RESUMO

The aim of this study was to elucidate whether glutathione is involved in lithium's ability to decrease carbonylation and nitration produced by complex I inhibition, which is consistently found in BD. Neuroblastoma cells were treated with rotenone, a complex I inhibitor. Our results suggest that glutathione is essential for lithium's ability to ameliorate rotenone-induced protein carbonylation, but not nitration.

Assuntos

Complexo I de Transporte de Elétrons/antagonistas & inibidores , Glutationa/metabolismo , Compostos de Lítio/farmacologia , Carbonilação Proteica/efeitos dos fármacos , Tirosina/análogos & derivados , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Sobrevivência Celular/fisiologia , Humanos , Imuno-Histoquímica , Neuroblastoma/metabolismo , Rotenona/farmacologia , Tirosina/metabolismo , Desacopladores/farmacologia