathological injury of the penis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pênis / Priapismo / Vasodilatadores / Traumatismo por Reperfusão / Dipiridamol / Isquemia Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Int Braz J Urol Assunto da revista: UROLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pênis / Priapismo / Vasodilatadores / Traumatismo por Reperfusão / Dipiridamol / Isquemia Tipo de estudo: Evaluation_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Int Braz J Urol Assunto da revista: UROLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil