RESUMO
OBJECTIVE: The aim of this study was to assess analgesic and adjuvant anesthetic effects of submucosal tramadol after third molar extraction. STUDY DESIGN: In this double-blind, split-mouth, placebo-controlled, single-dose, crossover investigation, 52 patients underwent mandibular third molar extraction under local anesthesia. Surgical side was randomly assigned to submucosal 2 mL 100 mg tramadol injection (group T) or normal saline solution (group P) immediately after surgery. Anesthetic blockade duration, time of intake and amount of analgesic rescue drug, and postoperative pain intensity were recorded immediately after anesthesia cessation and 4, 8, 24, 48, and 72 hours after surgery. Data were submitted to analysis of variance and Wilcoxon tests. RESULTS: Anesthetic blockade duration between groups was similar. Group T took significantly less rescue drug after 72 hours (P = .008). Time elapsed before first intake of rescue drug was longer (P = .006), and pain intensity was significantly lower (P = .001) in group T. CONCLUSIONS: Submucosal tramadol injection after oral surgery improved postoperative analgesia, but did not extend anesthetic action duration.
Assuntos
Adjuvantes Anestésicos/uso terapêutico , Analgésicos Opioides/uso terapêutico , Dente Serotino/cirurgia , Extração Dentária , Tramadol/uso terapêutico , Adjuvantes Anestésicos/administração & dosagem , Adolescente , Adulto , Analgésicos Opioides/administração & dosagem , Anestesia Local/métodos , Estudos Cross-Over , Método Duplo-Cego , Feminino , Humanos , Injeções , Masculino , Mandíbula/cirurgia , Medição da Dor , Dor Pós-Operatória/prevenção & controle , Placebos , Estudos Prospectivos , Tramadol/administração & dosagemRESUMO
AIMS: The effects of glargine insulin therapy in pregnancies are not well established. We compared maternal and neonatal outcomes of women with pregestational and gestational diabetes treated with glargine or NPH insulin. METHODS: A prospective cohort study was conducted analyzing outcomes from 56 women with pregestational and 82 with gestational diabetes treated with either insulin regimen. RESULTS: Comparisons were performed among 138 women: 56 with pregestational and 82 with gestational diabetes. In relation to maternal complications, worsening of retinopathy and nephropathy, preeclampsia, micro and macroalbuminuria, and all kinds of hypoglycemia were found higher in women with pregestational diabetes NPH-treated vs. glargine-treated. In women with gestational diabetes NPH-treated, it was observed increased incidence of prepregnancy and new-onset pregnancy hypertension, micro and macroalbuminuria, as well as mild and frequent hypoglycemia, compared to glargine-treated. Among the neonatal outcomes, 1-min Apgar score <7, necessity of intensive care unit and fetal death in pregestational, while jaundice and congenital malformations in gestational diabetes, respectively, were more frequently observed in infants born to NPH-treated, compared to glargine-treated. CONCLUSIONS: Glargine use during pregnancy from preconception through delivery, showed to be safe since it is associated with decreased maternal and neonatal adverse outcomes compared with NPH insulin-treated patients.
Assuntos
Diabetes Gestacional/tratamento farmacológico , Diabetes Gestacional/epidemiologia , Insulina Isófana/administração & dosagem , Insulina/análogos & derivados , Gravidez em Diabéticas/tratamento farmacológico , Gravidez em Diabéticas/epidemiologia , Adulto , Complicações do Diabetes/tratamento farmacológico , Complicações do Diabetes/epidemiologia , Feminino , Seguimentos , Humanos , Hipoglicemiantes/administração & dosagem , Incidência , Recém-Nascido , Doenças do Recém-Nascido/epidemiologia , Insulina/administração & dosagem , Insulina Glargina , Insulina de Ação Prolongada , Gravidez , Resultado da Gravidez/epidemiologia , Prevalência , Estudos Prospectivos , Fatores de Risco , Resultado do Tratamento , Adulto JovemRESUMO
Objetivos: Avaliamos o efeito crônico do Verapamil (agente bloqueador de canais para cálcio) sobre o processo de reparação tecidual em ratos diabéticos. Material e Métodos: Foram utilizados 36 ratos albinos Wistar, subdivididos em três grupos: Controle (C), Diabético(D); Diabético tratado com verapamil IP 10 mg/Kg peso corpóreo/dia (DVe). A indução do diabetes foi promovida pela administração de alloxano (40mg/Kg peso corpóreo) e confirmada através de análise plasmática de glicose (glucosímetro).Todos os animais foram sacrificados nos períodos de 15, 30, 45 e 60 dias após ciriurgia do incisivo central superior, e submetidos a análises histológicas e histomorfométricas. Resultados: Observamos variações significativas nos valores de formação da matriz óssea nos Grupos D e DVe em todos os períodos avaliados. Conclusões: O uso crônico do verapamil (grupo Dve) alterou significativamente a matriz óssea neoformada (p<0.01) quando comparado ao grupo Diabético. A qualidade da estrutura óssea nos grupos induzidos a condição diabética foram semelhantes. A velocidade do processo de reparação tecidual foi maior no grupo Dve comparado ao grupo D (p<0.01).